Publications

Du C, Guan X, Yan J. (2022) Two-pore channel blockade by phosphoinositide kinase inhibitors YM201636 and PI-103 determined by a histidine residue near pore-entrance. bioRxiv, DOI: 10.3389/fphys.2021.796540

Chen G, Li Q, Yan J. The leucine-rich repeat domains of BK channel auxiliary γ subunits regulate their expression, trafficking, and channel-modulation functions. Journal of Biological Chemistry (2022) In press DOI: 10.1016/j.jbc.2022.101664

Shah KR, Guan X, Yan J. (2022) Structural and functional coupling of calcium-activated BK channels and calcium-permeable channels within nanodomain signaling complexes. Frontiers in Physiology 12:796540 PMID: 35095560

Zhang J, Guan X, Shah K, Yan J. (2021) Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles. Nature Communications 12(1):4739 PMID: 34362892  DOI: 10.1038/s41467-021-24735-z

Zhou MH, Chen SR, Wang L, Huang Y, Deng M, Zhang J, Zhang J, Chen H, Yan J, Pan HL. (2021) Protein Kinase C-Mediated Phosphorylation and α2δ-1 Interdependently Regulate NMDA Receptor Trafficking and Activity. Journal of Neuroscience 41(30):6415-6429 PMID: 34252035

Vouga AG, Rockman ME, Yan J, Jacobson MA, Rothberg BS. State-dependent inhibition of BK channels by the opioid agonist loperamide. (2021) Journal of General Physiology 153(9). PMCID: PMC8352719. PMID: 34357374

Zhang J, Guan X, Li Q, Meredith AL, Pan HL, Yan J. (2018) Glutamate-activated BK channel complexes formed with NMDA receptors. Proceedings of the National Academy of Sciences of the United States of America 115(38):E9006-E9014

Li Q, Li Y, Wei H, Pan HM, Vouga AG, Rothberg BS, Wu Y, Yan J. (2018) Molecular determinants of Ca2+ sensitivity at the intersubunit interface of the BK channel gating ring. Scientific Reports. 8(1): 509. PMID: 29323236.

Erasso D, Tender GC, Li Q, Yan J, Culicchia F, Abdi S, Cui J. (2018) The effects of agrin isoforms on diabetic neuropathic pain in a rat streptozotocin model. Anesthesia & Analgesia 127(4):1051-1057. PMID: 29369095.

Xin G, Li Q, Yan J. (2017) Relationship between auxiliary gamma subunits and mallotoxin on BK channel modulation. Scientific Reports 7: 42240. PMCID: PMC5292707.

Kshatri AS, Li Q, Yan J, Large RJ, Sergeant GP, McHale NG, Thornbury KD, Hollywood MA. (2017) Differential efficacy of GoSlo-SR compounds on BKα and BKαγ1-4 channels. Channels (Austin) 11(1):66-78, PMCID: PMC5279879.

Yan J, Li Q, Aldrich RW. (2016) Closed-state-coupled C-type inactivation in BK channels. Proceedings of the National Academy of Sciences of the United States of America 113(25):6991-6.  PMID: 27298368

Li Q, Yan J. (2016) Modulation of BK channel function by auxiliary beta and gamma subunits. International Review of Neurobiology 128:51-90. PMID: 27238261

Li Q, Xin G, Yen K, Zhang J, Yan J. (2016) The single transmembrane segment determines the modulatory function of the BK channel auxiliary γ subunit. Journal of General Physiology 147(4):337-51. PMID: 27022192

Li Y, Adamek P, Zhang H, Tatsui CE, Rhines LD, Mrozkova P, Li Q, Kosturakis AK, Cassidy RM, Harrison DS, Cata JP, Sapire K, Zhang H, Kennamer-Chapman RM, Jawad AB, Ghetti A, Yan J, Palecek J, Dougherty PM. (2015) The cancer chemotherapeutic paclitaxel increases human and rodent sensory neuron responses to TRPV1 by activation of TLR4. Journal of Neuroscience 35(39):13487-500, PMID: 26424893

Li Q, Fan F, Kwak HR, Yan J. (2015) Molecular basis for differential modulation of BK channel voltage-dependent gating by auxiliary γ subunits. Journal of General Physiology  145(6):543-54. PMID: 26009545

Zhang J, Yan J (2014) Regulation of BK channels by auxiliary γ subunits. Frontiers in Physiology 5:401. PMCID: PMC4197896

Chen X, Yan J, Aldrich RW (2014) BK channel opening involves side-chain reorientation of multiple deep-pore residues. Proceedings of the National Academy of Sciences of the United States of America 111(1):E79-88. PMID: 24367115

Zhang X, Tanaka K, Yan J, Li J, Peng D, Jiang Y, Yang Z, Barton MC, Wen H, Shi X (2013) Regulation of estrogen receptor α by histone methyltransferase SMYD2-mediated protein methylation. Proceedings of the National Academy of Sciences of the United States of America 110 (43):17284-9. PMID: 24101509

Yan J and Aldrich RW (2012) BK potassium channel modulation by leucine-rich repeat-containing proteins. Proceedings of the National Academy of Sciences of the United States of America 109(20):7917-7922. PMID: 22547800

Yan J, Aldrich RW (2010) LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium. Nature 466(7305):513-516. PMID: 20613726

Yan J, Olsen JV, Park KS, Li W, Bildl W, Schulte U, Aldrich RW, Fakler B, Trimmer JS (2008) Profiling the phospho-status of the BKCa channel a subunit in rat brain reveals unexpected patterns and complexity. Molecular & Cellular Proteomics  7(11):2188-2198. PMID: 18573811

Yan J, Dashdorj N, Baniulis D, Yamashita E, Savikhin S, Cramer WA (2008) On the structural role of the aromatic residue environment of the chlorophyll a in the cytochrome b6f complex. Biochemistry  47(12):3654-3661. PMID: 18302324

Yan J, Kurisu G, Cramer WA (2006) Intraprotein transfer of the quinone analogue inhibitor 2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone in the cytochrome b6f complex. Proceedings of the National Academy of Sciences of the United States of America 103(1):69–74. PMID: 16371475

Cramer WA, Zhang H, Yan J, Kurisu G, Smith JL (2006) Transmembrane traffic in the cytochrome b6f complex. Annual Review of Biochemistry 75:769-790. PMID: 16756511

Cramer WA, Yan J, Zhang H, Kurisu G, Smith JL (2005) Structure of the cytochrome b6f complex: new prosthetic groups, Q-space, and the "hors d'oeuvres hypothesis" for assembly of the complex. Photosynthesis Research 85(1):133-144. PMID: 15977064

Adams KL, Tsoi S, Yan J, Durbin SM, Ramdas AK, Cramer WA, Sturhahn W, Ercan Alp E, Schulz C (2006) Fe vibrational spectroscopy of myoglobin and cytochrome f. Journal of Physical Chemistry B 110(1):530-536.  PMID: 16471565

Kim H, Dashdorj N, Zhang H, Yan J, Cramer WA, Savikhin S (2005) An anomalous distance dependence of intra-protein chlorophyll-carotenoid triplet energy transfer. Biophysical Journal 89(4):28-30. PMID: 16055550

Dashdorj N, Zhang H, Kim H, Yan J, Cramer WA, Savikhin S (2005) The single chlorophyll a molecule in the cytochrome b6f complex: unusual optical properties protect the complex against singlet oxygen. Biophysical Journal 88(6):4178-4187 PMID: 15778449

Yan J and Cramer WA (2004) Molecular control of a bimodal distribution of quinone- analogue inhibitor binding sites in the cytochrome b6f complex. Journal of Molecular Biology 344(2):481-493. PMID: 15522300

Cramer WA, Zhang H, Yan J, Kurisu G, Smith JL (2004) Evolution of photosynthesis: Time independent structure of the cytochrome b6f complex of oxygenic photosynthesis. Biochemistry 43(20):5921-5929. PMID: 15147175

Smith JL, Zhang H, Yan J, Kurisu G, Cramer WA (2004) Cytochrome bc complexes: a common core of structure and function surrounded by diversity in the outlying provinces. Current Opinion in Structural Biology 14(4):432-439. PMID: 15313237

Yan J, Cramer WA (2003) Functional insensitivity of the cytochrome b6f complex to structure changes in the hinge region of the Rieske iron-sulfur protein. Journal of Biological Chemistry 278(23):20925-20933. PMID: 12672829

Yan J, Liu Y, Mao D, Li L, Kuang T (2001) The presence of 9-cis-b-carotene in cytochrome b6f complex from spinach. Biochimica et Biophysica Acta - Bioenergetics 1506(3):182-188. PMID: 11779551

Li X, Li Z, Yan J, Li H, Han B, Hu K, Wang A (2001) Investigation of structural change of purple membrane in storage by transmission electron microscope and atomic force microscope. Chinese Science Bulletin 46:1753-1756.

Yan J, Mao D, Chen H, Kuang T, Li B (2000) Effects of membrane lipids on the electron transfer activity of cytochrome b6f complex from spinach. Acta Bot Sin 42:1267-1270.