Schadler Laboratory

The Schadler lab has two broad categories of interest: tumor vascular biology and the utilization of exercise as a therapeutic adjuvant. We use mouse models of pediatric bone sarcomas and melanoma to a) determine the molecular pathways in tumor endothelium that regulate the vascular response to exercise; b) determine how the anti-tumor immune response is changed by exercise; c) determine whether exercise and diet modifications can be used to protect against chemotherapy-induced cardiac toxicity; d) identify potential therapeutic targets in tumor endothelium to induce tumor vessel normalization. We also collaborate closely with clinicians in order to perform clinical trials in which cancer patients participate in exercise studies.