Publications

Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition. Yan L, Tu B, Yao J, Gong J, Carugo A, Bristow CA, Wang Q, Zhu C, Dai B, Kang Y, Han L, Feng N, Jin Y, Fleming J, Heffernan TP, Yao W, Ying H. Cancer Res. 2021 Aug 1;81(15):4054-4065. doi: 10.1158/0008-5472.CAN-20-3792. Epub 2021 Jun 11. PMID: 34117030

Recent insights into the biology of pancreatic cancer. Yao W, Maitra A, Ying H. EBioMedicine. 2020 Mar;53:102655. doi: 10.1016/j.ebiom.2020.102655. Epub 2020 Mar 2. PMID: 32139179

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer. Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, Zhong Y, Wu CJ, Sadanandam A, Hu B, Chang Q, Chu GC, Al-Khalil R, Jiang S, Xia H, Fletcher-Sananikone E, Lim C, Horwitz GI, Viale A, Pettazzoni P, Sanchez N, Wang H, Protopopov A, Zhang J, Heffernan T, Johnson RL, Chin L, Wang YA, Draetta G, DePinho RA. Cell. 2019 Nov 14;179(5):1239. doi: 10.1016/j.cell.2019.10.037. PMID: 31730860

Glucose Metabolism in Pancreatic Cancer. Yan L, Raj P, Yao W, Ying H. Cancers (Basel). 2019 Sep 29;11(10):1460. doi: 10.3390/cancers11101460. PMID: 31569510

YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinoma. Tu B, Yao J, Ferri-Borgogno S, Zhao J, Chen S, Wang Q, Yan L, Zhou X, Zhu C, Bang S, Chang Q, Bristow CA, Kang Y, Zheng H, Wang H, Fleming JB, Kim M, Heffernan TP, Draetta GF, Pan D, Maitra A, Yao W, Gupta S, Ying H. JCI Insight. 2019 Nov 1;4(21):e130811. doi: 10.1172/jci.insight.130811. PMID: 31557131

Pooled library screening with multiplexed Cpf1 library. Liu J, Srinivasan S, Li CY, Ho IL, Rose J, Shaheen M, Wang G, Yao W, Deem A, Bristow C, Hart T, Draetta G. Nat Commun. 2019 Jul 17;10(1):3144. doi: 10.1038/s41467-019-10963-x. PMID: 31316073

Hear Pancreatic Cancer Stem Cells ROR. Yao W, Maitra A. Cell. 2019 Apr 18;177(3):516-518. doi: 10.1016/j.cell.2019.04.002. PMID: 31002791

Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer. Yao W, Rose JL, Wang W, Seth S, Jiang H, Taguchi A, Liu J, Yan L, Kapoor A, Hou P, Chen Z, Wang Q, Nezi L, Xu Z, Yao J, Hu B, Pettazzoni PF, Ho IL, Feng N, Ramamoorthy V, Jiang S, Deng P, Ma GJ, Den P, Tan Z, Zhang SX, Wang H, Wang YA, Deem AK, Fleming JB, Carugo A, Heffernan TP, Maitra A, Viale A, Ying H, Hanash S, DePinho RA, Draetta GF. Nature. 2019 Apr;568(7752):410-414. doi: 10.1038/s41586-019-1062-1. Epub 2019 Mar 27. PMID: 30918400

In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer. Carugo A, Genovese G, Seth S, Nezi L, Rose JL, Bossi D, Cicalese A, Shah PK, Viale A, Pettazzoni PF, Akdemir KC, Bristow CA, Robinson FS, Tepper J, Sanchez N, Gupta S, Estecio MR, Giuliani V, Dellino GI, Riva L, Yao W, Di Francesco ME, Green T, D'Alesio C, Corti D, Kang Y, Jones P, Wang H, Fleming JB, Maitra A, Pelicci PG, Chin L, DePinho RA, Lanfrancone L, Heffernan TP, Draetta GF. Cell Rep. 2016 Jun 28;16(1):133-147. doi: 10.1016/j.celrep.2016.05.063. Epub 2016 Jun 16. PMID: 27320920

Genetics and biology of pancreatic ductal adenocarcinoma. Ying H, Dey P, Yao W, Kimmelman AC, Draetta GF, Maitra A, DePinho RA. Genes Dev. 2016 Feb 15;30(4):355-85. doi: 10.1101/gad.275776.115. PMID: 26883357

Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression. Wang G, Lu X, Dey P, Deng P, Wu CC, Jiang S, Fang Z, Zhao K, Konaparthi R, Hua S, Zhang J, Li-Ning-Tapia EM, Kapoor A, Wu CJ, Patel NB, Guo Z, Ramamoorthy V, Tieu TN, Heffernan T, Zhao D, Shang X, Khadka S, Hou P, Hu B, Jin EJ, Yao W, Pan X, Ding Z, Shi Y, Li L, Chang Q, Troncoso P, Logothetis CJ, McArthur MJ, Chin L, Wang YA, DePinho RA. Cancer Discov. 2016 Jan;6(1):80-95. doi: 10.1158/2159-8290.CD-15-0224. Epub 2015 Dec 23. PMID: 26701088

Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer. Pettazzoni P, Viale A, Shah P, Carugo A, Ying H, Wang H, Genovese G, Seth S, Minelli R, Green T, Huang-Hobbs E, Corti D, Sanchez N, Nezi L, Marchesini M, Kapoor A, Yao W, Francesco ME, Petrocchi A, Deem AK, Scott K, Colla S, Mills GB, Fleming JB, Heffernan TP, Jones P, Toniatti C, DePinho RA, Draetta GF. Cancer Res. 2015 Mar 15;75(6):1091-101. doi: 10.1158/0008-5472.CAN-14-1854. Epub 2015 Mar 3. PMID: 25736685

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sánchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, Deem AK, Kapoor A, Yao W, Brunetto E, Kang Y, Yuan M, Asara JM, Wang YA, Heffernan TP, Kimmelman AC, Wang H, Fleming JB, Cantley LC, DePinho RA, Draetta GF. Nature. 2014 Oct 30;514(7524):628-32. doi: 10.1038/nature13611. Epub 2014 Aug 10. PMID: 25119024

Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axis. Yao W, Ji S, Qin Y, Yang J, Xu J, Zhang B, Xu W, Liu J, Shi S, Liu L, Liu C, Long J, Ni Q, Li M, Yu X. Mol Cancer. 2014 Aug 7;13:187. doi: 10.1186/1476-4598-13-187. PMID: 25103363

Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, Zhong Y, Wu CJ, Sadanandam A, Hu B, Chang Q, Chu GC, Al-Khalil R, Jiang S, Xia H, Fletcher-Sananikone E, Lim C, Horwitz GI, Viale A, Pettazzoni P, Sanchez N, Wang H, Protopopov A, Zhang J, Heffernan T, Johnson RL, Chin L, Wang YA, Draetta G, DePinho RA. Cell. 2014 Jul 3;158(1):185-197. doi: 10.1016/j.cell.2014.06.003. Epub 2014 Jun 19. PMID: 24954535

Overactivated neddylation pathway as a therapeutic target in lung cancer. Li L, Wang M, Yu G, Chen P, Li H, Wei D, Zhu J, Xie L, Jia H, Shi J, Li C, Yao W, Wang Y, Gao Q, Jeong LS, Lee HW, Yu J, Hu F, Mei J, Wang P, Chu Y, Qi H, Yang M, Dong Z, Sun Y, Hoffman RM, Jia L. J Natl Cancer Inst. 2014 May 22;106(6):dju083. doi: 10.1093/jnci/dju083. Print 2014 Jun. PMID: 24853380

Significance of caveolin-1 regulators in pancreatic cancer. Chen T, Liu L, Xu HX, Wang WQ, Wu CT, Yao WT, Yu XJ. Asian Pac J Cancer Prev. 2013;14(8):4501-7. doi: 10.7314/apjcp.2013.14.8.4501. PMID: 24083692

MAGI2 enhances the sensitivity of BEL-7404 human hepatocellular carcinoma cells to staurosporine-induced apoptosis by increasing PTEN stability. Li X, Li Z, Li N, Qi J, Fan K, Yin P, Zhao C, Liu Y, Yao W, Cai X, Wang L, Zha X. Int J Mol Med. 2013 Aug;32(2):439-47. doi: 10.3892/ijmm.2013.1411. Epub 2013 Jun 7. PMID: 23754155

Silencing of MBD1 reverses pancreatic cancer therapy resistance through inhibition of DNA damage repair. Xu J, Zhu W, Xu W, Cui X, Chen L, Ji S, Qin Y, Yao W, Liu L, Liu C, Long J, Li M, Yu X. Int J Oncol. 2013 Jun;42(6):2046-52. doi: 10.3892/ijo.2013.1901. Epub 2013 Apr 16. PMID: 23588667

Down-regulation of DNA methyltransferase 3B in staurosporine-induced apoptosis and its mechanism in human hepatocarcinoma cell lines. Zhao C, Yin P, Mei C, Li N, Yao W, Li X, Qi J, Fan K, Li Z, Wang L, Shi Y, Qiu S, Fan J, Zha X. Mol Cell Biochem. 2013 Apr;376(1-2):111-9. doi: 10.1007/s11010-012-1556-8. Epub 2013 Feb 9. PMID: 23397112

Amplifications of NCOA3 gene in colorectal cancers in a Chinese population. Li Z, Fang ZY, Ding Y, Yao WT, Yang Y, Zhu ZQ, Wang W, Zhang QX. World J Gastroenterol. 2012 Feb 28;18(8):855-60. doi: 10.3748/wjg.v18.i8.855. PMID: 22371647 

Sp1 is involved in regulation of cystathionine γ-lyase gene expression and biological function by PI3K/Akt pathway in human hepatocellular carcinoma cell lines. Yin P, Zhao C, Li Z, Mei C, Yao W, Liu Y, Li N, Qi J, Wang L, Shi Y, Qiu S, Fan J, Zha X. Cell Signal. 2012 Jun;24(6):1229-40. doi: 10.1016/j.cellsig.2012.02.003. Epub 2012 Feb 13. PMID: 22360859

RGD-conjugated albumin nanoparticles as a novel delivery vehicle in pancreatic cancer therapy. Ji S, Xu J, Zhang B, Yao W, Xu W, Wu W, Xu Y, Wang H, Ni Q, Hou H, Yu X. Cancer Biol Ther. 2012 Feb 15;13(4):206-15. doi: 10.4161/cbt.13.4.18692. PMID: 22354009

Combinational therapy: new hope for pancreatic cancer? Shi S, Yao W, Xu J, Long J, Liu C, Yu X. Cancer Lett. 2012 Apr 28;317(2):127-35. doi: 10.1016/j.canlet.2011.11.029. Epub 2011 Dec 2. PMID: 22138436

Profilin1 facilitates staurosporine-triggered apoptosis by stabilizing the integrin β1-actin complex in breast cancer cells. Yao W, Yu X, Fang Z, Yin P, Zhao C, Li N, Wang L, Li Z, Zha X. J Cell Mol Med. 2012 Apr;16(4):824-35. doi: 10.1111/j.1582-4934.2011.01369.x. PMID: 21692986 

Attenuated expression of HRH4 in colorectal carcinomas: a potential influence on tumor growth and progression. Fang Z, Yao W, Xiong Y, Li J, Liu L, Shi L, Zhang W, Zhang C, Nie L, Wan J. BMC Cancer. 2011 May 24;11:195:1-11. doi: 10.1186/1471-2407-11-195. PMID: 21609450

The effect of epidermal growth factor receptor variant III on glioma cell migration by stimulating ERK phosphorylation through the focal adhesion kinase signaling pathway. Liu M, Yang Y, Wang C, Sun L, Mei C, Yao W, Liu Y, Shi Y, Qiu S, Fan J, Cai X, Zha X. Arch Biochem Biophys. 2010 Oct 15;502(2):89-95. doi: 10.1016/j.abb.2010.07.014. Epub 2010 Jul 27. PMID: 20650261

Functional elucidation and methylation-mediated downregulation of ITGA5 gene in breast cancer cell line MDA-MB-468. Fang Z, Yao W, Xiong Y, Zhang J, Liu L, Li J, Zhang C, Wan J. J Cell Biochem. 2010 Aug 1;110(5):1130-41. doi: 10.1002/jcb.22626. PMID: 20564209

Transcriptional and post-transcriptional control of DNA methyltransferase 3B is regulated by phosphatidylinositol 3 kinase/Akt pathway in human hepatocellular carcinoma cell lines. Mei C, Sun L, Liu Y, Yang Y, Cai X, Liu M, Yao W, Wang C, Li X, Wang L, Li Z, Shi Y, Qiu S, Fan J, Zha X. J Cell Biochem. 2010 Sep 1;111(1):158-67. doi: 10.1002/jcb.22684. PMID: 20506537

Increased integrin alpha5beta1 heterodimer formation and reduced c-Jun expression are involved in integrin beta1 overexpression-mediated cell growth arrest. Fang Z, Yao W, Fu Y, Wang LY, Li Z, Yang Y, Shi Y, Qiu S, Fan J, Zha X. J Cell Biochem. 2010 Feb 1;109(2):383-95. doi: 10.1002/jcb.22416. PMID: 19960514

Post-transcriptional and post-translational regulation of PTEN by transforming growth factor-beta1. Yang Y, Zhou F, Fang Z, Wang L, Li Z, Sun L, Wang C, Yao W, Cai X, Jin J, Zha X. J Cell Biochem. 2009 Apr 15;106(6):1102-12. doi: 10.1002/jcb.22100. PMID: 19206163

Enhanced bioactivity of bone morphogenetic protein-2 with low dose of 2-N, 6-O-sulfated chitosan in vitro and in vivo. Zhou H, Qian J, Wang J, Yao W, Liu C, Chen J, Cao X. Biomaterials. 2009 Mar;30(9):1715-24. doi: 10.1016/j.biomaterials.2008.12.016. Epub 2009 Jan 7. PMID: 19131102

E-cadherin decreased human breast cancer cells sensitivity to staurosporine by up-regulating Bcl-2 expression. Wang L, Li Z, Wang C, Yang Y, Sun L, Yao W, Cai X, Wu G, Zhou F, Zha X. Arch Biochem Biophys. 2009 Jan 1;481(1):116-22. doi: 10.1016/j.abb.2008.10.021. Epub 2008 Nov 1. PMID: 18983973

Angiopoietin-like protein 3 modulates barrier properties of human glomerular endothelial cells through a possible signaling pathway involving phosphatidylinositol-3 kinase/protein kinase B and integrin alphaVbeta3. Li Y, Sun L, Xu H, Fang Z, Yao W, Guo W, Rao J, Zha X. Acta Biochim Biophys Sin (Shanghai). 2008 Jun;40(6):459-65. doi: 10.1111/j.1745-7270.2008.00421.x. PMID: 18535744