Publications

Correction to: High-Yielding Radiosynthesis of [68 Ga]Ga-PSMA-11 Using a Low-Cost Microfluidic Device. Zhang X, Liu F, Payne AC, Nickels ML, Bellan LM, Manning HC. Mol Imaging Biol. 2021 Aug 2. doi: 10.1007/s11307-021-01633-w. Online ahead of print. PMID: 34338960

Cell-programmed nutrient partitioning in the tumour microenvironment. Reinfeld BI, Madden MZ, Wolf MM, Chytil A, Bader JE, Patterson AR, Sugiura A, Cohen AS, Ali A, Do BT, Muir A, Lewis CA, Hongo RA, Young KL, Brown RE, Todd VM, Huffstater T, Abraham A, O'Neil RT, Wilson MH, Xin F, Tantawy MN, Merryman WD, Johnson RW, Williams CS, Mason EF, Mason FM, Beckermann KE, Vander Heiden MG, Manning HC, Rathmell JC, Rathmell WK. Nature. 2021 May;593(7858):282-288. doi: 10.1038/s41586-021-03442-1. Epub 2021 Apr 7. PMID: 33828302

First-in-human PET imaging and estimated radiation dosimetry of L-[5-11C]-glutamine in patients with metastatic colorectal cancer. Cohen AS, Grudzinski J, Smith GT, Peterson TE, Whisenant JG, Hickman TL, Ciombor KK, Cardin D, Eng C, Goff LW, Das S, Coffey RJ, Berlin JD, Manning HC. J Nucl Med. 2021 Apr 30:jnumed.120.261594. doi: 10.2967/jnumed.120.261594. Online ahead of print. PMID: 33931465

 Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer. Edwards DN, Ngwa VM, Raybuck AL, Wang S, Hwang Y, Kim LC, Cho SH, Paik Y, Wang Q, Zhang S, Manning HC, Rathmell JC, Cook RS, Boothby MR, Chen J. J Clin Invest. 2021 Feb 15;131(4):e140100. doi: 10.1172/JCI140100. PMID: 33320840

TSPO-targeted PET and Optical Probes for the Detection and Localization of Premalignant and Malignant Pancreatic Lesions. Cohen AS, Li J, Hight MR, McKinley E, Fu A, Payne A, Liu Y, Zhang D, Xie Q, Bai M, Ayers GD, Tantawy MN, Smith JA, Revetta F, Washington MK, Shi C, Merchant N, Manning HC. Clin Cancer Res. 2020 Nov 15;26(22):5914-5925. doi: 10.1158/1078-0432.CCR-20-1214. Epub 2020 Sep 15. PMID: 32933996

Combined blockade of EGFR and glutamine metabolism in preclinical models of colorectal cancer. Cohen AS, Geng L, Zhao P, Fu A, Schulte ML, Graves-Deal R, Washington MK, Berlin J, Coffey RJ, Manning HC. Transl Oncol. 2020 Oct;13(10):100828. doi: 10.1016/j.tranon.2020.100828. Epub 2020 Jul 8. PMID: 32652471

High-Yielding Radiosynthesis of [68Ga]Ga-PSMA-11 Using a Low-Cost Microfluidic Device. Zhang X, Liu F, Payne AC, Nickels ML, Bellan LM, Manning HC. Mol Imaging Biol. 2020 Oct;22(5):1370-1379. doi: 10.1007/s11307-020-01515-7. PMID: 32632739

Co-Clinical Imaging Resource Program (CIRP): Bridging the Translational Divide to Advance Precision Medicine. Shoghi KI, Badea CT, Blocker SJ, Chenevert TL, Laforest R, Lewis MT, Luker GD, Manning HC, Marcus DS, Mowery YM, Pickup S, Richmond A, Ross BD, Vilgelm AE, Yankeelov TE, Zhou R. Tomography. 2020 Sep;6(3):273-287. doi: 10.18383/j.tom.2020.00023. PMID: 32879897

N-[18F]-Fluoroacetylcrizotinib: A Potentially Potent and Selective PET Tracer for Molecular Imaging of Non–small Cell Lung Cancer. Buck, JR, Saleh S, Claus T, Lovly C, Hight MR, Nickels ML, Tantay MN, Manning HC. Bio Org Med Chem Let 30(16), 8/2020. PMCID: PMC7357882

The Current Role of Microfluidics in Radiofluorination Chemistry. Knapp KA, Nickels ML, Manning HC. Mol Imaging Biol. 2020 Jun;22(3):463-475. doi: 10.1007/s11307-019-01414-6. PMID: 31485889

Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX-1 in Ovarian Cancer. Uddin MJ, Wilson AJ, Crews BC, Malerba P, Uddin MI, Kingsley PJ, Ghebreselasie K, Daniel CK, Nickels ML, Tantawy MN, Jashim E, Manning HC, Khabele D, Marnett LJ. ACS Omega. 2019 May 31;4(5):9251-9261. doi: 10.1021/acsomega.9b01093. Epub 2019 May 24. PMID: 31172046

Preclinical Evaluation of a Novel TSPO PET Ligand 2-(7-Butyl-2-(4-(2-[18F]Fluoroethoxy)phenyl)-5-Methylpyrazolo[1,5-a]Pyrimidin-3-yl)-N,N-Diethylacetamide (18F-VUIIS1018A) to Image Glioma. Tang D, Li J, Nickels ML, Huang G, Cohen AS, Manning HC. Mol Imaging Biol. 2019 Feb;21(1):113-121. doi: 10.1007/s11307-018-1198-7. PMID: 29869061

Correction: 18F-Fluoroestradiol PET/CT Measurement of Estrogen Receptor Suppression during a Phase I Trial of the Novel Estrogen Receptor-Targeted Therapeutic GDC-0810: Using an Imaging Biomarker to Guide Drug Dosage in Subsequent Trials. Wang Y, Ayres KL, Goldman DA, Dickler MN, Bardia A, Mayer IA, Winer E, Fredrickson J, Arteaga CL, Baselga J, Manning HC, Mahmood U, Ulaner GA. Clin Cancer Res. 2019 Feb 15;25(4):1435. doi: 10.1158/1078-0432.CCR-18-4266. PMID: 30770494

Correction: The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer. Joseph JD, Darimont B, Zhou W, Arrazate A, Young A, Ingalla E, Walter K, Blake RA, Nonomiya J, Guan Z, Kategaya L, Govek SP, Lai AG, Kahraman M, Brigham D, Sensintaffar J, Lu N, Shao G, Qian J, Grillot K, Moon M, Prudente R, Bischoff E, Lee KJ, Bonnefous C, Douglas KL, Julien JD, Nagasawa JY, Aparicio A, Kaufman J, Haley B, Giltnane JM, Wertz IE, Lackner MR, Nannini MA, Sampath D, Schwarz L, Manning HC, Tantawy MN, Arteaga CL, Heyman RA, Rix PJ, Friedman L, Smith ND, Metcalfe C, Hager JH. Elife. 2019 Jan 7;8:e44851. doi: 10.7554/eLife.44851. PMID: 30614786 

Translocator Protein PET Imaging in a Preclinical Prostate Cancer Model. Tantawy MN, Manning HC, Peterson TE, Colvin DC, Gore JC, Lu W, Chen Z, Chad Quarles C. Mol Imaging Biol 20(2):200-204, 2018. PMCID: PMC5903879.

Automated radiosynthesis of 5-[11C]l-glutamine, an important tracer for glutamine utilization. Rosenberg AJ, Nickels ML, Schulte ML, Manning HC. Nucl Med Biol. 2018 Dec;67:10-14. doi: 10.1016/j.nucmedbio.2018.09.002. Epub 2018 Oct 15. PMID: 30359787

Ventral striatal dopamine transporter availability is associated with lower trait motor impulsivity in healthy adults. Smith CT, San Juan MD, Dang LC, Katz DT, Perkins SF, Burgess LL, Cowan RL, Manning HC, Nickels ML, Claassen DO, Samanez-Larkin GR, Zald DH. Transl Psychiatry. 2018 Dec 7;8(1):269. doi: 10.1038/s41398-018-0328-y. PMID: 30531858 

Report from the SWOG Radiation Oncology Committee: Research Objectives Workshop 2017. Okunieff P, Casey-Sawicki K, Lockney NA, Hoppe BS, Enderling H, Pinnix C, Welsh J, Krishnan S, Yothers G, Brown M, Knox S, Bristow R, Spellman P, Mitin T, Nabavizadeh N, Jaboin J, Manning HC, Feng F, Galbraith S, Solanki AA, Harkenrider MM, Tuli R, Decker RH, Finkelstein SE, Hsu CC, Ha CS, Jagsi R, Shumway D, Daly M, Wang TJC, Fitzgerald TJ, Laurie F, Marshall DT, Raben D, Constine L, Thomas CR Jr, Kachnic LA. Clin Cancer Res. 2018 Aug 1;24(15):3500-3509. doi: 10.1158/1078-0432.CCR-17-3202. Epub 2018 Apr 16. PMID: 29661779

A simple microfluidic platform for rapid and efficient production of the radiotracer [18F]fallypride. Zhang X, Liu F, Knapp KA, Nickels ML, Manning HC, Bellan LM. Lab Chip. 2018 May 1;18(9):1369-1377. doi: 10.1039/c8lc00167g. PMID: 29658049

Evaluation of the novel TSPO radiotracer 2-(7-butyl-2-(4-(2-([18F]fluoroethoxy)phenyl)-5-methylpyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide in a preclinical model of neuroinflammation. Tang D, Fujinaga M, Hatori A, Zhang Y, Yamasaki T, Xie L, Mori W, Kumata K, Liu J, Manning HC, Huang G, Zhang MR. Eur J Med Chem. 2018 Apr 25;150:1-8. doi: 10.1016/j.ejmech.2018.02.076. Epub 2018 Feb 24. PMID: 29505933

Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. Schulte ML, Fu A, Zhao P, Li J, Geng L, Smith ST, Kondo J, Coffey RJ, Johnson MO, Rathmell JC, Sharick JT, Skala MC, Smith JA, Berlin J, Washington MK, Nickels ML, Manning HC. Nat Med. 2018 Feb;24(2):194-202. doi: 10.1038/nm.4464. Epub 2018 Jan 15. PMID: 29334372

Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells. Zhang Q, Jeppesen DK, Higginbotham JN, Demory Beckler M, Poulin EJ, Walsh AJ, Skala MC, McKinley ET, Manning HC, Hight MR, Schulte ML, Watt KR, Ayers GD, Wolf MM, Andrejeva G, Rathmell JC, Franklin JL, Coffey RJ. Cell Mol Gastroenterol Hepatol. 2018 Jan 31;5(4):627-629.e6. doi: 10.1016/j.jcmgh.2018.01.013.eCollection 2018. PMID: 29930982 

DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer. Luo N, Nixon MJ, Gonzalez-Ericsson PI, Sanchez V, Opalenik SR, Li H, Zahnow CA, Nickels ML, Liu F, Tantawy MN, Sanders ME, Manning HC, Balko JM. Nat Commun. 2018 Jan 16;9(1):248. doi: 10.1038/s41467-017-02630-w. PMID: 29339738 

Intracardiac Metastases Detected by 18F-FSPG PET/CT. Magarik MA, Walker RC, Gilbert J, Manning HC, Massion PP. Clin Nucl Med. 2018 Jan;43(1):28-30. doi: 10.1097/RLU.0000000000001883. PMID: 29076915

Evaluation of TSPO PET Ligands [18F]VUIIS1009A and [18F]VUIIS1009B: Tracers for Cancer Imaging. Tang D, Li J, Buck JR, Tantawy MN, Xia Y, Harp JM, Nickels ML, Meiler J, Manning HC. Mol Imaging Biol. 2017 Aug;19(4):578-588. doi: 10.1007/s11307-016-1027-9. PMID: 27853987 

Non-Invasive Glutamine PET Reflects Pharmacological Inhibition of BRAFV600E In Vivo. Schulte ML, Hight MR, Ayers GD, Liu Q, Shyr Y, Washington MK, Manning HC. Mol Imaging Biol. 2017 Jun;19(3):421-428. doi: 10.1007/s11307-016-1008-z. PMID: 27770401

18F-Fluoroestradiol PET/CT Measurement of Estrogen Receptor Suppression during a Phase I Trial of the Novel Estrogen Receptor-Targeted Therapeutic GDC-0810: Using an Imaging Biomarker to Guide Drug Dosage in Subsequent Trials. Wang Y, Ayres KL, Goldman DA, Dickler MN, Bardia A, Mayer IA, Winer E, Fredrickson J, Arteaga CL, Baselga J, Manning HC, Mahmood U, Ulaner GA. Clin Cancer Res. 2017 Jun 15;23(12):3053-3060. doi: 10.1158/1078-0432.CCR-16-2197. Epub 2016 Dec 23. PMID: 28011460 0

Optimized Translocator Protein Ligand for Optical Molecular Imaging and Screening. Li J, Smith JA, Dawson ES, Fu A, Nickels ML, Schulte ML, Manning HC. Bioconjug Chem. 2017 Apr 19;28(4):1016-1023. doi: 10.1021/acs.bioconjchem.6b00711. Epub 2017 Feb 13. PMID: 28156095

A comparative assessment of preclinical chemotherapeutic response of tumors using quantitative non-Gaussian diffusion MRI. Xu J, Li K, Smith RA, Waterton JC, Zhao P, Ding Z, Does MD, Manning HC, Gore JC. Magn Reson Imaging. 2017 Apr;37:195-202. doi: 10.1016/j.mri.2016.12.002. Epub 2016 Dec 3. PMID: 27919785

Utility of [18F]FSPG PET to Image Hepatocellular Carcinoma: First Clinical Evaluation in a US Population. Kavanaugh G, Williams J, Morris AS, Nickels ML, Walker R, Koglin N, Stephens AW, Washington MK, Geevarghese SK, Liu Q, Ayers D, Shyr Y, Manning HC. Mol Imaging Biol. 2016 Dec;18(6):924-934. doi: 10.1007/s11307-016-1007-0. PMID: 27677886 

18F-FLT Positron Emission Tomography (PET) is a Pharmacodynamic Marker for EWS-FLI1 Activity and Ewing Sarcoma. Osgood CL, Tantawy MN, Maloney N, Madaj ZB, Peck A, Boguslawski E, Jess J, Buck J, Winn ME, Manning HC, Grohar PJ. Sci Rep. 2016 Sep 27;6:33926. doi: 10.1038/srep33926. PMID: 27671553 

Activation of GRP/GRP-R signaling contributes to castration-resistant prostate cancer progression. Qiao J, Grabowska MM, Forestier-Roman IS, Mirosevich J, Case TC, Chung DH, Cates JM, Matusik RJ, Manning HC, Jin R. Oncotarget. 2016 Sep 20;7(38):61955-61969. doi: 10.18632/oncotarget.11326. PMID: 27542219 

New structure-activity relationships of N-acetamide substituted pyrazolopyrimidines as pharmacological ligands of TSPO. Li J, Schulte ML, Nickels ML, Manning HC. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3472-7. doi: 10.1016/j.bmcl.2016.06.041. Epub 2016 Jun 16. PMID: 27353534 

The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer. Joseph JD, Darimont B, Zhou W, Arrazate A, Young A, Ingalla E, Walter K, Blake RA, Nonomiya J, Guan Z, Kategaya L, Govek SP, Lai AG, Kahraman M, Brigham D, Sensintaffar J, Lu N, Shao G, Qian J, Grillot K, Moon M, Prudente R, Bischoff E, Lee KJ, Bonnefous C, Douglas KL, Julien JD, Nagasawa JY, Aparicio A, Kaufman J, Haley B, Giltnane JM, Wertz IE, Lackner MR, Nannini MA, Sampath D, Schwarz L, Manning HC, Tantawy MN, Arteaga CL, Heyman RA, Rix PJ, Friedman L, Smith ND, Metcalfe C, Hager JH. Elife. 2016 Jul 13;5:e15828. doi: 10.7554/eLife.15828. PMID: 27410477 

Identification and characterization of EGF receptor in individual exosomes by fluorescence-activated vesicle sorting. Higginbotham JN, Zhang Q, Jeppesen DK, Scott AM, Manning HC, Ochieng J, Franklin JL, Coffey RJ. J Extracell Vesicles. 2016 Jun 24;5:29254. doi: 10.3402/jev.v5.29254. eCollection 2016. PMID: 27345057 

Preclinical Evaluation of 4-[18F]Fluoroglutamine PET to Assess ASCT2 Expression in Lung Cancer. Hassanein M, Hight MR, Buck JR, Tantawy MN, Nickels ML, Hoeksema MD, Harris BK, Boyd K, Massion PP, Manning HC. Mol Imaging Biol. 2016 Feb;18(1):18-23. doi: 10.1007/s11307-015-0862-4. PMID: 25971659 

Mouse Models of Breast Cancer: Platforms for Discovering Precision Imaging Diagnostics and Future Cancer Medicine. Manning HC, Buck JR, Cook RS. J Nucl Med. 2016 Feb;57 Suppl 1(Suppl 1):60S-8S. doi: 10.2967/jnumed.115.157917. PMID: 26834104 

2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport. Schulte ML, Khodadadi AB, Cuthbertson ML, Smith JA, Manning HC. Bioorg Med Chem Lett. 2016 Feb 1;26(3):1044-1047. doi: 10.1016/j.bmcl.2015.12.031. Epub 2015 Dec 11. PMID: 26750251 

Preclinical TSPO Ligand PET to Visualize Human Glioma Xenotransplants: A Preliminary Study. Buck JR, McKinley ET, Fu A, Abel TW, Thompson RC, Chambless L, Watchmaker JM, Harty JP, Cooper MK, Manning HC. PLoS One. 2015 Oct 30;10(10):e0141659. doi: 10.1371/journal.pone.0141659. eCollection 2015. PMID: 26517124 

Molecular imaging of folate receptor β-positive macrophages during acute lung inflammation. Han W, Zaynagetdinov R, Yull FE, Polosukhin VV, Gleaves LA, Tanjore H, Young LR, Peterson TE, Manning HC, Prince LS, Blackwell TS. Am J Respir Cell Mol Biol. 2015 Jul;53(1):50-9. doi: 10.1165/rcmb.2014-0289OC. PMID: 25375039 

[(18)F]-FLT PET to predict early response to neoadjuvant therapy in KRAS wild-type rectal cancer: a pilot study. McKinley ET, Watchmaker JM, Chakravarthy AB, Meyerhardt JA, Engelman JA, Walker RC, Washington MK, Coffey RJ, Manning HC. Ann Nucl Med. 2015 Jul;29(6):535-42. doi: 10.1007/s12149-015-0974-6. Epub 2015 Apr 22. PMID: 25899481 

World Molecular Imaging Congress 2015: precision medicine visualized. Manning HC. Mol Imaging Biol. 2015 Jun;17(3):295-6. doi: 10.1007/s11307-015-0855-3. PMID: 25862478

High-yielding, automated production of 3'-deoxy-3'-[(18)F]fluorothymidine using a modified Bioscan Coincidence FDG reaction module. Cheung YY, Nickels ML, McKinley ET, Buck JR, Manning HC. Appl Radiat Isot. 2015 Mar;97:47-51. doi: 10.1016/j.apradiso.2014.11.011. Epub 2014 Dec 15. PMID: 25531913

Utility of [18 F]FLT-PET to assess treatment response in trastuzumab-resistant and trastuzumab-sensitive HER2-overexpressing human breast cancer xenografts. Whisenant JG, McIntyre JO, Peterson TE, Kang H, Sánchez V, Manning HC, Arteaga CL, Yankeelov TE. Mol Imaging Biol. 2015 Feb;17(1):119-28. doi: 10.1007/s11307-014-0770-z. PMID: 25034624 

2-Substituted Nγ-glutamylanilides as novel probes of ASCT2 with improved potency. Schulte ML, Dawson ES, Saleh SA, Cuthbertson ML, Manning HC. Bioorg Med Chem Lett. 2015 Jan 1;25(1):113-6. doi: 10.1016/j.bmcl.2014.10.098. Epub 2014 Nov 11. PMID: 25435145 

Acetate dependence of tumors. Comerford SA, Huang Z, Du X, Wang Y, Cai L, Witkiewicz AK, Walters H, Tantawy MN, Fu A, Manning HC, Horton JD, Hammer RE, McKnight SL, Tu BP. Cell. 2014 Dec 18;159(7):1591-602. doi: 10.1016/j.cell.2014.11.020. PMID: 25525877 

Preclinical imaging evaluation of novel TSPO-PET ligand 2-(5,7-Diethyl-2-(4-(2-[(18)F]fluoroethoxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide ([ (18)F]VUIIS1008) in glioma. Tang D, Nickels ML, Tantawy MN, Buck JR, Manning HC. Mol Imaging Biol. 2014 Dec;16(6):813-20. doi: 10.1007/s11307-014-0743-2. PMID: 24845529 

3'-Deoxy-3'-[18F]-Fluorothymidine PET imaging reflects PI3K-mTOR-mediated pro-survival response to targeted therapy in colorectal cancer. McKinley ET, Zhao P, Coffey RJ, Washington MK, Manning HC. PLoS One. 2014 Sep 23;9(9):e108193. doi: 10.1371/journal.pone.0108193. eCollection 2014. PMID: 25247710 

Facile synthesis of SSR180575 and discovery of 7-chloro-N,N,5-trimethyl-4-oxo-3(6-[(18)F]fluoropyridin-2-yl)-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, a potent pyridazinoindole ligand for PET imaging of TSPO in cancer. Cheung YY, Nickels ML, Tang D, Buck JR, Manning HC. Bioorg Med Chem Lett. 2014 Sep 15;24(18):4466-4471. doi: 10.1016/j.bmcl.2014.07.091. Epub 2014 Aug 8. PMID: 25172419 

Inducible loss of one Apc allele in Lrig1-expressing progenitor cells results in multiple distal colonic tumors with features of familial adenomatous polyposis. Powell AE, Vlacich G, Zhao ZY, McKinley ET, Washington MK, Manning HC, Coffey RJ. Am J Physiol Gastrointest Liver Physiol. 2014 Jul 1;307(1):G16-23. doi: 10.1152/ajpgi.00358.2013. Epub 2014 May 15. PMID: 24833705

PET radiotracer [¹⁸F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: preliminary investigation. Perrone MG, Malerba P, Uddin J, Vitale P, Panella A, Crews BC, Daniel CK, Ghebreselasie K, Nickels M, Tantawy MN, Manning HC, Marnett LJ, Scilimati A. Eur J Med Chem. 2014 Jun 10;80:562-568. doi: 10.1016/j.ejmech.2014.04.074. Epub 2014 Apr 29. PMID: 24832612

A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells. Hight MR, Cheung YY, Nickels ML, Dawson ES, Zhao P, Saleh S, Buck JR, Tang D, Washington MK, Coffey RJ, Manning HC. Clin Cancer Res. 2014 Apr 15;20(8):2126-35. doi: 10.1158/1078-0432.CCR-13-2444. Epub 2014 Feb 26. PMID: 24573549

Microwave-assisted, one-pot reaction of 7-azaindoles and aldehydes: a facile route to novel di-7-azaindolylmethanes. Uddin MI, Buck JR, Schulte ML, Tang D, Saleh SA, Cheung YY, Harp J, Manning HC. Tetrahedron Lett. 2014 Jan 1;55(1):10.1016/j.tetlet.2013.10.143. doi: 10.1016/j.tetlet.2013.10.143. PMID: 24396154 

Knockdown of aberrantly upregulated aryl hydrocarbon receptor reduces tumor growth and metastasis of MDA-MB-231 human breast cancer cell line. Goode GD, Ballard BR, Manning HC, Freeman ML, Kang Y, Eltom SE. Int J Cancer. 2013 Dec 15;133(12):2769-80. doi: 10.1002/ijc.28297. Epub 2013 Jul 5. PMID: 23733406

Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia. Katsha A, Soutto M, Sehdev V, Peng D, Washington MK, Piazuelo MB, Tantawy MN, Manning HC, Lu P, Shyr Y, Ecsedy J, Belkhiri A, El-Rifai W. Gastroenterology. 2013 Dec;145(6):1312-22.e1-8. doi: 10.1053/j.gastro.2013.08.050. Epub 2013 Aug 29. PMID: 23993973

Translocator protein 18 kDa (TSPO) is regulated in white and brown adipose tissue by obesity. Thompson MM, Manning HC, Ellacott KL. PLoS One. 2013 Nov 18;8(11):e79980. doi: 10.1371/journal.pone.0079980. eCollection 2013. PMID: 24260329 

Global phosphotyrosine proteomics identifies PKCδ as a marker of responsiveness to Src inhibition in colorectal cancer. McKinley ET, Liu H, McDonald WH, Luo W, Zhao P, Coffey RJ, Hanks SK, Manning HC. PLoS One. 2013 Nov 8;8(11):e80207. doi: 10.1371/journal.pone.0080207. eCollection 2013. PMID: 24260357

Optical metabolic imaging identifies glycolytic levels, subtypes, and early-treatment response in breast cancer. Walsh AJ, Cook RS, Manning HC, Hicks DJ, Lafontant A, Arteaga CL, Skala MC. Cancer Res. 2013 Oct 15;73(20):6164-74. doi: 10.1158/0008-5472.CAN-13-0527. PMID: 24130112

A novel reporter system for molecular imaging and high-throughput screening of anticancer drugs. Xie J, Wang C, Virostko J, Manning HC, Pham W, Bauer J, Gore JC. Chembiochem. 2013 Aug 19;14(12):1494-503. doi: 10.1002/cbic.201300142. Epub 2013 Jul 24. PMID: 23881799

Synthesis and structure-activity relationships of 5,6,7-substituted pyrazolopyrimidines: discovery of a novel TSPO PET ligand for cancer imaging. Tang D, McKinley ET, Hight MR, Uddin MI, Harp JM, Fu A, Nickels ML, Buck JR, Manning HC. J Med Chem. 2013 Apr 25;56(8):3429-33. doi: 10.1021/jm4001874. Epub 2013 Apr 3. PMID: 23521048

3'-Deoxy-3'-18F-fluorothymidine PET predicts response to (V600E)BRAF-targeted therapy in preclinical models of colorectal cancer. McKinley ET, Smith RA, Zhao P, Fu A, Saleh SA, Uddin MI, Washington MK, Coffey RJ, Manning HC. J Nucl Med. 2013 Mar;54(3):424-30. doi: 10.2967/jnumed.112.108456. Epub 2013 Jan 22. PMID: 23341544

Limits of [18F]-FLT PET as a biomarker of proliferation in oncology. McKinley ET, Ayers GD, Smith RA, Saleh SA, Zhao P, Washington MK, Coffey RJ, Manning HC. PLoS One. 2013;8(3):e58938. doi: 10.1371/journal.pone.0058938. Epub 2013 Mar 15. PMID: 23554961

Characterizing tumor response to chemotherapy at various length scales using temporal diffusion spectroscopy. Xu J, Li K, Smith RA, Waterton JC, Zhao P, Chen H, Does MD, Manning HC, Gore JC. PLoS One. 2012;7(7):e41714. doi: 10.1371/journal.pone.0041714. Epub 2012 Jul 24. PMID: 22911846

[18F]FLT-PET to predict pharmacodynamic and clinical response to cetuximab therapy in Ménétrier's disease. McKinley ET, Smith RA, Tanksley JP, Washington MK, Walker R, Coffey RJ, Manning HC. Ann Nucl Med. 2012 Nov;26(9):757-63. doi: 10.1007/s12149-012-0636-x. Epub 2012 Jul 22. PMID: 22821337

Simultaneous PET-MRI in oncology: a solution looking for a problem? Yankeelov TE, Peterson TE, Abramson RG, Izquierdo-Garcia D, Arlinghaus LR, Li X, Atuegwu NC, Catana C, Manning HC, Fayad ZA, Gore JC. Magn Reson Imaging. 2012 Nov;30(9):1342-56. doi: 10.1016/j.mri.2012.06.001. Epub 2012 Jul 15. PMID: 22795930

Evaluation of CD44 and CD133 as cancer stem cell markers for colorectal cancer. Wang C, Xie J, Guo J, Manning HC, Gore JC, Guo N. Oncol Rep. 2012 Oct;28(4):1301-8. doi: 10.3892/or.2012.1951. Epub 2012 Aug 6. PMID: 22895640 

Rapid, Microwave-Assisted Organic Synthesis of Selective (V600E)BRAF Inhibitors for Preclinical Cancer Research. Buck JR, Saleh S, Uddin MI, Manning HC. Tetrahedron Lett. 2012 Aug 8;53(32):4161-4165. doi: 10.1016/j.tetlet.2012.05.137. Epub 2012 Jun 6. PMID: 23180892

Preclinical molecular imaging of the translocator protein (TSPO) in a metastases model based on breast cancer xenografts propagated in the murine brain. Wyatt SK, Manning HC, Bai M, Ehtesham M, Mapara KY, Thompson RC, Bornhop DJ. Curr Mol Med. 2012 May;12(4):458-66. doi: 10.2174/156652412800163361. PMID: 22348613

Quantitative preclinical imaging of TSPO expression in glioma using N,N-diethyl-2-(2-(4-(2-18F-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide. Tang D, Hight MR, McKinley ET, Fu A, Buck JR, Smith RA, Tantawy MN, Peterson TE, Colvin DC, Ansari MS, Nickels M, Manning HC. J Nucl Med. 2012 Feb;53(2):287-94. doi: 10.2967/jnumed.111.095653. Epub 2012 Jan 17. PMID: 22251555

Protein expression signatures for inhibition of epidermal growth factor receptor-mediated signaling. Myers MV, Manning HC, Coffey RJ, Liebler DC. Mol Cell Proteomics. 2012 Feb;11(2):M111.015222. doi: 10.1074/mcp.M111.015222. Epub 2011 Dec 5. PMID: 22147731

A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer. Fox EM, Miller TW, Balko JM, Kuba MG, Sánchez V, Smith RA, Liu S, González-Angulo AM, Mills GB, Ye F, Shyr Y, Manning HC, Buck E, Arteaga CL. Cancer Res. 2011 Nov 1;71(21):6773-84. doi: 10.1158/0008-5472.CAN-11-1295. Epub 2011 Sep 9. PMID: 21908557

ERα-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer. Miller TW, Balko JM, Fox EM, Ghazoui Z, Dunbier A, Anderson H, Dowsett M, Jiang A, Smith RA, Maira SM, Manning HC, González-Angulo AM, Mills GB, Higham C, Chanthaphaychith S, Kuba MG, Miller WR, Shyr Y, Arteaga CL. Cancer Discov. 2011 Sep;1(4):338-51. doi: 10.1158/2159-8290.CD-11-0101. Epub 2011 Jul 20. PMID: 22049316

Magnetic resonance in the era of molecular imaging of cancer. Gore JC, Manning HC, Quarles CC, Waddell KW, Yankeelov TE. Magn Reson Imaging. 2011 Jun;29(5):587-600. doi: 10.1016/j.mri.2011.02.003. Epub 2011 Apr 27. PMID: 21524870

18FDG-PET predicts pharmacodynamic response to OSI-906, a dual IGF-1R/IR inhibitor, in preclinical mouse models of lung cancer. McKinley ET, Bugaj JE, Zhao P, Guleryuz S, Mantis C, Gokhale PC, Wild R, Manning HC. Clin Cancer Res. 2011 May 15;17(10):3332-40. doi: 10.1158/1078-0432.CCR-10-2274. Epub 2011 Jan 21. PMID: 21257723

A novel in vitro assay to assess phosphorylation of 3'-[(18)F]fluoro-3'-deoxythymidine. Guo N, Xie J, Manning HC, Deane NG, Ansari MS, Coffey RJ, Gore J, Price RR, Baldwin RM, McIntyre JO. Mol Imaging Biol. 2011 Apr;13(2):257-64. doi: 10.1007/s11307-010-0351-8. PMID: 20532643

Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase. Garrett JT, Olivares MG, Rinehart C, Granja-Ingram ND, Sánchez V, Chakrabarty A, Dave B, Cook RS, Pao W, McKinely E, Manning HC, Chang J, Arteaga CL. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5021-6. doi: 10.1073/pnas.1016140108. Epub 2011 Mar 8. PMID: 21385943 

Multispectral fluorescence imaging to assess pH in biological specimens. Hight MR, Nolting DD, McKinley ET, Lander AD, Wyatt SK, Gonyea M, Zhao P, Manning HC. J Biomed Opt. 2011 Jan-Feb;16(1):016007. doi: 10.1117/1.3533264. PMID: 21280913

Quantitative, preclinical PET of translocator protein expression in glioma using 18F-N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline. Buck JR, McKinley ET, Hight MR, Fu A, Tang D, Smith RA, Tantawy MN, Peterson TE, Colvin D, Ansari MS, Baldwin RM, Zhao P, Guleryuz S, Manning HC. J Nucl Med. 2011 Jan;52(1):107-14. doi: 10.2967/jnumed.110.081703. Epub 2010 Dec 13. PMID: 21149488

Molecular imaging metrics to evaluate response to preclinical therapeutic regimens. Smith RA, Guleryuz S, Manning HC. Front Biosci (Landmark Ed). 2011 Jan 1;16:393-410. doi: 10.2741/3694. PMID: 21196177

Microwave-assisted Organic Synthesis of a High-affinity Pyrazolo-pyrimidinyl TSPO Ligand. Tang D, Buck JR, Hight MR, Manning HC. Tetrahedron Lett. 2010 Sep 1;51(35):4595-4598. doi: 10.1016/j.tetlet.2010.06.074. PMID: 20689673

Molecular imaging of the translocator protein (TSPO) in a pre-clinical model of breast cancer. Wyatt SK, Manning HC, Bai M, Bailey SN, Gallant P, Ma G, McIntosh L, Bornhop DJ. Mol Imaging Biol. 2010 Jun;12(3):349-58. doi: 10.1007/s11307-009-0270-8. Epub 2009 Dec 1. PMID: 19949989

Volume of preclinical xenograft tumors is more accurately assessed by ultrasound imaging than manual caliper measurements. Ayers GD, McKinley ET, Zhao P, Fritz JM, Metry RE, Deal BC, Adlerz KM, Coffey RJ, Manning HC. J Ultrasound Med. 2010 Jun;29(6):891-901. doi: 10.7863/jum.2010.29.6.891. PMID: 20498463

Binding of NIR-conPK and NIR-6T to astrocytomas and microglial cells: evidence for a protein related to TSPO. Sexton M, Woodruff G, Cudaback E, Kreitzer FR, Xu C, Lin YH, Möller T, Bai M, Manning HC, Bornhop D, Stella N. PLoS One. 2009 Dec 18;4(12):e8271. doi: 10.1371/journal.pone.0008271. PMID: 20020060 

Inhibition of mammalian target of rapamycin is required for optimal antitumor effect of HER2 inhibitors against HER2-overexpressing cancer cells. Miller TW, Forbes JT, Shah C, Wyatt SK, Manning HC, Olivares MG, Sanchez V, Dugger TC, de Matos Granja N, Narasanna A, Cook RS, Kennedy JP, Lindsley CW, Arteaga CL. Clin Cancer Res. 2009 Dec 1;15(23):7266-76. doi: 10.1158/1078-0432.CCR-09-1665. Epub 2009 Nov 24. PMID: 19934303

Frontiers of Biomedical Imaging Science 2009: workshop report and research opportunities. Yankeelov TE, Avison MJ, Damon BM, Manning HC, Peterson TE, Gore JC. Cancer Res. 2009 Oct 15;69(20):7902-4. doi: 10.1158/0008-5472.CAN-09-2521. Epub 2009 Oct 6. PMID: 19808955 

Molecular imaging: 18F-FDG PET and a whole lot more. Peterson TE, Manning HC. J Nucl Med Technol. 2009 Sep;37(3):151-61. doi: 10.2967/jnmt.109.062729. Epub 2009 Aug 19. PMID: 19692452

Imaging biomarkers predict response to anti-HER2 (ErbB2) therapy in preclinical models of breast cancer. Shah C, Miller TW, Wyatt SK, McKinley ET, Olivares MG, Sanchez V, Nolting DD, Buck JR, Zhao P, Ansari MS, Baldwin RM, Gore JC, Schiff R, Arteaga CL, Manning HC. Clin Cancer Res. 2009 Jul 15;15(14):4712-21. doi: 10.1158/1078-0432.CCR-08-2635. Epub 2009 Jul 7. PMID: 19584166

A molecular imaging paradigm to rapidly profile response to angiogenesis-directed therapy in small animals. Virostko J, Xie J, Hallahan DE, Arteaga CL, Gore JC, Manning HC. Mol Imaging Biol. 2009 May-Jun;11(3):204-12. doi: 10.1007/s11307-008-0193-9. Epub 2009 Jan 7. PMID: 19130143

Multispectral molecular imaging of capillary endothelium to facilitate preoperative endovascular brain mapping. Manning HC, Shay SD, Mericle RA. J Neurosurg. 2009 May;110(5):975-80. doi: 10.3171/2008.9.JNS08420. PMID: 19231927

Molecular imaging of therapeutic response to epidermal growth factor receptor blockade in colorectal cancer. Manning HC, Merchant NB, Foutch AC, Virostko JM, Wyatt SK, Shah C, McKinley ET, Xie J, Mutic NJ, Washington MK, LaFleur B, Tantawy MN, Peterson TE, Ansari MS, Baldwin RM, Rothenberg ML, Bornhop DJ, Gore JC, Coffey RJ. Clin Cancer Res. 2008 Nov 15;14(22):7413-22. doi: 10.1158/1078-0432.CCR-08-0239. PMID: 19010858

Accelerating the development of novel molecular imaging probes: a role for high-throughput screening. Manning HC, Lander A, McKinley E, Mutic NJ. J Nucl Med. 2008 Sep;49(9):1401-4. doi: 10.2967/jnumed.108.053009. Epub 2008 Aug 14. PMID: 18703594

Targeted imaging of colonic tumors in smad3-/- mice discriminates cancer and inflammation. Deane NG, Manning HC, Foutch AC, Washington MK, Aronow BJ, Bornhop DJ, Coffey RJ. Mol Cancer Res. 2007 Apr;5(4):341-9. doi: 10.1158/1541-7786.MCR-06-0225. PMID: 17426249

Endovascular Brain Mapping: An Intraoperative Strategy for Visualizing Functional Brain Parenchyma. Manning HC, Shay SD, Santra S, Richter EO, Mericle RA. Brain Research 1(4):217-34, 2007.

A peripheral benzodiazepine receptor targeted agent for in vitro imaging and screening. Manning HC, Smith SM, Sexton M, Haviland S, Bai M, Cederquist K, Stella N, Bornhop DJ. Bioconjug Chem. 2006 May-Jun;17(3):735-40. doi: 10.1021/bc060020b. PMID: 16704212

Density-functional theory structures of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid complexes for ions across the lanthanide series. Smentek L, Hess BA, Cross JP, Manning HC, Bornhop DJ. J Chem Phys 123(24), 12/2005. PMID: 16396532.

Expeditious synthesis of 'P'-protected macrocycles en route to lanthanide chelate metal complexes. Manning HC, Bai MF, Anderson BM, Lisiak R, Samuelson LE, Bornhop DJ. Tetrahedron letters 46(28):4707-10, 2005.

Targeted molecular imaging agents for cellular-scale bimodal imaging. Manning HC, Goebel T, Thompson RC, Price RR, Lee H, Bornhop DJ. Bioconjug Chem. 2004 Nov-Dec;15(6):1488-95. doi: 10.1021/bc049904q. PMID: 15546219

Rapid removal of benzyloxycarbonyl groups from 1,4,7,10-tetraazacyclododecane derivatives by catalytic transfer hydrogenation. Manning HC, Skwierawska A, Marx JN, Bornhop DJ. Synthetic Commun 33(3):457-61, 2003.

Facile, efficient conjugation of a trifunctional lanthanide chelate to a peripheral benzodiazepine receptor ligand. Manning HC, Goebel T, Marx JN, Bornhop DJ. Org Lett. 2002 Apr 4;4(7):1075-8. doi: 10.1021/ol017155b. PMID: 11922786

Simple, high yielding synthesis of trifunctional fluorescent lanthanide chelates. Griffin JMM, Skwierawska AM, Manning HC, Marx JN, Bornhop DJ. Tetrahedron letters 42(23):3823-5, 2001. PMID: ISI:000168959100014.