Publications
Li Y, Uhelski ML, North RY, Mwirigi JM, Tatsui CE, Cata JP, Corrales G, Price TJ, Dougherty PM. MNK inhibitor eFT508 (Tomivosertib) suppresses ectopic activity in human dorsal root ganglion neurons from dermatomes with radicular neuropathic pain. bioRxiv. 2023 Jun 14:2023.06.13.544811. doi: 10.1101/2023.06.13.544811. Preprint. PMID: 37398249.
Ray PR, Shiers S, Caruso JP, Tavares-Ferreira D, Sankaranarayanan I, Uhelski ML, Li Y, North RY, Tatsui C, Dussor G, Burton MD, Dougherty PM, Price TJ. RNA profiling of human dorsal root ganglia reveals sex differences in mechanisms promoting neuropathic pain. Brain. 2023 Feb 13;146(2):749-766. doi: 10.1093/brain/awac266. PubMed PMID: 35867896.
Li Y, Tatsui CE, Rhines LD, North RY, Harrison DS, Cassidy RM, Johansson CA, Kosturakis AK, Edwards DD, Zhang H, Dougherty PM. Dorsal root ganglion neurons become hyperexcitable and increase expression of voltage-gated T-type calcium channels (Cav3.2) in paclitaxel-induced peripheral neuropathy. Pain. 2017 Mar;158(3):417-429. doi: 10.1097/j.pain.0000000000000774. PubMed PMID: 27902567; PubMed Central PMCID: PMC5303135.
Megat S, Ray PR, Moy JK, Lou TF, Barragán-Iglesias P, Li Y, Pradhan G, Wanghzou A, Ahmad A, Burton MD, North RY, Dougherty PM, Khoutorsky A, Sonenberg N, Webster KR, Dussor G, Campbell ZT, Price TJ. Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain. J Neurosci. 2019 Jan 16;39(3):393-411. doi: 10.1523/JNEUROSCI.2661-18.2018. Epub 2018 Nov 20. PubMed PMID: 30459229; PubMed Central PMCID: PMC6335757.
Li Y, Marri T, North RY, Rhodes HR, Uhelski ML, Tatsui CE, Rhines LD, Rao G, Corrales G, Abercrombie TJ, Johansson CA, Dougherty PM. Chemotherapy-induced peripheral neuropathy in a dish: dorsal root ganglion cells treated in vitro with paclitaxel show biochemical and physiological responses parallel to that seen in vivo. Pain. 2021 Jan;162(1):84-96. doi: 10.1097/j.pain.0000000000002005. PubMed PMID: 32694383; PubMed Central PMCID: PMC7744394.
North RY, Odem MA, Li Y, Tatsui CE, Cassidy RM, Dougherty PM, Walters ET. Electrophysiological Alterations Driving Pain-Associated Spontaneous Activity in Human Sensory Neuron Somata Parallel Alterations Described in Spontaneously Active Rodent Nociceptors. J Pain. 2022 Aug;23(8):1343-1357. doi: 10.1016/j.jpain.2022.02.009. Epub 2022 Mar 12. PubMed PMID: 35292377; PubMed Central PMCID: PMC9357108.
North RY, Lazaro TT, Dougherty PM. Ectopic Spontaneous Afferent Activity and Neuropathic Pain. Neurosurgery. 2018 Sep 1;65(CN_suppl_1):49-54. doi: 10.1093/neuros/nyy119. PubMed PMID: 31076785.
Li Y, North RY, Rhines LD, Tatsui CE, Rao G, Edwards DD, Cassidy RM, Harrison DS, Johansson CA, Zhang H, Dougherty PM. DRG Voltage-Gated Sodium Channel 1.7 Is Upregulated in Paclitaxel-Induced Neuropathy in Rats and in Humans with Neuropathic Pain. J Neurosci. 2018 Jan 31;38(5):1124-1136. doi: 10.1523/JNEUROSCI.0899-17.2017. Epub 2017 Dec 18. PubMed PMID: 29255002; PubMed Central PMCID: PMC5792474.
North RY, Li Y, Ray P, Rhines LD, Tatsui CE, Rao G, Johansson CA, Zhang H, Kim YH, Zhang B, Dussor G, Kim TH, Price TJ, Dougherty PM. Electrophysiological and transcriptomic correlates of neuropathic pain in human dorsal root ganglion neurons. Brain. 2019 May 1;142(5):1215-1226. doi: 10.1093/brain/awz063. PubMed PMID: 30887021; PubMed Central PMCID: PMC6487328.