Publications

Preprints

Mu Y, Chen Z, Plummer JB, Zelazowska MA, Dong Q, Krug LT, McBride KM. UNG-RPA interaction governs the choice between high-fidelity and mutagenic uracil repair. bioRxiv. 2024 May 3:2024.04.30.591927. doi: 10.1101/2024.04.30.591927.PMID: 38746347 

Mu Y, Plummer JB, Zelazowska MA, Paul S, Dong Q, Chen Z, Krug LT, McBride KM. A Recombinant Antibody For Tracking Murine Gammaherpesvirus 68 Uracil DNA Glycosylase Expression. bioRxiv. 2023 May 18:2023.05.17.541089. doi: 10.1101/2023.05.17.541089. Preprint. PMID: 37293087 

Peer-reviewed

Marshall VA, Cornejo Castro EM, Goodman CA, Labo N, Liu I, Fisher NC, Moore KN, Nair A, Immonen T, Keele BF, Polizzotto MN, Uldrick TS, Mu Y, Saswat T, Krug LT, McBride KM, Lurain K, Ramaswami R, Yarchoan R, Whitby D.  Sequencing of Kaposi's Sarcoma Herpesvirus (KSHV) genomes from persons of diverse ethnicities and provenances with KSHV-associated diseases demonstrate multiple infections, novel polymorphisms, and low intra-host variance. PLoS Pathog. 2024 Jul 15;20(7):e1012338.

Hogan CH, Owens SM, Reynoso GV, Liao Y, Meyer TJ, Zelazowska MA, Liu B, Li X, Grosskopf AK, Khairallah C, Kirillov V, Reich NC, Sheridan BS, McBride KM, Gewurz BE, Hickman HD, Forrest JC, Krug LT.  Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through in vivo B cell knockout models. mBio. 2024 Feb 14;15(2):e0299823

Ying Z, Hardikar S, Plummer JB, Hamidi T, Liu B, Chen Y, Shen J, Mu Y, McBride KM, Chen T.  Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24. Cell Mol Immunol. 2023 Dec;20(12):1487-1498.

Smith KR, Paul S, Dong Q, Anannya O, Oldenburg DG, Forrest JC, McBride KM, Krug LT. Uracil-DNA glycosylase of murine gammaherpesvirus 68 binds cognate viral replication factors independently of its catalytic residues. mSphere. 2023 Oct 24;8(5):e0027823

Liu KJ, Zelazowska MA, McBride KM. The Longitudinal Analysis of Convergent Antibody VDJ Regions in SARS-CoV-2-Positive Patients Using RNA-Seq. Viruses. 2023 May 26;15(6):1253.

Mu Y, Zelazowska MA, Chen Z, Plummer JB, Dong Q, Krug LT, McBride KM. Divergent structures of Mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity. DNA Repair (Amst). 2023 Aug;128:103515. 

Farria AT, Plummer JB, Salinger AP, Shen JJ, Lin K, Lu Y, McBride KM, Dent S. Transcriptional activation of Myc-induced genes by Gcn5 promotes B cell lymphomagenesis. Cancer Res.  2020 Dec 15;80(24):5543-5553.

Hwang T, Reh S, Dunbayev Y, Zhong Y, Takata Y, Shen J, McBride K, Murnane J, Bhak J, Lee S, Wood R, Takata K. Defining the mutation signature of DNA polymerase θ in cancer genomes. NAR Cancer.  2020 Sep;2(3):zcaa017.

Zelazowska MA, Dong Q, Plummer JB, Zhong Y, Liu B, Krug LT, McBride KM. Gammaherpesvirus-infected germinal center cells express a distinct immunoglobulin repertoire. Life Sci Alliance .2020 Feb 6;3(3):e201900526.

Hardikar S, Ying Z, Zeng Y, Zhao H, Liu B, Veland N, McBride K, Cheng X, Chen T. The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation. Protein Cell. 11(3):214-218, 2020.

Helmink BA, Reddy SM, Gao J, Zhang S, Basar R, Thakur R, Yizhak K, Sade-Feldman M, Blando J, Han G, Gopalakrishnan V, Xi Y, Zhao H, Amaria RN, Tawbi HA, Cogdill AP, Liu W, LeBleu VS, Kugeratski FG, Patel S, Davies MA, Hwu P, Lee JE, Gershenwald JE, Lucci A, Arora R, Woodman S, Keung EZ, Gaudreau PO, Reuben A, Spencer CN, Burton EM, Haydu LE, Lazar AJ, Zapassodi R, Hudgens CW, Ledesma DA, Ong S, Bailey M, Warren S, Rao D, Krijgsman O, Rozeman EA, Peeper D, Blank CU, Schumacher TN, Butterfield LH, Zelazowska MA, McBride KM, Kalluri R, Allison J, Petitprez F, Fridman WH, Sautès-Fridman C, Hacohen N, Rezvani K, Sharma P, Tetzlaff MT, Wang L, Wargo JA. B-cells and tertiary lymphoid structures promote immunotherapy response. Nature.  2020 Jan;577(7791):549-555. 

McBride KM, Kil H, Mu Y, Plummer JB, Lee J, Zelazowski MJ, Sebastian M, Abba MC, Aldaz CM. Wwox Deletion in Mouse B Cells Leads to Genomic Instability, Neoplastic Transformation, and Monoclonal Gammopathies. Front Oncol. 2019 Jun 19;9:517.

Dong Q, Smith KR, Oldenburg DG, Shapiro M, Schutt WR, Malik L, Plummer JB, Mu Y, MacCarthy T, White DW, McBride KM, Krug LT. Combinatorial Loss of the Enzymatic Activities of Viral Uracil-DNA Glycosylase and Viral dUTPase Impairs Murine Gammaherpesvirus Pathogenesis and Leads to Increased Recombination-Based Deletion in the Viral Genome. MBio. 2018 Oct 30;9(5):e01831-18.

Mu, Y., Zelazowska, M., McBride, KM. Phosphorylation Promotes Activation-Induced Cytidine Deaminase Activity at the Myc Oncogene. J Exp Med. 2017 Dec 4;214(12):3543-3552.

Takata KI, Reh S, Yousefzadeh MJ, Zelazowski MJ, Bhetawal S, Trono D, Lowery MG, Sandoval M, Takata Y, Lu Y, Lin K, Shen J, Kusewitt DF, McBride KM, Cole F, Wood RD.  Analysis of DNA polymerase v function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance. PLoS Genet. 2017 Jun 1;13(6):e1006818.

Perfetti M, Baughman B, Dickson B, Mu Y, Cui G, Mader P, Dong A, Norris J, Rothbart S, Strahl B, Brown P, Jansen W, Arrowsmith C, Mer G, McBride KM, James L, Frye S.  Identification of a Fragment-like Small Molecule Ligand for the Methyl-lysine Binding Protein, 53BP1.  ACS Chem Biol. Apr 17;10(4):1072-81.

Minkah N, Macaluso M, Oldenburg D, Paden C, White D, McBride KM, Krug L. Absence of the Uracil DNA Glycosylase of Murine Gammaherpesvirus 68 Impairs Replication and Delays the Establishment of Latency In Vivo.  J Virol.  2015 Mar;89(6):3366-79.

Kracker S. Di Virgilio M, Schwartzentruber J, Cuenin C, Forveille M, Deau M, McBride KM, Majewski J, Gazumyan A, Seneviratne S, Grimbacher B, Kutukculer N, Herceg Z, Calvo M, Jabado N, Nussenzweig M, Fischer A, Durandy A. An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex. J Allergy Clin Immunol. 2015 Apr;135(4):998-1007.e6. 

Yousefzadeh, M, Wyatt D, Takata K, Mu Y, Hensley S, Tomida J, Bylund G, Doublie S, Johansson E, Ramsden D, McBride KM, Wood, R. Mechanism of suppression of chromosomal instability by DNA polymerase POLQ. PLoS Genet. 2014 Oct 2;10(10):e1004654.

Yang Y, McBride KM, Hensley S, Lu Y, Chedin F, Bedford M. Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation. Mol Cell. 2014 Feb 6;53(3):484-97.

Yates JL, Racine R, McBride KM, Winslow GM. T cell-dependent IgM memory B cells generated during bacterial infection are required for IgG responses to antigen challenge. J Immunol. 2013 Aug 1;191(3):1240-9

Gazumyan A, Bothmer A, Klein IA, Nussenzweig MC, McBride KM. Activation-induced cytidine deaminase in antibody diversification and chromosome translocation. Adv Cancer Res. 2012;113:167-90.

Gazumyan A, Timachova K, Yuen G, Siden E, Di Virgilio M, Woo EM, Chait BT, Reina San-Martin B, Nussenzweig MC, McBride KM.  Amino terminal phosphorylation of activation-induced cytidine deaminase suppresses c-myc/IgH translocation.  Mol Cell Biol. 2011 Feb;31(3):442-9.

Yamane A, Resch W, Kuo N, Kuchen S, Li Z, Sun HW, Robbiani DF, McBride K, Nussenzweig MC, Casellas R.  Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes.  Nat Immunol. 2011 Jan;12(1):62-9.

Robbiani DF, Bunting S, Feldhahn N, Bothmer A, Camps J, Deroubaix S, McBride KM, Klein IA, Stone G, Eisenreich TR, Ried T, Nussenzweig A, Nussenzweig MC. AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations.  Mol Cell. 2009 Nov 25;36(4):631-41.

McBride KM, Gazumyan A, Woo EM, Schwickert TA, Chait BT, Nussenzweig MC. Regulation of class switch recombination and somatic mutation by AID phosphorylation. J Exp Med. 2008 Oct 27;205(11):2585-94.

Dorsett Y, McBride KM, Jankovic M, Gazumyan A, Thai TH, Robbiani DF, Di Virgilio M, Reina San-Martin B, Heidkamp G, Schwickert TA, Eisenreich T, Rajewsky K, Nussenzweig MC.  MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity. 2008 May;28(5):630-8.           

Shen HM, Bozek G, Pinkert CA, McBride KM, Wang L, Kenter A, Storb U.  Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney.  Mol Immunol. 2008 Apr;45(7):1883-92.

Chatterji M, Unniraman S, McBride KM, Schatz DG. Role of activation-induced deaminase protein kinase A phosphorylation sites in Ig gene conversion and somatic hypermutation. J Immunol. 2007 Oct 15;179(8):5274-80.

Callén E, Jankovic M, Difilippantonio S, Daniel JA, Chen HT, Celeste A, Pellegrini M, McBride KM, Wangsa D, Bredemeyer AL, Sleckman BP, Ried T, Nussenzweig M, Nussenzweig A. ATM prevents the persistence and propagation of chromosome breaks in lymphocytes.  Cell. 2007 Jul 13;130(1):63-75.

Ramiro A, Reina San-Martin B, McBride KM, Jankovic M, Barreto V, Nussenzweig A, Nussenzweig MC. The role of activation-induced deaminase in antibody diversification and chromosome translocations. Adv Immunol. 2007;94:75-107. 

McBride KM, Gazumyan A, Woo EM, Barreto VM, Robbiani DF, Chait BT, Nussenzweig MC.  Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation. Proc Natl Acad Sci. 2006 Jun;103(23):8798-803.

Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature. 2006 Mar 2;440(7080):105-9.

Liu L, McBride KM, Reich NC. STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3. Proc Natl Acad Sci USA. 2005 Jun 7;102(23):8150-5.

McBride KM, Barreto V, Ramiro AR, Stavropoulos P, Nussenzweig MC.  Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase. J Exp Med. 2004 May 3;199(9):1235-44.

Barreto V, Reina-San-Martin B, Ramiro AR, McBride KM, Nussenzweig MC.  C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. Mol Cell. 2003 Aug;12(2):501-8.

Brown MT, McBride, KM, Baniecki ML, Reich NC, Marriott G, Mangel WF. Actin can act as a cofactor for a viral proteinase in the cleavage of the cytoskeleton.  J Biol Chem. 2002 Nov 29;277(48):46298-303.

McBride KM, Banninger G, McDonald C, and Reich NC. Regulated nuclear import of the STAT1 transcription factor by direct binding of Importin-alpha.  EMBO J. 2002 Apr 2;21(7):1754-63.

McBride KM, McDonald C, Reich NC. Nuclear export signal located within the DNA-binding domain of the STAT1transcription factor. EMBO J. 2000 Nov 15;19(22):6196-206.

Kumar KP, McBride KM, Weaver BK, Dingwall C, and Reich NC. Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1. Mol Cell Biol. 2000 Jun;20(11):4159-68.

Reviews

Zelazowska MA, McBride K, Krug LT. Dangerous Liaisons: Gammaherpesvirus Subversion of the Immunoglobulin Repertoire. Viruses. 12(8):788, 2020

Mu Y, McBride KM. Targeting mutagenesis in B cells: Phosphorylation goes beyond AID association. Mol Cell Oncol. 5(5):e1432259, 2018.

McBride KM and Reich NC. The ins and outs of STAT1 nuclear transport. Sci STKE. 2003(195):RE13, Review, 2003.

Book Chapters

McBride KM and Reich NC. Nuclear Trafficking of STAT Proteins. pp. 269-283. In: Signal Transducers and Activators of Transcription (STATs): Activation and Biology,  (Sehgal PB, Levy DE and Hirano T, Eds.) Kluwer Academic Press/Springer, The Netherlands, 2003.