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Selected Lab Publications

Dorta-Estremera S, Nehete PN, Yang G, He H, Nehete BP, Shelton KA, Barry MA, Sastry KJ. Minimally invasive monitoring of CD4 T cells at multiple mucosal tissues after intranasal vaccination in rhesus macaques. PLoS One. 2017 Dec 8;12(12):e0188807. doi: 10.1371/journal.pone.0188807. eCollection 2017.
Khan A, Singh S, Galvan G, Jagannath C, Sastry KJ. Prophylactic Sublingual Immunization with Mycobacterium tuberculosis Subunit Vaccine Incorporating the Natural Killer T Cell Agonist Alpha-Galactosylceramide Enhances Protective Immunity to Limit Pulmonary and Extra-Pulmonary Bacterial Burden in Mice. Vaccines (Basel) 5(4), 2017. e-Pub 2017. PMID: 29210987.
Nehete PN, Magden ER, Nehete BP, Williams LE, Abee CR, Sastry KJ. Age- and Sex-associated Differences in Phenotypic and Functional Characteristics of Peripheral Blood Lymphocytes in Chimpanzees (Pan troglodytes). J Am Assoc Lab Anim Sci 56(5):509-519, 2017. PMID: 28903821.
Dorta-Estremera S, Nehete PN, Yang G, He H, Nehete BP, Shelton KK, Barry MA, Sastry KJ. Minimally invasive monitoring of CD4 T cells at multiple mucosal tissues after intranasal vaccination in rhesus macaques. PLoS One 12(12):e0188807, 2017. e-Pub 2017. PMID: 29220358.
Singh S, Schluns KS, Yang G, Anthony SM, Barry MA, Sastry KJ. Intranasal Vaccination Affords Localization and Persistence of Antigen-Specific CD8? T Lymphocytes in the Female Reproductive Tract. Vaccines (Basel) 4(1), 2016. e-Pub 2016. PMID: 26999228.
Bartkowiak T, Singh S, Yang G, Galvan G, Haria D, Ai M, Allison JP, Sastry KJ, Curran MA. Unique potential of 4-1BB agonist antibody to promote durable regression of HPV+ tumors when combined with an E6/E7 peptide vaccine. Proc Natl Acad Sci U S A 112(38):E5290-9, 2015. e-Pub 2015. PMID: 26351680.
Singh S, Yang G, Byrareddy SN, Barry MA, Sastry KJ. Natural killer T cell and TLR9 agonists as mucosal adjuvants for sublingual vaccination with clade C HIV-1 envelope protein. Vaccine 32(51):6934-6940, 2014. e-Pub 2014. PMID: 25444819.
Singh S, Nehete PN, Yang G, He H, Nehete B, Hanley PW, Barry MA, Sastry KJ. Enhancement of Mucosal Immunogenicity of Viral Vectored Vaccines by the NKT Cell Agonist Alpha-Galactosylceramide as Adjuvant. Vaccines (Basel) 2(4):686-706, 2014. PMID: 25553254.
Singh S, Yang G, Schluns KS, Anthony SM, Sastry KJ. Sublingual vaccination induces mucosal and systemic adaptive immunity for protection against lung tumor challenge. PLoS One 9(3):e90001, 2014. e-Pub 2014. PMID: 24599269.
Nehete PN, Hanley PW, Nehete BP, Yang G, Ruiz JC, Williams L, Abee CR, Sastry KJ. Phenotypic and functional characterization of lymphocytes from different age groups of Bolivian squirrel monkeys (Saimiri boliviensis boliviensis). PLoS One 8(11):e79836, 2013. e-Pub 2013. PMID: 24282512.
Singh S, Shenoy S, Nehete PN, Yang P, Nehete B, Fontenot D, Yang G, Newman RA, Sastry KJ. Nerium oleander derived cardiac glycoside oleandrin is a novel inhibitor of HIV infectivity. Fitoterapia 84:32-9, 2013. e-Pub 2012. PMID: 23127567.
Courtney AN, Thapa P, Singh S, Wishahy AM, Zhou D, Sastry J. Intranasal but not intravenous delivery of the adjuvant α-galactosylceramide permits repeated stimulation of natural killer T cells in the lung. Eur J Immunol 41(11):3312-22, 2011. e-Pub 2011. PMID: 21818755.
He H, Nehete PN, Nehete B, Wieder E, Yang G, Buchl S, Sastry KJ. Functional impairment of central memory CD4 T cells is a potential early prognostic marker for changing viral load in SHIV-infected rhesus macaques. PLoS One 6(5):e19607, 2011. e-Pub 2011. PMID: 21602924.
He H, Courtney AN, Wieder E, Sastry KJ. Multicolor flow cytometry analyses of cellular immune response in rhesus macaques. J Vis Exp(38), 2010. e-Pub 2010. PMID: 20414189.
Nehete PN, Nehete B, He H, Sastry KJ. In vivo targeting of an HIV synthetic peptide cocktail vaccine to dendritic cells in rhesus macaques to prime antigen-specific cell-mediated immunity. Current Topics in Peptide & Protein Research 11:37-48, 2010.
Fontenot D, He H, Hanabuchi S, Nehete PN, Zhang M, Chang M, Nehete B, Wang YH, Wang YH, Ma ZM, Lee HC, Ziegler SF, Courtney AN, Miller CJ, Sun SC, Liu YJ, Sastry KJ. TSLP production by epithelial cells exposed to immunodeficiency virus triggers DC-mediated mucosal infection of CD4+ T cells. Proc Natl Acad Sci U S A 106(39):16776-81, 2009. e-Pub 2009. PMID: 19805372.
Courtney AN, Nehete PN, Nehete BP, Thapa P, Zhou D, Sastry KJ. Alpha-galactosylceramide is an effective mucosal adjuvant for repeated intranasal or oral delivery of HIV peptide antigens. Vaccine 27(25-26):3335-41, 2009. e-Pub 2009. PMID: 19200849.
Nehete PN, Nehete BP, Hill L, Manuri PR, Baladandayuthapani V, Feng L, Simmons J, Sastry KJ. Selective induction of cell-mediated immunity and protection of rhesus macaques from chronic SHIV(KU2) infection by prophylactic vaccination with a conserved HIV-1 envelope peptide-cocktail. Virology 370(1):130-41, 2008. e-Pub 2007. PMID: 17920095.
Fontenot D, Jones JK, Hossain MM, Nehete PN, Vela EM, Dwyer VA, Jagannadha Sastry K. Critical role of Arg59 in the high-affinity gp120-binding region of CD4 for human immunodeficiency virus type 1 infection. Virology 363(1):69-78, 2007. e-Pub 2007. PMID: 17320923.
Manuri PR, Nehete B, Nehete PN, Reisenauer R, Wardell S, Courtney AN, Gambhira R, Lomada D, Chopra AK, Sastry KJ. Intranasal immunization with synthetic peptides corresponding to the E6 and E7 oncoproteins of human papillomavirus type 16 induces systemic and mucosal cellular immune responses and tumor protection. Vaccine 25(17):3302-10, 2007. e-Pub 2007. PMID: 17291642.
Sarkar AK, Tortolero-Luna G, Follen M, Sastry KJ. Inverse correlation of cellular immune responses specific to synthetic peptides from the E6 and E7 oncoproteins of HPV-16 with recurrence of cervical intraepithelial neoplasia in a cross-sectional study. Gynecol Oncol 99(3 Suppl 1):S251-61, 2005. e-Pub 2005. PMID: 16188303.
Nehete PN, Nehete BP, Manuri P, Hill L, Palmer JL, Sastry KJ. Protection by dendritic cells-based HIV synthetic peptide cocktail vaccine: preclinical studies in the SHIV-rhesus model. Vaccine 23(17-18):2154-9, 2005. PMID: 15755586.
Lomada D, Gambhira R, Nehete PN, Guhad FA, Chopra AK, Peterson JW, Sastry KJ. A two-codon mutant of cholera toxin lacking ADP-ribosylating activity functions as an effective adjuvant for eliciting mucosal and systemic cellular immune responses to peptide antigens. Vaccine 23(4):555-65, 2004. PMID: 15530705.
Starost MF, Hill LR, Nehete PN, Sastry KJ. Extramedullary hematopoiesis in the mandibular lymph node of simian-human immunodeficiency virus-infected rhesus monkeys (Macaca mulatta): a report of three cases. Vet Pathol 41(2):186-90, 2004. PMID: 15017035.
Hill LR, Nehete PN, Schapiro SJ, Nehete BP, Sastry KJ. SHIV transmission and susceptibility to re-exposure through social contact following vaccination with an HIV synthetic peptide-cocktail: a case study. J Med Primatol 33(1):10-5, 2004. PMID: 15061727.
Nehete PN, Gambhira R, Nehete BP, Sastry KJ. Dendritic cells enhance detection of antigen-specific cellular immune responses by lymphocytes from rhesus macaques immunized with an HIV envelope peptide cocktail vaccine. J Med Primatol 32(2):67-73, 2003. PMID: 12823628.
Keeney TS, Nomura LE, Maecker HT, Sastry KJ. Flow cytometric analysis of macaque whole blood for antigen-specific intracellular cytokine production by T lymphocytes. J Med Primatol 32(1):23-30, 2003. PMID: 12733599.
Nehete PN, Vela EM, Hossain MM, Sarkar AK, Yahi N, Fantini J, Sastry KJ. A post-CD4-binding step involving interaction of the V3 region of viral gp120 with host cell surface glycosphingolipids is common to entry and infection by diverse HIV-1 strains. Antiviral Res 56(3):233-51, 2002. PMID: 12406507.
Nehete PN, Chitta S, Hossain MM, Hill L, Bernacky BJ, Baze W, Arlinghaus RB, Sastry KJ. Protection against chronic infection and AIDS by an HIV envelope peptide-cocktail vaccine in a pathogenic SHIV-rhesus model. Vaccine 20(5-6):813-25, 2001. PMID: 11738745.
Dolbier CL, Cocke RR, Leiferman JA, Steinhardt MA, Schapiro SJ, Nehete PN, Perlman JE, Sastry J. Differences in functional immune responses of high vs. low hardy healthy individuals. J Behav Med 24(3):219-29, 2001. PMID: 11436543.
Sastry KJ, Nehete PN, Savary CA. Impairment of antigen-specific cellular immune responses under simulated microgravity conditions. In Vitro Cell Dev Biol Anim 37(4):203-8, 2001. PMID: 11409684.
Schapiro SJ, Nehete PN, Perlman JE, Sastry KJ. A comparison of cell-mediated immune responses in rhesus macaques housed singly, in pairs, or in groups. Appl Anim Behav Sci 68(1):67-84, 2000. PMID: 10771316.
Sarkar AK, Mitchell MF, Hamada K, Buchl SJ, Satterfield WC, Schapiro SJ, Keeling ME, Sastry KJ. Evaluation of cellular immune responses in rhesus monkeys subjected to adenovirus-mediated gene transfer into the cervix. Cancer Gene Ther 6(3):220-7, 1999. PMID: 10359207.
Schapiro SJ, Nehete PN, Perlman JE, Bloomsmith MA, Sastry KJ. Effects of dominance status and environmental enrichment on cell-mediated immunity in rhesus macaques. Appl Anim Behav Sci 56:319-32, 1998.
Nehete PN, Lewis DE, Tang DN, Pollack MS, Sastry KJ. Presence of HLA-C-restricted cytotoxic T-lymphocyte responses in long-term nonprogressors infected with human immunodeficiency virus. Viral Immunol 11(3):119-29, 1998. PMID: 9918403.
Nehete PN, Schapiro SJ, Johnson PC, Murthy KK, Satterfield WC, Sastry KJ. A synthetic peptide from the first conserved region in the envelope protein gp160 is a strong T-cell epitope in HIV-infected chimpanzees and humans. Viral Immunol 11(3):147-58, 1998. PMID: 9918406.
Casement KS, Arlinghaus KB, Sastry KJ. Cytotoxic T-lymphocyte response induced by a V3 loop synthetic peptide from an African HIV-1 isolate is cross-reactive against HIV-1 strains from North America/Europe region. AIDS 10(12):1440-1, 1996. PMID: 8902081.
Sastry KJ, Marin MC, Nehete PN, McConnell K, el-Naggar AK, McDonnell TJ. Expression of human immunodeficiency virus type I tat results in down-regulation of bcl-2 and induction of apoptosis in hematopoietic cells. Oncogene 13(3):487-93, 1996. PMID: 8760290.
Nehete PN, Johnson PC, Schapiro SJ, Arlinghaus RB, Sastry KJ. Cross-reactive T-cell proliferative responses to V3 peptides corresponding to different geographical HIV-1 isolates in HIV-seropositive individuals. J Clin Immunol 16(2):115-24, 1996. PMID: 8690775.
Casement KS, Nehete PN, Arlinghaus RB, Sastry KJ. Cross-reactive cytotoxic T lymphocytes induced by V3 loop synthetic peptides from different strains of human immunodeficiency virus type 1. Virology 211(1):261-7, 1995. PMID: 7645219.
Nehete PN, Murthy KK, Satterfield WC, Arlinghaus RB, Sastry KJ. Studies on V3-specific cross-reactive T-cell responses in chimpanzees chronically infected with HIV-1IIIB. AIDS 9(6):567-72, 1995. PMID: 7662194.
Nehete PN, Casement KS, Arlinghaus RB, Sastry KJ. Studies on in vivo induction of HIV-1 envelope-specific cytotoxic T lymphocytes by synthetic peptides from the V3 loop region of HIV-1 IIIB gp 120. Cell Immunol 160(2):217-23, 1995. PMID: 7720083.
Sarkar AK, Tortolero-Luna G, Nehete PN, Arlinghaus RB, Mitchell MF, Sastry KJ. Studies on in vivo induction of cytotoxic T lymphocyte responses by synthetic peptides from E6 and E7 oncoproteins of human papillomavirus type 16. Viral Immunol 8(3):165-74, 1995. PMID: 8833270.
Nehete PN, Arlinghaus RB, Sastry KJ. Use of helper T cell-inducing peptides from conserved regions in HIV-1 env in a noncovalent mixture with a CTL-inducing V3-loop peptide for in vivo induction of long-lasting systemic CTL response. Viral Immunol 7(4):189-97, 1994. PMID: 7576033.
Nehete PN, Arlinghaus RB, Sastry KJ. Inhibition of human immunodeficiency virus type 1 infection and syncytium formation in human cells by V3 loop synthetic peptides from gp120. J Virol 67(11):6841-6, 1993. PMID: 7692087.
Nehete PN, Satterfield WC, Matherne CM, Arlinghaus RB, Sastry KJ. Induction of human immunodeficiency virus-specific T cell responses in rhesus monkeys by synthetic peptides from gp160. AIDS Res Hum Retroviruses 9(3):235-40, 1993. PMID: 8471313.

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