Cancer cells often develop genetic mutations that initiate and sustain the growth of tumors. The most frequently mutated of these oncogenic driver genes, called KRAS, is associated with some of the most fatal cancer types: lung, pancreatic and colorectal cancers.

The replacement of the amino acid glycine at position 12 leads to mutations that have been dubbed G12C, G12D, G12R, G12V and others, depending on which amino acid replaces...