Publications
2023–2024
Shi W, Wang Y, Zhao Y, Kim JJ, Li H, Meng C, Chen F, Zhang J, Mak DH, Van V, Leo J, St Croix B, Aparicio A, Zhao D. Immune Checkpoint B7-H3 is a Therapeutic Vulnerability in Prostate Cancer Harboring PTEN and TP53 Deficiencies. Sci Transl Med. 15(695):eadf6724, 5/2023. Epub 2023 May. PMID: 37163614; PMCID: PMC10574140.
Li H, Gigi L, Zhao D. CHD1, a multifaceted epigenetic remodeler in prostate cancer. Frontiers in Oncology. 1/2023. 13. doi: 10.3389/fonc.2023.1123362. Epub 2023 Jan. PMID: 36776288; PMCID: PMC9909554.
2021–2022
Li H, Wang Y, Lin K, Venkadakrishnan VB, Bakht M, Shi W, Meng C, Zhang J, Tremble K, Liang X, Song JH, Feng X, Van V, Deng P, Burks JK, Aparicio A, Keyomarsi K, Chen J, Lu Y, Beltran H, Zhao D. CHD1 promotes sensitivity to Aurora kinase inhibitors by suppressing interaction of AURKA with its coactivator TPX2. Cancer Res. 2022 Jun 30:can.22.0631. doi: 10.1158/0008-5472.CAN-22-0631. Epub ahead of print. PMID: 35771632; PMCID: PMC9444962.
Lee R, Li J, Li J, Wu CJ, Jiang S, Hsu WH, Chakravarti D, Chen P, LaBella KA, Li J, Spring DJ, Zhao D, Wang YA, DePinho RA. Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer. Cancer Discov. 2022 Jul 6;12(7):1702-1717. doi: 10.1158/2159-8290.CD-21-0680. PMID: 35537038; PMCID: PMC9262860.
Miyahira AK, Zarif JC, Coombs CC, Flavell RR, Russo JW, Zaidi S, Zhao D, Zhao SG, Pienta KJ, Soule HR. Prostate cancer research in the 21st century; report from the 2021 Coffey-Holden prostate cancer academy meeting. Prostate. 2022 Feb;82(2):169-181. doi: 10.1002/pros.24262. Epub 2021 Nov 3. PMID: 34734426; PMCID: PMC8688282.
Deng Y, Xia X, Zhao Y, Zhao Z, Martinez C, Yin W, Yao J, Hang Q, Wu W, Zhang J, Yu Y, Xia W, Yao F, Zhao D, Sun Y, Ying H, Hung MC, Ma L. Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance. Nat Commun. 2021 Dec 6;12(1):7041. doi: 10.1038/s41467-021-27349-7. PMID: 34873175; PMCID: PMC8649069.
2019–2020
Chakravarti D, Hu B, Mao X, Rashid A, Li J, Li J, Liao WT, Whitley EM, Dey P, Hou P, LaBella KA, Chang A, Wang G, Spring DJ, Deng P, Zhao D, Liang X, Lan Z, Lin Y, Sarkar S, Terranova C, Deribe YL, Blutt SE, Okhuysen P, Zhang J, Vilar E, Nielsen OH, Dupont A, Younes M, Patel KR, Shroyer NF, Rai K, Estes MK, Wang YA, Bertuch AA, DePinho RA. Telomere dysfunction activates YAP1 to drive tissue inflammation. Nat Commun. 2020 Sep 21;11(1):4766. doi: 10.1038/s41467-020-18420-w. PMID: 32958778; PMCID: PMC7505960.
Zhao D#, Cai L#, Lu X#, Liang X, Li J, Chen P, Ittmann MM, Shang X, Jiang S, Li H, Meng C, Flores I, Song JH, Horner JW, Lan Z, Wu CJ, Li J, Chang Q, Chen KC, Wang G, Deng P, Spring DJ, Wang YA, DePinho RA. Chromatin Regulator, CHD1, Remodels Immunosuppressive Tumor Microenvironment in PTEN-Deficient Prostate Cancer. Cancer Discov. 2020 May 8; CD-19-1352. doi: 10.1158/2159-8290. PMID: 32385075; PMCID: PMC7483306.
Chen P, Zhao D, Li J, Liang X, Li J, Chang A, Henry V, Lan Z, Spring DJ, Rao G, Wang Y, DePinho RA. Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma. Cancer Cell. 2019 Jun 10;35(6):868-884.e6. PMID: 31185211; PMCID: PMC6561349.
Liao W, Overman MJ, Boutin AT, Shang X, Zhao D, Dey P, Li J, Wang G, Lan Z, Li J, Tang M, Jiang S, Ma X, Chen P, Katkhuda R, Korphaisarn K, Chakravarti D, Chang A, Spring DJ, Chang Q, Zhang J, Maru DM, Maeda DY, Zebala JA, Kopetz S, Wang YA, DePinho RA. KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer. Cancer Cell. 2019 Apr 15;35(4):559-572.e7. doi: 10.1016/j.ccell.2019.02.008. Epub 2019 Mar 21. PMID: 30905761; PMCID: PMC6467776.
2017–2018
Wang G#, Zhao D#, Spring DJ, DePinho RA. Genetics and Biology of Prostate Cancer. Genes & Dev. 2018 Sep 1;32(17-18):1105-1140. PMID: 30181359; PMCID: PMC6120714.
Lu X, Pan X, Wu CJ, Zhao D, Feng S, Zang Y, Lee R, Khadka S, Amin SB, Jin EJ, Shang X, Deng P, Luo Y, Morgenlander WR, Weinrich J, Lu X, Jiang S, Chang Q, Navone NM, Troncoso P, DePinho RA, Wang YA. An in vivo screen identifies PYGO2 as a driver for metastatic prostate cancer. Cancer Res. 2018 Jul 15;78(14):3823-3833. doi: 10.1158/0008-5472.CAN-17-3564. Epub 2018 May 16. PMID: 29769196; PMCID: PMC6381393.
Zhao D, DePinho RA. Synthetic Essentiality: Targeting tumor suppressor deficiencies in cancer. BioEssays. 2017 Aug;39(8). PMID: 28675450; PMCID: PMC8610080.
Zhao D, Lu X, Wang G, Lan Z, Liao W, Li J, Liang X, Chen JR, Shah S, Shang X, Tang M, Deng P, Dey P, Chakravarti D, Chen P, Spring DJ, Navone NM, Troncoso P, Zhang J, Wang YA, DePinho RA. Synthetic essentiality of chromatin remodeling factor CHD1 in PTEN-deficient cancer. Nature. 2017; 542(7642): 484-488. PMID: 28166537; PMCID: PMC5448706.
Dey P, Baddour J, Muller F, Wu CC, Wang H, Liao WT, Lan Z, Chen A, Gutschner T, Kang Y, Fleming J, Satani N, Zhao D, Achreja A, Yang L, Lee J, Chang E, Genovese G, Viale A, Ying H, Draetta G, Maitra A, Wang YA, Nagrath D, DePinho RA. Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. Nature. 2017; 542(7639): 119-123. doi: 10.1038/nature21052. Epub 2017 Jan 18. PMID: 28099419; PMCID: PMC5398413.
2016 and earlier
Wang G, Lu X, Dey P, Deng P, Wu CC, Jiang S, Fang Z, Zhao K, Konaparthi R, Hua S, Zhang J, Li-Ning-Tapia EM, Kapoor A, Wu CJ, Patel NB, Guo Z, Ramamoorthy V, Tieu TN, Heffernan T, Zhao D, Shang X, Khadka S, Hou P, Hu B, Jin EJ, Yao W, Pan X, Ding Z, Shi Y, Li L, Chang Q, Troncoso P, Logothetis CJ, McArthur MJ, Chin L, Wang YA, DePinho RA. Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression. Cancer Discovery. 2016; 6(1): 80-95. doi: 10.1158/2159-8290.CD-15-0224. Epub 2015 Dec 23. PMID: 26701088; PMCID: PMC4707102.
Zhao D, Mo Y, Li MT, Zou SW, Cheng ZL, Sun YP, Xiong Y, Guan KL, Lei QY. NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. J Clin. Invest. 2014; 124(12): 5453-5465. doi: 10.1172/JCI76611. Epub 2014 Nov 10. PMID: 25384215; PMCID: PMC4348941.
Zhao D#, Zou SW#, Liu Y, Zhou X, Mo Y, Wang P, Xu YH, Dong B, Xiong Y, Lei QY, Guan KL. Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer. Cancer Cell. 2013; 23(4): 464-476. doi: 10.1016/j.ccr.2013.02.005. Epub 2013 Mar 21. PMID: 23523103; PMCID: PMC3885615.
Lv L#, Xu YP#, Zhao D, Li FL, Wang W, Sasaki N, Jiang Y, Zhou X, Li TT, Guan KL, Lei QY, Xiong Y. Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization. Molecular Cell. 2013; 52(3): 340-352. doi: 10.1016/j.molcel.2013.09.004. Epub 2013 Oct 10. PMID: 24120661; PMCID: PMC4183148.
Zhao D, Xiong Y, Lei QY, Guan KL. LDH-A Acetylation: Implication in Cancer. Oncotarget. 2013; 4(6): 802-803. doi: 10.18632/oncotarget.1007. PMID: 23868819; PMCID: PMC3757233.
Lv L, Li D, Zhao D, Lin R, Chu Y, Zhang H, Zha Z, Liu Y, Li Z, Xu Y, Wang G, Huang Y, Xiong Y, Guan KL, Lei QY. Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Molecular Cell. 2011; Jun 24;42(6):719-30. doi: 10.1016/j.molcel.2011.04.025. PMID: 21700219; PMCID: PMC4879880.
Lv L, Li D, Zhao D, Lin R, Chu Y, Zhang H, Zha Z, Liu Y, Li Z, Xu Y, Wang G, Huang Y, Xiong Y, Guan KL, Lei QY. Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol Cell. 2011 Jun 24;42(6):719-30. doi: 10.1016/j.molcel.2011.04.025. PMID: 21700219; PMCID: PMC4879880.
Liu CY, Zha ZY, Zhou X, Zhang H, Huang W, Zhao D, Li T, Chan SW, Lim CJ, Hong W, Zhao S, Xiong Y, Lei QY, Guan KL. The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF β-TrCP E3 ligase. J Biol Chem, 2010. Nov 26;285(48):37159-69. doi: 10.1074/jbc.M110.152942. Epub 2010 Sep 21. PMID: 20858893; PMCID: PMC2988322.