Publications
Zou G, Park JI. WNT Signaling in Liver Regeneration, Disease, and Cancer. Clin Mol Hepatol. 2022 Jul 4;. doi: 10.3350/cmh.2022.0058. [Epub ahead of print] Review. PubMed PMID: 35785913.
Ko KP, Zhang J, Park JI. Establishing transgenic murine esophageal organoids. STAR Protoc. 2022 Jun 17;3(2):101317. doi: 10.1016/j.xpro.2022.101317. eCollection 2022 Jun 17. PubMed PMID: 35496812; PubMed Central PMCID: PMC9048136.
Kim KB, Kabra A, Kim DW, Xue Y, Huang Y, Hou PC, Zhou Y, Miranda LJ, Park JI, Shi X, Bender TP, Bushweller JH, Park KS. KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer. Sci Adv. 2022 Feb 18;8(7):eabl4618. doi: 10.1126/sciadv.abl4618. Epub 2022 Feb 16. PubMed PMID: 35171684; PubMed Central PMCID: PMC8849394.
Zheng B, Ko KP, Fang X, Wang X, Zhang J, Jun S, Kim BJ, Luo W, Kim MJ, Jung YS, Cervantes CL, Park JI. A new murine esophageal organoid culture method and organoid-based model of esophageal squamous cell neoplasia. iScience. 2021 Dec 17;24(12):103440. doi: 10.1016/j.isci.2021.103440. eCollection 2021 Dec 17. PubMed PMID: 34877497; PubMed Central PMCID: PMC8633967.
Kim MJ, Cervantes C, Jung YS, Zhang X, Zhang J, Lee SH, Jun S, Litovchick L, Wang W, Chen J, Fang B, Park JI. PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis. Mol Cell. 2021 Apr 15;81(8):1698-1714.e6. doi: 10.1016/j.molcel.2021.02.001. Epub 2021 Feb 23. PubMed PMID: 33626321; PubMed Central PMCID: PMC8052288.
Jung YS, Stratton SA, Lee SH, Kim MJ, Jun S, Zhang J, Zheng B, Cervantes CL, Cha JH, Barton MC, Park JI. TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis. Hepatology. 2021 Feb;73(2):776-794. doi: 10.1002/hep.31305. Epub 2020 Nov 17. PubMed PMID: 32380568; PubMed Central PMCID: PMC7647947.
Kim HK, Bae J, Lee SH, Hwang SH, Kim MS, Kim MJ, Jun S, Cervantes CL, Jung YS, Back S, Lee H, Lee SE, Dougherty PM, Lee SW, Park JI, Abdi S. Blockers of Wnt3a, Wnt10a, or β-Catenin Prevent Chemotherapy-Induced Neuropathic Pain In Vivo. Neurotherapeutics. 2021 Jan;18(1):601-614. doi: 10.1007/s13311-020-00956-w. Epub 2020 Oct 30. PubMed PMID: 33128175; PubMed Central PMCID: PMC8116404.
Shen X, Wang R, Kim MJ, Hu Q, Hsu CC, Yao J, Klages-Mundt N, Tian Y, Lynn E, Brewer TF, Zhang Y, Arun B, Gan B, Andreeff M, Takeda S, Chen J, Park JI, Shi X, Chang CJ, Jung SY, Qin J, Li L. A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia. Mol Cell. 2020 Dec 17;80(6):1013-1024.e6. doi: 10.1016/j.molcel.2020.11.040. PubMed PMID: 33338401; PubMed Central PMCID: PMC8600940.
Kim MJ, Huang Y, Park JI. Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views. Cancers (Basel). 2020 Dec 4;12(12). doi: 10.3390/cancers12123638. Review. PubMed PMID: 33291655; PubMed Central PMCID: PMC7761926.
Jung YS, Park JI. Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex. Exp Mol Med. 2020 Feb;52(2):183-191. doi: 10.1038/s12276-020-0380-6. Epub 2020 Feb 10. Review. PubMed PMID: 32037398; PubMed Central PMCID: PMC7062731.
Jung YS, Kim MJ, Park JI. LncGata6-controlled stemness in regeneration and cancer. Noncoding RNA Investig. 2019 Jan;3. doi: 10.21037/ncri.2019.01.02. Epub 2019 Jan 15. PubMed PMID: 30775691; PubMed Central PMCID: PMC6377203.
Jung YS, Jun S, Kim MJ, Lee SH, Suh HN, Lien EM, Jung HY, Lee S, Zhang J, Yang JI, Ji H, Wu JY, Wang W, Miller RK, Chen J, McCrea PD, Kopetz S, Park JI. TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling. Nat Cell Biol. 2018 Dec;20(12):1421-1433. doi: 10.1038/s41556-018-0219-8. Epub 2018 Oct 29. PubMed PMID: 30374053; PubMed Central PMCID: PMC6261670.
Jung YS, Wang W, Jun S, Zhang J, Srivastava M, Kim MJ, Lien EM, Shang J, Chen J, McCrea PD, Zhang S, Park JI. Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin. Nat Cell Biol. 2018 Nov;20(11):1303-1314. doi: 10.1038/s41556-018-0215-z. Epub 2018 Oct 22. PubMed PMID: 30361697; PubMed Central PMCID: PMC6261439.
Kim MJ, Xia B, Suh HN, Lee SH, Jun S, Lien EM, Zhang J, Chen K, Park JI. PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis. Dev Cell. 2018 Mar 12;44(5):582-596.e4. doi: 10.1016/j.devcel.2018.02.010. PubMed PMID: 29533773; PubMed Central PMCID: PMC5854208.
Suh HN, Kim MJ, Jung YS, Lien EM, Jun S, Park JI. Quiescence Exit of Tert+ Stem Cells by Wnt/β-Catenin Is Indispensable for Intestinal Regeneration. Cell Rep. 2017 Nov 28;21(9):2571-2584. doi: 10.1016/j.celrep.2017.10.118. PubMed PMID: 29186692; PubMed Central PMCID: PMC5726811.
Suh HN, Jun S, Oh AY, Srivastava M, Lee S, Taniguchi CM, Zhang S, Lee WS, Chen J, Park BJ, Park JI. Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia. Sci Rep. 2016 Dec 6;6:38273. doi: 10.1038/srep38273. PubMed PMID: 27922049; PubMed Central PMCID: PMC5138641.
Jun S, Jung YS, Suh HN, Wang W, Kim MJ, Oh YS, Lien EM, Shen X, Matsumoto Y, McCrea PD, Li L, Chen J, Park JI. LIG4 mediates Wnt signalling-induced radioresistance. Nat Commun. 2016 Mar 24;7:10994. doi: 10.1038/ncomms10994. PubMed PMID: 27009971; PubMed Central PMCID: PMC4820809.
Wang X, Jung YS, Jun S, Lee S, Wang W, Schneider A, Sun Oh Y, Lin SH, Park BJ, Chen J, Keyomarsi K, Park JI. PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness. Nat Commun. 2016 Feb 4;7:10633. doi: 10.1038/ncomms10633. PubMed PMID: 26843124; PubMed Central PMCID: PMC4743006.
Jung YS, Jun S, Lee SH, Sharma A, Park JI. Wnt2 complements Wnt/β-catenin signaling in colorectal cancer. Oncotarget. 2015 Nov 10;6(35):37257-68. doi: 10.18632/oncotarget.6133. PubMed PMID: 26484565; PubMed Central PMCID: PMC4741928.
Wang W, Li X, Lee M, Jun S, Aziz KE, Feng L, Tran MK, Li N, McCrea PD, Park JI, Chen J. FOXKs promote Wnt/β-catenin signaling by translocating DVL into the nucleus. Dev Cell. 2015 Mar 23;32(6):707-18. doi: 10.1016/j.devcel.2015.01.031. PubMed PMID: 25805136; PubMed Central PMCID: PMC4374128.
Lee M, Ji H, Furuta Y, Park JI, McCrea PD. p120-catenin regulates REST and CoREST, and modulates mouse embryonic stem cell differentiation. J Cell Sci. 2014 Sep 15;127(Pt 18):4037-51. doi: 10.1242/jcs.151944. Epub 2014 Jul 29. PubMed PMID: 25074806; PubMed Central PMCID: PMC4163646.
Jun S, Lee S, Kim HC, Ng C, Schneider AM, Ji H, Ying H, Wang H, DePinho RA, Park JI. PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis. Cell Rep. 2013 Oct 31;5(2):314-22. doi: 10.1016/j.celrep.2013.09.026. PubMed PMID: 24209743; PubMed Central PMCID: PMC4157353.
Jung HY, Jun S, Lee M, Kim HC, Wang X, Ji H, McCrea PD, Park JI. PAF and EZH2 induce Wnt/β-catenin signaling hyperactivation. Mol Cell. 2013 Oct 24;52(2):193-205. doi: 10.1016/j.molcel.2013.08.028. Epub 2013 Sep 19. PubMed PMID: 24055345; PubMed Central PMCID: PMC4040269.
Wang X, Singh S, Jung HY, Yang G, Jun S, Sastry KJ, Park JI. HIV-1 Vpr protein inhibits telomerase activity via the EDD-DDB1-VPRBP E3 ligase complex. J Biol Chem. 2013 May 31;288(22):15474-80. doi: 10.1074/jbc.M112.416735. Epub 2013 Apr 23. PubMed PMID: 23612978; PubMed Central PMCID: PMC3668709.
Jung HY, Wang X, Jun S, Park JI. Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation. J Biol Chem. 2013 Mar 8;288(10):7252-62. doi: 10.1074/jbc.M112.416792. Epub 2013 Jan 28. PubMed PMID: 23362280; PubMed Central PMCID: PMC3591633.
Wang W, Huang J, Wang X, Yuan J, Li X, Feng L, Park JI, Chen J. PTPN14 is required for the density-dependent control of YAP1. Genes Dev. 2012 Sep 1;26(17):1959-71. doi: 10.1101/gad.192955.112. PubMed PMID: 22948661; PubMed Central PMCID: PMC3435498.
Hong JY, Park JI, Lee M, Muñoz WA, Miller RK, Ji H, Gu D, Ezan J, Sokol SY, McCrea PD. Down's-syndrome-related kinase Dyrk1A modulates the p120-catenin-Kaiso trajectory of the Wnt signaling pathway. J Cell Sci. 2012 Feb 1;125(Pt 3):561-9. doi: 10.1242/jcs.086173. PubMed PMID: 22389395; PubMed Central PMCID: PMC3367828.
Hong JY, Park JI, Cho K, Gu D, Ji H, Artandi SE, McCrea PD. Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members. J Cell Sci. 2010 Dec 15;123(Pt 24):4351-65. doi: 10.1242/jcs.067199. Epub 2010 Nov 23. PubMed PMID: 21098636; PubMed Central PMCID: PMC2995616.
Park JI, Venteicher AS, Hong JY, Choi J, Jun S, Shkreli M, Chang W, Meng Z, Cheung P, Ji H, McLaughlin M, Veenstra TD, Nusse R, McCrea PD, Artandi SE. Telomerase modulates Wnt signalling by association with target gene chromatin. Nature. 2009 Jul 2;460(7251):66-72. doi: 10.1038/nature08137. PubMed PMID: 19571879; PubMed Central PMCID: PMC4349391.
Lyons JP, Miller RK, Zhou X, Weidinger G, Deroo T, Denayer T, Park JI, Ji H, Hong JY, Li A, Moon RT, Jones EA, Vleminckx K, Vize PD, McCrea PD. Requirement of Wnt/beta-catenin signaling in pronephric kidney development. Mech Dev. 2009 Mar-Apr;126(3-4):142-59. doi: 10.1016/j.mod.2008.11.007. Epub 2008 Dec 7. PubMed PMID: 19100832; PubMed Central PMCID: PMC2684468.
McCrea PD, Park JI. Developmental functions of the P120-catenin sub-family. Biochim Biophys Acta. 2007 Jan;1773(1):17-33. doi: 10.1016/j.bbamcr.2006.06.009. Epub 2006 Jul 1. Review. PubMed PMID: 16942809.
Park JI, Ji H, Jun S, Gu D, Hikasa H, Li L, Sokol SY, McCrea PD. Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct catenin subfamilies promote Wnt signals. Dev Cell. 2006 Nov;11(5):683-95. doi: 10.1016/j.devcel.2006.09.022. PubMed PMID: 17084360.
Park JI, Kim SW, Lyons JP, Ji H, Nguyen TT, Cho K, Barton MC, Deroo T, Vleminckx K, Moon RT, McCrea PD. Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets. Dev Cell. 2005 Jun;8(6):843-54. doi: 10.1016/j.devcel.2005.04.010. PubMed PMID: 15935774; NIHMSID:NIHMS134023.
Kim SW, Park JI, Spring CM, Sater AK, Ji H, Otchere AA, Daniel JM, McCrea PD. Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin. Nat Cell Biol. 2004 Dec;6(12):1212-20. doi: 10.1038/ncb1191. Epub 2004 Nov 14. PubMed PMID: 15543138.
Fang X, Ji H, Kim SW, Park JI, Vaught TG, Anastasiadis PZ, Ciesiolka M, McCrea PD. Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac. J Cell Biol. 2004 Apr;165(1):87-98. doi: 10.1083/jcb.200307109. Epub 2004 Apr 5. PubMed PMID: 15067024; PubMed Central PMCID: PMC2172091.
Park JI, Lee MG, Cho K, Park BJ, Chae KS, Byun DS, Ryu BK, Park YK, Chi SG. Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways. Oncogene. 2003 Jul 10;22(28):4314-32. doi: 10.1038/sj.onc.1206478. PubMed PMID: 12853969.
Byun DS, Cho K, Ryu BK, Lee MG, Park JI, Chae KS, Kim HJ, Chi SG. Frequent monoallelic deletion of PTEN and its reciprocal association with PIK3CA amplification in gastric carcinoma. Int J Cancer. 2003 Apr 10;104(3):318-27. doi: 10.1002/ijc.10962. PubMed PMID: 12569555.
Park BJ, Park JI, Byun DS, Park JH, Chi SG. Mitogenic conversion of transforming growth factor-beta1 effect by oncogenic Ha-Ras-induced activation of the mitogen-activated protein kinase signaling pathway in human prostate cancer. Cancer Res. 2000 Jun 1;60(11):3031-8. PubMed PMID: 10850453.
Kang MJ, Park BJ, Byun DS, Park JI, Kim HJ, Park JH, Chi SG. Loss of imprinting and elevated expression of wild-type p73 in human gastric adenocarcinoma. Clin Cancer Res. 2000 May;6(5):1767-71. PubMed PMID: 10815895.