Publications

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Actin dysregulation induces immune evasion via oxidative stress-activated PD-L1 in gastric cancer
Seo Y, Jang J, Ko KP, Zou G, Huang Y, Zhang S, Zhang J, Jun S, Chu W, Venkatesan V, Dhakshinamoorthy S, Park JI
bioRxiv 10.1101/2024.12.18.629227​ PMID: 39763993; PMCID: PMC11702617

Actin dysregulation induces neuroendocrine plasticity and immune evasion: a vulnerability of small cell lung cancer
Seo Y, Zhang S, Jang J, Ko KP, Kim KB, Huang Y, Kim DW, Kim B, Zou G, Zhang J, Jun S, Chu W, Kirk NA, Hwang YE, Ban YH, Dhar SS, Chan JM, Lee MG, Rudin CM, Park KS, Park JI
bioRxiv 10.1101/2023.02.15.528365; PMID: 36824957; PMCID: PMC9949038​

PCLAF-DREAM drives alveolar cell plasticity for lung regeneration
Kim B, Huang Y, Ko KP, Zhang S, Zou G, Zhang J, Kim MJ, Little D, Ellis LV, Paschini M, Jun S, Park KS, Chen J, Kim C, Park JI
Nature Communications 2024 Oct 24;15(1):9169; 15:9159. PMID: 39448571; PMCID: PMC11502753

In vivo CRISPR screens identify Mga as an immunotherapy target in triple-negative breast cancer
Feng X, Yang C, Huang Y, Su D, Wang C, Wilson LL, Yin L, Tang M, Li S, Chen Z, Zhu D, Wang S, Zhang S, Zhang J, Zhang H, Nie L, Huang M, Park JI, Hart T, Jiang D, Jiang K, Chen J
Proceedings of the National Academy of Sciences Sept, 2024; 121 (39) e2406325121

CRACD loss induces neuroendocrine cell plasticity of lung adenocarcinoma
Kim B, Zhang S, Huang Y, Ko KP, Jung YS, Jang J, Zou G, Zhang J, Jun S, Kim KB, Park KS, Park JI
Cell Reports 2024 May 25; 43(6):114286. doi: 10.1016/j.celrep.2024.114286. PMID: 38796854; PMCID: PMC11216895

Tumor niche network-defined subtypes predict immunotherapy response of esophageal squamous cell cancer
Ko KP, Zhang S, Huang Y, Kim B, Zou G, Jun S, Zhang J, Zhao Y, Martin C, Dunbar KJ, Efe G, Rustgi AK, Nakagawa H, Zhang H, Liu Z, Park JI
iScience 2024 April 22;27(5):109795. doi: 10.1016/j.isci.2024.109795. PMID: 38741711, PMCID: PMC11089351

E-cadherin loss promotes diffuse-type gastric cancer tumorigenesis via EZH2-mediated reprogramming
Zou G*, Huang Y*, Zhang S, Ko KP, Kim B, Zhang J, Venkatesan V, Pizzi MP, Fan Y, Jun S, Niu N, Wang H, Song S, Ajani JA, Park JI
Journal of Experimental Medicine 2024 Feb; 221 (4): e20230561. https://doi.org/10.1084/jem.20230561PMID: 38411616, PMCID: PMC10899090

Key genetic determinants driving esophageal squamous cell carcinoma initiation and immune evasion
Ko KP, Huang Y, Zhang S, Zou G, Kim B, Zhang J, Jun S, Martin C, Dunbar KJ, Efe G, Rustgi AK, Nakagawa H, Park JI
Gastroenterology 2023 Sep;165(3):613-628.e20.doi.org/10.1053/j.gastro.2023.05.030. PMID: 37257519, PMCID: PMC10527250

Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling integrity is required for mammary tumorigenesis
Zhang S, Lee SH, Nie L, Huang Y, Zou G, Jung YS, Jun S, Zhang J, Lien EM, Chen J, Park JI
Cancer Communications 2023 Jan;43(1):159-163. PMID: 36336962, PMCID: PMC9859727, DOI: 10.1002/cac2.12382

Nuclear Actin Dynamics in Gene Expression, DNA Repair, and Cancer
Huang Y,* Zhang S*, Park JI
In: Kloc, M., Kubiak, J.Z. (eds) Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine. Results and Problems in Cell Differentiation, vol 70. Springer, Cham. https://doi.org/10.1007/978-3-031-06573-6_23 (PDF), PMID: 36348125, PMCID: PMC9677682

WNT5A-RHOA signaling is a driver of tumorigenesis and represents a therapeutically actionable vulnerability in small cell lung cancer
Kim KB, Kim DW, Kim Y, Tang J, Kirk N, Gan Y, Kim B, Fang B, Park JL, Zheng Y, Park KS
Cancer Research 14 Sep 2022, CAN-22-1170. doi: 10.1158/0008-5472.CAN-22-1170, PMID: 36102736, PMCID: PMC9669186

WNT Signaling in Liver Regeneration, Disease, and Cancer
Zou G, Park JI
Clin Mol Hepatol 2022 Jul 4;. doi: 10.3350/cmh.2022.0058. PMID: 35785913

Establishing Transgenic Murine Esophageal Organoids
Ko KP, Zhang J, Park JI
STAR Protocols Volume 3, Issue 2, 17 June 2022, 101317, https://doi.org/10.1016/j.xpro.2022.101317, PMID: 35496812, PMCID: PMC9048136

KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small-cell lung cancer
Kim KB, Kabra A, Kim DW, Xue Y, Huang Y, Hou PC, Zhou Y, Miranda LJ, Park JI, Shi X, Bender TP, Bushweller JH, Park KS
Science Advances 2022 Feb 18;8(7):eabl4618. doi: 10.1126/sciadv.abl4618. Epub 2022 Feb 16, PMID: 35171684

A New Murine Esophageal Organoid Culture Method and Organoid-Based Model of Esophageal Squamous Cell Neoplasia
Zheng B*, Ko KP*, Fang X, Wang X, Zhang J, Jun S, Kim BJ, Luo W, Kim MJ, Jung YS, Cervantes CL, Park JI
iScience 2021 Nov 15; 103440, DOI:https://doi.org/10.1016/j.isci.2021.103440, PMID: 34877497, PMC8633967

Yap/Taz-Activated Tert-Expressing Acinar Cells Are Required for Pancreatic Regeneration
Suh HN, Kim MJ, Lee SH, Jun S, Zhang J, Johnson RL, Park JI
bioRxiv 2021 Sep; doi: https://doi.org/10.1101/2021.08.30.458292

PAF Remodels the DREAM Complex to Bypass Cell Quiescence and Promote Lung Tumorigenesis
Kim MJ, Cervantes C, Jung YS, Zhang X, Zhang J, Lee SH, Jun S, Litovchick L, Wang W, Chen J, Fang B, Park JI
Molecular Cell 2021 Feb 17;S1097-2765(21)00087-3, doi: 10.1016/j.molcel.2021.02.001, PMID: 33626321, PMC8052288

TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis
Jung YS, Stratton SA, Lee SH, Kim MJ, Jun S, Zhang J, Zheng B, Cervantes CL, Cha JH, Barton MC, Park JI
Hepatology 2021 Feb;73(2):776-794. doi: 10.1002/hep.31305. Epub 2020 Nov 17. PMID: 32380568; PMCID: PMC7062731. 

A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia
Shen X, Wang R, Kim MJ, Hu Q, Hsu CC, Yao J, Klages-Mundt N, Tian Y, Lynn E, Brewer TF, Zhang Y, Arun B, Gan B, Andreeff M, Takeda S, Chen J, Park JI, Shi X, Chang CJ, Jung SY, Qin J, Li L
Molecular Cell 2020 Dec 17;80(6):1013-1024.e6. doi: 10.1016/j.molcel.2020.11.040. PubMed PMID: 33338401.

Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views
Kim MJ*, Huang Y*, Park JI
Cancers (Basel) 2020 Dec 4;12(12). doi: 10.3390/cancers12123638. PubMed PMID: 33291655.

Blockers of Wnt3a, Wnt10a or β-catenin prevent chemotherapy-induced neuropathic pain in vivo
Kim HK, Bae J, Lee SH, Hwang SH, Kim MS, Kim MJ, Jun S, Cervantes CL, Jung YS, Back S, Lee H, Lee SE, Dougherty PM, Lee SW, Park JI, Abdi S
Neurotherapeutics 2020 Oct 30. PMID: 33128175; DOI: 10.1007/s13311-020-00956-w

Wnt Signaling in Cancer: Therapeutic Targeting of Wnt Signaling beyond β-Catenin and Destruction Complex
Jung YS, Park JI
Experimental Molecular Medicine 2020 Feb 10;. doi: 10.1038/s12276-020-0380-6. PMID: 32037398, PMCID: PMC7062731

LncGata6-Controlled Stemness in Regeneration and Cancer
Jung YS*, Kim MJ*, Park JI
Non-coding RNA Investig pii: 4. doi: 10.21037/ncri.2019.01.02., 1/2019, PMCID: PMC6377203

TMEM9 Promotes Intestinal Tumorigenesis via v-ATPase-Activated Wnt/β-Catenin Signaling 
Jung YS, Jun S, Kim MJ, Lee SH, Suh HN, Lien EM, Jung HY, Lee S, Zhang J, Yang JI, Ji H, Wu JY, Wang W, Miller RK, Chen J, McCrea PD, Kopetz S, Park JI
Nature Cell Biology 20, 1421-1433, 12/2018, PMCID: PMC6261670.

Deregulation of CRAD-Controlled Cytoskeleton Initiates Mucinous Colorectal Cancer via β-Catenin
Jung YS, Wang W, Jun S, Zhang J, Srivastava M, Kim MJ, Lien EM, Shang J, Chen J, McCrea PD, Zhang S, Park JI
Nature Cell Biology 20, 1303-1314, 11/2018, PMCID: PMC6261439

PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis
Kim MJ, Xia B, Suh HN, Lee SH, Jun S, Lien EM, Zhang J, Chen K, Park JI
Developmental Cell 44, 582-596, 3/2018 PMCID: PMC5854208.

Quiescence Exit of Tert+ Stem Cells by Wnt/β-Catenin Is Indispensable for Intestinal Regeneration
Suh HN, Kim MJ, Jung YS, Lien EM, Jun S, Park JI
Cell Reports 21, 2571-2584 11/2017 PMCID: PMC5726811.

Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia
Suh HN,* Jun S,* Oh AY, Srivastava M, Lee S, Taniguchi CM, Zhang S, Lee WS, Chen J, Park BJ, Park JI
Scientific Reports 6:38273, 12/2016. e-Pub 12/2016. PMCID: PMC5138641

LIG4 mediates Wnt signalling-induced radioresistance
Jun S,* Jung YS,* Suh HN, Wang W, Kim MJ, Oh YS, Lien EM, Shen X, Matsumoto Y, McCrea PD, Li L, Chen J, Park JI
Nature Communications 7:10994, 2016. e-Pub 3/2016. PMCID: PMC4820809

PAF-Wnt Signaling-Induced Cell Plasticity Is Required for Maintenance of Breast Cancer Cell Stemness
Wang X,* Jung YS,* Jun S, Lee S, Wang W, Schneider A, Sun Oh Y, Lin SH, Park BJ, Chen J, Keyomarsi K, Park JI
Nature Communications doi:10.1038/ncomms10633:10633, 2016. e-Pub 2/2016. PMCID: PMC4743006

Wnt2 complements Wnt/β-catenin signaling in colorectal cancer
Jung YS, Jun S, Lee SH, Sharma A, Park JI
Oncotarget 6(35)(35):37257-68, 11/2015. e-Pub 10/2015. PMCID: PMC4741928.

PAF and EZH2 Induce Wnt/β-Catenin Signaling Hyperactivation
Jung HY, Jun S, Lee M, Kim HC, Wang X, Ji H, McCrea PD, Park JI
Molecular Cell 52(2):193-205, 10/2013. e-Pub 9/2013. PMCID: PMC4040269

PAF-Mediated MAPK Signaling Hyperactivation via LAMTOR3 Induces Pancreatic Tumorigenesis
Jun S, Lee SH, Kim HC, Ng C, Schneider AM, Ji H, Ying H, Wang H, DePinho RA, Park JI
Cell Reports e-Pub 10/2013. PMCID: PMC4157353

FOXKs Promote Wnt/β-Catenin Signaling by Translocating DVL into the Nucleus
Wang W, Li X, Lee M, Jun S, Aziz KE, Feng L, Tran MK, Li N, McCrea PD, Park JI, Chen J
Developmental Cell 32(6):707-18, 3/2015. PMCID: PMC4374128

P120-catenin regulates REST/CoREST, and modulates mouse embryonic stem cell differentiation
Lee M, Ji H, Furuta Y, Park JI, McCrea PD
Journal of Cell Science 127(Pt 18):4037-51, 9/2014. e-Pub 7/2014. PMCID: PMC4163646

HIV-1 Vpr Inhibits Telomerase Activity Via EDD-DDB1-VPRB3 E3 Ligase Complex
Wang X, Singh S, Jung HY, Yang G, Jun S, Sastry KJ, Park JI
Journal of Biological Chemistry 288(22):15474-80, 5/2013. e-Pub 4/2013. PMCID: PMC3668709

Dyrk2-Associated EDD-DDB1-VprBP E3 Ligase Inhibits Telomerase by TERT Degradation
Jung HY, Wang X, Jun S, Park JI
Journal of Biological Chemistry 288(10):7252-62, 3/2013. e-Pub 1/2013. PMCID: PMC3591633

Down's-syndrome-related kinase Dyrk1A modulates the p120-catenin-Kaiso trajectory of the Wnt signaling pathway
Hong JY, Park JI, Lee M, Muñoz WA, Miller RK, Ji H, Gu D, Ezan J, Sokol SY, McCrea PD
Journal of Cell Science 125(Pt 3):561-9, 2/2012. PMCID: PMC3367828

PTPN14 is required for the density-dependent control of YAP1
Wang W, Huang J, Wang X, Yuan J, Li X, Feng L, Park JI, Chen J
Genes and Development 26(17):1959-71, 9/2012. PMCID: PMC3435498

Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members
Hong JY, Park JI, Cho K, Gu D, Ji H, Artandi SE, McCrea PD
Journal of Cell Science 123(Pt 24):4351-4365, 12/2010. e-Pub 11/2010. PMCID: PMC2995616

Telomerase modulates Wnt signalling by association with target gene chromatin
Park JI, Venteicher AS, Hong JY, Choi J, Jun S, Shkreli M, Chang W, Meng Z, Cheung P, Ji H, McLaughlin M, Veenstra TD, Nusse R, McCrea PD, Artandi SE
Nature 460 (7251):66-72, 7/2009. PMCID: PMC4349391

Requirement of Wnt/beta-catenin signaling in pronephric kidney development
Lyons JP, Miller RK, Zhou X, Weidinger G, Deroo T, Denayer T, Park JI, Ji H, Hong JY, Li A, Moon RT, Jones EA, Vleminckx K, Vize PD, McCrea PD
Mechanisms of Development e-Pub 12/2008. PMCID: PMC2684468. 126(3-4):142-59, 3/2009

Developmental functions of the P120-catenin sub-family
McCrea PD, Park JI
Biochimica et Biophysica Acta 2007; 1773(1):17-33. PMID: 16942809

Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct catenin subfamilies promote Wnt signals
Park JI, Ji H, Jun S, Gu D, Hikasa H, Li L, Sokol SY, McCrea PD
Developmental Cell 11(5):683-95, 11/2006. PMID: 17084360

Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets
Park JI, Kim SW, Lyons JP, Ji H, Nguyen TT, Cho K, Barton MC, Deroo T, Vleminckx K, Moon RT, McCrea PD
Developmental Cell 8(6):843-54, 6/2005. PMID: 15935774.

Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin
Kim SW, Park JI, Spring CM, Sater AK, Ji H, Otchere AA, Daniel JM, McCrea PD
Nature Cell Biology 6(12):1212-20, 12/2004. e-Pub 11/2004. PMID: 15543138.

Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac
Fang X, Ji H, Kim SW, Park JI, Vaught TG, Anastasiadis PZ, Ciesiolka M, McCrea PD
Journal of Cell Biology 165(1):87-98, 4/2004. e-Pub 4/2004. PMCID: PMC2172091.

Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways
Park JI, Lee MG, Cho K, Park BJ, Chae KS, Byun DS, Ryu BK, Park YK, Chi SG
Oncogene 22(28):4314-32, 7/2003. PMID: 12853969.

Frequent monoallelic deletion of PTEN and its reciprocal association with PIK3CA amplification in gastric carcinoma
Byun DS, Cho K, Ryu BK, Lee MG, Park JI, Chae KS, Kim HJ, Chi SG
International Journal of Cancer 104(3):318-27, 4/2003. PMID: 12569555.

Mitogenic conversion of transforming growth factor-beta1 effect by oncogenic Ha-Ras-induced activation of the mitogen-activated protein kinase signaling pathway in human prostate cancer
Park BJ, Park JI, Byun DS, Park JH, Chi SG
Cancer Research 60(11):3031-8, 6/2000. PMID: 10850453.

Loss of imprinting and elevated expression of wild-type p73 in human gastric adenocarcinoma
Kang MJ, Park BJ, Byun DS, Park JI, Kim HJ, Park JH, Chi SG
Clinical Cancer Research 6(5):1767-71, 5/2000. PMID: 10815895

*Equally contributed authors