Research

The goals of this theme are to identify druggable pathways to enhance radiation/chemoradiation effect on tumor cells and to identify therapeutic targets to reverse radiation resistance. To do so, we use high throughput clonogenic survival with genomic variants (KRAS, LKB1, KEAP1) and radiation resistance models.

The goals of this theme are to identify novel immune effectors of radiation therapy and therapeutic targets that would enhance immunologic response to radiation therapy.

This theme's goals are to identify tumor-microenvironmental factors involved in mediating CRT response and to assess the use of non-invasive imaging to predict treatment response for proper risk stratification of patients.

Liquid biopsy and imaging to determine CRT response (ctDNA, exosome...)