Publications
2023
- Parra, E. R., Zhang, J., Jiang, M., Tamegnon, A., Pandurengan, R. K., Behrens, C., Solis, L., Haymaker, C., Heymach, J. V., Moran, C., Lee, J. J., Gibbons, D. & Wistuba, I. I. Immune cellular patterns of distribution affect outcomes of patients with non-small cell lung cancer. Nat. Commun. 14, 2364 (2023).
- Iyengar, P., Gandhi, A. Y., Granados, J., Guo, T., Gupta, A., Yu, J., Llano, E. M., Zhang, F., Gao, A., Kandathil, A., Williams, D., Gao, B., Girard, L., Malladi, V. S., Shelton, J. M., Evers, B. M., Hannan, R., Ahn, C., Minna, J. D. & Infante, R. E. Tumor loss-of-function mutations in STK11/LKB1 induce cachexia. JCI Insight 8, (2023).
- Patel, S. A., Nilsson, M. B., Yang, Y., Le, X., Tran, H. T., Elamin, Y. Y., Yu, X., Zhang, F., Poteete, A., Ren, X., Shen, L., Wang, J., Moghaddam, S. J., Cascone, T., Curran, M., Gibbons, D. L. & Heymach, J. V. IL6 Mediates Suppression of T- and NK-cell Function in EMT-associated TKI-resistant EGFR-mutant NSCLC. Clin. Cancer Res. 29, 1292–1304 (2023).
- Concannon, K., Morris, B. B., Gay, C. M. & Byers, L. A. Combining targeted DNA repair inhibition and immune-oncology approaches for enhanced tumor control. Mol. Cell 83, 660–680 (2023).
- Kim, J. & Minna, J. D. Moving toward precision medicine with lung cancer organoids. Cell Rep. Med. 4, 100952 (2023).
- Wang, S., Rong, R., Yang, D. M., Fujimoto, J., Bishop, J. A., Yan, S., Cai, L., Behrens, C., Berry, L. D., Wilhelm, C., Aisner, D., Sholl, L., Johnson, B. E., Kwiatkowski, D. J., Wistuba, I. I., Bunn, P. A., Minna, J., Xiao, G., Kris, M. G. & Xie, Y. Features of tumor-microenvironment images predict targeted therapy survival benefit in patients with EGFR-mutant lung cancer. J. Clin. Invest. 133, (2023).
- Patel, S. A., Nilsson, M. B., Le, X., Cascone, T., Jain, R. K. & Heymach, J. V. Molecular mechanisms and future implications of VEGF/VEGFR in cancer therapy. Clin. Cancer Res. 29, 30–39 (2023).
- Sun, B., Laberiano-Fernández, C., Salazar-Alejo, R., Zhang, J., Solorzano Rendon, J. L., Lee, J., Solis Soto, L. M., Wistuba, I. I. & Parra, E. R. Impact of Region-of-Interest Size on Immune Profiling Using Multiplex Immunofluorescence Tyramide Signal Amplification for Paraffin-Embedded Tumor Tissues. Pathobiology 90, 1–12 (2023).
- Huffman, K. E., Li, L. S., Carstens, R., Park, H., Girard, L., Avila, K., Wei, S., Kollipara, R., Timmons, B., Sudderth, J., Bendris, N., Kim, J., Villalobos, P., Fujimoto, J., Schmid, S., Deberardinis, R. J., Wistuba, I., Heymach, J., Kittler, R., Akbay, E. A., Posner, B., Wang, Y., Lam, S., Kliewer, S. A., Mangelsdorf, D. J. & Minna, J. D. Glucocorticoid mediated inhibition of LKB1 mutant non-small cell lung cancers. Front. Oncol. 13, 1025443 (2023).
2022
- Pongor, L. S., Tlemsani, C., Elloumi, F., Arakawa, Y., Jo, U., Gross, J. M., Mosavarpour, S., Varma, S., Kollipara, R. K., Roper, N., Teicher, B. A., Aladjem, M. I., Reinhold, W., Thomas, A., Minna, J. D., Johnson, J. E. & Pommier, Y. Integrative epigenomic analyses of small cell lung cancer cells demonstrates the clinical translational relevance of gene body methylation. iScience 25, 105338 (2022).
- Park, J. V., Chandra, R., Cai, L., Ganguly, D., Li, H., Toombs, J. E., Girard, L., Brekken, R. A. & Minna, J. D. Tumor Cells Modulate Macrophage Phenotype in a Novel In Vitro Co-Culture Model of the NSCLC Tumor Microenvironment. J. Thorac. Oncol. 17, 1178–1191 (2022).
- Moore, C., Bae, J., Liu, L., Li, H., Fu, Y.-X. & Qiao, J. Exogenous signaling repairs defective T cell signaling inside the tumor microenvironment for better immunity. JCI Insight 7, (2022).
- Pachnis, P., Wu, Z., Faubert, B., Tasdogan, A., Gu, W., Shelton, S., Solmonson, A., Rao, A. D., Kaushik, A. K., Rogers, T. J., Ubellacker, J. M., LaVigne, C. A., Yang, C., Ko, B., Ramesh, V., Sudderth, J., Zacharias, L. G., Martin-Sandoval, M. S., Do, D., Mathews, T. P., Zhao, Z., Mishra, P., Morrison, S. J. & DeBerardinis, R. J. In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors. Sci. Adv. 8, eabn9550 (2022).
- Kelenis, D. P., Rodarte, K. E., Kollipara, R. K., Pozo, K., Choudhuri, S. P., Spainhower, K. B., Wait, S. J., Stastny, V., Oliver, T. G. & Johnson, J. E. Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer. Cancer Res. 82, 3058–3073 (2022).
- Cai, L., DeBerardinis, R. J., Xiao, G., Minna, J. D. & Xie, Y. A Pan-Cancer Assessment of RB1/TP53 Co-Mutations. Cancers (Basel) 14, (2022).
- Terajima, M., Taga, Y., Nakamura, T., Guo, H.-F., Kayashima, Y., Maeda-Smithies, N., Parag-Sharma, K., Kim, J. S., Amelio, A. L., Mizuno, K., Kurie, J. M. & Yamauchi, M. Lysyl hydroxylase 2 mediated collagen post-translational modifications and functional outcomes. Sci. Rep. 12, 14256 (2022).
- von Itzstein, M. S., Gerber, D. E. & Minna, J. D. Circulating mitochondrial DNA as a biomarker for lung cancer screening. Transl. Lung Cancer Res. 11, 1522–1525 (2022).
- Wang, Y., Song, B., Wang, S., Chen, M., Xie, Y., Xiao, G., Wang, L. & Wang, T. Sprod for de-noising spatially resolved transcriptomics data based on position and image information. Nat. Methods 19, 950–958 (2022).
- Han, J. H., Kim, Y. K., Kim, H., Lee, J., Oh, M. J., Kim, S. B., Kim, M., Kim, K. H., Yoon, H. J., Lee, M.-S., Minna, J. D., White, M. A. & Kim, H. S. Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells. Cancer Commun (Lond) 42, 716–749 (2022).
- Bartolacci, C., Andreani, C., Vale, G., Berto, S., Melegari, M., Crouch, A. C., Baluya, D. L., Kemble, G., Hodges, K., Starrett, J., Politi, K., Starnes, S. L., Lorenzini, D., Raso, M. G., Solis Soto, L. M., Behrens, C., Kadara, H., Gao, B., Wistuba, I. I., Minna, J. D., McDonald, J. G. & Scaglioni, P. P. Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer. Nat. Commun. 13, 4327 (2022).
- DeBerardinis, R. J. & Keshari, K. R. Metabolic analysis as a driver for discovery, diagnosis, and therapy. Cell 185, 2678–2689 (2022).
- Muraki, N., Yamada, M., Doki, H., Nakai, R., Komeda, K., Goto, D., Kawabe, N., Matsuoka, K., Matsushima, M., Kawabe, T., Tanaka, I., Morise, M., Shay, J. W., Minna, J. D. & Sato, M. Resistance to mutant KRASV12-induced senescence in an hTERT/Cdk4-immortalized normal human bronchial epithelial cell line. Exp. Cell Res. 414, 113053 (2022).
- Bajaj, R., Warner, A. N., Fradette, J. F. & Gibbons, D. L. Dance of the golgi: understanding golgi dynamics in cancer metastasis. Cells 11, (2022).
- Kim, S. T., Chu, Y., Misoi, M., Suarez-Almazor, M. E., Tayar, J. H., Lu, H., Buni, M., Kramer, J., Rodriguez, E., Hussain, Z., Neelapu, S. S., Wang, J., Shah, A. Y., Tannir, N. M., Campbell, M. T., Gibbons, D. L., Cascone, T., Lu, C., Blumenschein, G. R., Altan, M., Lim, B., Valero, V., Loghin, M. E., Tu, J., Westin, S. N., Naing, A., Garcia-Manero, G., Abdel-Wahab, N., Tawbi, H. A., Hwu, P., Oliva, I. C. G., Davies, M. A., Patel, S. P., Zou, J., Futreal, A., Diab, A., Wang, L. & Nurieva, R. Distinct molecular and immune hallmarks of inflammatory arthritis induced by immune checkpoint inhibitors for cancer therapy. Nat. Commun. 13, 1970 (2022).
- Meraz, I. M., Majidi, M., Shao, R., Meng, F., Ha, M. J., Shpall, E. & Roth, J. A. TUSC2 immunogene enhances efficacy of chemo-immuno combination on KRAS/LKB1 mutant NSCLC in humanized mouse model. Commun. Biol. 5, 167 (2022).
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