Selected Publications
Gonclaves MD, Lu C, Tutnauer J, Hartman TE, Hwang S, Murphy CJ, Pauli C, Morris R, Taylor S, Bosch K, Yang S, Wang Y, Riper J, Lekaye HC, Roper J, Kim Y, Chen Q, Gross SS, Rhee KY, Cantley LC*, and Yun J*. High-fructose corn syrup enhances intestinal tumor growth in mice. Science (2019) March 22;363 (6433): 1345-1349 (*co-corresponding authors)
Ngo B, Cantley LC*, Yun J*. Targeting Cancer Vulnerabilities with High Dose Vitamin C. Nature Reviews Cancer (2019) April 9, Vol 19, p271–282 (2019) (*co-corresponding authors).
Shim H, Wu C, Ramsamooj S, Bosch K, Chen Z, Emerling B, Yun J, Liu H, Choo-Wing L, Yang Z, Wulf GM, Kuchroo V, Cantley LC. Deletion of Pip4k2c, a novel phosphatidylinositol kinase results in hyperactivation of the immune system. PNAS, 2016 Jul 5;113(27):7596-601.
Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio IIC, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, Pappin DJ, Dow LE, Papadopoulos N, Gross SG, Cantley LC. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science (2015) Dec 11;350(6266): 1391-6 (Published online Express on 5 November 2015).
Roper J, Sinnamon MJ, Coffee EM, Belmont P, Keung L, Georgeon-Richard L, Wang WV, Faber AC, Yun J, Yilmaz ÖH, Bronson RT, Martin ES, Tsichlis PN, Hung KE. Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer. Cancer Lett. 2014 Jun 1;347(2):204-11.
Parkhitko AA, Priolo C, Coloff JL, Yun J, Wu JJ, Mizumura K, Xu W, Malinowska I, Yu J, Kwaitkowski DJ, Brugge JS, Locasale J, Asara J, Choi A, Finkel T, Henske EP. Autophagy-dependent metabolic reprograming leads to pentose phosphate pathway addiction in cells with hyperactive mTORC1. Molecular Cancer Research, 2013 Dec 2 [Epub ahead of print]
Yun J, Johnson JL, Hanigan CL and Locasale JW. Interactions between epigenetics and metabolism in cancers. Frontiers in Molecular and Cellular Oncology. (2012) 2:163. doi: 10.3389
Yun J. Allosteric AKT inhibitors as a targeted cancer therapy. Cancer Biol Ther. (2010) 9(7): 504-506.
Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, Schmidt K, Wilson JKV, MarkowitzS, Zhou S, Diaz LA, Velculescu V, Lengauer C, Kinzler KW, Vogelstein B, Papadopoulos N. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science (2009) 325 (5947): 1555-9 (Published online Express on 6 August 2009)
Lee YJ, Hong KH, Yun J, Oh SP. Generation of activin receptor type IIB isoform-specific hypomorphic alleles. Genesis (2006) 44(10): 487-94
Seki T, Hong KH, Yun J, Kim SJ, Oh SP. Isolation of a regulatory region of activin receptor-like kinase 1 gene sufficient for arterial endothelium-specific expression.Circ Res. (2004) 94(8):72-7
Seki T, Yun J, Oh SP. Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling. Circ Res. (2003) 93(7):682-9 Circ Res. (2003) 93(7):682-9
Yun J, Park CW, Lee YJ, Chung JH. Allele-specific methylation in the promoter-associated CpG island of mouse Copg2. Mamm. Genome (2003) 14(6):376-82
Kim J, Hahn Y, Sohn EH, Lee YJ, Yun JH, Kim JM, Chung JH. A phenotypic variation of Thr704Met mutation in skeletal sodium channel gene in a paralysis periodica paramyotonia family. J. Neurol. Neurosurg. Psych. (2001) 70(5):618-623
Lee YJ, Park CW, Hahn Y, Park J, Lee J, Yun JH, Hyun B, Chung JH. Mit1/Lb9and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest. FEBS Lett. (2000) 472(2-3):230-234
Hahn Y, Lee YJ, Yun JH, Yang SK, Mita K, Huh TL, Rhee M, Chung JH. Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate,insect and plant evolution. FEBS Lett. (2000) 482(1-2):31-3