Publications

Karl-Heinz Tomaszowski, Yue Chen, Sunetra Roy, Momo Harris, Jianhua Zhang, Chi-lin Tsai, Katharina Schlacher, (2024) Diet induced mitochondrial DNA replication instability in Rad51c mutant mice drives sex-bias in anemia of inflammation. bioRxiv 2024.09.21.613572

Michael A. Longo, Syed Moiz Ahmed, Yue Chen, Chi-Lin Tsai, Sarita Namjoshi, Xiaoyan Wang, Rajika L. Perera, Andy Arvai, Miyoung Lee, Li Ren Kong, Wilfried Engl, Woei Shyuan, Ziqing Winston Zhao, Ashok R. Venkitaraman, John A. Tainer, Katharina Schlacher. (2024) BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability. bioRxiv 2024.09.21.614229

Longo, M., Roy, S., Chen, Y., Tomaszowski, K., Arvai, A.S., Pepper, J. T., Boisvert, R, A., Kunnimalaiyaan, S., Keshvani, C., Schild, D., Bacolla, A., Williams, G. J., Tainer J. A., and Schlacher. K. (2023) RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles. Nature Communications

Lozen M, Chen Y, Boisvert RA, Schlacher K. (2023) Mitochondrial Replication Assay (MIRA) for Efficient in situ Quantification of Nascent mtDNA and Protein Interactions with Nascent mtDNA (mitoSIRF). Bio Protocol

Tomaszowski, K., Roy S., Keshvani, C., Guerrero, C.  Shukla, P., Keshvani, C., Chen, Y., Ott, M., Wu, X., Zhang, J., DiNardo, C.D., Schindler, D., and Schlacher, K. (2023) Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replication stress. Nature Communications

Luzwick JW, Dombi E, Boisvert RA, Roy S, Park S, Kunnimalaiyaan S, Goffart S, Schindler D, Schlacher K. (2021) MRE11-dependent instability in mitochondrial DNA fork protection activates a cGAS immune signaling pathway. Science Advances

Roy S, Schlacher K. (2019). SIRF: A Single-cell Assay for in situ Protein Interaction with Nascent DNA Replication Forks. Bio Protocol

Schlacher K (2019) Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics, JCB  Published online: 19 February 2019

Schlacher K (2018) A new road to cancer-drug resistance, Nature  Published online: 31 October 2018

Roy S, Tomaszowski KH, Luzwick JW, Park S, Li J, Murphy M, Schlacher K (2018). p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways. eLife
<<“Insight” preview in eLife (2018)

Roy, S.,J.W. Luzwick, K. Schlacher (2018). SIRF: Quantitative in situ analysis of protein interactions at DNA replication forks. JCB
Spotlight in JCB (2018)

Schlacher, K.(2017). PARPi focuses the spotlight on replication fork protection in cancer. Nature Cell Biology

Schlacher, K., Wu, H. and *Jasin M. (2012). A Novel Replication Fork Protection Pathway connects Fanconi Anemia Tumor Suppressor to RAD51-BRCA1/2. Cancer Cell 

Schlacher, K., Christ, N., Siaud, N., Egashira, A., Wu, H., and *Jasin, M. (2011). Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11. Cell               
<<Faculty of 1000 «must read» Research Highlight in Nature Revs. Mol. Cell Biol.

Schlacher, K., and Goodman, M.F. (2007). Lessons from 50 years of SOS DNA-damage-induced mutagenesis. Nature Revs. Mol. Cell Biol. 

Schlacher, K., Cox, M.M., Woodgate, R., Goodman, M.F. (2006). RecA acts in trans to allow replication of damaged DNA. Nature    
 <<Faculty of 1000 «recommended»

Schlacher, K., Jiang, Q., Woodgate, R., Goodman, M.F. (2006). Purification and Characterization of Escherichia Coli DNA Polymerase V. Meth. of Enz.

Schlacher, K., Pham, P., Cox, M. M., Goodman, M. F. (2006). Roles of DNA Polymerase V and RecA Protein in SOS Damage-Induced Mutation. Chemical Rev. 

Schlacher, K., Leslie, K., Wyman, C., Woodgate, R., Cox, M. M., Goodman, M. F. (2005). DNA polymerase V and RecA protein, a minimal mutasome. Mol. Cell
News and views in Nature Struct. & Mol. Biol.  (2005)

Collaborative publications

Wörmann SM, Zhang A, Thege FI, Cowan RW, Rupani DN, Wang R, Manning SL, Gates C, Wu W, Levin-Klein R, Rajapakshe KI, Yu M, Multani AS, Kang Y, Taniguchi CM, Schlacher K, Bellin MD, Katz MHG, Kim MP, Fleming JB, Gallinger S, Maddipati R, Harris RS, Notta F, Ross SR, Maitra A, Rhim AD. (2021). APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis. Nature Cancer

Hambarde S, Tsai CL, Pandita RK, Bacolla A, Maitra A, Charaka V, Hunt CR, Kumar R, Limbo O, Le Meur R, Chazin WJ, Tsutakawa SE, Russell P, Schlacher K, Pandita TK, Tainer JA. (2021). EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart. Molecular Cell

Msaouel P, Malouf GG, Su X, Yao H, Tripathi DN, Soeung M, Gao J, Rao P, Coarfa C, Creighton CJ, Bertocchio JP, Kunnimalaiyaan S, Multani AS, Blando J, He R, Shapiro DD, Perelli L, Srinivasan S, Carbone F, Pilié PG, Karki M, Seervai RNH, Vokshi BH, Lopez-Terrada D, Cheng EH, Tang X, Lu W, Wistuba II, Thompson TC, Davidson I, Giuliani V, Schlacher K, Carugo A, Heffernan TP, Sharma P, Karam JA, Wood CG, Walker CL, Genovese G, Tannir NM. (2020). Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma. Cancer Cell

Lazarchuk P, Roy S, Schlacher K, Sidorova J. (2019). Detection and Quantitation of Acetylated Histones on Replicating DNA Using In Situ Proximity Ligation Assay and Click-It Chemistry. Methods Molecular Biology

Ma S, Pradeep S, Villar-Prados A, Wen Y, Bayraktar E, Mangala LS, Kim MS, Wu SY, Hu W, Rodriguez-Aguayo C, Leuschner C, Liang X, Ram PT, Schlacher K, Coleman RL, Sood AK. (2019). GnRH-R-Targeted Lytic Peptide Sensitizes BRCA Wild-type Ovarian Cancer to PARP Inhibition. Molecular Cancer Therapy

Gadhikar MA, Zhang J, Shen L., Schlacher K, Frederick MJ, Myers JN. (2018). CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition. Cancer Research

Tian, Y., Shen, X., Wang, R., Klages-Mundt, N., Lynn, E.J., Martin, S.K., Ye, Y., Gao, M., Chen, J., Schlacher, K.,Li, L.(2017). Constitutive role of the Fanconi anemia D2 gene in the replication stress response. Journal of Biological Chemistry

Xu S., Wu X., Wu L., Castillo A., Liu J., Atkinson E., Paul A., Su D., Schlacher K.,Komatsu Y., You MJ., Wang B. (2017). Abro1 maintains genome stability and limits replication stress by protecting replication fork stability. Genes & Development

Liu, W., Zhou, M., Li, Z., Li, H., Polaczek, P., Dai, H., Wu, Q., Liu, C., Karanja, K., Popuri, V., Shan., S., Schlacher., K., Zheng, L., Campbell, J., Shen, B. (2016). Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy. EbioMedicine

Guo, C., Kumagai, A., Schlacher, K., Shevchenko, A., Shevchenko, A. and Dunphy, W.G. (2015) Interaction of Chk1 with Treslin Negatively Regulates the Initiation of Chromosomal DNA Replication. Mol. Cell

Siaud, N., Barbera M, Egashira, A., Lam I., Christ, N. Schlacher, K. Xia B., and Jasin, M. (2011). Plasticity of BRCA2 Function in Homologous Recombination. PLOS Genet.
<<Faculty of 1000 «must read»