Publications
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Wang J*, Lu Q*, Chen X*, Aifantis I. Targeting MHC-I inhibitory pathways for cancer immunotherapy. Trends Immunol. 2024 Mar;45(3):177-187. doi: 10.1016/j.it.2024.01.009. Epub 2024 Mar 2. PMID: 38433029.
Chen X*, Lu Q*, Zhou H, Liu J, Nadorp B, Lasry A, Sun Z, Lai B, Rona G, Zhang J, Cammer M, Wang K, Al-Santli W, Ciantra Z, Guo Q, You J, Sengupta D, Boukhris A, Zhang H, Liu C, Cresswell P, Dahia PLM, Pagano M, Aifantis I, Wang J. A membrane-associated MHC-I inhibitory axis for cancer immune evasion. Cell. 2023 Aug 31;186(18):3903-3920.e21. doi: 10.1016/j.cell.2023.07.016. Epub 2023 Aug 8. PMID: 37557169; PMCID: PMC10961051.
Glytsou C*, Chen X*, Zacharioudakis E*, Al-Santli W, Zhou H, Nadorp B, Lee S, Lasry A, Sun Z, Papaioannou D, Cammer M, Wang K, Zal T, Zal MA, Carter BZ, Ishizawa J, Tibes R, Tsirigos A, Andreeff M, Gavathiotis E, Aifantis I. Mitophagy Promotes Resistance to BH3 Mimetics in Acute Myeloid Leukemia. Cancer Discov. 2023 Jul 7;13(7):1656-1677. doi: 10.1158/2159-8290.CD-22-0601. PMID: 37088914; PMCID: PMC10330144.
Chen X*, Glytsou C*, Zhou H, Narang S, Reyna DE, Lopez A, Sakellaropoulos T, Gong Y, Kloetgen A, Yap YS, Wang E, Gavathiotis E, Tsirigos A, Tibes R, Aifantis I. Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment. Cancer Discov. 2019 Jul;9(7):890-909. doi: 10.1158/2159-8290.CD-19-0117. Epub 2019 May 2. PMID: 31048321; PMCID: PMC6606342.
Chen X*, Zhao J*, Gu C, Cui Y, Dai Y, Song G, Liu H, Shen H, Liu Y, Wang Y, Xing H, Zhu X, Hao P, Guo F, Liu X. Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells. Nat Commun. 2018 Sep 14;9(1):3746. doi: 10.1038/s41467-018-06282-2. PMID: 30218073; PMCID: PMC6138688.
Chen X, Aifantis I. The effect of chromatin states on cancer: big data lead the way. Lancet Haematol. 2018 Jun;5(6):e237-e238. doi: 10.1016/S2352-3026(18)30066-8. PMID: 29859610; PMCID: PMC6880929.
Zhao J*, Chen X*, Song G, Zhang J, Liu H, Liu X. Uhrf1 controls the self-renewal versus differentiation of hematopoietic stem cells by epigenetically regulating the cell-division modes. Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E142-E151. doi: 10.1073/pnas.1612967114. Epub 2016 Dec 12. PMID: 27956603; PMCID: PMC5240722.
Cui Y*, Chen X*, Zhang J, Sun X, Liu H, Bai L, Xu C, Liu X. Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis. Cell Rep. 2016 Apr 12;15(2):256-63. doi: 10.1016/j.celrep.2016.03.016. Epub 2016 Mar 31. PMID: 27050515.
Chen X*, Zhang J*, Zhao J, Liu H, Sun X, Zhao M, Liu X. Lis1 is required for the expansion of hematopoietic stem cells in the fetal liver. Cell Res. 2014 Aug;24(8):1013-6. doi: 10.1038/cr.2014.69. Epub 2014 May 23. PMID: 24853954; PMCID: PMC4123292.
Hockemeyer K, Sakellaropoulos T, Chen X, Ivashkiv O, Sirenko M, Zhou H, Gambi G, Battistello E, Avrampou K, Sun Z, Guillamot M, Chiriboga L, Jour G, Dolgalev I, Corrigan K, Bhatt K, Osman I, Tsirigos A, Kourtis N, Aifantis I. The stress response regulator HSF1 modulates natural killer cell anti-tumour immunity. Nat Cell Biol. 2024 Oct;26(10):1734-1744. doi: 10.1038/s41556-024-01490-z. Epub 2024 Sep 2. PMID: 39223375.
Battistello E, Hixon KA, Comstock DE, Collings CK, Chen X, Rodriguez Hernaez J, Lee S, Cervantes KS, Hinkley MM, Ntatsoulis K, Cesarano A, Hockemeyer K, Haining WN, Witkowski MT, Qi J, Tsirigos A, Perna F, Aifantis I, Kadoch C. Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion. Mol Cell. 2023 Apr 20;83(8):1216-1236.e12. doi: 10.1016/j.molcel.2023.02.026. Epub 2023 Mar 20. PMID: 36944333; PMCID: PMC10121856.
Wang E, Zhou H, Nadorp B, Cayanan G, Chen X, Yeaton AH, Nomikou S, Witkowski MT, Narang S, Kloetgen A, Thandapani P, Ravn-Boess N, Tsirigos A, Aifantis I. Surface antigen-guided CRISPR screens identify regulators of myeloid leukemia differentiation. Cell Stem Cell. 2021 Apr 1;28(4):718-731.e6. doi: 10.1016/j.stem.2020.12.005. Epub 2021 Jan 14. PMID: 33450187; PMCID: PMC8145876.
Lu Q, Liu J, Zhao S, Gomez Castro MF, Laurent-Rolle M, Dong J, Ran X, Damani-Yokota P, Tang H, Karakousi T, Son J, Kaczmarek ME, Zhang Z, Yeung ST, McCune BT, Chen RE, Tang F, Ren X, Chen X, Hsu JCC, Teplova M, Huang B, Deng H, Long Z, Mudianto T, Jin S, Lin P, Du J, Zang R, Su TT, Herrera A, Zhou M, Yan R, Cui J, Zhu J, Zhou Q, Wang T, Ma J, Koralov SB, Zhang Z, Aifantis I, Segal LN, Diamond MS, Khanna KM, Stapleford KA, Cresswell P, Liu Y, Ding S, Xie Q, Wang J. SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2. Immunity. 2021 Jun 8;54(6):1304-1319.e9. doi: 10.1016/j.immuni.2021.05.006. Epub 2021 May 9. PMID: 34048708; PMCID: PMC8106883.
Kloetgen A, Thandapani P, Ntziachristos P, Ghebrechristos Y, Nomikou S, Lazaris C, Chen X, Hu H, Bakogianni S, Wang J, Fu Y, Boccalatte F, Zhong H, Paietta E, Trimarchi T, Zhu Y, Van Vlierberghe P, Inghirami GG, Lionnet T, Aifantis I, Tsirigos A. Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia. Nat Genet. 2020 Apr;52(4):388-400. doi: 10.1038/s41588-020-0602-9. Epub 2020 Mar 23. PMID: 32203470; PMCID: PMC7138649.
DiNardo CD, Tiong IS, Quaglieri A, MacRaild S, Loghavi S, Brown FC, Thijssen R, Pomilio G, Ivey A, Salmon JM, Glytsou C, Fleming SA, Zhang Q, Ma H, Patel KP, Kornblau SM, Xu Z, Chua CC, Chen X, Blombery P, Flensburg C, Cummings N, Aifantis I, Kantarjian H, Huang DCS, Roberts AW, Majewski IJ, Konopleva M, Wei AH. Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML. Blood. 2020 Mar 12;135(11):791-803. doi: 10.1182/blood.2019003988. PMID: 31932844; PMCID: PMC7068032.
Wang E, Lu SX, Pastore A, Chen X, Imig J, Chun-Wei Lee S, Hockemeyer K, Ghebrechristos YE, Yoshimi A, Inoue D, Ki M, Cho H, Bitner L, Kloetgen A, Lin KT, Uehara T, Owa T, Tibes R, Krainer AR, Abdel-Wahab O, Aifantis I. Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia. Cancer Cell. 2019 Mar 18;35(3):369-384.e7. doi: 10.1016/j.ccell.2019.01.010. Epub 2019 Feb 21. PMID: 30799057; PMCID: PMC6424627.
Chen J, Cai Z, Zhang L, Yin Y, Chen X, Chen C, Zhang Y, Zhai S, Long X, Liu X, Wang X. Lis1 Regulates Germinal Center B Cell Antigen Acquisition and Affinity Maturation. J Immunol. 2017 Jun 1;198(11):4304-4311. doi: 10.4049/jimmunol.1700159. Epub 2017 Apr 26. PMID: 28446568.
Sun Y, Zhu X, Chen X, Liu H, Xu Y, Chu Y, Wang G, Liu X. The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity. Nat Commun. 2014 Oct 10;5:5225. doi: 10.1038/ncomms6225. PMID: 25301163.
Cao Y, Li H, Sun Y, Chen X, Liu H, Gao X, Liu X. Interferon regulatory factor 4 regulates thymocyte differentiation by repressing Runx3 expression. Eur J Immunol. 2010 Nov;40(11):3198-209. doi: 10.1002/eji.201040570. Epub 2010 Oct 27. PMID: 21061442.
* indicates co-first author