Manning Laboratory
H. Charles Manning, Ph.D.
Principal Investigator
Areas of Research
- Cancer Metabolism
- Chemical Inhibitors
- Colorectal Cancer
- Drug Development
- Early Cancer Detection
- Gene Expression
- Imaging
- Liver Cancer
- Pancreatic Cancer
- Targeted Therapy
The overarching objective of the Manning Laboratory is to develop new positron emission tomography (PET) imaging tracers and therapies that enable non-invasive visualization and quantification of specific molecular events in cancer cells and the targeting of these events for treatment of various types of cancer.
Our Research
Our goals are to discover, rigorously validate, and translate new tracers to elucidate the molecular underpinnings of tumors with PET and to use quantitative PET imaging to advance precision cancer medicine. Our current efforts seek PET tracers to improve cancer diagnosis and to quantify early responses of tumors to therapy. Our lab is very interested in quantifying cellular metabolism non-invasively, including high-affinity ligands for receptor-based targets and metabolic substrate transporters elevated in cancer cells. Our lab is also developing pharmacological inhibitors targeting cancer cell metabolism.
About Dr. Manning
Charles Manning, Ph.D., is a professor in the Department of Cancer Systems Imaging at The University of Texas MD Anderson Cancer Center. He serves an additional role as the Scientific Director, Department of Center for Advanced Biomedical Imaging.