Publications

* Co-first authors, # Corresponding authors

2023

Kong Q*#, Xia S*, Pan X, Ye K, Li Z, Li H, Tang X, Sahni N, Yi SS, Liu X, Wu H, Elowitz MB, Lieberman J, Zhang Z#. Alternative splicing of GSDMB modulates killer lymphocyte-triggered pyroptosis. Sci Immunol. 2023 Apr 28;8(82):eadg3196.doi:10.1126/sciimmunol.adg3196. Epub 2023 Apr 28.PMID: 37115914 

Kong Q, Zhang Z. Cancer-associated pyroptosis: A new license to kill tumor. Front Immunol. 2023 Jan 18;14:1082165. doi: 10.3389/fimmu.2023.1082165. eCollection 2023.PMID: 36742298 

2022

Deng W, Bai Y, Deng F, Pan Y, Mei S, Zheng Z, Min R, Wu Z, Li W, Miao R, Zhang Z, Kupper TS, Lieberman J, Liu X. Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis. Nature. 2022 Feb 2:1-7.

Meza-Sosa KF, Miao R, Navarro F, Zhang Z, Zhang Y, Hu JJ, Hartford CC, Li XL, Pedraza-Alva G, Pérez-Martínez L, Lal A, Wu H, Lieberman J. SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage. Molecular Cell. 2022 Jan 31.

2021

Liu X*#, Xia S*, Zhang Z*, Wu H#, Lieberman J#. Channeling inflammation: gasdermins in physiology and disease. Nat Rev Drug Discov. 2021 May;20(5):384-405. PMID: 33692549; PMCID: PMC7944254.

Zheng Z, Deng W, Bai Y, Miao R, Mei S, Zhang Z, Pan Y, Wang Y, Min R, Deng F, Wu Z, Li W, Chen P, Ma T, Lou X, Liberman J, Liu X. The lysosomal Rag-Ragulator complex licenses RIPK1–and caspase-8–mediated pyroptosis by Yersinia. Science. 2021 Jun 25;372(6549):eabg0269.

Zhang Z, Zhang Y, Lieberman J. Lighting a Fire: Can We Harness Pyroptosis to Ignite Antitumor Immunity? Cancer Immunol Res. 2021 Jan;9(1):2-7. PMID: 33397791; PMCID: PMC7789047.

Xia S, Zhang Z, Magupalli VG, Pablo JL, Dong Y, Vora SM, Wang L, Fu TM, Jacobson MP, Greka A, Lieberman J, Ruan J, Wu H. Gasdermin D pore structure reveals preferential release of mature interleukin-1. Nature. 2021 May;593(7860):607-611. PMID: 33883744; PMCID: PMC8588876.

Liu Y, Zhong X, Zhang Z, Lan J, Huang X, Tian H, Li X, Zhang Y. Receptor-like kinases MDS1 and MDS2 promote SUMM2-mediated immunity. J Integr Plant Biol. 2021 Feb;63(2):277-282. PMID: 32497412.

2020

Zhang Z, Lieberman J. Lighting a fire on the reef. Sci Immunol. 2020 Dec 4;5(54):eabf0905. PMID: 33277372; PMCID: PMC7900804.

Hu JJ*, Liu X*#, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth LR, Magupalli VG, Zhao L, Luo HR, Kim J, Lieberman J#, Wu H#. FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nat Immunol. 2020 Jul;21(7):736-745. PMID: 32367036; PMCID: PMC7316630.

Zhang Z*#, Zhang Y*, Xia S, Kong Q, Li S, Liu X, Junqueira C, Meza-Sosa KF, Mok TMY, Ansara J, Sengupta S, Yao Y, Wu H, Lieberman J#. Gasdermin E suppresses tumor growth by activating anti-tumor immunity. Nature. 2020 Mar;579(7799):415-420. PMID: 32188940; PMCID: PMC7123794.

Research Highlight: Minton K. Pyroptosis heats tumour immunity. Nat Rev Immunol. 2020 May;20(5):274-275. PMID: 32203327.

Editors’ Choice: Foley JF. Destroying tumors with pyroptosis. Sci Signal. 2020 Mar 24;13(624).

Research Highlight: Shen C, Pandey A, Man SM. Gasdermins deliver a deadly punch to cancer. Cell Res. 2020 Jun;30(6):463-464. PMID: 32327717; PMCID: PMC7264324.

2018

Liu X, Fu R, Pan Y, Meza-Sosa KF, Zhang Z, Lieberman J. PNPT1 Release from Mitochondria during Apoptosis Triggers Decay of Poly(A) RNAs. Cell. 2018 Jun 28;174(1):187-201. PMID: 29779946.

2017

Li X, Zhang Z, Li L, Gong W, Lazenby AJ, Swanson BJ, Herring LE, Asara JM, Singer JD, Wen H. Myeloid-derived cullin 3 promotes STAT3 phosphorylation by inhibiting OGT expression and protects against intestinal inflammation. J Exp Med.2017 Apr 3;214(4):1093-1109. PMID: 28280036; PMCID: PMC5379975.

Zhang Z*, Liu Y*, Huang H*, Gao M, Wu D, Kong Q, Zhang Y. The NLR protein SUMM2 senses the disruption of an immune signaling MAP kinase cascade via CRCK3. EMBO Rep. 2017 Feb;18(2):292-302. PMID: 27986791; PMCID: PMC5286374. 

2016

Liu X*, Zhang Z*, Ruan J*, Pan Y, Magupalli VG, Wu H, Lieberman J. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature. 2016 Jul 7;535(7610):153-8. PMID: 27383986; PMCID: PMC5539988.

News and Commentary: Wright JA, Bryant CE. The killer protein Gasdermin D. Cell Death Differ. 2016 Dec;23(12):1897-1898. PMID: 27636106; PMCID: PMC5136481.

News and Views: Gaidt MM, Hornung V. Pore formation by GSDMD is the effector mechanism of pyroptosis. EMBO J. 2016 Oct 17;35(20):2167-2169. PMID: 27572465; PMCID: PMC5069554.

Comment: Rühl S, Broz P. The gasdermin-D pore: Executor of pyroptotic cell death. Oncotarget. 2016 Sep 6;7(36):57481-57482. PMID: 27557502; PMCID: PMC5295365.

Kong Q, Sun T, Qu N, Ma J, Li M, Cheng YT, Zhang Q, Wu D, Zhang Z, Zhang Y. Two Redundant Receptor-Like Cytoplasmic Kinases Function Downstream of Pattern Recognition Receptors to Regulate Activation of SA Biosynthesis. Plant Physiol. 2016 Jun;171(2):1344-54. PMID: 27208222; PMCID: PMC4902587.

2014

Zhang Z*, Liu Y*, Ding P, Li Y, Kong Q, Zhang Y. Splicing of receptor-like kinase-encoding SNC4 and CERK1 is regulated by two conserved splicing factors that are required for plant immunity. Mol Plant. 2014 Dec;7(12):1766-75. PMID: 25267732; PMCID: PMC4261838. 

Zhao C, Gillette DD, Li X, Zhang Z, Wen H. Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation. J Biol Chem. 2014 Jun 13;289(24):17020-9. PMID: 24798340; PMCID: PMC4059144.

2012

Zhang Z, Wu Y, Gao M, Zhang J, Kong Q, Liu Y, Ba H, Zhou J, Zhang Y. Disruption of PAMP-induced MAP kinase cascade by a Pseudomonas syringae effector activates plant immunity mediated by the NB-LRR protein SUMM2. Cell Host Microbe. 2012 Mar 15;11(3):253-63. PMID: 22423965.

Kong Q, Qu N, Gao M, Zhang Z, Ding X, Yang F, Li Y, Dong OX, Chen S, Li X, Zhang Y. The MEKK1-MKK1/MKK2-MPK4 kinase cascade negatively regulates immunity mediated by a mitogen-activated protein kinase kinase kinase in Arabidopsis. Plant Cell. 2012 May;24(5):2225-36. PMID: 22643122; PMCID: PMC3442598.

2011

Xu S, Zhang Z, Jing B, Gannon P, Ding J, Xu F, Li X, Zhang Y. Transportin-SR is required for proper splicing of resistance genes and plant immunity. PLoS Genet. 2011 Jun;7(6):e1002159. PMID: 21738492; PMCID: PMC3128105.

2009

Ge J, Xu H, Li T, Zhou Y, Zhang Z, Li S, Liu L, Shao F. A Legionella type IV effector activates the NF-kappaB pathway by phosphorylating the IkappaB family of inhibitors. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13725-30. PMID: 19666608; PMCID: PMC2728961.

Gao M, Wang X, Wang D, Xu F, Ding X, Zhang Z, Bi D, Cheng YT, Chen S, Li X, Zhang Y. Regulation of cell death and innate immunity by two receptor-like kinases in Arabidopsis. Cell Host Microbe. 2009 Jul 23;6(1):34-44. PMID: 19616764.

2008

Gao M, Liu J, Bi D, Zhang Z, Cheng F, Chen S, Zhang Y. MEKK1, MKK1/MKK2 and MPK4 function together in a mitogen-activated protein kinase cascade to regulate innate immunity in plants. Cell Res. 2008 Dec;18(12):1190-8. PMID: 18982020.