Selected Publications
- Karlsson K#, Przybilla M#, Kotler E, Khan A, Xu H, Karagyozova K, Sockell A, Wong WH, Liu K, Mah A, Lo YH, Lu B, Houlahan KE, Ma Z, Suarez CJ, Barnes CP, Kuo CJ, Curtis C. Deterministic evolution and stringent selection during preneoplasia. Nature. 2023 Jun;618(7964):383-393. PMID:37258665 (#equal contribution)
- Dao V, Yuki K, Lo YH, Nakano M, Kuo CJ. Immune organoids: from tumor modeling to precision oncology. Trends Cancer. 2022 Oct;8(10):870-880. PMID:35773148.
- Lo YH, Kolahi KS, Du Y, Chang CY, Krokhotin A, Nair A, Karlsson K, Sobba WD, Jones SJ, Longacre TA, Mah AT, Tercan B, Sockell A, Xu H, Seoane JA, Chen J, Shmulevich I, Weissman JS, Curtis C, Califano A, Fu H, Crabtree GR, Kuo CJ. A CRISPR/Cas9-engineered ARID1A-deficient human gastric cancer organoid model reveals essential and non-essential modes of oncogenic transformation. Cancer Discov. 2021 Jan;11(6):1562-1581 PMID:33451982.
- Lo YH, Karlsson K, Kuo CJ. Applications of organoids for cancer biology and precision medicine. Nat Cancer. 2020 Aug;1(8):761-773. PMID:34142093.
- Han K, Pierce SE, Li A, Spees K, Anderson GR, Seoane JA, Lo YH, Dubreuil M, Olivas M, Kamber RA, Wainberg M, Kostyrko K, Kelly MR, Yousefi M, Simpkins SW, Yao D, Lee K, Kuo CJ, Jackson PK, Sweet-Cordero A, Kundaje A, Gentles AJ, Curtis C, Winslow MM, Bassik MC. CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities. Nature. 2020 Apr;580(7801):136-141. PMID: 32238925.
- Santos AJM, Lo YH, Mah AT, Kuo CJ. The intestinal stem cell niche: homeostasis and adaptations. Trends Cell Biol. 2018 Dec;28(12):1062-1078. PMID: 30195922.
- Lo YH, Noah TK, Chen MS, Zou W, Borras E, Vilar E, Shroyer NF. SPDEF induces quiescence of colorectal cancer cells by changing the transcriptional targets of β-catenin. Gastroenterology. 2017 Jul;153(1):205-218.e8. PMID: 28390865.
- Editorial Highlight: Making cancer quiescent: SPDEF de-cycles beta-catenin. PMID: 28572010.
- Editorial Highlight: Making cancer quiescent: SPDEF de-cycles beta-catenin. PMID: 28572010.
- Lo YH, Chung E, Li Z, Wan YW, Mahe MM, Chen MS, Noah TK, Bell KN, Yalamanchili HK, Klisch TJ, Liu Z, Park JS, Shroyer NF. Transcriptional regulation by ATOH1 and its target SPDEF in the intestine. Cell Mol Gastroenterol Hepatol. 2016 Oct 21;3(1):51-71. PMID: 28174757.
- Cover Story & Cover Art
- Editorial Highlight: Drawing details into the lineage tree. PMID: 28174751.
- Lindemans CA#, Calafiore M#, Mertelsmann AM#, O'Connor MH#, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML, O'Rourke KP, Lo YH, Mokry M, Romera-Hernandez M, Cupedo T, Dow L, Nieuwenhuis EE, Shroyer NF, Liu C, Kolesnick R, van den Brink MRM*, Hanash AM*. Interleukin-22 promotes intestinal stem cell-mediated epithelial regeneration. Nature. 2015 Dec 24;528(7583):560-4. PMID:26649819. (#,*equal contribution)
- Lo YH, Bell KN Shroyer NF. Book Chapter – Biology of intestinal epithelial stem cells. Intestinal Tumorigenesis. 2015 Sept. (edited by Dr. Vincent Yang and Dr. Agnieszka Bialkowska and published by Springer International Publishing Switzerland)
- Noah TK, Lo YH, Price A, Chen G, King E, Washington MK, Aronow BJ, Shroyer NF. SPDEF functions as a colorectal tumor suppressor by inhibiting β-catenin activity. Gastroenterology. 2013 May;144(5):1012-1023. PMID: 23376423.
Give Now
Your gift will help make a tremendous difference.
Research Areas
Find out about the four types of research taking place at MD Anderson.
Subscribe
Get the latest information on our cancer breakthroughs.