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HREMF transmission electron microscopy is featured in high impact publications
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers in Western countries, with a dormant subpopulation of cancer cells being able to survive oncogene ablation and cause tumor relapse. Analysis of surviving cells suggests mitochondrial and autophagic functions are enhanced. In this work, the authors rely on our expertise with transmission electron microscopy to identify autophagic structures in PDAC cells and to examine the morphology of mitochondria in surviving cancer cells.
Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sanchex N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, Deem AK, Kapoor A, Yao W, Brunetto E, Kang Y, Yuan M, Asara JM, Wang YA, Heffernan TP, Kimmelman AC, Wang H, Fleming JB, Cantley LC, DePinho RA, Draetta GF. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature 514(7524):628-32, 2014.
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Zhang L. et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature 527(7576):100-4, 2015.
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