Publications
Lee, S.-H., Mayr, C. Gain of additional BIRC3 protein functions through 3′UTR-mediated protein complex formation. Molecular Cell. 2019 May 16;74(4):701-712.e9. PMCID: PMC6581197.
Lee, S.-H.*, Singh, I.*, Tisdale S., Abdel-Wahab, O., Leslie, C. S., Mayr, C. Widespread intronic polyadenylation inactivates tumor suppressor genes in leukemia. Nature. 2018 Sep;561(7721):127-131. PMCID: PMC6527314. (*equal contribution)
Spotlight Comment: Trends in Cancer 2018 Oct 28; F1000 2018 Oct.
Research Highlight: Nature Reviews Cancer 2018 Sep 21.
News in Brief: Cancer Discovery 2018 Sep 14.
Singh, I., Lee, S.-H., Samur, M, Tai, Y.-T., Munshi, N., Mayr, C., Leslie, C. S. Widespread intronic polyadenylation diversifies immune cell transcriptomes. Nat Commun. 2018 Apr 30;9(1):1716. PMCID: PMC5928244.
Kalwa, M., Hänzelmann, S., Otto S., Kuo, C.-C., Franzen J., Joussen, S., Fernandez-Rebollo, E., Rath B., Koch, C., Hofmann, A., Lee, S.-H., Teschendorff, A. E., Denecke, B., Lin, Q., Widschwendter, M., Weinhold E., Costa, I. G., and Wagner W. The lncRNA HOTAIR impacts on mesenchymal stem cells via triple helix formation. Nucleic Acids Res. 2016 Dec 15; 44(22): 10631-10643. PMCID: PMC5159544.
Teschendorff, A. E., Lee, S.-H., Jones, A., Fiegl, H., Kalwa, M., Wagner, W., Chindera, K., Evans, I., Dubeau, L., Orjalo, A., Horlings, H. M., Niederreiter, L., Kaser, A., Yang, W., Goode, E. L., Fridley, B. L., Jenner, R. G., Berns, E. M. J. J., Wik, E., Salvesen, H. B., Wisman, G. B. A., van der Zee, A. G. J., Davidson, B., Trope, C. G., Lambrechts, S., Vergote, I., Calvert, H., Jacobs, I. J., Widschwendter, M. HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer. Genome Med, 2015 Oct 24;7:108. PMCID: PMC4619324.
Jones, A.*, Teschendorff, A. E.*, Li, Q.*, Hayward, J. D., Kannan, A., Mould, T., West, J., Zikan, M., Cibula, D., Fiegl, H., Lee, S.-H., Wik, E., Hadwin, R., Arora, R., Lemech, C., Turunen, H., Pakarinen, P., Jacobs, I. J., Salvesen, H. B., Bagchi, M. K., Bagchi, I. C., Widschwendter, M. Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development. PLoS Med 2013 Nov;10(11):e1001551. PMCID: PMC3825654. (*equal contribution)
Zhuang, J., Jones, A., Lee, S.-H., Ng, E., Fiegl, H., Zikan, M., Cibula, D., Sargent, A., Salvesen, H. B., Jacobs, I. J., Kitchener, H. C., Teschendorff, A. E., Widschwendter, M. The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer. PLoS Genet 2012 8(2):e1002517. PMCID: PMC3276553.
Jeyapalan, J. N.*, Noor, D. A.*, Lee, S.-H., Tan, C. L., Appleby, V. A., Kilday, J. P., Palmer, R. D., Schwalbe, E. C., Clifford, S. C., Walker, D. A., Murray, M. J., Coleman, N., Nicholson, J. C., Scotting, P. J. Methylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance. Br J Cancer 2011 Aug 9;105(4):575-85 PMCID: PMC3170957. (*equal contribution)
Lee, S.-H., Appleby, V., Jeyapalan, J. N., Palmer, R. D., Nicholson, J. C., Sottile, V., Gao, E., Coleman, N., Scotting, P. J. Variable methylation of the imprinted gene, SNRPN, supports a relationship between intracranial germ cell tumours and neural stem cells. J Neurooncol. 2011 Feb;101(3):419-28. PMID: 20582452.
Lee, S.-H., Jeyapalan, J. N., Appleby, V., Mohamed Noor, D. A., Sottile, V., Scotting, P. J. Dynamic methylation and expression of Oct4 in early neural stem cells. J Anat. 2010 Sep;217(3):203-13. PMCID: PMC2972534.