Rugang Zhang Laboratory

METTL3-mediated chromatin contacts promote phase separation through metabolic reprogramming during senescence

Nat Commun 15(1):5410, 2024. PMID: 38926365 Opens a new window

Wang C, Tanizawa H, Hill C, Havas A, Zhang Q, Liao L, Hao X, Lei X, Wang L, Hao N, Qi Y, Tian B, Gardini A, Kossenkov AV, Goldman A, Berger SL, Noma K, Adams PD, Zhang R

Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade

Nat Commun 15(1):2853, 2024. PMID: 38565883 Opens a new window

Nie H, Saini P, Miyamoto T, Liao L, Zielinski RJ, Liu H, Zhou W, Wang C, Murphy B, Towers M, Yang T, Qi Y, Kannan T, Kossenkov A, Tateno H, Claiborne DT, Zhang N, Abdel-Mohsen M, Zhang R

TXNRD1 drives the innate immune response in senescent cells with implications for age-associated inflammation

Nat Aging 4(2): 185-197, 2024. PMID: 38267705 Opens a new window

Hao X, Zhao B, Towers M, Liao L, Monteiro EL, Xu X, Freeman C, Peng H, Tang HY, Havas A, Kossenkov AV, Berger SL, Adams PD, Speicher DW, Schultz D, Marmorstein R, Zaret KS, Zhang R

Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis

Cancer Cell 41(4):740-756, 2023. PMID: 36963401 Opens a new window

Zhou W, Liu H, Yuan Z, Zundell J, Towers M, Lin J, Lombardi S, Nie H, Murphy B, Yang T, Wang C, Liao L, Goldman AR, Kannan T, Kossenkov AV, Drapkin R, Montaner LJ, Claiborne DT, Zhang N, Wu S, Zhang R

ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16INK4a levels

Nat Cell Biol 24(8):1202-1210, 2022. PMID: 35851616 Opens a new window

Hao X, Shiromoto Y, Sakurai M, Towers M, Zhang Q, Wu S, Havas A, Wang L, Berger S, Adams PD, Tian B, Nishikura K, Kossenkov AV, Liu P, Zhang R

m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype

Nat Cell Biol 23(4):355-365, 2021. PMID: 33795874 Opens a new window

Liu P, Li F, Lin J, Fukumoto T, Nacarelli T, Hao X, Kossenkov AV, Simon MC, Zhang R

Targeting glutamine dependence through GLS1 inhibition suppresses ARID1A-inactivated clear cell ovarian carcinoma

Nat Cancer 2(2):189-200, 2021. PMID: 34085048 Opens a new window

Wu S, Fukumoto T, Lin J, Nacarelli T, Wang Y, Ong D, Liu H, Fatkhutdinov N, Zundell JA, Karakashev S, Zhou W, Schwartz LE, Tang HY, Drapkin R, Liu Q, Huntsman DG, Kossenkov AV, Speicher DW, Schug ZT, Van Dang C, Zhang R

EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition

Cancer Cell 37(2):157-167, 2020. PMID: 32004442 Opens a new window

Karakashev S, Fukumoto T, Zhao B, Lin J, Wu S, Fatkhutdinov N, Park PH, Semenova G, Jean S, Cadungog MG, Borowsky ME, Kossenkov AV, Liu Q, Zhang R