Publications

De A, Lattier JM, Morales JE, Kelly JR, Zheng X, Chen Z, Sebastian S, Nassiri Toosi Z, Huse JT, Lang FF, McCarty JH. Glial Cell Adhesion Molecule (GlialCAM) Determines Proliferative versus Invasive Cell States in Glioblastoma. J Neurosci. 2023 Nov 22;43(47):8043-8057. doi: 10.1523/JNEUROSCI.1401-23.2023. PubMed PMID: 37722850; PubMed Central PMCID: PMC10669794.

McCarty, JH. αvβ8 integrin adhesion and signaling pathways in development, physiology and disease. J Cell Sci. 2020 Jun 15;133(12):jcs239434. doi: 10.1242/jcs.239434. PMID: 32540905; PMCID: PMC7328133.

Morales JE, De A, Miller AA, Chen Z, McCarty JH. Mlc1-Expressing Perivascular Astrocytes Promote Blood-Brain Barrier Integrity. J Neurosci. 2022 Feb 23;42(8):1406-1416. doi: 10.1523/JNEUROSCI.1918-21.2021. Epub 2021 Dec 29. PMID: 34965971; PMCID: PMC8883848.

De A, Chen Z, Morales JE, Sebastian S, McCarty JH. The Beta-8 Integrin Cytoplasmic Domain Activates Extracellular Matrix Adhesion During Brain Neurovascular Development, Development. 2022 Mar 15;149(6):dev200472. doi: 10.1242/dev.200472. Epub 2022 Mar 18. PMID: 35217866; PMCID: PMC8977100.

Yosef N, Xi Y, McCarty JH. Isolation and transcriptional characterization of mouse perivascular astrocytes. PLoS One. 2020 Oct 8;15(10):e0240035. doi: 10.1371/journal.pone.0240035. PMID: 33031376; PMCID: PMC7544046.

Lattier JM, De A, Chen Z, Morales JE, Lang FF, Huse JT, McCarty JH. Megalencephalic leukoencephalopathy with subcortical cysts 1 (MLC1) promotes glioblastoma cell invasion in the brain microenvironment. Oncogene. 2020 Dec;39(50):7253-7264. doi: 10.1038/s41388-020-01503-9. Epub 2020 Oct 10. PMID: 33040087; PMCID: PMC7736299.

Chen Z, Morales JE, Avci N, Guerrero PA, Rao G, Seo JH, McCarty JH. The vascular endothelial cell-expressed prion protein doppel promotes angiogenesis and blood-brain barrier development. Development. 2020 Sep 23;147(18):dev193094. doi: 10.1242/dev.193094. PMID: 32895288; PMCID: PMC7522017.

Morales JE, De A, Miller AA, Chen Z, McCarty JH. Mlc1-Expressing Perivascular Astrocytes Promote Blood-Brain Barrier Integrity. J Neurosci. 2022 Feb 23;42(8):1406-1416. doi: 10.1523/JNEUROSCI.1918-21.2021. Epub 2021 Dec 29. PMID: 34965971; PMCID: PMC8883848.

De A, Morales JE, Chen Z, Sebastian S, McCarty JH. The β8 integrin cytoplasmic domain activates extracellular matrix adhesion to promote brain neurovascular development. Development. 2022 Mar 15;149(6):dev200472. doi: 10.1242/dev.200472. Epub 2022 Mar 18. PMID: 35217866; PMCID: PMC8977100.

Tiwary S, Morales JE, Kwiatkowski SC, Lang FF, Rao G, McCarty JH. Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a. Sci Rep. 2018 May 29;8(1):8267. doi: 10.1038/s41598-018-26636-6. PMID: 29844613; PMCID: PMC5974340.

Toutounchian JJ, McCarty JH. Selective expression of eGFP in mouse perivascular astrocytes by modification of the Mlc1 gene using T2A-based ribosome skipping. Genesis. 2017 Oct;55(10):10.1002/dvg.23071. doi: 10.1002/dvg.23071. Epub 2017 Oct 6. PMID: 28929580; PMCID: PMC5771503. *Cover article.

Guerrero PA, Tchaicha JH, Chen Z, Morales JE, McCarty N, Wang Q, Sulman EP, Fuller G, Lang FF, Rao G, McCarty JH. Glioblastoma stem cells exploit the αvβ8 integrin-TGFβ1 signaling axis to drive tumor initiation and progression. Oncogene. 2017 Nov 23;36(47):6568-6580. doi: 10.1038/onc.2017.248. Epub 2017 Aug 7. PMID: 28783169; PMCID: PMC5882487.

Kwiatkowski SC, Guerrero PA, Hirota S, Chen Z, Morales JE, Aghi M, McCarty JH. Neuropilin-1 modulates TGFβ signaling to drive glioblastoma growth and recurrence after anti-angiogenic therapy. PLoS One. 2017 Sep 22;12(9):e0185065. doi: 10.1371/journal.pone.0185065. PMID: 28938007; PMCID: PMC5609745.

Cheerathodi M, Avci NG, Guerrero PA, Tang LK, Popp J, Morales JE, Chen Z, Carnero A, Lang FF, Ballif BA, Rivera GM, McCarty JH. The Cytoskeletal Adapter Protein Spinophilin Regulates Invadopodia Dynamics and Tumor Cell Invasion in Glioblastoma. Mol Cancer Res. 2016 Dec;14(12):1277-1287. doi: 10.1158/1541-7786.MCR-16-0251. Epub 2016 Sep 21. PMID: 27655131; PMCID: PMC5136334.

Lee, H. S., Cheerathodi, M., Chaki, S. L., Reyes, S. B., Zheng, Y., DerMardirossian, C., Lu, Z., Lacy-Hulbert, A., Rivera, G. M. and McCarty, J. H. (2015) A Signaling Unit Comprised of b8 Integrin and PTP-PEST Regulates Spatiotemporal Patterns of RhoGDI1 Activation in Migrating Cells, Molecular and Cellular Biology, 35: 1401-1413. PMCID: PMC4372704, *Cover article.

Savar A, Acin S, Gonzalez CL, El-Sawy T, Mejia O, Li Z, Esmaeli B, Lacy-Hulbert A, El-Naggar AK, McCarty JH, Caulin C. Loss of epithelial p53 and αv integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironment. Oncogene. 2015 Jan 22;34(4):516-24. doi: 10.1038/onc.2013.585. Epub 2014 Jan 27. PMID: 24469034; PMCID: PMC4303549.

McCarty JH. Glioblastoma resistance to anti-VEGF therapy: has the challenge been MET? Clin Cancer Res. 2013 Apr 1;19(7):1631-3. doi: 10.1158/1078-0432.CCR-13-0051. Epub 2013 Feb 12. PMID: 23403631; PMCID: PMC3618531.

Narayanan AS, Reyes SB, Um K, McCarty JH, Tolias KF. The Rac-GAP Bcr is a novel regulator of the Par complex that controls cell polarity. Mol Biol Cell. 2013 Dec;24(24):3857-68. doi: 10.1091/mbc.E13-06-0333. Epub 2013 Oct 23. PMID: 24152735; PMCID: PMC3861082.

Reyes SB, Narayanan AS, Lee HS, Tchaicha JH, Aldape KD, Lang FF, Tolias KF, McCarty JH. αvβ8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion. Mol Biol Cell. 2013 Feb;24(4):474-82. doi: 10.1091/mbc.E12-07-0521. Epub 2013 Jan 2. PMID: 23283986; PMCID: PMC3571870.

Allinson KR, Lee HS, Fruttiger M, McCarty JH, Arthur HM. Endothelial expression of TGFβ type II receptor is required to maintain vascular integrity during postnatal development of the central nervous system. PLoS One. 2012;7(6):e39336. doi: 10.1371/journal.pone.0039336. Epub 2012 Jun 26. Erratum in: PLoS One. 2012 Sep;7(9). doi: 10.1371/annotation/8d859757-284b-406d-9cb9-a8776ad32fb1. McCarty, Joseph [corrected to McCarty, Joseph H]. PMID: 22745736; PMCID: PMC3383742.

Hirota S, Liu Q, Lee HS, Hossain MG, Lacy-Hulbert A, McCarty JH. The astrocyte-expressed integrin αvβ8 governs blood vessel sprouting in the developing retina. Development. 2011 Dec;138(23):5157-66. doi: 10.1242/dev.069153. PMID: 22069187; PMCID: PMC3253036.

Tchaicha JH, Reyes SB, Shin J, Hossain MG, Lang FF, McCarty JH. Glioblastoma angiogenesis and tumor cell invasiveness are differentially regulated by β8 integrin. Cancer Res. 2011 Oct 15;71(20):6371-81. doi: 10.1158/0008-5472.CAN-11-0991. Epub 2011 Aug 22. PMID: 21859829; PMCID: PMC3193578.

Jung Y, Kissil JL, McCarty JH. β8 integrin and band 4.1B cooperatively regulate morphogenesis of the embryonic heart. Dev Dyn. 2011 Jan;240(1):271-7. doi: 10.1002/dvdy.22513. PMID: 21181944.

Nguyen HL, Lee YJ, Shin J, Lee E, Park SO, McCarty JH, Oh SP. TGF-β signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development. Lab Invest. 2011 Nov;91(11):1554-63. doi: 10.1038/labinvest.2011.124. Epub 2011 Aug 29. PMID: 21876535; PMCID: PMC3802535.

Mobley AK, McCarty JH. β8 integrin is essential for neuroblast migration in the rostral migratory stream. Glia. 2011 Nov;59(11):1579-87. doi: 10.1002/glia.21199. Epub 2011 Jun 14. PMID: 21674628.

Tchaicha JH, Mobley AK, Hossain MG, Aldape KD, McCarty JH. A mosaic mouse model of astrocytoma identifies alphavbeta8 integrin as a negative regulator of tumor angiogenesis. Oncogene. 2010 Aug 5;29(31):4460-72. doi: 10.1038/onc.2010.199. Epub 2010 Jun 7. PMID: 20531304; PMCID: PMC3037767.

Mobley AK, Tchaicha JH, Shin J, Hossain MG, McCarty JH. Beta8 integrin regulates neurogenesis and neurovascular homeostasis in the adult brain. J Cell Sci. 2009 Jun 1;122(Pt 11):1842-51. doi: 10.1242/jcs.043257. Erratum in: J Cell Sci. 2009 Jul 1;122(Pt 13):2322. PMID: 19461074; PMCID: PMC2694619.

McCarty JH, Lacy-Hulbert A, Charest A, Bronson RT, Crowley D, Housman D, Savill J, Roes J, Hynes RO. Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development. 2005 Jan;132(1):165-76. doi: 10.1242/dev.01551. Epub 2004 Dec 2. PMID: 15576410.

McCarty JH, Cook AA, Hynes, RO. An Interaction between avb8 Integrin and Band 4.1B via a Highly Conserved Region of the Band 4.1 C-Terminal Domain. Proceedings of the National Academy of Sciences,  2005 Mar;102: 13479-83.