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Publications

2023

Huntoon K, Anderson SK, Ballman KV, Twohy E, Dooley K, Jiang W, An Y, Li J, von Roemeling C, Qie Y, Ross OA, Cerhan JH, Whitton AC, Greenspoon JN, Parney IF, Ashman JB, Bahary JP, Hadjipanayis C, Urbanic JJ, Farace E, Khuntia D, Laack NN, Brown PD, Roberge D, Kim BYS. Association of circulating markers with cognitive decline after radiation therapy for brain metastasis. Neuro Oncol. 2023 Jun 2;25(6):1123-1131. doi: 10.1093/neuonc/noac262. PubMed PMID: 36472389; PubMed Central PMCID: PMC10237411.
Huntoon K, Jiang W, Kim BY. Waking immune-resistant tumors with neddylation. J Clin Invest. 2023 Feb 15;133(4). doi: 10.1172/JCI167894. PubMed PMID: 36787255; PubMed Central PMCID: PMC9927922.
You Y, Tian Y, Yang Z, Shi J, Kwak KJ, Tong Y, Estania AP, Cao J, Hsu WH, Liu Y, Chiang CL, Schrank BR, Huntoon K, Lee D, Li Z, Zhao Y, Zhang H, Gallup TD, Ha J, Dong S, Li X, Wang Y, Lu WJ, Bahrani E, Lee LJ, Teng L, Jiang W, Lan F, Kim BYS, Lee AS. Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy. Nat Biomed Eng. 2023 Jan 12;. doi: 10.1038/s41551-022-00989-w. [Epub ahead of print] PubMed PMID: 36635419.

2022

Lu Y, Huntoon K, Lee D, Wang Y, Ha J, Qie Y, Li X, Schrank BR, Dong S, Gallup TD, Kang M, Zhao H, An Y, Yang Z, Li J, Kim BYS, Jiang W. Immunological conversion of solid tumours using a bispecific nanobioconjugate for cancer immunotherapy. Nat Nanotechnol. 2022 Dec;17(12):1332-1341. doi: 10.1038/s41565-022-01245-7. Epub 2022 Nov 10. PubMed PMID: 36357792; PubMed Central PMCID: PMC10036139.
Huang X, Liu Q, Zhong G, Peng Y, Liu Y, Liang L, Hong H, Feng W, Yang S, Zhang Y, Xian S, Li Z, Zhou Y, Zhang Z, Jiang W, Liang J, Liu ZG. Neoadjuvant toripalimab combined with gemcitabine and cisplatin in resectable locally advanced head and neck squamous cell carcinoma (NeoTGP01): An open label, single-arm, phase Ib clinical trial. J Exp Clin Cancer Res. 2022 Oct 12;41(1):300. doi: 10.1186/s13046-022-02510-2. PubMed PMID: 36224603; PubMed Central PMCID: PMC9558942.
Li X, Khorsandi S, Wang Y, Santelli J, Huntoon K, Nguyen N, Yang M, Lee D, Lu Y, Gao R, Kim BYS, de Gracia Lux C, Mattrey RF, Jiang W, Lux J. Cancer immunotherapy based on image-guided STING activation by nucleotide nanocomplex-decorated ultrasound microbubbles. Nat Nanotechnol. 2022 Aug;17(8):891-899. doi: 10.1038/s41565-022-01134-z. Epub 2022 May 30. PubMed PMID: 35637356; PubMed Central PMCID: PMC9378430.
Li J, Xue C, Wang H, Dong S, Yang Z, Cao Y, Zhao B, Cheng B, Xie X, Mo X, Jiang W, Yuan H, Pan J. Hybrid Nanofibrous Composites with Anisotropic Mechanics and Architecture for Tendon/Ligament Repair and Regeneration. Small. 2022 Jul;18(27):e2201147. doi: 10.1002/smll.202201147. Epub 2022 Jun 9. PubMed PMID: 35686342.
George J, Chen Y, Abdelfattah N, Yamamoto K, Gallup TD, Adamson SI, Rybinski B, Srivastava A, Kumar P, Lee MG, Baskin DS, Jiang W, Choi JM, Flavahan W, Chuang JH, Kim BY, Xu J, Jung SY, Yun K. Cancer stem cells, not bulk tumor cells, determine mechanisms of resistance to SMO inhibitors. Cancer Res Commun. 2022 Jun;2(6):402-416. doi: 10.1158/2767-9764.crc-22-0124. Epub 2022 Jun 6. PubMed PMID: 36688010; PubMed Central PMCID: PMC9853917.
Hein DM, Deng W, Bleile M, Kazmi SA, Rhead B, De La Vega FM, Jones AL, Kainthla R, Jiang W, Cantarel B, Sanford NN. Racial and Ethnic Differences in Genomic Profiling of Early Onset Colorectal Cancer. J Natl Cancer Inst. 2022 May 9;114(5):775-778. doi: 10.1093/jnci/djac014. PubMed PMID: 35134211; PubMed Central PMCID: PMC9086761.
Dong S, Bi Y, Sun X, Zhao Y, Sun R, Hao F, Sun Y, Wang Y, Li X, Deng W, Liu X, Ha J, Teng L, Gong P, Xie J, Kim BYS, Yang Z, Jiang W, Teng L. Dual-Loaded Liposomes Tagged with Hyaluronic Acid Have Synergistic Effects in Triple-Negative Breast Cancer. Small. 2022 Apr;18(16):e2107690. doi: 10.1002/smll.202107690. Epub 2022 Mar 11. PubMed PMID: 35277914.
Abdelfattah N, Kumar P, Wang C, Leu JS, Flynn WF, Gao R, Baskin DS, Pichumani K, Ijare OB, Wood SL, Powell SZ, Haviland DL, Parker Kerrigan BC, Lang FF, Prabhu SS, Huntoon KM, Jiang W, Kim BYS, George J, Yun K. Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target. Nat Commun. 2022 Feb 9;13(1):767. doi: 10.1038/s41467-022-28372-y. PubMed PMID: 35140215; PubMed Central PMCID: PMC8828877.

2021

Yu S, Wei S, Savani M, Lin X, Du K, Mender I, Siteni S, Vasilopoulos T, Reitman ZJ, Ku Y, Wu D, Liu H, Tian M, Chen Y, Labrie M, Charbonneau CM, Sugarman E, Bowie M, Hariharan S, Waitkus M, Jiang W, McLendon RE, Pan E, Khasraw M, Walsh KM, Lu Y, Herlyn M, Mills G, Herbig U, Wei Z, Keir ST, Flaherty K, Liu L, Wu K, Shay JW, Abdullah K, Zhang G, Ashley DM. A Modified Nucleoside 6-Thio-2'-Deoxyguanosine Exhibits Antitumor Activity in Gliomas. Clin Cancer Res. 2021 Dec 15;27(24):6800-6814. doi: 10.1158/1078-0432.CCR-21-0374. Epub 2021 Sep 30. PubMed PMID: 34593527; PubMed Central PMCID: PMC8678347.
Sun Z, Deng G, Peng X, Xu X, Liu L, Peng J, Ma Y, Zhang P, Wen A, Wang Y, Yang Z, Gong P, Jiang W, Cai L. Intelligent photothermal dendritic cells restart the cancer immunity cycle through enhanced immunogenic cell death. Biomaterials. 2021 Dec;279:121228. doi: 10.1016/j.biomaterials.2021.121228. Epub 2021 Oct 26. PubMed PMID: 34717198.
Liu M, Wu K, Lin J, Xie Q, Liu Y, Huang Y, Zeng J, Yang Z, Wang Y, Dong S, Deng W, Yang M, Wu S, Jiang W, Li X. Emerging Biological Functions of IL-17A: A New Target in Chronic Obstructive Pulmonary Disease?. Front Pharmacol. 2021;12:695957. doi: 10.3389/fphar.2021.695957. eCollection 2021. Review. PubMed PMID: 34305606; PubMed Central PMCID: PMC8294190.
Lee D, Huntoon K, Wang Y, Jiang W, Kim BYS. Harnessing Innate Immunity Using Biomaterials for Cancer Immunotherapy. Adv Mater. 2021 Jul;33(27):e2007576. doi: 10.1002/adma.202007576. Epub 2021 May 29. Review. PubMed PMID: 34050699.
Liu Y, Yang Z, Wang L, Sun L, Kim BYS, Jiang W, Yuan Y, Liu C. Spatiotemporal Immunomodulation Using Biomimetic Scaffold Promotes Endochondral Ossification-Mediated Bone Healing. Adv Sci (Weinh). 2021 Jun;8(11):e2100143. doi: 10.1002/advs.202100143. Epub 2021 Mar 16. PubMed PMID: 34105266; PubMed Central PMCID: PMC8188258.
Zhang N, Yin R, Zhou P, Liu X, Fan P, Qian L, Dong L, Zhang C, Zheng X, Deng S, Kuai J, Liu Z, Jiang W, Wang X, Wu D, Huang Y. DLL1 orchestrates CD8+ T cells to induce long-term vascular normalization and tumor regression. Proc Natl Acad Sci U S A. 2021 Jun 1;118(22). doi: 10.1073/pnas.2020057118. PubMed PMID: 34035167; PubMed Central PMCID: PMC8179177.
Sun X, Yu K, Zhou Y, Dong S, Hu W, Sun Y, Li Y, Xie J, Lee RJ, Sun F, Ma Y, Wang S, Kim BYS, Wang Y, Yang Z, Jiang W, Li Y, Teng L. Self-Assembled pH-Sensitive Polymeric Nanoparticles for the Inflammation-Targeted Delivery of Cu/Zn-Superoxide Dismutase. ACS Appl Mater Interfaces. 2021 Apr 21;13(15):18152-18164. doi: 10.1021/acsami.1c03589. Epub 2021 Mar 25. PubMed PMID: 33764751.
Xie S, Shalaby-Rana E, Hester A, Honeycutt J, Fu CL, Boyett D, Jiang W, Hsieh MH. Macroscopic and microscopic imaging modalities for diagnosis and monitoring of urogenital schistosomiasis. Adv Parasitol. 2021;112:51-76. doi: 10.1016/bs.apar.2021.01.001. Epub 2021 Mar 11. Review. PubMed PMID: 34024359.
Ma Y, Dong S, Li X, Kim BYS, Yang Z, Jiang W. Extracellular Vesicles: An Emerging Nanoplatform for Cancer Therapy. Front Oncol. 2020;10:606906. doi: 10.3389/fonc.2020.606906. eCollection 2020. Review. PubMed PMID: 33628730; PubMed Central PMCID: PMC7897670.
Jiang W, Wang Y, Wargo JA, Lang FF, Kim BYS. Considerations for designing preclinical cancer immune nanomedicine studies. Nat Nanotechnol. 2021 Jan;16(1):6-15. doi: 10.1038/s41565-020-00817-9. Epub 2020 Dec 21. Review. PubMed PMID: 33349682; PubMed Central PMCID: PMC8103921.

2020

Hong WX, Haebe S, Lee AS, Westphalen CB, Norton JA, Jiang W, Levy R. Intratumoral Immunotherapy for Early-stage Solid Tumors. Clin Cancer Res. 2020 Jul 1;26(13):3091-3099. doi: 10.1158/1078-0432.CCR-19-3642. Epub 2020 Feb 18. Review. PubMed PMID: 32071116; PubMed Central PMCID: PMC7439755.
Li Q, Wang Y, Jia W, Deng H, Li G, Deng W, Chen J, Kim BYS, Jiang W, Liu Q, Liu J. Low-Dose Anti-Angiogenic Therapy Sensitizes Breast Cancer to PD-1 Blockade. Clin Cancer Res. 2020 Apr 1;26(7):1712-1724. doi: 10.1158/1078-0432.CCR-19-2179. Epub 2019 Dec 17. PubMed PMID: 31848190.
von Roemeling CA, Wang Y, Qie Y, Yuan H, Zhao H, Liu X, Yang Z, Yang M, Deng W, Bruno KA, Chan CK, Lee AS, Rosenfeld SS, Yun K, Johnson AJ, Mitchell DA, Jiang W, Kim BYS. Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity. Nat Commun. 2020 Mar 20;11(1):1508. doi: 10.1038/s41467-020-15129-8. PubMed PMID: 32198351; PubMed Central PMCID: PMC7083893.
Yang Z, Shi J, Xie J, Wang Y, Sun J, Liu T, Zhao Y, Zhao X, Wang X, Ma Y, Malkoc V, Chiang C, Deng W, Chen Y, Fu Y, Kwak KJ, Fan Y, Kang C, Yin C, Rhee J, Bertani P, Otero J, Lu W, Yun K, Lee AS, Jiang W, Teng L, Kim BYS, Lee LJ. Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation. Nat Biomed Eng. 2020 Jan;4(1):69-83. doi: 10.1038/s41551-019-0485-1. Epub 2019 Dec 16. PubMed PMID: 31844155; PubMed Central PMCID: PMC7080209.

2019

Zheng X, Zhang N, Qian L, Wang X, Fan P, Kuai J, Lin S, Liu C, Jiang W, Qin S, Chen H, Huang Y. CTLA4 blockade promotes vessel normalization in breast tumors via the accumulation of eosinophils. Int J Cancer. 2020 Mar 15;146(6):1730-1740. doi: 10.1002/ijc.32829. Epub 2019 Dec 28. PubMed PMID: 31840816.
Meng F, Sun Y, Lee RJ, Wang G, Zheng X, Zhang H, Fu Y, Yan G, Wang Y, Deng W, Parks E, Kim BYS, Yang Z, Jiang W, Teng L. Folate Receptor-Targeted Albumin Nanoparticles Based on Microfluidic Technology to Deliver Cabazitaxel. Cancers (Basel). 2019 Oct 16;11(10). doi: 10.3390/cancers11101571. PubMed PMID: 31623082; PubMed Central PMCID: PMC6827099.
Feng M, Jiang W, Kim BYS, Zhang CC, Fu YX, Weissman IL. Phagocytosis checkpoints as new targets for cancer immunotherapy. Nat Rev Cancer. 2019 Oct;19(10):568-586. doi: 10.1038/s41568-019-0183-z. Epub 2019 Aug 28. Review. PubMed PMID: 31462760; PubMed Central PMCID: PMC7002027.
Li N, Wang Y, Neri S, Zhen Y, Fong LWR, Qiao Y, Li X, Chen Z, Stephan C, Deng W, Ye R, Jiang W, Zhang S, Yu Y, Hung MC, Chen J, Lin SH. Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling. Nat Commun. 2019 Sep 25;10(1):4363. doi: 10.1038/s41467-019-12377-1. PubMed PMID: 31554794; PubMed Central PMCID: PMC6761205.
Liu Z, Wang Y, Huang Y, Kim BYS, Shan H, Wu D, Jiang W. Tumor Vasculatures: A New Target for Cancer Immunotherapy. Trends Pharmacol Sci. 2019 Sep;40(9):613-623. doi: 10.1016/j.tips.2019.07.001. Epub 2019 Jul 20. Review. PubMed PMID: 31331639; PubMed Central PMCID: PMC7925217.
Yang Z, Wang L, Yu H, Wang R, Gou Y, Zhang M, Kang C, Liu T, Lan Y, Wang X, Liu J, Cooper MA, Li X, Yue K, Yu Y, Wang L, Kim BYS, Jiang W, Sun W. Membrane TLR9 Positive Neutrophil Mediated MPLA Protects Against Fatal Bacterial Sepsis. Theranostics. 2019;9(21):6269-6283. doi: 10.7150/thno.37139. eCollection 2019. PubMed PMID: 31534550; PubMed Central PMCID: PMC6735515.
Leong HS, Butler KS, Brinker CJ, Azzawi M, Conlan S, Dufés C, Owen A, Rannard S, Scott C, Chen C, Dobrovolskaia MA, Kozlov SV, Prina-Mello A, Schmid R, Wick P, Caputo F, Boisseau P, Crist RM, McNeil SE, Fadeel B, Tran L, Hansen SF, Hartmann NB, Clausen LPW, Skjolding LM, Baun A, Ågerstrand M, Gu Z, Lamprou DA, Hoskins C, Huang L, Song W, Cao H, Liu X, Jandt KD, Jiang W, Kim BYS, Wheeler KE, Chetwynd AJ, Lynch I, Moghimi SM, Nel A, Xia T, Weiss PS, Sarmento B, das Neves J, Santos HA, Santos L, Mitragotri S, Little S, Peer D, Amiji MM, Alonso MJ, Petri-Fink A, Balog S, Lee A, Drasler B, Rothen-Rutishauser B, Wilhelm S, Acar H, Harrison RG, Mao C, Mukherjee P, Ramesh R, McNally LR, Busatto S, Wolfram J, Bergese P, Ferrari M, Fang RH, Zhang L, Zheng J, Peng C, Du B, Yu M, Charron DM, Zheng G, Pastore C. On the issue of transparency and reproducibility in nanomedicine. Nat Nanotechnol. 2019 Jul;14(7):629-635. doi: 10.1038/s41565-019-0496-9. PubMed PMID: 31270452; PubMed Central PMCID: PMC6939883.
Liu Z, Xu C, Jiang R, Liu G, Liu Q, Zhou J, Liu F, Yao J, Wang S, Jiang W. Treatment of Locally Advanced Nasopharyngeal Carcinoma by Helical Tomotherapy: An Observational, Prospective Analysis. Transl Oncol. 2019 May;12(5):757-763. doi: 10.1016/j.tranon.2019.02.011. Epub 2019 Mar 15. PubMed PMID: 30878894; PubMed Central PMCID: PMC6423362.
Wang Y, Liu ZG, Yuan H, Deng W, Li J, Huang Y, Kim BYS, Story MD, Jiang W. The Reciprocity between Radiotherapy and Cancer Immunotherapy. Clin Cancer Res. 2019 Mar 15;25(6):1709-1717. doi: 10.1158/1078-0432.CCR-18-2581. Epub 2018 Nov 9. Review. PubMed PMID: 30413527; PubMed Central PMCID: PMC6420874.
Chen Y, Liu X, Yuan H, Yang Z, von Roemeling CA, Qie Y, Zhao H, Wang Y, Jiang W, Kim BYS. Therapeutic Remodeling of the Tumor Microenvironment Enhances Nanoparticle Delivery. Adv Sci (Weinh). 2019 Mar 6;6(5):1802070. doi: 10.1002/advs.201802070. eCollection 2019 Mar 6. PubMed PMID: 30886813; PubMed Central PMCID: PMC6402396.
Liu Y, Song Y, Lin D, Lei L, Mei Y, Jin Z, Gong H, Zhu Y, Hu B, Zhang Y, Zhao L, Teo HY, Qiu J, Jiang W, Dong C, Wu D, Huang Y, Liu H. NCR- group 3 innate lymphoid cells orchestrate IL-23/IL-17 axis to promote hepatocellular carcinoma development. EBioMedicine. 2019 Mar;41:333-344. doi: 10.1016/j.ebiom.2019.02.050. Epub 2019 Mar 1. PubMed PMID: 30827928; PubMed Central PMCID: PMC6443584.

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