Recent Publications

Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function
Sci Signal. 2024 Mar 12;17(827):eade0580. Cover Story. PMID: 38470957
Santi A, Kay EJ, Neilson LJ, McGarry L, Lilla S, Mullin M, Paul NR, Fercoq F, Koulouras G, Rodriguez Blanco G, Athineos D, Mason S, Hughes M, Thomson G, Kieffer Y, Nixon C, Blyth K, Mechta-Grigoriou F, Carlin LM, Zanivan S

Omentum-derived matrix enables the study of metastatic ovarian cancer and stromal cell functions in a physiologically relevant environment
Matrix Biol Plus. 2023 Nov 22;19-20:100136. PMID: 38223308
Neilson LJ, Cartwright D, Risteli M, Jokinen EM, McGarry L, Sandvik T, Nikolatou K, Hodge K, Atkinson S, Vias M, Kay EJ, Brenton JD, Carlin LM, Bryant DM, Salo T, Zanivan S

Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix
Nat Metab. 2022 Jun;4(6):693-710. PMID: 35760868
Kay EJ, Paterson K, Riero-Domingo C, Sumpton D, Däbritz JHM, Tardito S, Boldrini C, Hernandez-Fernaud JR, Athineos D, Dhayade S, Stepanova E, Gjerga E, Neilson LJ, Lilla S, Hedley A, Koulouras G, McGregor G, Jamieson C, Johnson RM, Park M, Kirschner K, Miller C, Kamphorst JJ, Loayza-Puch F, Saez-Rodriguez J, Mazzone M, Blyth K, Zagnoni M, Zanivan S

Hypoxic cancer-associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling
Science Signaling 2019 12(567), eaan8247. Cover Story. Editor’s choice in Science Signaling 12(569), eaax0155. PMID: 30723174
Kugeratski FG, Atkinson SJ, Neilson LJ, Lilla S, Knight JRP, Serneels J, Juin A, Ismail S, Bryant DM, Markert EK, Machesky LM, Mazzone M, Sansom OJ, Zanivan S

Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress
Nat Commun. 2018 9(1):1581. PMID: 29679077
van der Reest J, Lilla S, Zheng L, Zanivan S, Gottlieb E

Proline metabolism shapes the tumor microenvironment: from collagen deposition to immune evasion
Curr Opin Biotechnol, 2023 Oct 19;84:103011. Review. PMID: 37864905
Kay EJ, Zanivan S, Rufini A

Extracellular vesicles as central regulators of blood vessel function in cancer
Sci Signal. 2022 Sep 27;15(753):eaaz4742. Review. PMID: 36166511
Kugeratski FG, Santi A, Zanivan S

Metabolic pathways fuelling protumourigenic cancer-associated fibroblast functions
Curr Opin Syst Biol. 2021 Dec, 28. Review
Kay EJ, Zanivan S

Regulation of Extracellular Matrix Production in Activated Fibroblasts: Roles of Amino Acid Metabolism in Collagen Synthesis
Front Oncol. 2021 Aug 27;11:719922. Review. PMID: 34513697
Kay EJ, Koulouras G, Zanivan S