Publications

1.  Okhuysen PC, Jiang ZD, Carlin L, Forbes C, DuPont HL. Post-diarrhea chronic intestinal symptoms and irritable bowel syndrome in North American travelers to Mexico. Am J Gastroenterol 99(9):1774-1778, 9/2004.

2.  Huang DB, Chappell C, Okhuysen PC. Cryptosporidiosis in children. Semin Pediatr Infect Dis 15(4):253-9, 10/2004.

3.  Kjos SA, Jenkins M, Okhuysen PC, Chappell CL. Evaluation of recombinant oocyst protein CP41 for detection of cryptosporidium-specific antibodies. Clin Diagn Lab Immunol 12(2):268-72, 2/2005. PMCID: PMC549316.

4.  DuPont HL, Jiang ZD, Okhuysen PC, Ericsson CD, de la Cabada FJ, Ke S, DuPont MW, Martinez-Sandoval F. A randomized, double-blind, placebo-controlled trial of rifaximin to prevent travelers' diarrhea. Ann Intern Med 142(10):805-12, 5/2005.

5   Okhuysen PC, Chappell CL, Lewis DE, Robinson P, White AC. Treatment of chronic cryptosporidiosis in AIDS with rIL-12 induces an immune response associated with improvement but severe side-effects. AIDS 19(12):1333-4, 8/2005.

6.  Mohr JF, McKinnon PS, Peymann PJ, Kenton I, Septimus E, Okhuysen PC. A retrospective, comparative evaluation of dysglycemias in hospitalized patients receiving gatifloxacin, levofloxacin, ciprofloxacin, or ceftriaxone. Pharmacotherapy 25(10):1303-9, 10/2005.

7.  DuPont HL, Jiang ZD, Okhuysen PC, Ericsson CD, de la Cabada FJ, Ke S, DuPont MW, Martinez-Sandoval F. Antibacterial chemoprophylaxis in the prevention of traveler's diarrhea: evaluation of poorly absorbed oral rifaximin. Clin Infect Dis 41 Suppl 8:S571-6, 12/2005.

8.  Okhuysen PC. Current concepts in travelers' diarrhea: epidemiology, antimicrobial resistance and treatment. Curr Opin Infect Dis 18(6):522-6, 12/2005.

9.  Ko G, Garcia C, Jiang ZD, Okhuysen PC, Belkind-Gerson J, Glass RI, DuPont HL. Noroviruses as a cause of traveler's diarrhea among students from the United States visiting Mexico. J Clin Microbiol 43(12):6126-9, 12/2005. PMCID: PMC1317226.

10.  Jiang ZD, DuPont HL, Garey K, Price M, Graham G, Okhuysen P, Dao-Tran T, LaRocco M. A common polymorphism in the interleukin 8 gene promoter is associated with Clostridium difficile diarrhea. Am J Gastroenterol 101(5):1112-6, 5/2006.

11.  Ko G, Jiang ZD, Okhuysen PC, DuPont HL. Fecal cytokines and markers of intestinal inflammation in international travelers with diarrhea due to Noroviruses. J Med Virol 78(6):825-8, 6/2006.

12.  Huang DB, Nataro JP, DuPont HL, Kamat PP, Mhatre AD, Okhuysen PC, Chiang T. Enteroaggregative Escherichia coli is a cause of acute diarrheal illness: a meta-analysis. Clin Infect Dis 43(5):556-63, 9/2006. e-Pub 7/2006.

13.  Huang DB, Mohanty A, DuPont HL, Okhuysen PC, Chiang T. A review of an emerging enteric pathogen: enteroaggregative Escherichia coli. J Med Microbiol 55(Pt 10):1303-11, 10/2006.

14.  Chappell CL, Okhuysen PC, Langer-Curry R, Widmer G, Akiyoshi DE, Tanriverdi S, Tzipori S. Cryptosporidium hominis: experimental challenge of healthy adults. Am J Trop Med Hyg 75(5):851-7, 11/2006.

15.  The Strategies for Management of Antiretroviral Therapy (SMART) Study Group. CD4+ Count-Guided Interruption of Antiretroviral Treatment. N. Engl J Med(355):2283-2296, 2006.

16.  Mohamed JA, Huang DB, Jiang ZD, DuPont HL, Nataro JP, Belkind-Gerson J, Okhuysen PC. Association of putative enteroaggregative Escherichia coli virulence genes and biofilm production in isolates from travelers to developing countries. J Clin Microbiol 45(1):121-6, 1/2007. e-Pub 11/2006. PMCID: PMC1828990.

17.  Wang HC, Dann SM, Okhuysen PC, Lewis DE, Chappell CL, Adler DG, White AC. High levels of CXCL10 are produced by intestinal epithelial cells in AIDS patients with active cryptosporidiosis but not after reconstitution of immunity. Infect Immun 75(1):481-7, 1/2007. e-Pub 10/2006. PMCID: PMC1828373.

18.  DuPont HL, Haake R, Taylor DN, Ericsson CD, Jiang ZD, Okhuysen PC, Steffen R. Rifaximin treatment of pathogen-negative travelers' diarrhea. J Travel Med 14(1):16-9, Jan-Feb, 1/2007.

19.  Mohamed JA, DuPont HL, Jiang ZD, Belkind-Gerson J, Figueroa JF, Armitige LY, Tsai A, Nair P, Martinez-Sandoval FJ, Guo DC, Hayes P, Okhuysen PC. A novel single-nucleotide polymorphism in the lactoferrin gene is associated with susceptibility to diarrhea in North American travelers to Mexico. Clin Infect Dis 44(7):945-52, 4/2007. e-Pub 2/2007.

20.  Dupont HL, Jiang ZD, Belkind-Gerson J, Okhuysen PC, Ericsson CD, Ke S, Huang DB, Dupont MW, Adachi JA, De La Cabada FJ, Taylor DN, Jaini S, Martinez Sandoval F. Treatment of travelers' diarrhea: randomized trial comparing rifaximin, rifaximin plus loperamide, and loperamide alone. Clin Gastroenterol Hepatol 5(4):451-6, 4/2007. e-Pub 3/2007.

21.  Aguirre-García MM, Okhuysen PC. Cryptosporidium parvum: identification and characterization of an acid phosphatase. Parasitol Res 101(1):85-9, 6/2007. e-Pub 1/2007.

22.  Jiang ZD, Garey KW, Price M, Graham G, Okhuysen P, Dao-Tran T, LaRocco M, DuPont HL. Association of interleukin-8 polymorphism and immunoglobulin G anti-toxin A in patients with Clostridium difficile-associated diarrhea. Clin Gastroenterol Hepatol 5(8):964-8, 8/2007. e-Pub 7/2007.

23.  Ericsson CD, DuPont HL, Okhuysen PC, Jiang ZD, DuPont MW. Loperamide plus azithromycin more effectively treats travelers' diarrhea in Mexico than azithromycin alone. J Travel Med 14(5):312-9, Sep-Oct, 9/2007.

24.  Huang DB, Mohamed JA, Nataro JP, DuPont HL, Jiang ZD, Okhuysen PC. Virulence characteristics and the molecular epidemiology of enteroaggregative Escherichia coli isolates from travellers to developing countries. J Med Microbiol 56(Pt 10):1386-92, 10/2007.

25.  Planque S, Mitsuda Y, Taguchi H, Salas M, Morris MK, Nishiyama Y, Kyle R, Okhuysen P, Escobar M, Hunter R, Sheppard HW, Hanson C, Paul S. Characterization of gp120 hydrolysis by IgA antibodies from humans without HIV infection. AIDS Res Hum Retroviruses 23(12):1541-54, 12/2007.

26.  The ESPRIT Research Group. Predictors of CD4 count change over 8 months of follow up in HIV-1-infected patients with a CD4 count>/=300 cells/muL who were assigned to 7.5 MIU interleukin-2. HIV Med(8):112-123, 2007.

27.  DuPont HL, Haake R, Taylor DN, Ericsson CD, Jiang ZD, Okhuysen PC, Steffen R. Rifaximin treatment of pathogen-negative travelers' diarrhea. J Travel Med 14(1):16-9, Jan-Feb, 2007.

28.  Huang DB, Brown EL, DuPont HL, Cerf J, Carlin L, Flores J, Belkind-Gerson J, Nataro JP, Okhuysen PC. Seroprevalence of the enteroaggregative Escherichia coli virulence factor dispersin among USA travellers to Cuernavaca, Mexico: a pilot study. J Med Microbiol 57(Pt 4):476-9, 4/2008.

29.  Flores J, DuPont HL, Jiang ZD, Belkind-Gerson J, Mohamed JA, Carlin LG, Padda RS, Paredes M, Martinez-Sandoval JF, Villa NA, Okhuysen PC. Enterotoxigenic Escherichia coli heat-labile toxin seroconversion in US travelers to Mexico. J Travel Med 15(3):156-61, May-Jun, 5/2008.

30.  Lupo PJ, Langer-Curry RC, Robinson M, Okhuysen PC, Chappell CL. Cryptosporidium muris in a Texas canine population. Am J Trop Med Hyg 78(6):917-21, 6/2008.

31.  Frech SA, Dupont HL, Bourgeois AL, McKenzie R, Belkind-Gerson J, Figueroa JF, Okhuysen PC, Guerrero NH, Martinez-Sandoval FG, Meléndez-Romero JH, Jiang ZD, Asturias EJ, Halpern J, Torres OR, Hoffman AS, Villar CP, Kassem RN, Flyer DC, Andersen BH, Kazempour K, Breisch SA, Glenn GM. Use of a patch containing heat-labile toxin from Escherichia coli against travellers' diarrhoea: a phase II, randomised, double-blind, placebo-controlled field trial. Lancet 371(9629):2019-25, 6/2008.

32.  Grimes KA, Mohamed JA, Dupont HL, Padda RS, Jiang ZD, Flores J, Belkind-Gerson J, Martinez-Sandoval FG, Okhuysen PC. PCR-based assay using occult blood detection cards for detection of diarrheagenic Escherichia coli in specimens from U.S. travelers to Mexico with acute diarrhea. J Clin Microbiol 46(7):2227-30, 7/2008. e-Pub 5/2008. PMCID: PMC2446931.

33.  Nair P, Mohamed JA, DuPont HL, Figueroa JF, Carlin LG, Jiang ZD, Belkind-Gerson J, Martinez-Sandoval FG, Okhuysen PC. Epidemiology of cryptosporidiosis in North American travelers to Mexico. Am J Trop Med Hyg 79(2):210-4, 8/2008. PMCID: PMC2560987.

34.  Flores J, DuPont HL, Lee SA, Belkind-Gerson J, Paredes M, Mohamed JA, Armitige LY, Guo DC, Okhuysen PC. Influence of host interleukin-10 polymorphisms on development of traveler's diarrhea due to heat-labile enterotoxin-producing Escherichia coli in travelers from the United States who are visiting Mexico. Clin Vaccine Immunol 15(8):1194-8, 8/2008. e-Pub 6/2008. PMCID: PMC2519301.

35.  Nallapareddy SR, Singh KV, Okhuysen PC, Murray BE. A functional collagen adhesin gene, acm, in clinical isolates of Enterococcus faecium correlates with the recent success of this emerging nosocomial pathogen. Infect Immun 76(9):4110-9, 9/2008. e-Pub 6/2008. PMCID: PMC2519430.

36.  Carr A, Grund B, Neuhaus J, El-Sadr WM, Grandits G, Gibert C, Prineas RJ and SMART study Investigators. Asymptomatic myocardial ischaemia in HIV-infected adults. AIDS(22):257-267, 2008.

37.  Strategies for Management of Antiretroviral Therapy Study Group. Emery S, Neuhaus JA, Phillips AN, Babiker A, Cohen CJ, Gatell JM, Girard PM, Grund B, Law M, Losso MH, Palfreeman A, Wood R. Major clinical outcomes in antiretroviral therapy (ART)-naive participants and in those not receiving ART at baseline in the SMART study. J Infect Dis(197):1133-1144, 2008.

38.  SMART Study Group. El-Sadr WM, Grund B, Neuhaus J, Babiker A, Cohen CJ, Darbshire J, Emery S, Lundgren JD, Philips A, Neaton JD. Risk of Opportunistic Disease and Death after Re-initiating Continuous Antiretroviral Therapy in Patients with HIV Previously Receiving Episodic therapy: A randomized Trial. Ann Intern Med(149):289-299, 2008.

39.  SMART Study Group. A, Cohen C, Neuhaus J, Baxter J, Emery S, Hirschel B, Hullsiek KH, Stephan C, Lundgren J Fox Z, Phillips. Viral resuppression and detection of drug resistance following interruption of a suppressive non-nucleoside reverse transcriptase inhibitor-based regimen. AIDS 12(22):2279-2289, 2008.

40.  Flores J, Okhuysen PC. Enteroaggregative Escherichia coli infection. Curr Opin Gastroenterol 25(1):8-11, 1/2009.

41.  INSIGHT-SMART Study Group. Mocroft A, Wyatt C, Szczech L, Neuhaus J, El-Sadr W, Tracy R, Kuller L, Shlipak M, Angus B, Klinker H, Ross M. Interruption of antiretroviral therapy is associated with increased plasma cystatin C. AIDS 23(1):71-82, 1/2009.

42.  Mohamed JA, DuPont HL, Jiang ZD, Flores J, Carlin LG, Belkind-Gerson J, Martinez-Sandoval FG, Guo D, White AC, Okhuysen PC. A single-nucleotide polymorphism in the gene encoding osteoprotegerin, an anti-inflammatory protein produced in response to infection with diarrheagenic Escherichia coli, is associated with an increased risk of nonsecretory bacterial diarrhea in North American travelers to Mexico. J Infect Dis 199(4):477-85, 2/2009. PMCID: PMC2742228.

43.  INSIGHT-SMART Study Group. Grund B, Peng G, Gibert CL, Hoy JF, Isaksson RL, Shlay JC, Martinez E, Reiss P, Visnegarwala F, Carr AD. Continuous antiretroviral therapy decreases bone mineral density. AIDS 23(12):1519-1529, 7/2009.

44.  INSIGHT-SMART Study Group. Rodger AJ, Fox Z, Lundgren JD, Kuller LH, Boesecke C, Gey D, Skoutelis A, Goetz MB, Phillips AN. Activation and coagulation biomarkers are independent predictors of the development of opportunistic disease in patients with HIV infection. J Infect Dis 200(6):973-983, 9/2009.

45.  Flores J, Okhuysen PC. Genetics of susceptibility to infection with enteric pathogens. Curr Opin Infect Dis 22(5):471-6, 10/2009. PMCID: PMC2897815.

46.  INSIGHT-ESPRIT Study Group. Abrams D, Levy Y, Losso MH, Babiker A, Collins G, Cooper DA, Darbyshire J, Emery S, Fox L, Gordin F, Lane HC, Lundgren JD, Mitsuyasu R, Neaton JD, Phillips A, Routy JP, Tambussi G, Wentworth D. Interleukin-2 therapy in patients with HIV infection. N Engl J Med 361(16):1548-1559, 10/2009.

47.  INSIGHT-SMART Study Group. Martinez E, Visnegarwala F, Grund B, Thomas A, Gibert C, Shlay J, Drummond F, Pearce D, Edwards S, Reiss P, El-Sadr W, Carr A. The effects of intermittent, CD4-guided antiretroviral therapy on body composition and metabolic parameters. AIDS 24(3):353-363, 1/2010.

48.  Martinez-Sandoval F, Ericsson CD, Jiang ZD, Okhuysen PC, Romero JH, Hernandez N, Forbes WP, Shaw A, Bortey E, DuPont HL. Prevention of travelers' diarrhea with rifaximin in US travelers to Mexico. J Travel Med 17(2):111-7, Mar-Apr, 3/2010.

49.  Koo HL, Ajami NJ, Jiang ZD, Neill FH, Atmar RL, Ericsson CD, Okhuysen PC, Taylor DN, Bourgeois AL, Steffen R, DuPont HL. Noroviruses as a cause of diarrhea in travelers to Guatemala, India, and Mexico. J Clin Microbiol 48(5):1673-6, 5/2010. e-Pub 3/2010. PMCID: PMC2863947.

50.  Flores J, DuPont HL, Paredes-Paredes M, Aguirre-Garcia MM, Rojas A, Gonzalez A, Okhuysen PC. Pilot study of whole-blood gamma interferon response to the Vibrio cholerae toxin B subunit and resistance to enterotoxigenic Escherichia coli-associated diarrhea. Clin Vaccine Immunol 17(5):879-81, 5/2010. e-Pub 3/2010. PMCID: PMC2863377.

51.  Ouyang-Latimer J, Ajami NJ, Jiang ZD, Okhuysen PC, Paredes M, Flores J, Dupont HL. Biochemical and genetic diversity of enterotoxigenic Escherichia coli associated with diarrhea in United States students in Cuernavaca and Guadalajara, Mexico, 2004-2007. J Infect Dis 201(12):1831-8, 6/2010.

52.  Okhuysen PC, Dupont HL. Enteroaggregative Escherichia coli (EAEC): a cause of acute and persistent diarrhea of worldwide importance. J Infect Dis 202(4):503-5, 8/2010.

53.  Ajami N, Koo H, Darkoh C, Atmar RL, Okhuysen PC, Jiang ZD, Flores J, Dupont HL. Characterization of norovirus-associated traveler's diarrhea. Clin Infect Dis 51(2):123-130, July 15, 2010.

54.  Villa NA, Okhuysen PC, Flores-Figueroa J, Jiang ZD, Belkind-Gerson J, Paredes M, Mohamed JA, Nair P, Carlin L, DuPont HL. Campylobacter jejuni is not an important pathogen as a cause of diarrhea in US travelers to Mexico. J Travel Med 18(1):56-8, Jan-Feb, 1/2011. e-Pub 11/2010. PMCID: PMC3057522.

55.  Paredes-Paredes M, Okhuysen PC, Flores J, Mohamed JA, Padda RS, Gonzalez-Estrada A, Haley CA, Carlin LG, Nair P, DuPont HL. Seasonality of diarrheagenic Escherichia coli pathotypes in the US students acquiring diarrhea in Mexico. J Travel Med 18(2):121-5, Mar-Apr, 3/2011. e-Pub 2/2011. PMCID: PMC3074619.

56.  Cozzi-Lepri A, French MA, Baxter J, Okhuysen P, Plana M, Neuhaus J, Landay A, INSIGHT SMART study group. Resumption of HIV replication is associated with monocyte/macrophage derived cytokine and chemokine changes: results from a large international clinical trial. AIDS 25(9):1207-17, 6/2011. PMCID: PMC3101710.

57.  Mohamed JA, DuPont HL, Flores J, Palur H, Nair P, Jiang ZD, Guo D, Belkind-Gerson J, Okhuysen PC. Single nucleotide polymorphisms in the promoter of the gene encoding the lipopolysaccharide receptor CD14 are associated with bacterial diarrhea in US and Canadian travelers to Mexico. Clin Infect Dis 52(11):1332-41, 6/2011. PMCID: PMC3140174.

58.  Chappell CL, Okhuysen PC, Langer-Curry RC, Akiyoshi DE, Widmer G, Tzipori S. Cryptosporidium meleagridis: infectivity in healthy adult volunteers. Am J Trop Med Hyg 85(2):238-42, 8/2011. PMCID: PMC3144819.

59.  Flores J, Dupont HL, Jiang ZD, Okhuysen PC, Melendez-Romero JH, Gonzalez-Estrada A, Carrillo I, Paredes M. A randomized, double-blind, pilot study of rifaximin 550 mg versus placebo in the prevention of travelers' diarrhea in Mexico during the dry season. J Travel Med 18(5):333-6, Sep-Oct, 9/2011. e-Pub 8/2011.

60.  Flores-Figueroa J, Okhuysen PC, von Sonnenburg F, DuPont HL, Libman MD, Keystone JS, Hale DC, Burchard G, Han PV, Wilder-Smith A, Freedman DO, GeoSentinel Surveillance Network. Patterns of illness in travelers visiting Mexico and Central America: the GeoSentinel experience. Clin Infect Dis 53(6):523-31, 9/2011. e-Pub 8/2011.

61.  Gautret P, Gaudart J, Leder K, Schwartz E, Castelli F, Lim PL, Murphy H, Keystone J, Cramer J, Shaw M, Boddaert J, von Sonnenburg F, Parola P; GeoSentinel Surveillance Network. Travel-associated illness in older adults (>60 y). J Travel Med 19(3):169-177, May-Jun, 2012.

62.  McGrath DM, Barbu EM, Driessen WH, Lasco TM, Tarrand JJ, Okhuysen PC, Kontoyiannis DP, Sidman RL, Pasqualini R, Arap W. Mechanism of action and initial evaluation of a membrane active all-D-enantiomer antimicrobial peptidomimetic. Proc Natl Acad Sci U S A 110(9):3477-82, 2/2013. e-Pub 1/2013. PMCID: PMC3587187.

63.  Bjerk SM, Baker JV, Emery S, Neuhaus J, Angus B, Gordin FM, Pett SL, Stephan C, Kunisaki KM; INSIGHT SMART Study Group. Biomarkers and bacterial pneumonia risk in patients with treated HIV infection: a case-control study. PLoS One(8):e56249, 2013.

64.  Leder K, Torresi J, Libman MD, Cramer JP, Castelli F, Schlagenhauf P, Wilder-Smith A, Wilson ME, Keystone JE, Schwartz E, Barnett ED, von Sonnenburg F, Brownstein JS, Cheng AC, Sotir MJ, Esposito DH, Freedman, DO. GeoSentinel Surveillance of Illness in Returned Travelers, 2007-2011. Ann Intern Med 6(158):456-468, 2013.

65.  Matteelli A, Schlagenhauf P, Carvalho AC, Weld L, Davis XM, Wilder-Smith A, Barnett ED, Parola P, Pandey P, Han P, Castelli F; GeoSentinel Surveillance Network. Travel-associated sexually transmitted infections: an observational cross-sectional study of the GeoSentinel surveillance database. Lancet Infect Dis(13):205-213, 2013.

66.  Borges AH, O'Connor JL, Phillips AN, Baker JV, Vjecha MJ, Losso MH, Klinker H, Lopardo G, Williams I, Lundgren JD; INSIGHT SMART Study Group; ESPRIT Study Group; SILCAAT Scientific Committee. Factors associated with D-dimer levels in HIV-infected individuals. PLoS One 9(3), 3/2014.

67.  Nordell AD, McKenna M, Borges ÁH, Duprez D, Neuhaus J, Neaton JD; INSIGHT SMART, ESPRIT Study Groups; SILCAAT Scientific Committee. Severity of cardiovascular disease outcomes among patients with HIV is related to markers of inflammation and coagulation. J Am Heart Assoc 3(3), 4/2014.

68.  Mahale P, Okhuysen PC, Torres HA. Does chemotherapy cause hepatitis C viral relapse in cancer patients who were successfully treated with antivirals? Clin Gastroenterol Hepatol 12(6):1051-1054, 6/2014.

69.  Nair P, Okhuysen PC, Jiang ZD, Carlin LG, Belkind-Gerson J, Flores J, Paredes M, DuPont HL. Persistent abdominal symptoms in US adults after short-term stay in Mexico. J Travel Med 21(3):153-158, 2014.

70.  Ajami NJ, Kavanagh OV, Ramani S, Crawford SE, Atmar RL, Jiang ZD, Okhuysen, PC. Seroepidemiology of Norovirus-Associated Traveler’s Diarrhea. J. Trav. Med 21(1):6-11, 2014.