Selected Publications

Loo BW Jr, Verginadis II, Sørensen BS, Mascia AE, Perentesis JP, Koong AC, Schüler E, Rankin EB, Maxim PG, Limoli CL, Vozenin MC. Navigating the Critical Translational Questions for Implementing FLASH in the Clinic. Semin Radiat Oncol. 2024 Jul;34(3):351-364. doi: 10.1016/j.semradonc.2024.04.008. PMID: 38880544. 

Kim M, Maldonado JA, Pandey P, El Alam MB, Kouzy R, Christopherson K, Minsky BD, Nugyen QN, Grosshans D, Lin LL, Mitchell MP, Klopp AH, Lee PP, Bird J, Satcher R, Lewis VO, Lin PP, Tang C, Koong AC, Moon B, Colbert LE. Single-fraction radiation retreatment for bone metastases: role of a rapid access clinic. BMJ Support Palliat Care. 2024 Jun 6:spcare-2023-004497. doi: 10.1136/spcare-2023-004497. Epub ahead of print. PMID: 38843933. 

Jiang D, Guo Y, Wang T, Wang L, Yan Y, Xia L, Bam R, Yang Z, Lee H, Iwawaki T, Gan B, Koong AC. IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis. Nature  Communications. 2024 May 15;15(1):4114. doi: 10.1038/s41467-024-48330-0. PMID: 38750057; PMCID: PMC11096184.

Chang E, Wong FCL, Chasen BA, Erwin WD, Das P, Holliday EB, Koong AC, Ludmir EB, Minsky BD, Noticewala SS, Smith GL, Taniguchi CM, Rodriguez MJ, Beddar S, Martin-Paulpeter RM, Niedzielski JS, Sawakuchi GO, Schueler E, Perles LA, Xiao L, Szklaruk J, Park PC, Dasari AN, Kaseb AO, Kee BK, Lee SS, Overman MJ, Willis JA, Wolff RA, Tzeng CD, Vauthey JN, Koay EJ. Phase I trial of single-photon emission computed tomography-guided liver-directed radiotherapy for patients with low functional liver volume. JNCI Cancer Spectr. 2024 Apr 30;8(3):pkae037. doi: 10.1093/jncics/pkae037. PMID: 38730548; PMCID: PMC11164414. 

Lee D, Huntoon K, Wang Y, Kang M, Lu Y, Jeong SD, Link TM, Gallup TD, Qie Y, Li X, Dong S, Schrank BR, Grippin AJ, Antony A, Ha J, Chang M, An Y, Wang L, Jiang D, Li J, Koong AC, Tainer JA, Jiang W, Kim BYS. Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells. Nat Biomed Eng. 2024 May;8(5):593-610. doi: 10.1038/s41551-024-01194-7. Epub 2024 Apr 19. PMID: 38641710; PMCID: PMC11162332. 

Williams HL, Dias Costa A, Zhang J, Raghavan S, Winter PS, Kapner KS, Ginebaugh SP, Väyrynen SA, Väyrynen JP, Yuan C, Navia AW, Wang J, Yang A, Bosse TL, Kalekar RL, Lowder KE, Lau MC, Elganainy D, Morales-Oyarvide V, Rubinson DA, Singh H, Perez K, Cleary JM, Clancy TE, Wang J, Mancias JD, Brais LK, Hill ER, Kozak MM, Linehan DC, Dunne RF, Chang DT, Koong AC, Hezel AF, Hahn WC, Shalek AK, Aguirre AJ, Nowak JA, Wolpin BM. Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity. Cancer Res 83(3):441-455, 2/2023. PMCID: PMC10548885.

Hernandez S, Das P, Holliday EB, Shen L, Lu W, Johnson B, Messick CA, Taniguchi CM, Skibber J, Ludmir EB, You YN, Smith GL, Bednarski B, Kostousov L, Koay EJ, Minsky BD, Tillman M, Portier S, Eng C, Koong AC, Chang GJ, Foo WC, Wang J, Soto LS, Morris VK. Differential Spatial Gene and Protein Expression Associated with Recurrence Following Chemoradiation for Localized Anal Squamous Cell Cancer. Cancers (Basel) 15(6), 3/2023. e-Pub 3/2023. PMCID: PMC10046657.

Dodoo GN, De B, Lee SS, Abi Jaoude J, Vauthey JN, Tzeng CD, Tran Cao HS, Katlowitz KA, Mandel JJ, Beckham TH, Minsky BD, Smith GL, Holliday EB, Koong AC, Das P, Taniguchi CM, Javle M, Koay EJ, Ludmir EB. Brain Metastases from Biliary Tract Cancer: Case Series and Clinicogenomic Analysis. Oncologist 28(4):327-332, 4/2023. e-Pub 1/2023. PMCID: PMC10078902.

Valdés Zayas A, Kumari N, Liu K, Neill D, Delahoussaye A, Gonçalves Jorge P, Geyer R, Lin SH, Bailat C, Bochud F, Moeckli R, Koong AC, Bourhis J, Taniguchi CM, Herrera FG, Schüler E. Independent Reproduction of the FLASH Effect on the Gastrointestinal Tract: A Multi-Institutional Comparative Study. Cancers (Basel) 15(7), 4/2023. e-Pub 4/2023. PMCID: PMC10093322.

Rooney MK, De B, Corrigan K, Smith GL, Taniguchi C, Minsky BD, Ludmir EB, Koay EJ, Das P, Koong AC, Peacock O, Chang G, You YN, Morris VK, Nogueras-González G, Holliday EB. Patient-reported Bowel Function and Bowel-related Quality of Life After Pelvic Radiation for Rectal Adenocarcinoma: The Impact of Radiation Fractionation and Surgical Resection. Clin Colorectal Cancer 22(2):211-221, 6/2023. e-Pub 2/2023. PMCID: PMC10213111.

Toesca DAS, Susko M, von Eyben R, Baclay JRM, Pollom EL, Jeffrey RB, Poullos PD, Poultsides GA, Fisher GA, Visser BC, Koong AC, Feng M, Chang DT. Validation of a Resectability Scoring System for Prediction of Pancreatic Adenocarcinoma Surgical Outcomes. Ann Surg Oncol 30(6):3479-3488, 6/2023. e-Pub 2/2023. PMID: 36792768.

De B, Upadhyay R, Liao K, Kumala T, Shi C, Dodoo G, Abi Jaoude J, Corrigan KL, Manzar GS, Marqueen KE, Bernard V, Lee SS, Raghav KPS, Vauthey JN, Tzeng CD, Tran Cao HS, Lee G, Wo JY, Hong TS, Crane CH, Minsky BD, Smith GL, Holliday EB, Taniguchi CM, Koong AC, Das P, Javle M, Ludmir EB, Koay EJ. Definitive Liver Radiotherapy for IntrahepaticCholangiocarcinoma with Extrahepatic Metastases. Liver Cancer 12(3):198-208, 8/2023. e-Pub 3/2023. PMCID: PMC10427952.

Rhee DJ, Beddar S, Jaoude JA, Sawakuchi G, Martin R, Perles L, Yu C, He Y, Court LE, Ludmir EB, Koong AC, Das P, Koay EJ, Taniguichi C, Niedzielski JS. Dose Escalation for Pancreas SBRT: Potential and Limitations of using Daily Online Adaptive Radiation Therapy and an Iterative Isotoxicity Automated Planning Approach. Adv Radiat Oncol 8(4):101164, 2023. e-Pub 2/2023. PMCID: PMC9926193.

Cazacu IM, Singh BS, Martin-Paulpeter RM, Beddar S, Chun S, Holliday EB, Koong AC, Das P, Koay EJ, Taniguchi C, Herman JM, Bhutani MS. Endoscopic Ultrasound-Guided Fiducial Placement for Stereotactic Body Radiation Therapy in Patients with Pancreatic Cancer. Cancers (Basel) 15(22), 11/2023. e-Pub 11/2023. PMCID: PMC10670468.

Beach C, MacLean D, Majorova D, Melemenidis S, Nambiar DK, Kim RK, Valbuena GN, Guglietta S, Krieg C, Darvish-Damavandi M, Suwa T, Easton A, Hillson LV, McCulloch AK, McMahon RK, Pennel K, Edwards J, O'Cathail SM, Roxburgh CS, Domingo E, Moon EJ, Jiang D, Jiang Y, Zhang Q, Koong AC, Woodruff TM, Graves EE, Maughan T, Buczacki SJ, Stucki M, Le QT, Leedham SJ, Giaccia AJ, Olcina MM. Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. J Clin Invest 133(23), 12/2023. e-Pub 12/2023. PMCID: PMC10688992.

Rooney MK, Pasli M, Chang GJ, Das P, Koay EJ, Koong AC, Ludmir EB, Minsky BD, Noticewala SS, Peacock O, Smith GL, Holliday EB. Patient-Reported Sexual Function, Bladder Function and Quality of Life for Patients with Low Rectal Cancers with or without a Permanent Ostomy. Cancers (Basel) 16(1), 12/2023. e-Pub 12/2023. PMCID: PMC10778006.

Colbert LE, Alam MBE, Lynn EJ, Bronk J, Karpinets TV, Wu X, Chapman BV, Sims TT, Lin D, Kouzy R, Sammouri J, Biegert G, Delgado Medrano AY, Olvera A, Sastry KJ, Eifel PJ, Jhingran A, Lin L, Ramondetta LM, Futreal AP, Jazaeri AA, Schmeler KM, Yue J, Mitra A, Yoshida-Court K, Wargo JA, Solley TN, Hegde V, Nookala SS, Yanamandra AV, Dorta-Estremera S, Mathew G, Kavukuntla R, Papso C, Ahmed-Kaddar M, Kim M, Zhang J, Reuben A, Holliday EB, Minsky BD, Koong AC, Koay EJ, Das P, Taniguchi CM, Klopp A. Expansion of Candidate HPV-Specific T Cells in the Tumor Microenvironment During Chemoradiotherapy Is Prognostic in HPV16+ Cancers. Cancer Immunol Res. e-Pub 1/2022. PMID: 35045973. 

Khan Z, Rooney MK, Das P, Ludmir EB, Koay EJ, Smith GL, Taniguchi C, Minsky BD, Koong AC, Sawakuchi G, Beddar S, Martin RM, Rodriguez-Bigas M, Peacock O, Chang G, Holliday EB. Intraoperative Radiation After Pelvic Short Course Radiation-Based Total Neoadjuvant Therapy for Patients With Rectal Adenocarcinoma at High Risk for Local Recurrence. Clin Colorectal Cancer. e-Pub 1/2022. PMID: 35125321. 

Corrigan KL, Kry S, Howell RM, Kouzy R, Jaoude JA, Patel RR, Jhingran A, Taniguchi C, Koong AC, McAleer MF, Nitsch P, Rödel C, Fokas E, Minsky BD, Das P, Fuller CD, Ludmir EB. The radiotherapy quality assurance gap among phase III cancer clinical trials. Radiother Oncol 166:51-57, 1/2022. e-Pub 11/2021. PMCID: PMC8900671. 

Holliday EB, Morris VK, Johnson B, Eng C, Ludmir EB, Das P, Minsky BD, Taniguchi C, Smith GL, Koay EJ, Koong AC, Delclos ME, Skibber JM, Rodriguez-Bigas MA, You YN, Bednarski BK, Tillman MM, Chang GJ, Jennings K, Messick CA. Definitive Intensity-Modulated Chemoradiation for Anal Squamous Cell Carcinoma: Outcomes and Toxicity of 428 Patients Treated at a Single Institution. Oncologist 27(1):40-47, 2/2022. PMCID: PMC8842324. 

Bagley AF, Ludmir EB, Maitra A, Minsky BD, Li Smith G, Das P, Koong AC, Holliday EB, Taniguchi CM, Katz MHG, Tamm EP, Wolff RA, Overman MJ, Patel S, Kim MP, Tzeng CD, Ikoma N, Bhutani MS, Koay EJ. NBTXR3, a first-in-class radioenhancer for pancreatic ductal adenocarcinoma: Report of first patient experience. Clin Transl Radiat Oncol 33:66-69, 3/2022. e-Pub 1/2022. PMCID: PMC8783106.

Manzar GS, De BS, Abana CO, Lee SS, Javle M, Kaseb AO, Vauthey JN, Tran Cao HS, Koong AC, Smith GL, Taniguchi CM, Holliday EB, Das P, Koay EJ, Ludmir EB. Outcomes and Toxicities of Modern Combined Modality Therapy with Atezolizumab Plus Bevacizumab and Radiation Therapy for Hepatocellular Carcinoma. Cancers (Basel) 14(8), 4/2022. e-Pub 4/2022. PMCID: PMC9032898. 

Wang CX, Elganainy D, Zaid MM, Butner JD, Agrawal A, Nizzero S, Minsky BD, Holliday EB, Taniguchi CM, Smith GL, Koong AC, Herman JM, Das P, Maitra A, Wang H, Wolff RA, Katz MH, Crane CH, Cristini V, Koay EJ. Mass transport model of radiation response: calibration and application to chemoradiation for pancreatic cancer. Int J Radiat Oncol Biol Phys. e-Pub 5/2022. PMID: 35643254. 

Papaioannou A, Centonze F, Metais A, Maurel M, Negroni L, Gonzalez-Quiroz M, Mahdizadeh SJ, Svensson G, Zare E, Blondel A, Koong AC, Hetz C, Pedeux R, Tremblay ML, Eriksson LA, Chevet E. Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs. Life Sci Alliance 5(5), 5/2022. e-Pub 2/2022. PMCID: PMC8899846.

De B, Tran Cao HS, Vauthey JN, Manzar GS, Corrigan KL, Raghav KPS, Lee SS, Tzeng CD, Minsky BD, Smith GL, Holliday EB, Taniguchi CM, Koong AC, Das P, Javle M, Ludmir EB, Koay EJ. Ablative liver radiotherapy for unresected intrahepatic cholangiocarcinoma: Patterns of care and survival in the United States. Cancer 128(13):2529-2539, 7/2022. e-Pub 4/2022. PMCID: PMC9177808.

 Yang M, Wang X, Guan F, Titt U, Iga K, Jiang D, Takaoka T, Totake S, Katayose T, Umezawa M, Schüler E, Frank SJ, Lin SH, Sahoo N, Koong AC, Mohan R, Zhu XR. Adaptation and dosimetric commissioning of a synchrotron-based proton beamline for FLASH experiments. Phys Med Biol. e-Pub 7/2022. PMID: 35853442. 

Moningi S, Lei X, Fang P, Taniguchi CM, Holliday EB, Koay EJ, Koong AC, Ludmir EB, Minsky BD, Das P, Giordano SH, Smith GL. Contemporary use and outcomes of radiation and chemotherapy for unresectable pancreatic cancer. Clin Transl Radiat Oncol 35:9-16, 7/2022. e-Pub 4/2022. PMCID: PMC9058953. 

Koay EJ, Zaid M, Aliru M, Bagereka P, Van Wieren A, Rodriguez MJ, Jacobson G, Wolff RA, Overman M, Varadhachary G, Pant S, Wang H, Tzeng CW, Ikoma N, Kim M, Lee JE, Katz MH, Tamm E, Bhosale P, Taniguchi CM, Holliday EB, Smith GL, Ludmir EB, Minsky BD, Crane CH, Koong AC, Das P, Wang X, Javle M, Krishnan S. Nab-Paclitaxel, Capecitabine, and Radiation Therapy Following Induction Chemotherapy in Treating Patients with Locally Advanced and Borderline Resectable Pancreatic Cancer: Phase I Trial and Imaging-based Biomarker Validation. Int J Radiat Oncol Biol Phys. e-Pub 7/2022. PMID: 35863672. 

Corrigan KL, De B, Rooney MK, Ludmir EB, Das P, Smith GL, Taniguchi CM, Minsky BD, Koay EJ, Koong AC, Holliday EB. Patient-Reported Outcomes After Chemoradiation in Patients With Anal Cancer: A Qualitative Analysis. Adv Radiat Oncol 7(4):100986, Jul-Aug, 7/2022. e-Pub 4/2022. PMCID: PMC9157211. 

Miao YR, Thakkar K, Cenik C, Jiang D, Mizuno K, Jia C, Li CG, Zhao H, Diep A, Xu Y, Zhang XE, Yang TTC, Liedtke M, Abidi P, Leung WS, Koong AC, Giaccia AJ. Developing high-affinity decoy receptors to treat multiple myeloma and diffuse large B cell lymphoma. J Exp Med 219(9), 9/2022. e-Pub 7/2022. PMID: 35881112. 

Lin SH, Liao K, Lei X, Verma V, Shaaban S, Lee P, Chen AB, Koong AC, Hoftstetter WL, Frank SJ, Liao Z, Shih YT, Giordano SH, Smith GL. Health Care Resource Utilization for Esophageal Cancer Using Proton versus Photon Radiation Therapy. Int J Part Ther 9(1):18-27, 2022. e-Pub 6/2022. PMCID: PMC9238132. 

Dias Costa A, Väyrynen SA, Chawla A, Zhang J, Väyrynen JP, Lau MC, Williams HL, Yuan C, Morales-Oyarvide V, Elganainy D, Singh H, Cleary JM, Perez K, Ng K, Freed-Pastor W, Mancias JD, Dougan SK, Wang J, Rubinson DA, Dunne RF, Kozak MM, Brais L, Reilly E, Clancy T, Linehan DC, Chang DT, Hezel AF, Koong AC, Aguirre A, Wolpin BM, Nowak JA. Neoadjuvant chemotherapy is associated with altered immune cell infiltration and an anti-tumorigenic microenvironment in resected pancreatic cancer. Clin Cancer Res. 2022 Sep 21:CCR-22-1125. doi: 10.1158/1078-0432.CCR-22-1125. Online ahead of print. PMID: 36129461 

Pasalic D, Fuller CD, Mainwaring W, Lin TA, Miller AB, Jethanandani A, Espinoza AF, Grossberg AJ, Jagsi R, Das P, Koong AC, Rödel C, Fokas E, Thomas CR, Minsky BD, Ludmir EB. Detecting the Dark Matter of Unpublished Clinical Cancer Studies: An Analysis of Phase 3 Randomized Controlled Trials. Mayo Clin Proc 96(2):420-426, 2/2021. PMID: 33549260. 

Moningi S, Abi Jaoude J, Kouzy R, Lin D, Nguyen ND, Garcia CJ, Phan JL, Avila S, Smani D, Cazacu IM, Singh BS, Smith GL, Holliday EB, Koay EJ, Das P, Bhutani MS, Herman JM, Minsky BD, Koong AC, Taniguchi CM. Impact of Fiducial Marker Placement Before Stereotactic Body Radiation Therapy on Clinical Outcomes in Patients with Pancreatic Cancer. Adv Radiat Oncol 6(2):100621, Mar-Apr 3/2021. e-Pub 11/2020. PMCID: PMC8071717. 

Augustyn A, Reed VI, Ahmad N, Bhutani MS, Bloom ES, Bowers JR, Chronowski GM, Das P, Holliday EB, Delclos ME, Huey RW, Koay EJ, Lee SS, Nelson CL, Taniguchi CM, Koong AC, Chun SG. Implementation of a Stereotactic Body Radiotherapy Program for Unresectable Pancreatic Cancer in an Integrated Community Academic Radiation Oncology Satellite Network. Clin Transl Radiat Oncol 27:147-151, 3/2021. e-Pub 2/2021. PMCID: PMC7907676. 

Christopherson KM, Das P, Berlind C, Lindsay WD, Ahern C, Smith BD, Subbiah IM, Koay EJ, Koong AC, Holliday EB, Ludmir EB, Minsky BD, Taniguchi CM, Smith GL. A Machine Learning Model Approach to Risk-Stratify Gastrointestinal (GI) Cancer Patients for Hospitalization and Mortality Outcomes. Int J Radiat Oncol Biol Phys 111(1):135-142, 9/2021. e-Pub 4/2021. PMID: 33933480. 

Ning MS, Das P, Rosenthal DI, Dabaja BS, Liao Z, Chang JY, Gomez DR, Klopp AH, Gunn GB, Allen PK, Nitsch PL, Natter RB, Briere TM, Herman JM, Wells R, Koong AC, McAleer MF. Early and Midtreatment Mortality in Palliative Radiotherapy: Emphasizing Patient Selection in High-Quality End-of-Life Care. J Natl Compr Canc Netw:1-9. e-Pub 4/2021. PMID: 33878727. 

Taku N, Yi-Qian YN, Chang GJ, Ludmir EB, Raghav KPS, Rodriguez-Bigas MA, Holliday EB, Smith GL, Minsky BD, Overman MJ, Messick C, Boyce-Fappiano D, Koong AC, Skibber JM, Koay EJ, Dasari A, Taniguchi CM, Bednarski BK, Morris VK, Kopetz S, Das P. Benchmarking Outcomes for Definitive Treatment of Young-Onset, Locally Advanced Rectal Cancer. Clin Colorectal Cancer. e-Pub 10/2021. PMID: 34794903. 

De B, Ludmir EB, Messick CA, Cagley MC, Morris VK, Das P, Minsky BD, Taniguchi CM, Smith GL, Koay EJ, Koong AC, Mohan R, Holliday EB. Prognostic Impact of Lymphopenia and Neutrophil-Lymphocyte Ratio for Patients with Anal Squamous Cell Carcinoma. J Gastrointest Oncol 12(5):2412-2422, 10/2021. PMCID: PMC8576202. 

Titt U, Yang M, Wang X, Iga K, Fredette N, Schueler E, Lin SH, Zhu XR, Sahoo N, Koong AC, Zhang X, Mohan R. Design and Validation of a Synchrotron Proton Beam Line for FLASH Radiotherapy Preclinical Research Experiments. Med Phys. e-Pub 11/2021. PMID: 34800037. 

Scott MKD, Limaye M, Schaffert S, West R, Ozawa MG, Chu P, Nair VS, Koong AC, Khatri P. A Multi-Scale Integrated Analysis Identifies KRT8 as a Pan-Cancer Early Biomarker. Pac Symp Biocomput 26:297-308, 2021. PMCID: PMC7958996.

De B, Ng SP, Liu AY, Avila S, Tao R, Holliday EB, Brownlee Z, Kaseb A, Lee S, Raghav K, Vauthey JN, Minsky BD, Herman JM, Das P, Smith GL, Taniguchi CM, Krishnan S, Crane CH, Grassberger C, Hong TS, Lin SH, Koong AC, Mohan R, Koay EJ. Radiation-Associated Lymphopenia and Outcomes of Patients with Unresectable Hepatocellular Carcinoma Treated with Radiotherapy. J Hepatocell Carcinoma 8:57-69, 2021. e-Pub 3/2021. PMCID: PMC7937383.

Slagowski JM, Colbert LE, Cazacu IM, Singh BS, Martin R, Koay EJ, Taniguchi CM, Koong AC, Bhutani MS, Herman JM, Beddar S. Evaluation of the Visibility and Artifacts of 11 Common Fiducial Markers for Image Guided Stereotactic Body Radiation Therapy in the Abdomen. Pract Radiat Oncol. e-Pub 1/2020. PMID: 31988039.

Benson KRK, Aggarwal S, Carter JN, von Eyben R, Pradhan P, Prionas ND, Bui JL, Soltys SG, Hancock S, Gensheimer MF, Koong AC, Chang DT. Predicting Survival for Patients with Metastatic Disease. Int J Radiat Oncol Biol Phys 106(1):52-60, 1/2020. e-Pub 11/2019. PMID: 31682969.

Aguilera TA, Elghonaimy EA, Shehade H, Rafat M, Castellini L, Jiang D, Kariolis M, Koong AC, Le QT, Ellies LG, Rankin EB, Graves EE, Giaccia AJ. Induced Tumor Heterogeneity Reveals Factors Informing Radiation and Immunotherapy Combinations. Clin Cancer Res. e-Pub 2/2020. PMID: 32098769. 

Avila S, Chang GJ, Dasari NA, Smani DA, Das P, Herman JM, Koay E, Koong A, Krishnan S, Minsky BD, Smith GL, Taniguchi C, Taggart MW, Kaur H, Holliday EB. Pathologic Response and Postoperative Complications After Short-course Radiation Therapy and Chemotherapy for Patients with Rectal Adenocarcinoma. Clin Colorectal Cancer. e-Pub 2/2020. PMID: 32173279. 

Koong AJ, Toesca DAS, Baclay JRM, Pollom EL, von Eyben R, Koong AC, Chang DT. The Utility of Stereotactic Ablative Radiation Therapy for Palliation of Metastatic Pancreatic Adenocarcinoma. Pract Radiat Oncol. e-Pub 2/2020. PMID: 32119922.

Chun SG, Liao Z, Jeter MD, Chang JY, Lin SH, Komaki RU, Guerrero TM, Mayo RC, Korah BM, Koshy SM, Heymach JV, Koong AC, Skinner HD. Metabolic Responses to Metformin in Inoperable Early-stage Non-Small Cell Lung Cancer Treated with Stereotactic Radiotherapy: Results of a Randomized Phase II Clinical Trial. Am J Clin Oncol 43(4):231-235, 4/2020. PMID: 31990759. 

McGinnis GJ, Ning MS, Nitsch PL, O'Reilly MS, McAleer MF, Koong AC, Chang JY. Rapid Detection of Asymptomatic Coronavirus Disease 2019 by Computed Tomography Image Guidance for Stereotactic Ablative Radiotherapy. J Thorac Oncol. e-Pub 4/2020. PMCID: PMC7162784. 

Ibragimov B, Toesca DAS, Chang DT, Yuan Y, Koong AC, Xing L, Vogelius IR. Deep Learning for Identification of Critical Regions Associated with Toxicities After Liver Stereotactic Body Radiation Therapy. Med Phys. e-Pub 5/2020. PMID: 32406531. 

Chung KM, Singh J, Lawres L, Dorans KJ, Garcia C, Burkhardt DB, Robbins R, Bhutkar A, Cardone R, Zhao X, Babic A, Vayrynen SA, Dias Costa A, Nowak JA, Chang DT, Dunne RF, Hezel AF, Koong AC, Wilhelm JJ, Bellin MD, Nylander V, Gloyn AL, McCarthy MI, Kibbey RG, Krishnaswamy S, Wolpin BM, Jacks T, Fuchs CS, Muzumdar MD. Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma. Cell 181(4):832-847.e18, 5/2020. e-Pub 4/2020. PMID: 32304665. 

Lin SH, Hobbs BP, Verma V, Tidwell RS, Smith GL, Lei X, Corsini EM, Mok I, Wei X, Yao L, Wang X, Komaki RU, Chang JY, Chun SG, Jeter MD, Swisher SG, Ajani JA, Blum-Murphy M, Vaporciyan AA, Mehran RJ, Koong AC, Gandhi SJ, Hofstetter WL, Hong TS, Delaney TF, Liao Z, Mohan R. Randomized Phase IIB Trial of Proton Beam Therapy Versus Intensity-Modulated Radiation Therapy for Locally Advanced Esophageal Cancer. J Clin Oncol 38(14): JCO1902503, 5/2020. e-Pub 3/2020. PMCID: PMC7213588. 

Noticewala SS, Ludmir EB, Bishop AJ, Chung C, Ghia AJ, Grosshans D, McGovern S, Paulino AC, Wang C, Woodhouse KD, Yeboa DN, Prabhu SS, Weathers SP, Das P, Koong AC, McAleer MF, Li J. Radiation for Glioblastoma in the Era of Coronavirus Disease 2019 (COVID-19): Patient Selection and Hypofractionation to Maximize Benefit and Minimize Risk. Adv Radiat Oncol 5(4):743-745, Jul-Aug 7/2020. e-Pub 5/2020. PMCID: PMC7251361. 

Du C, da Silva A, Morales-Oyarvide V, Dias Costa A, Kozak MM, Dunne RF, Rubinson DA, Perez K, Masugi Y, Hamada T, Brais LK, Yuan C, Babic A, Ducar MD, Thorner AR, Aguirre A, Kulke MH, Ng K, Clancy TE, Findeis-Hosey JJ, Chang DT, Hornick JL, Fuchs CS, Ogino S, Koong AC, Hezel AF, Wolpin BM, Nowak JA. Insulin-Like Growth Factor-1 Receptor Expression and Disease Recurrence and Survival in Patients with Resected Pancreatic Ductal Adenocarcinoma. Cancer Epidemiol Biomarkers Prev 29(8):1586-1595, 8/2020. e-Pub 5/2020. PMCID: PMC7415636. 

Toesca DAS, Ahmed F, Kashyap M, Richelcyn M Baclay J, von Eyben R, Pollom EL, Koong AC, Chang DT. Intensified Systemic Therapy and Stereotactic Ablative Radiotherapy Dose for Patients with Unresectable Pancreatic Adenocarcinoma. Radiother Oncol. e-Pub 8/2020. PMID: 32763253. 

Kouzy R, Abi Jaoude J, Minsky BD, Das P, Koong AC, Subbiah IM, Ludmir EB, Taniguchi CM. Gastrointestinal Malignancies and Supportive Care Trials: A Snapshot of the Last Two Decades. BMJ Support Palliat Care. e-Pub 9/2020. PMID: 32943466.

Levy K, Natarajan S, Wang J, Chow S, Eggold JT, Loo PE, Manjappa R, Melemenidis S, Lartey FM, Schüler E, Skinner L, Rafat M, Ko R, Kim A, H Al-Rawi D, von Eyben R, Dorigo O, Casey KM, Graves EE, Bush K, Yu AS, Koong AC, Maxim PG, Loo BW, Rankin EB. Abdominal FLASH Irradiation Reduces Radiation-Induced Gastrointestinal Toxicity for the Treatment of Ovarian Cancer in Mice. Sci Rep 10(1):21600, 12/2020. e-Pub 12/2020. PMCID: PMC7728763.

Väyrynen SA, Zhang J, Yuan C, Väyrynen JP, Dias Costa A, Williams H, Morales-Oyarvide V, Lau MC, Rubinson DA, Dunne RF, Kozak MM, Wang W, Agostini-Vulaj D, Drage MG, Brais LK, Reilly E, Rahma OE, Clancy TE, Wang J, Linehan DC, Aguirre A, Fuchs CS, Coussens LM, Chang DT, Koong AC, Hezel AF, Ogino S, Nowak JA, Wolpin BM. Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer. Clin Cancer Res. e-Pub 12/2020. PMID: 33262135.

Nambiar DK, Aguilera T, Cao H, Kwok S, Kong C, Bloomstein J, Wang Z, Rangan VS, Jiang D, von Eyben R, Liang R, Agarwal S, Colevas AD, Korman A, Allen CT, Uppaluri R, Koong AC, Giaccia A1, Le QT. Galectin-1-driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance. J Clin Invest. 2019 Dec 2;129(12):5553-5567. doi: 10.1172/JCI129025. PMID: 31710313; PMCID: PMC6877340.

Moningi S, Ludmir EB, Polamraju P, Williamson T, Melkun MM, Herman JD, Krishnan S, Koay EJ, Koong AC, Minsky BD, Smith GL, Taniguchi C, Das P, Holliday EB. Definitive hyperfractionated, accelerated proton reirradiation for patients with pelvic malignancies. Clin Transl Radiat Oncol. 2019 Aug 27;19:59-65. doi: 10.1016/j.ctro.2019.08.004. PMID: 31517071; PMCID: PMC6734102.

Zhao W, Shen L, Han B, Yang Y, Cheng K, Toesca DAS, Koong AC, Chang DT, Xing L. Markerless Pancreatic Tumor Target Localization Enabled By Deep Learning. Int J Radiat Oncol Biol Phys. 2019 Oct 1;105(2):432-439. doi: 10.1016/j.ijrobp.2019.05.071. Epub 2019 Jun 13. PubMed PMID: 31201892; PubMed Central PMCID: PMC6732032.

Palta M, Godfrey D, Goodman KA, Hoffe S, Dawson LA, Dessert D, Hall WA, Herman JM, Khorana AA, Merchant N, Parekh A, Patton C, Pepek JM, Salama JK, Tuli R, Koong AC. Radiation Therapy for Pancreatic Cancer: Executive Summary of an ASTRO Clinical Practice Guideline. Pract Radiat Oncol. 2019 Sep - Oct;9(5):322-332. doi: 10.1016/j.prro.2019.06.016. PubMed PMID: 31474330.

Ibragimov B, Toesca DAS, Yuan Y, Koong AC, Chang DT, Xing L. Neural Networks for Deep Radiotherapy Dose Analysis and Prediction of Liver SBRT Outcomes. IEEE J Biomed Health Inform. 2019 Sep;23(5):1821-1833. doi: 10.1109/JBHI.2019.2904078. Epub 2019 Mar 11. PubMed PMID: 30869633.

Choi GW, Suh Y, Das P, Herman J, Holliday E, Koay E, Koong AC, Krishnan S, Minsky BD, Smith GL, Taniguchi CM, Beddar S. Assessment of setup uncertainty in hypofractionated liver radiation therapy with a breath-hold technique using automatic image registration-based image guidance. Radiat Oncol. 2019 Aug 30;14(1):154. doi: 10.1186/s13014-019-1361-6. PubMed PMID: 31470860; PubMed Central PMCID: PMC6717376.

Yu M, Nguyen ND, Huang Y, Lin D, Fujimoto TN, Molkentine JM, Deorukhkar A, Kang Y, San Lucas FA, Fernandes CJ, Koay EJ, Gupta S, Ying H, Koong AC, Herman JM, Fleming JB, Maitra A, Taniguchi CM. Mitochondrial fusion exploits a therapeutic vulnerability of pancreatic cancer. JCI Insight. 2019 Jul 23;5. doi: 10.1172/jci.insight.126915. PubMed PMID: 31335325.

Ludmir EB, Mainwaring W, Lin TA, Miller AB, Jethanandani A, Espinoza AF, Mandel JJ, Lin SH, Smith BD, Smith GL, VanderWalde NA, Minsky BD, Koong AC, Stinchcombe TE, Jagsi R, Gomez DR, Thomas CR Jr, Fuller CD. Factors Associated With Age Disparities Among Cancer Clinical Trial Participants. JAMA Oncol. 2019 Jun 3;. doi: 10.1001/jamaoncol.2019.2055. [Epub ahead of print] PubMed PMID: 31158272; PubMed Central PMCID: PMC6547133.

Toesca DAS, Jeffrey RB, von Eyben R, Pollom EL, Poullos PD, Poultsides GA, Fisher GA Jr, Visser BC, Koong AC, Chang DT. Predicting Pancreatic Cancer Resectability and Outcomes Based on an Objective Quantitative Scoring System. Pancreas. 2019 May/Jun;48(5):622-628. doi: 10.1097/MPA.0000000000001314. PubMed PMID: 31091207; PubMed Central PMCID: PMC6553971.

Bhutani MS, Cazacu IM, Luzuriaga Chavez AA, Singh BS, Wong FCL, Erwin WD, Tamm EP, Mathew GG, Le DB, Koay EJ, Taniguchi CM, Minsky BD, Pant S, Tzeng CD, Koong AC, Varadhachary GR, Katz MHG, Wolff RA, Fogelman DR, Herman JM. Novel EUS-guided brachytherapy treatment of pancreatic cancer with phosphorus-32 microparticles: first United States experience. VideoGIE. 2019 May;4(5):223-225. doi: 10.1016/j.vgie.2019.02.009. eCollection 2019 May. PubMed PMID: 31065616; PubMed Central PMCID: PMC6495077.

Yang Z, Chang Y, Brock KK, Cazoulat G, Koay EJ, Koong AC, Herman JM, Park PC, Poenisch F, Li Q, Yang K, Wu G, Anderson B, Ohrt AN, Li Y, Zhu XR, Zhang X, Li H. Effect of setup and inter-fraction anatomical changes on the accumulated dose in CT-guided breath-hold intensity modulated proton therapy of liver malignancies. Radiother Oncol. 2019 May;134:101-109. doi: 10.1016/j.radonc.2019.01.028. Epub 2019 Feb 6. PubMed PMID: 31005203.

Deng W, Xu C, Liu A, van Rossum PSN, Deng W, Liao Z, Koong AC, Mohan R, Lin SH. The relationship of lymphocyte recovery and prognosis of esophageal cancer patients with severe radiation-induced lymphopenia after chemoradiation therapy. Radiother Oncol. 2019 Apr;133:9-15. doi: 10.1016/j.radonc.2018.12.002. Epub 2019 Jan 11. PubMed PMID: 30935587.

2018

Coronel E, Cazacu IM, Sakuraba A, Luzuriaga Chavez AA, Uberoi A, Geng Y, Tomizawa Y, Saftoiu A, Shin EJ, Taniguchi CM, Koong AC, Herman JM, Bhutani MS. EUS-guided fiducial placement for GI malignancies: a systematic review and meta-analysis. Gastrointest Endosc. 2019 Apr;89(4):659-670.e18. doi: 10.1016/j.gie.2018.10.047. Epub 2018 Nov 13. PubMed PMID: 30445001.

Yurgelun MB, Chittenden AB, Morales-Oyarvide V, Rubinson DA, Dunne RF, Kozak MM, Qian ZR, Welch MW, Brais LK, Da Silva A, Bui JL, Yuan C, Li T, Li W, Masuda A, Gu M, Bullock AJ, Chang DT, Clancy TE, Linehan DC, Findeis-Hosey JJ, Doyle LA, Thorner AR, Ducar MD, Wollison BM, Khalaf N, Perez K, Syngal S, Aguirre AJ, Hahn WC, Meyerson ML, Fuchs CS, Ogino S, Hornick JL, Hezel AF, Koong AC, Nowak JA, Wolpin BM. Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer. Genet Med. 2019 Jan;21(1):213-223. doi: 10.1038/s41436-018-0009-5. Epub 2018 Jul 2. PubMed PMID: 29961768; PubMed Central PMCID: PMC6666401.

Tao R, Ager B, Lloyd S, Torgeson A, Denney M, Gaffney D, Kharofa J, Lin SH, Koong AC, Anzai Y, Hoffman JM. Hypoxia imaging in upper gastrointestinal tumors and application to radiation therapy. J Gastrointest Oncol. 2018 Dec;9(6):1044-1053. doi: 10.21037/jgo.2018.09.15. Review. PubMed PMID: 30603123; PubMed Central PMCID: PMC6286953.

Qian Y, Von Eyben R, Liu Y, Chin FT, Miao Z, Apte S, Carter JN, Binkley MS, Pollom EL, Harris JP, Prionas ND, Kissel M, Simmons A, Diehn M, Shultz DB, Brown JM, Maxim PG, Koong AC, Graves EE, Loo BW Jr. 18F-EF5 PET-based Imageable Hypoxia Predicts Local Recurrence in Tumors Treated With Highly Conformal Radiation Therapy. Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):1183-1192. doi: 10.1016/j.ijrobp.2018.03.045. Epub 2018 Apr 18. PubMed PMID: 29859786.

Colbert LE, Rebueno N, Moningi S, Beddar S, Sawakuchi GO, Herman JM, Koong AC, Das P, Holliday EB, Koay EJ, Taniguchi CM. Dose escalation for locally advanced pancreatic cancer: How high can we go? Adv Radiat Oncol. 2018 Oct-Dec;3(4):693-700. doi: 10.1016/j.adro.2018.07.008. eCollection 2018 Oct-Dec. PubMed PMID: 30370371; PubMed Central PMCID: PMC6200902.

Gensheimer MF, Henry AS, Wood DJ, Hastie TJ, Aggarwal S, Dudley SA, Pradhan P, Banerjee I, Cho E, Ramchandran K, Pollom E, Koong AC, Rubin DL, Chang DT. Automated Survival Prediction in Metastatic Cancer Patients Using High-Dimensional Electronic Medical Record Data. J Natl Cancer Inst. 2018 Oct 21;. doi: 10.1093/jnci/djy178. [Epub ahead of print] PubMed PMID: 30346554; PubMed Central PMCID: PMC6579743.

Benej M, Hong X, Vibhute S, Scott S, Wu J, Graves E, Le QT, Koong AC, Giaccia AJ, Yu B, Chen CS, Papandreou I, Denko NC. Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10756-10761. doi: 10.1073/pnas.1808945115. Epub 2018 Sep 10. PubMed PMID: 30201710; PubMed Central PMCID: PMC6196495.

Toesca DAS, Koong AJ, von Eyben R, Koong AC, Chang DT. Stereotactic body radiation therapy for adrenal gland metastases: Outcomes and toxicity. Adv Radiat Oncol. 2018 Oct-Dec;3(4):621-629. doi: 10.1016/j.adro.2018.05.006. eCollection 2018 Oct-Dec. PubMed PMID: 30370363; PubMed Central PMCID: PMC6200881.

Elganainy D, Holliday EB, Taniguchi CM, Smith GL, Shroff R, Javle M, Raghav K, Kaseb A, Aloia TA, Vauthey JN, Tzeng CD, Herman JM, Koong AC, Krishnan SX, Minsky BD, Crane CH, Das P, Koay EJ. Dose escalation of radiotherapy in unresectable extrahepatic cholangiocarcinoma. Cancer Med. 2018 Oct;7(10):4880-4892. doi: 10.1002/cam4.1734. Epub 2018 Aug 27. PubMed PMID: 30152073; PubMed Central PMCID: PMC6198206.

Chiou SH, Dorsch M, Kusch E, Naranjo S, Kozak MM, Koong AC, Winslow MM, Grüner BM. Hmga2 is dispensable for pancreatic cancer development, metastasis, and therapy resistance. Sci Rep. 2018 Sep 18;8(1):14008. doi: 10.1038/s41598-018-32159-x. PubMed PMID: 30228296; PubMed Central PMCID: PMC6143627.

Fang P, Jiang W, Davuluri R, Xu C, Krishnan S, Mohan R, Koong AC, Hsu CC, Lin SH. High lymphocyte count during neoadjuvant chemoradiotherapy is associated with improved pathologic complete response in esophageal cancer. Radiother Oncol. 2018 Sep;128(3):584-590. doi: 10.1016/j.radonc.2018.02.025. Epub 2018 Mar 9. PubMed PMID: 29530432.

Smith GL, Das P, Herman JM, Koay EJ, Koong AC, Grossberg A, Ludmir E. Comparing Ablative Modalities for Hepatocellular Carcinoma: Cautions in Interpreting Big Data. J Clin Oncol. 2018 Aug 20;36(24):2565-2566. doi: 10.1200/JCO.2018.78.5428. Epub 2018 Jun 26. PubMed PMID: 29945520; PubMed Central PMCID: PMC6093787.

Chin AL, Aggarwal S, Pradhan P, Bush K, von Eyben R, Koong AC, Chang DT. The role of bone marrow and spleen irradiation in the development of acute hematologic toxicity during chemoradiation for esophageal cancer. Adv Radiat Oncol. 2018 Jul-Sep;3(3):297-304. doi: 10.1016/j.adro.2018.02.005. eCollection 2018 Jul-Sep. PubMed PMID: 30202799; PubMed Central PMCID: PMC6128098.

Danai LV, Babic A, Rosenthal MH, Dennstedt EA, Muir A, Lien EC, Mayers JR, Tai K, Lau AN, Jones-Sali P, Prado CM, Petersen GM, Takahashi N, Sugimoto M, Yeh JJ, Lopez N, Bardeesy N, Fernandez-Del Castillo C, Liss AS, Koong AC, Bui J, Yuan C, Welch MW, Brais LK, Kulke MH, Dennis C, Clish CB, Wolpin BM, Vander Heiden MG. Altered exocrine function can drive adipose wasting in early pancreatic cancer. Nature. 2018 Jun;558(7711):600-604. doi: 10.1038/s41586-018-0235-7. Epub 2018 Jun 20. PubMed PMID: 29925948; PubMed Central PMCID: PMC6112987.

Yang Z, Zhang J, Jiang D, Khatri P, Solow-Cordero DE, Toesca DAS, Koumenis C, Denko NC, Giaccia AJ, Le QT, Koong AC. A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α-XBP1 Activation. Mol Cancer Res. 2018 May;16(5):745-753. doi: 10.1158/1541-7786.MCR-17-0307. Epub 2018 Feb 9. PubMed PMID: 29440447; PubMed Central PMCID: PMC5932228.

Toesca DAS, Koong AJ, Poultsides GA, Visser BC, Haraldsdottir S, Koong AC, Chang DT. Management of Borderline Resectable Pancreatic Cancer. Int J Radiat Oncol Biol Phys. 2018 Apr 1;100(5):1155-1174. doi: 10.1016/j.ijrobp.2017.12.287. Review. PubMed PMID: 29722658.

Qian ZR, Rubinson DA, Nowak JA, Morales-Oyarvide V, Dunne RF, Kozak MM, Welch MW, Brais LK, Da Silva A, Li T, Li W, Masuda A, Yang J, Shi Y, Gu M, Masugi Y, Bui J, Zellers CL, Yuan C, Babic A, Khalaf N, Aguirre A, Ng K, Miksad RA, Bullock AJ, Chang DT, Tseng JF, Clancy TE, Linehan DC, Findeis-Hosey JJ, Doyle LA, Thorner AR, Ducar M, Wollison B, Laing A, Hahn WC, Meyerson M, Fuchs CS, Ogino S, Hornick JL, Hezel AF, Koong AC, Wolpin BM. Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma. JAMA Oncol. 2018 Mar 8;4(3):e173420. doi: 10.1001/jamaoncol.2017.3420. Epub 2018 Mar 8. PubMed PMID: 29098284; PubMed Central PMCID: PMC5844844.

Prayongrat A, Umegaki K, van der Schaaf A, Koong AC, Lin SH, Whitaker T, McNutt T, Matsufuji N, Graves E, Mizuta M, Ogawa K, Date H, Moriwaki K, Ito YM, Kobashi K, Dekura Y, Shimizu S, Shirato H. Present developments in reaching an international consensus for a model-based approach to particle beam therapy. J Radiat Res. 2018 Mar 1;59(suppl_1):i72-i76. doi: 10.1093/jrr/rry008. PubMed PMID: 29529229; PubMed Central PMCID: PMC5868183.

Toesca DAS, Ibragimov B, Koong AJ, Xing L, Koong AC, Chang DT. Strategies for prediction and mitigation of radiation-induced liver toxicity. J Radiat Res. 2018 Mar 1;59(suppl_1):i40-i49. doi: 10.1093/jrr/rrx104. PubMed PMID: 29432550; PubMed Central PMCID: PMC5868188.

Alagappan M, Pollom EL, von Eyben R, Kozak MM, Aggarwal S, Poultsides GA, Koong AC, Chang DT. Albumin and Neutrophil-Lymphocyte Ratio (NLR) Predict Survival in Patients With Pancreatic Adenocarcinoma Treated With SBRT. Am J Clin Oncol. 2018 Mar;41(3):242-247. doi: 10.1097/COC.0000000000000263. PubMed PMID: 26757436.

Boyko TV, Bam R, Jiang D, Wang Z, Bhatia N, Tran MC, Longaker MT, Koong AC, Yang GP. Inhibition of IRE1 results in decreased scar formation. Wound Repair Regen. 2017 Nov;25(6):964-971. doi: 10.1111/wrr.12603. Epub 2018 Feb 6. PubMed PMID: 29316036; PubMed Central PMCID: PMC5854534.

Rao AD, Liu Y, von Eyben R, Hsu CC, Hu C, Rosati LM, Parekh A, Ng K, Hacker-Prietz A, Zheng L, Pawlik TM, Laheru DA, Jaffee EM, Weiss MJ, Le DT, Hruban RH, De Jesus-Acosta A, Wolfgang CL, Narang AK, Chang DT, Koong AC, Herman JM. Multiplex Proximity Ligation Assay to Identify Potential Prognostic Biomarkers for Improved Survival in Locally Advanced Pancreatic Cancer Patients Treated With Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys. 2018 Feb 1;100(2):486-489. doi: 10.1016/j.ijrobp.2017.10.001. Epub 2017 Oct 12. PubMed PMID: 29157747.

Lin SH, Koong AC. Breathing New Life Into Hypoxia-Targeted Therapies for Non-Small Cell Lung Cancer. J Natl Cancer Inst. 2018 Jan 1;110(1). doi: 10.1093/jnci/djx163. PubMed PMID: 28922792.

2017

Morales-Oyarvide V, Rubinson DA, Dunne RF, Kozak MM, Bui JL, Yuan C, Qian ZR, Babic A, Da Silva A, Nowak JA, Khalaf N, Brais LK, Welch MW, Zellers CL, Ng K, Chang DT, Miksad RA, Bullock AJ, Tseng JF, Swanson RS, Clancy TE, Linehan DC, Findeis-Hosey JJ, Doyle LA, Hornick JL, Ogino S, Fuchs CS, Hezel AF, Koong AC, Wolpin BM. Lymph node metastases in resected pancreatic ductal adenocarcinoma: predictors of disease recurrence and survival. Br J Cancer. 2017 Dec 5;117(12):1874-1882. doi: 10.1038/bjc.2017.349. Epub 2017 Oct 5. PubMed PMID: 28982112; PubMed Central PMCID: PMC5729468.

Chin AL, Pollom EL, Qian Y, Koong AC, Chang DT. Impact of Intensity-Modulated Radiotherapy on Health Care Costs of Patients With Anal Squamous Cell Carcinoma. J Oncol Pract. 2017 Dec;13(12):e992-e1001. doi: 10.1200/JOP.2017.024810. Epub 2017 Oct 16. PubMed PMID: 29035618; PubMed Central PMCID: PMC6202035.

Qian Y, Chin AL, Toesca DAS, Koong AC, Chang DT. Nonoperative Management of Rectal Cancer: A Modern Perspective. Oncology (Williston Park). 2017 Oct 15;31(10):e13-e22. Review. PubMed PMID: 29083469.

Mello SS, Valente LJ, Raj N, Seoane JA, Flowers BM, McClendon J, Bieging-Rolett KT, Lee J, Ivanochko D, Kozak MM, Chang DT, Longacre TA, Koong AC, Arrowsmith CH, Kim SK, Vogel H, Wood LD, Hruban RH, Curtis C, Attardi LD. A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer. Cancer Cell. 2017 Oct 9;32(4):460-473.e6. doi: 10.1016/j.ccell.2017.09.007. PubMed PMID: 29017057; PubMed Central PMCID: PMC5659188.

Chiou SH, Risca VI, Wang GX, Yang D, Grüner BM, Kathiria AS, Ma RK, Vaka D, Chu P, Kozak M, Castellini L, Graves EE, Kim GE, Mourrain P, Koong AC, Giaccia AJ, Winslow MM. BLIMP1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer. Cancer Discov. 2017 Oct;7(10):1184-1199. doi: 10.1158/2159-8290.CD-17-0250. Epub 2017 Aug 8. PubMed PMID: 28790031; PubMed Central PMCID: PMC5628145.

Kozak MM, von Eyben R, Pai JS, Anderson EM, Welton ML, Shelton AA, Kin C, Koong AC, Chang DT. The Prognostic Significance of Pretreatment Hematologic Parameters in Patients Undergoing Resection for Colorectal Cancer. Am J Clin Oncol. 2017 Aug;40(4):405-412. doi: 10.1097/COC.0000000000000183. PubMed PMID: 25756348.

Jiang D, Turner B, Song J, Li R, Diehn M, Le QT, Khatri P, Koong AC. Comprehensive Analysis of the Unfolded Protein Response in Breast Cancer Subtypes. JCO Precis Oncol. 2017;2017. doi: 10.1200/PO.16.00073. Epub 2017 Jul 26. PubMed PMID: 29888341; PubMed Central PMCID: PMC5992919.

Koong AC, Tepper JE. Introduction. Semin Radiat Oncol. 2017 Jul;27(3):189. doi: 10.1016/j.semradonc.2017.03.005. Epub 2017 Mar 18. PubMed PMID: 28577825.

Toesca DAS, Osmundson EC, von Eyben R, Shaffer JL, Koong AC, Chang DT. Assessment of hepatic function decline after stereotactic body radiation therapy for primary liver cancer. Pract Radiat Oncol. 2017 May - Jun;7(3):173-182. doi: 10.1016/j.prro.2016.10.003. Epub 2016 Oct 17. PubMed PMID: 28343896.

Pollom EL, Wang G, Harris JP, Koong AC, Bendavid E, Bhattacharya J, Chang DT. The Impact of Intensity Modulated Radiation Therapy on Hospitalization Outcomes in the SEER-Medicare Population With Anal Squamous Cell Carcinoma. Int J Radiat Oncol Biol Phys. 2017 May 1;98(1):177-185. doi: 10.1016/j.ijrobp.2017.01.006. Epub 2017 Jan 7. PubMed PMID: 28258896; PubMed Central PMCID: PMC6193759.

Pollom EL, Lee K, Durkee BY, Grade M, Mokhtari DA, Wahl DR, Feng M, Kothary N, Koong AC, Owens DK, Goldhaber-Fiebert J, Chang DT. Cost-effectiveness of Stereotactic Body Radiation Therapy versus Radiofrequency Ablation for Hepatocellular Carcinoma: A Markov Modeling Study. Radiology. 2017 May;283(2):460-468. doi: 10.1148/radiol.2016161509. Epub 2017 Jan 3. PubMed PMID: 28045603; PubMed Central PMCID: PMC5410949.

Yuan W, Jiang D, Nambiar DK, Liew LP, Hay MP, Bloomstein J, Lu P, Turner B, Le QT, Tibshirani R, Khatri P, Moloney MG, Koong AC. Chemical Space Mimicry for Drug Discovery. J Chem Inf Model. 2017 Apr 24;57(4):875-882. doi: 10.1021/acs.jcim.6b00754. Epub 2017 Apr 3. PubMed PMID: 28257191; PubMed Central PMCID: PMC5802964.

Jones WE 3rd, Suh WW, Abdel-Wahab M, Abrams RA, Azad N, Das P, Dragovic J, Goodman KA, Jabbour SK, Konski AA, Koong AC, Kumar R, Lee P, Pawlik TM, Small W Jr, Herman JM. ACR Appropriateness Criteria® Resectable Pancreatic Cancer. Am J Clin Oncol. 2017 Apr;40(2):109-117. doi: 10.1097/COC.0000000000000370. Review. PubMed PMID: 28230650.

Kino A, Shaffer J, Maturen KE, Schmiedeskamp H, Koong AC, Chang DT, Fleischmann D, Kamaya A. Perfusion CT measurements predict tumor response in rectal carcinoma. Abdom Radiol (NY). 2017 Apr;42(4):1132-1140. doi: 10.1007/s00261-016-0983-5. PubMed PMID: 28008455.

Toesca DA, Pollom EL, Poullos PD, Flynt L, Cui Y, Quon A, von Eyben R, Koong AC, Chang DT. Assessing local progression after stereotactic body radiation therapy for unresectable pancreatic adenocarcinoma: CT versus PET. Pract Radiat Oncol. 2017 Mar - Apr;7(2):120-125. doi: 10.1016/j.prro.2016.09.002. Epub 2016 Sep 7. PubMed PMID: 28274396.

Kariolis MS, Miao YR, Diep A, Nash SE, Olcina MM, Jiang D, Jones DS 2nd, Kapur S, Mathews II, Koong AC, Rankin EB, Cochran JR, Giaccia AJ. Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. J Clin Invest. 2017 Jan 3;127(1):183-198. doi: 10.1172/JCI85610. Epub 2016 Nov 28. PubMed PMID: 27893463; PubMed Central PMCID: PMC5199716.

Pollom EL, Alagappan M, Park LS, Whittemore AS, Koong AC, Chang DT. Does radiotherapy still have a role in unresected biliary tract cancer?. Cancer Med. 2017 Jan;6(1):129-141. doi: 10.1002/cam4.975. Epub 2016 Nov 28. PubMed PMID: 27891822; PubMed Central PMCID: PMC5269698.

2016

Toesca DA, Osmundson EC, Eyben RV, Shaffer JL, Lu P, Koong AC, Chang DT. Central liver toxicity after SBRT: An expanded analysis and predictive nomogram. Radiother Oncol. 2017 Jan;122(1):130-136. doi: 10.1016/j.radonc.2016.10.024. Epub 2016 Nov 16. PubMed PMID: 27865544.

Aguilera TA, Rafat M, Castellini L, Shehade H, Kariolis MS, Hui AB, Stehr H, von Eyben R, Jiang D, Ellies LG, Koong AC, Diehn M, Rankin EB, Graves EE, Giaccia AJ. Reprogramming the immunological microenvironment through radiation and targeting Axl. Nat Commun. 2016 Dec 23;7:13898. doi: 10.1038/ncomms13898. PubMed PMID: 28008921; PubMed Central PMCID: PMC5196438.

Jiang D, Lynch C, Medeiros BC, Liedtke M, Bam R, Tam AB, Yang Z, Alagappan M, Abidi P, Le QT, Giaccia AJ, Denko NC, Niwa M, Koong AC. Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response. Sci Rep. 2016 Sep 16;6:33353. doi: 10.1038/srep33353. PubMed PMID: 27634301; PubMed Central PMCID: PMC5025885.

Cui Y, Song J, Pollom E, Alagappan M, Shirato H, Chang DT, Koong AC, Li R. Quantitative Analysis of (18)F-Fluorodeoxyglucose Positron Emission Tomography Identifies Novel Prognostic Imaging Biomarkers in Locally Advanced Pancreatic Cancer Patients Treated With Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys. 2016 Sep 1;96(1):102-9. doi: 10.1016/j.ijrobp.2016.04.034. Epub 2016 May 7. PubMed PMID: 27511850.

Jiang D, Tam AB, Alagappan M, Hay MP, Gupta A, Kozak MM, Solow-Cordero DE, Lum PY, Denko NC, Giaccia AJ, Le QT, Niwa M, Koong AC. Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma. Mol Cancer Ther. 2016 Sep;15(9):2055-65. doi: 10.1158/1535-7163.MCT-15-1023. Epub 2016 Jun 15. PubMed PMID: 27307600; PubMed Central PMCID: PMC5010920.

Small W Jr, Hayes JP, Suh WW, Abdel-Wahab M, Abrams RA, Azad N, Das P, Dragovic J, Goodman KA, Jabbour SK, Jones WE 3rd, Konski AA, Koong AC, Kumar R, Lee P, Pawlik TM, Herman JM. ACR Appropriateness Criteria® Borderline and Unresectable Pancreas Cancer. Oncology (Williston Park). 2016 Jul;30(7):619-24, 627, 632. Review. PubMed PMID: 27422109.

Shultz DB, Pai J, Chiu W, Ng K, Hellendag MG, Heestand G, Chang DT, Tu D, Moore MJ, Parulekar WR, Koong AC. A Novel Biomarker Panel Examining Response to Gemcitabine with or without Erlotinib for Pancreatic Cancer Therapy in NCIC Clinical Trials Group PA.3. PLoS One. 2016;11(1):e0147995. doi: 10.1371/journal.pone.0147995. eCollection 2016. PubMed PMID: 26808546; PubMed Central PMCID: PMC4725948.

Alagappan M, Jiang D, Denko N, Koong AC. A Multimodal Data Analysis Approach for Targeted Drug Discovery Involving Topological Data Analysis (TDA). Adv Exp Med Biol. 2016;899:253-68. doi: 10.1007/978-3-319-26666-4_15. PubMed PMID: 27325272; PubMed Central PMCID: PMC5519345.

Kozak MM, Anderson EM, von Eyben R, Pai JS, Poultsides GA, Visser BC, Norton JA, Koong AC, Chang DT. Statin and Metformin Use Prolongs Survival in Patients With Resectable Pancreatic Cancer. Pancreas. 2016 Jan;45(1):64-70. doi: 10.1097/MPA.0000000000000470. PubMed PMID: 26474429.

2015

Lu SL, Hsu FM, Tsai CL, Wu JK, Lee JM, Huang PM, Hsu CH, Koong AC, Chang DT, Cheng JC. Serum Transforming Growth Factor-β1 Change After Neoadjuvant Chemoradiation Therapy Is Associated With Postoperative Pulmonary Complications in Esophageal Cancer Patients Undergoing Combined Modality Therapy. Int J Radiat Oncol Biol Phys. 2015 Dec 1;93(5):1023-31. doi: 10.1016/j.ijrobp.2015.08.035. Epub 2015 Aug 28. PubMed PMID: 26475065.

White EC, Murphy JD, Chang DT, Koong AC. Low Toxicity in Inflammatory Bowel Disease Patients Treated With Abdominal and Pelvic Radiation Therapy. Am J Clin Oncol. 2015 Dec;38(6):564-9. doi: 10.1097/COC.0000000000000010. PubMed PMID: 24401668.

Papandreou I, Verras M, McNeil B, Koong AC, Denko NC. Plant stilbenes induce endoplasmic reticulum stress and their anti-cancer activity can be enhanced by inhibitors of autophagy. Exp Cell Res. 2015 Nov 15;339(1):147-53. doi: 10.1016/j.yexcr.2015.10.014. Epub 2015 Oct 17. PubMed PMID: 26477823; PubMed Central PMCID: PMC4822495.

Russo S, Blackstock AW, Herman JM, Abdel-Wahab M, Azad N, Das P, Goodman KA, Hong TS, Jabbour SK, Jones WE 3rd, Konski AA, Koong AC, Kumar R, Rodriguez-Bigas M, Small W Jr, Thomas CR Jr, Suh WW. ACR Appropriateness Criteria® Local Excision in Early Stage Rectal Cancer. Am J Clin Oncol. 2015 Oct;38(5):520-5. doi: 10.1097/COC.0000000000000197. Review. PubMed PMID: 26371522.

Shaffer JL, Osmundson EC, Visser BC, Longacre TA, Koong AC, Chang DT. Stereotactic body radiation therapy and central liver toxicity: A case report. Pract Radiat Oncol. 2015 Sep-Oct;5(5):282-285. doi: 10.1016/j.prro.2015.04.011. Epub 2015 Jun 27. PubMed PMID: 26127008.

Daroui P, Jabbour SK, Herman JM, Abdel-Wahab M, Azad N, Blackstock AW, Das P, Goodman KA, Hong TS, Jones WE 3rd, Kaur H, Konski AA, Koong AC, Kumar R, Pawlik TM, Small W Jr, Thomas CR Jr, Suh WW. ACR Appropriateness Criteria® Resectable Stomach Cancer. Oncology (Williston Park). 2015 Aug;29(8):595-602, C3. Review. PubMed PMID: 26281845.

Pollom EL, Koong AC, Ko AH. Treatment Approaches to Locally Advanced Pancreatic Adenocarcinoma. Hematol Oncol Clin North Am. 2015 Aug;29(4):741-59. doi: 10.1016/j.hoc.2015.04.005. Epub 2015 May 30. Review. PubMed PMID: 26226908.

Le QT, Shirato H, Giaccia AJ, Koong AC. Emerging Treatment Paradigms in Radiation Oncology. Clin Cancer Res. 2015 Aug 1;21(15):3393-401. doi: 10.1158/1078-0432.CCR-14-1191. Epub 2015 May 19. Review. PubMed PMID: 25991820; PubMed Central PMCID: PMC4526434.

Jiang D, Niwa M, Koong AC. Targeting the IRE1α-XBP1 branch of the unfolded protein response in human diseases. Semin Cancer Biol. 2015 Aug;33:48-56. doi: 10.1016/j.semcancer.2015.04.010. Epub 2015 May 16. Review. PubMed PMID: 25986851; PubMed Central PMCID: PMC4523453.

Pollom EL, Deng L, Pai RK, Brown JM, Giaccia A, Loo BW Jr, Shultz DB, Le QT, Koong AC, Chang DT. Gastrointestinal Toxicities With Combined Antiangiogenic and Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys. 2015 Jul 1;92(3):568-76. doi: 10.1016/j.ijrobp.2015.02.016. Review. PubMed PMID: 26068491; PubMed Central PMCID: PMC4816453.

Hsu FM, Cheng JC, Chang YL, Lee JM, Koong AC, Chuang EY. Circulating mRNA Profiling in Esophageal Squamous Cell Carcinoma Identifies FAM84B As A Biomarker In Predicting Pathological Response to Neoadjuvant Chemoradiation. Sci Rep. 2015 May 18;5:10291. doi: 10.1038/srep10291. PubMed PMID: 25980316; PubMed Central PMCID: PMC4434848.

Kozak MM, von Eyben R, Pai J, Vossler SR, Limaye M, Jayachandran P, Anderson EM, Shaffer JL, Longacre T, Pai RK, Koong AC, Chang DT. Smad4 inactivation predicts for worse prognosis and response to fluorouracil-based treatment in colorectal cancer. J Clin Pathol. 2015 May;68(5):341-5. doi: 10.1136/jclinpath-2014-202660. Epub 2015 Feb 13. PubMed PMID: 25681512.

Bazalova-Carter M, Liu M, Palma B, Dunning M, McCormick D, Hemsing E, Nelson J, Jobe K, Colby E, Koong AC, Tantawi S, Dolgashev V, Maxim PG, Loo BW Jr. Comparison of film measurements and Monte Carlo simulations of dose delivered with very high-energy electron beams in a polystyrene phantom. Med Phys. 2015 Apr;42(4):1606-13. doi: 10.1118/1.4914371. PubMed PMID: 25832051.

Osmundson EC, Wu Y, Luxton G, Bazan JG, Koong AC, Chang DT. Predictors of toxicity associated with stereotactic body radiation therapy to the central hepatobiliary tract. Int J Radiat Oncol Biol Phys. 2015 Apr 1;91(5):986-94. doi: 10.1016/j.ijrobp.2014.11.028. Epub 2015 Feb 3. PubMed PMID: 25659885.

Herman JM, Chang DT, Goodman KA, Dholakia AS, Raman SP, Hacker-Prietz A, Iacobuzio-Donahue CA, Griffith ME, Pawlik TM, Pai JS, O'Reilly E, Fisher GA, Wild AT, Rosati LM, Zheng L, Wolfgang CL, Laheru DA, Columbo LA, Sugar EA, Koong AC. Phase 2 multi-institutional trial evaluating gemcitabine and stereotactic body radiotherapy for patients with locally advanced unresectable pancreatic adenocarcinoma. Cancer. 2015 Apr 1;121(7):1128-37. doi: 10.1002/cncr.29161. Epub 2014 Dec 23. PubMed PMID: 25538019; PubMed Central PMCID: PMC4368473.

2014

Moningi S, Marciscano AE, Rosati LM, Ng SK, Teboh Forbang R, Jackson J, Chang DT, Koong AC, Herman JM. Stereotactic body radiation therapy in pancreatic cancer: the new frontier. Expert Rev Anticancer Ther. 2014 Dec;14(12):1461-75. doi: 10.1586/14737140.2014.952286. Epub 2014 Sep 3. Review. PubMed PMID: 25183386.

Pollom EL, Alagappan M, von Eyben R, Kunz PL, Fisher GA, Ford JA, Poultsides GA, Visser BC, Norton JA, Kamaya A, Cox VL, Columbo LA, Koong AC, Chang DT. Single- versus multifraction stereotactic body radiation therapy for pancreatic adenocarcinoma: outcomes and toxicity. Int J Radiat Oncol Biol Phys. 2014 Nov 15;90(4):918-25. doi: 10.1016/j.ijrobp.2014.06.066. Epub 2014 Oct 18. PubMed PMID: 25585785.

Tam AB, Koong AC, Niwa M. Ire1 has distinct catalytic mechanisms for XBP1/HAC1 splicing and RIDD. Cell Rep. 2014 Nov 6;9(3):850-8. doi: 10.1016/j.celrep.2014.09.016. Epub 2014 Oct 30. PubMed PMID: 25437541; PubMed Central PMCID: PMC4486022.

Paudel N, Kunz PL, Poultsides GA, Koong AC, Chang DT. False positive 18F-fluorodeoxyglucose positron emission tomography/computed tomography liver lesion mimicking metastasis in 2 patients with gastroesophageal cancer. Pract Radiat Oncol. 2014 Nov-Dec;4(6):368-71. doi: 10.1016/j.prro.2013.11.005. Epub 2013 Dec 16. PubMed PMID: 25407856.

Kuo P, Bratman SV, Shultz DB, von Eyben R, Chan C, Wang Z, Say C, Gupta A, Loo BW Jr, Giaccia AJ, Koong AC, Diehn M, Le QT. Galectin-1 mediates radiation-related lymphopenia and attenuates NSCLC radiation response. Clin Cancer Res. 2014 Nov 1;20(21):5558-69. doi: 10.1158/1078-0432.CCR-14-1138. Epub 2014 Sep 4. PubMed PMID: 25189484; PubMed Central PMCID: PMC4216761.

Goodman KA, Milgrom SA, Herman JM, Abdel-Wahab M, Azad N, Blackstock AW, Das P, Hong TS, Jabbour SK, Jones WE 3rd, Konski AA, Koong AC, Kumar R, Rodriguez-Bigas M, Small W Jr, Thomas CR Jr, Suh WW. ACR Appropriateness Criteria® rectal cancer: metastatic disease at presentation. Oncology (Williston Park). 2014 Oct;28(10):867-71, 876, 878. Review. PubMed PMID: 25323613.

Herman JM, Koong AC. Stereotactic body radiation therapy: a new standard option for pancreatic cancer?. J Natl Compr Canc Netw. 2014 Oct;12(10):1489-93. doi: 10.6004/jnccn.2014.0143. PubMed PMID: 25313185.

Xiao N, Lin Y, Cao H, Sirjani D, Giaccia AJ, Koong AC, Kong CS, Diehn M, Le QT. Neurotrophic factor GDNF promotes survival of salivary stem cells. J Clin Invest. 2014 Aug;124(8):3364-77. doi: 10.1172/JCI74096. Epub 2014 Jul 18. PubMed PMID: 25036711; PubMed Central PMCID: PMC4109543.

Dholakia AS, Chaudhry M, Leal JP, Chang DT, Raman SP, Hacker-Prietz A, Su Z, Pai J, Oteiza KE, Griffith ME, Wahl RL, Tryggestad E, Pawlik T, Laheru DA, Wolfgang CL, Koong AC, Herman JM. Baseline metabolic tumor volume and total lesion glycolysis are associated with survival outcomes in patients with locally advanced pancreatic cancer receiving stereotactic body radiation therapy. Int J Radiat Oncol Biol Phys. 2014 Jul 1;89(3):539-46. doi: 10.1016/j.ijrobp.2014.02.031. Epub 2014 Apr 18. PubMed PMID: 24751410; PubMed Central PMCID: PMC4372085.

Shultz DB, Chan C, Shaffer JL, Kunz PL, Koong AC, Chang DT. Postradiotherapy CA19-9 kinetics correlate with outcomes in patients with pancreatic adenocarcinoma. Pancreas. 2014 Jul;43(5):777-83. doi: 10.1097/MPA.0000000000000098. PubMed PMID: 24632549.

Cheng JC, Graber MS, Hsu FM, Tsai CL, Castaneda L, Lee JM, Chang DT, Koong AC. High serum levels of vascular endothelial growth factor-A and transforming growth factor-β1 before neoadjuvant chemoradiotherapy predict poor outcomes in patients with esophageal squamous cell carcinoma receiving combined modality therapy. Ann Surg Oncol. 2014 Jul;21(7):2361-8. doi: 10.1245/s10434-014-3611-z. Epub 2014 Mar 13. PubMed PMID: 24623035.

Cheng JC, Bazan JG, Wu JK, Koong AC, Chang DT. Lumbosacral spine and marrow cavity modeling of acute hematologic toxicity in patients treated with intensity modulated radiation therapy for squamous cell carcinoma of the anal canal. Pract Radiat Oncol. 2014 May-Jun;4(3):198-206. doi: 10.1016/j.prro.2013.07.011. Epub 2013 Aug 29. PubMed PMID: 24766688.

Trakul N, Koong AC, Chang DT. Stereotactic body radiotherapy in the treatment of pancreatic cancer. Semin Radiat Oncol. 2014 Apr;24(2):140-7. doi: 10.1016/j.semradonc.2013.11.008. Review. PubMed PMID: 24635871.

Hong TS, Pretz JL, Herman JM, Abdel-Wahab M, Azad N, Blackstock AW, Das P, Goodman KA, Jabbour SK, Jones WE 3rd, Konski AA, Koong AC, Rodriguez-Bigas M, Small W Jr, Thomas CR Jr, Zook J, Suh WW. ACR Appropriateness Criteria®-Anal Cancer. Gastrointest Cancer Res. 2014 Jan;7(1):4-14. PubMed PMID: 24558509; PubMed Central PMCID: PMC3924766.

2013

Wild AT, Hiniker SM, Chang DT, Tran PT, Khashab MA, Limaye MR, Laheru DA, Le DT, Kumar R, Pai JS, Hargens B, Sharabi AB, Shin EJ, Zheng L, Pawlik TM, Wolfgang CL, Koong AC, Herman JM. Re-irradiation with stereotactic body radiation therapy as a novel treatment option for isolated local recurrence of pancreatic cancer after multimodality therapy: experience from two institutions. J Gastrointest Oncol. 2013 Dec;4(4):343-51. doi: 10.3978/j.issn.2078-6891.2013.044. PubMed PMID: 24294505; PubMed Central PMCID: PMC3819776.

Bazan JG, Luxton G, Kozak MM, Anderson EM, Hancock SL, Kapp DS, Kidd EA, Koong AC, Chang DT. Impact of chemotherapy on normal tissue complication probability models of acute hematologic toxicity in patients receiving pelvic intensity modulated radiation therapy. Int J Radiat Oncol Biol Phys. 2013 Dec 1;87(5):983-91. doi: 10.1016/j.ijrobp.2013.09.017. Epub 2013 Oct 22. PubMed PMID: 24161422.

Li R, Han B, Meng B, Maxim PG, Xing L, Koong AC, Diehn M, Loo BW Jr. Clinical implementation of intrafraction cone beam computed tomography imaging during lung tumor stereotactic ablative radiation therapy. Int J Radiat Oncol Biol Phys. 2013 Dec 1;87(5):917-23. doi: 10.1016/j.ijrobp.2013.08.015. Epub 2013 Oct 8. PubMed PMID: 24113060; PubMed Central PMCID: PMC3888501.

Hong JC, Murphy JD, Wang SJ, Koong AC, Chang DT. Chemoradiotherapy before and after surgery for locally advanced esophageal cancer: a SEER-Medicare analysis. Ann Surg Oncol. 2013 Nov;20(12):3999-4007. doi: 10.1245/s10434-013-3072-9. Epub 2013 Jun 26. PubMed PMID: 23800897.

Lam MG, Abdelmaksoud MH, Chang DT, Eclov NC, Chung MP, Koong AC, Louie JD, Sze DY. Safety of 90Y radioembolization in patients who have undergone previous external beam radiation therapy. Int J Radiat Oncol Biol Phys. 2013 Oct 1;87(2):323-9. doi: 10.1016/j.ijrobp.2013.05.041. Epub 2013 Jul 9. PubMed PMID: 23849697.

Wild AT, Chang DT, Goodman KA, Laheru DA, Zheng L, Raman SP, Columbo LA, Wolfgang CL, Koong AC, Herman JM. A Phase 2 Multi-institutional Study to Evaluate Gemcitabine and Fractionated Stereotactic Radiotherapy for Unresectable, Locally Advanced Pancreatic Adenocarcinoma. Pract Radiat Oncol. 2013 Apr-Jun;3(2 Suppl 1):S4-5. doi: 10.1016/j.prro.2013.01.016. Epub 2013 Mar 25. PubMed PMID: 24674559.

Taniguchi CM, Murphy JD, Eclov N, Atwood TF, Kielar KN, Christman-Skieller C, Mok E, Xing L, Koong AC, Chang DT. Dosimetric analysis of organs at risk during expiratory gating in stereotactic body radiation therapy for pancreatic cancer. Int J Radiat Oncol Biol Phys. 2013 Mar 15;85(4):1090-5. doi: 10.1016/j.ijrobp.2012.07.2366. Epub 2012 Dec 27. PubMed PMID: 23273994.

2012

Sayers CM, Papandreou I, Guttmann DM, Maas NL, Diehl JA, Witze ES, Koong AC, Koumenis C. Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response. Mol Pharmacol. 2013 Mar;83(3):594-604. doi: 10.1124/mol.112.081810. Epub 2012 Dec 10. PubMed PMID: 23229510; PubMed Central PMCID: PMC3583498.

Tsai CL, Koong AC, Hsu FM, Graber M, Chen IS, Cheng JC. Biomarker studies on radiotherapy to hepatocellular carcinoma. Oncology. 2013;84 Suppl 1:64-8. doi: 10.1159/000345892. Epub 2013 Feb 20. Review. PubMed PMID: 23428861.

Bazan JG, Koong AC, Kapp DS, Quon A, Graves EE, Loo BW Jr, Chang DT. Metabolic tumor volume predicts disease progression and survival in patients with squamous cell carcinoma of the anal canal. J Nucl Med. 2013 Jan;54(1):27-32. doi: 10.2967/jnumed.112.109470. Epub 2012 Dec 12. PubMed PMID: 23236018.

Bazan JG, Luxton G, Mok EC, Koong AC, Chang DT. Normal tissue complication probability modeling of acute hematologic toxicity in patients treated with intensity-modulated radiation therapy for squamous cell carcinoma of the anal canal. Int J Radiat Oncol Biol Phys. 2012 Nov 1;84(3):700-6. doi: 10.1016/j.ijrobp.2011.12.072. Epub 2012 Mar 11. PubMed PMID: 22414279.

Jayachandran P, Pai RK, Quon A, Graves E, Krakow TE, La T, Loo BW Jr, Koong AC, Chang DT. Postchemoradiotherapy positron emission tomography predicts pathologic response and survival in patients with esophageal cancer. Int J Radiat Oncol Biol Phys. 2012 Oct 1;84(2):471-7. doi: 10.1016/j.ijrobp.2011.12.029. Epub 2012 Feb 28. PubMed PMID: 22381904.

Jones WE 3rd, Thomas CR Jr, Herman JM, Abdel-Wahab M, Azad N, Blackstock W, Das P, Goodman KA, Hong TS, Jabbour SK, Konski AA, Koong AC, Rodriguez-Bigas M, Small W Jr, Zook J, Suh WW. ACR appropriateness criteria®  resectable rectal cancer. Radiat Oncol. 2012 Sep 24;7:161. doi: 10.1186/1748-717X-7-161. PubMed PMID: 23006527; PubMed Central PMCID: PMC3488966.

Chang DT, Pai RK, Rybicki LA, Dimaio MA, Limaye M, Jayachandran P, Koong AC, Kunz PA, Fisher GA, Ford JM, Welton M, Shelton A, Ma L, Arber DA, Pai RK. Clinicopathologic and molecular features of sporadic early-onset colorectal adenocarcinoma: an adenocarcinoma with frequent signet ring cell differentiation, rectal and sigmoid involvement, and adverse morphologic features. Mod Pathol. 2012 Aug;25(8):1128-39. doi: 10.1038/modpathol.2012.61. Epub 2012 Apr 6. PubMed PMID: 22481281.

Song S, Hong JC, McDonnell SE, Koong AC, Minsky BD, Chang DT, Liauw SL. Combined modality therapy for rectal cancer: the relative value of posttreatment versus pretreatment CEA as a prognostic marker for disease recurrence. Ann Surg Oncol. 2012 Aug;19(8):2471-6. doi: 10.1245/s10434-012-2266-x. Epub 2012 Feb 11. PubMed PMID: 22327251.

Chennupati SK, Quon A, Kamaya A, Pai RK, La T, Krakow TE, Graves E, Koong AC, Chang DT. Positron emission tomography for predicting pathologic response after neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Am J Clin Oncol. 2012 Aug;35(4):334-9. doi: 10.1097/COC.0b013e3182118d12. PubMed PMID: 21422989.

Piccione EC, Lieu TJ, Gentile CF, Williams TR, Connolly AJ, Godwin AK, Koong AC, Wong AJ. A novel epidermal growth factor receptor variant lacking multiple domains directly activates transcription and is overexpressed in tumors. Oncogene. 2012 Jun 14;31(24):2953-67. doi: 10.1038/onc.2011.465. Epub 2011 Oct 10. PubMed PMID: 21986942; PubMed Central PMCID: PMC3368095.

Daly ME, Kapp DS, Maxim PG, Welton ML, Tran PT, Koong AC, Chang DT. Orthovoltage intraoperative radiotherapy for locally advanced and recurrent colorectal cancer. Dis Colon Rectum. 2012 Jun;55(6):695-702. doi: 10.1097/DCR.0b013e31824d464c. PubMed PMID: 22595850.

Pai RK, Jayachandran P, Koong AC, Chang DT, Kwok S, Ma L, Arber DA, Balise RR, Tubbs RR, Shadrach B, Pai RK. BRAF-mutated, microsatellite-stable adenocarcinoma of the proximal colon: an aggressive adenocarcinoma with poor survival, mucinous differentiation, and adverse morphologic features. Am J Surg Pathol. 2012 May;36(5):744-52. doi: 10.1097/PAS.0b013e31824430d7. PubMed PMID: 22314188; PubMed Central PMCID: PMC6362986.

Abelson JA, Murphy JD, Minn AY, Chung M, Fisher GA, Ford JM, Kunz P, Norton JA, Visser BC, Poultsides GA, Koong AC, Chang DT. Intensity-modulated radiotherapy for pancreatic adenocarcinoma. Int J Radiat Oncol Biol Phys. 2012 Mar 15;82(4):e595-601. doi: 10.1016/j.ijrobp.2011.09.035. Epub 2011 Dec 22. PubMed PMID: 22197234.

Trakul N, Koong AC, Maxim PG, Chang DT. Modern radiation therapy techniques for pancreatic cancer. Gastroenterol Clin North Am. 2012 Mar;41(1):223-35. doi: 10.1016/j.gtc.2011.12.011. Epub 2011 Dec 30. Review. PubMed PMID: 22341260.

Cao H, Banh A, Kwok S, Shi X, Wu S, Krakow T, Khong B, Bavan B, Bala R, Pinsky BA, Colevas D, Pourmand N, Koong AC, Kong CS, Le QT. Quantitation of human papillomavirus DNA in plasma of oropharyngeal carcinoma patients. Int J Radiat Oncol Biol Phys. 2012 Mar 1;82(3):e351-8. doi: 10.1016/j.ijrobp.2011.05.061. Epub 2011 Oct 8. PubMed PMID: 21985946; PubMed Central PMCID: PMC3257411.

2011

Murphy JD, Chang DT, Abelson J, Daly ME, Yeung HN, Nelson LM, Koong AC. Cost-effectiveness of modern radiotherapy techniques in locally advanced pancreatic cancer. Cancer. 2012 Feb 15;118(4):1119-29. doi: 10.1002/cncr.26365. Epub 2011 Jul 19. PubMed PMID: 21773972.

Ren Y, Fleischmann D, Foygel K, Molvin L, Lutz AM, Koong AC, Jeffrey RB, Tian L, Willmann JK. Antiangiogenic and radiation therapy: early effects on in vivo computed tomography perfusion parameters in human colon cancer xenografts in mice. Invest Radiol. 2012 Jan;47(1):25-32. doi: 10.1097/RLI.0b013e31823a82f6. PubMed PMID: 22178893; PubMed Central PMCID: PMC4446123.

Banh A, Xiao N, Cao H, Chen CH, Kuo P, Krakow T, Bavan B, Khong B, Yao M, Ha C, Kaplan MJ, Sirjani D, Jensen K, Kong CS, Mochly-Rosen D, Koong AC, Le QT. A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo. Clin Cancer Res. 2011 Dec 1;17(23):7265-72. doi: 10.1158/1078-0432.CCR-11-0179. Epub 2011 Oct 13. PubMed PMID: 21998334; PubMed Central PMCID: PMC3544360.

Schellenberg D, Kim J, Christman-Skieller C, Chun CL, Columbo LA, Ford JM, Fisher GA, Kunz PL, Van Dam J, Quon A, Desser TS, Norton J, Hsu A, Maxim PG, Xing L, Goodman KA, Chang DT, Koong AC. Single-fraction stereotactic body radiation therapy and sequential gemcitabine for the treatment of locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys. 2011 Sep 1;81(1):181-8. doi: 10.1016/j.ijrobp.2010.05.006. Epub 2011 May 5. PubMed PMID: 21549517.

Chang DT, Swaminath A, Kozak M, Weintraub J, Koong AC, Kim J, Dinniwell R, Brierley J, Kavanagh BD, Dawson LA, Schefter TE. Stereotactic body radiotherapy for colorectal liver metastases: a pooled analysis. Cancer. 2011 Sep 1;117(17):4060-9. doi: 10.1002/cncr.25997. Epub 2011 Mar 22. PubMed PMID: 21432842.

Bazan JG, Hara W, Hsu A, Kunz PA, Ford J, Fisher GA, Welton ML, Shelton A, Kapp DS, Koong AC, Goodman KA, Chang DT. Intensity-modulated radiation therapy versus conventional radiation therapy for squamous cell carcinoma of the anal canal. Cancer. 2011 Aug 1;117(15):3342-51. doi: 10.1002/cncr.25901. Epub 2011 Feb 1. PubMed PMID: 21287530.

Banh A, Zhang J, Cao H, Bouley DM, Kwok S, Kong C, Giaccia AJ, Koong AC, Le QT. Tumor galectin-1 mediates tumor growth and metastasis through regulation of T-cell apoptosis. Cancer Res. 2011 Jul 1;71(13):4423-31. doi: 10.1158/0008-5472.CAN-10-4157. Epub 2011 May 5. PubMed PMID: 21546572; PubMed Central PMCID: PMC3129397.

Minn AY, Koong AC, Chang DT. Stereotactic body radiation therapy for gastrointestinal malignancies. Front Radiat Ther Oncol. 2011;43:412-427. doi: 10.1159/000322505. Epub 2011 May 20. Review. PubMed PMID: 21625166.

Butler PD, Wang Z, Ly DP, Longaker MT, Koong AC, Yang GP. Unfolded protein response regulation in keloid cells. J Surg Res. 2011 May 1;167(1):151-7. doi: 10.1016/j.jss.2009.04.036. Epub 2009 May 20. PubMed PMID: 19631342; PubMed Central PMCID: PMC2888625.

Daly ME, Murphy JD, Mok E, Christman-Skieller C, Koong AC, Chang DT. Rectal and bladder deformation and displacement during preoperative radiotherapy for rectal cancer: Are current margin guidelines adequate for conformal therapy?. Pract Radiat Oncol. 2011 Apr-Jun;1(2):85-94. doi: 10.1016/j.prro.2010.11.006. Epub 2011 Apr 8. PubMed PMID: 24673921.

Papandreou I, Denko NC, Olson M, Van Melckebeke H, Lust S, Tam A, Solow-Cordero DE, Bouley DM, Offner F, Niwa M, Koong AC. Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood. 2011 Jan 27;117(4):1311-4. doi: 10.1182/blood-2010-08-303099. Epub 2010 Nov 16. PubMed PMID: 21081713; PubMed Central PMCID: PMC3056474.

Loo BW Jr, Chang JY, Dawson LA, Kavanagh BD, Koong AC, Senan S, Timmerman RD. Stereotactic ablative radiotherapy: what's in a name?. Pract Radiat Oncol. 2011 Jan-Mar;1(1):38-9. doi: 10.1016/j.prro.2010.07.001. Epub 2011 Jan 14. PubMed PMID: 24673868.

2010

Murphy JD, Christman-Skieller C, Kim J, Dieterich S, Chang DT, Koong AC. A dosimetric model of duodenal toxicity after stereotactic body radiotherapy for pancreatic cancer. Int J Radiat Oncol Biol Phys. 2010 Dec 1;78(5):1420-6. doi: 10.1016/j.ijrobp.2009.09.075. Epub 2010 Apr 14. PubMed PMID: 20399033.

Chang DT, Chapman CH, Norton JA, Visser B, Fisher GA, Kunz P, Ford JM, Koong AC, Pai RK. Expression of p16(INK4A) but not hypoxia markers or poly adenosine diphosphate-ribose polymerase is associated with improved survival in patients with pancreatic adenocarcinoma. Cancer. 2010 Nov 15;116(22):5179-87. doi: 10.1002/cncr.25481. PubMed PMID: 20665497.

Bachireddy P, Tseng D, Horoschak M, Chang DT, Koong AC, Kapp DS, Tran PT. Orthovoltage intraoperative radiation therapy for pancreatic adenocarcinoma. Radiat Oncol. 2010 Nov 8;5:105. doi: 10.1186/1748-717X-5-105. PubMed PMID: 21059255; PubMed Central PMCID: PMC2987939.

Goodman KA, Wiegner EA, Maturen KE, Zhang Z, Mo Q, Yang G, Gibbs IC, Fisher GA, Koong AC. Dose-escalation study of single-fraction stereotactic body radiotherapy for liver malignancies. Int J Radiat Oncol Biol Phys. 2010 Oct 1;78(2):486-93. doi: 10.1016/j.ijrobp.2009.08.020. Epub 2010 Mar 28. PubMed PMID: 20350791.

Minn AY, Hsu A, La T, Kunz P, Fisher GA, Ford JM, Norton JA, Visser B, Goodman KA, Koong AC, Chang DT. Comparison of intensity-modulated radiotherapy and 3-dimensional conformal radiotherapy as adjuvant therapy for gastric cancer. Cancer. 2010 Aug 15;116(16):3943-52. doi: 10.1002/cncr.25246. PubMed PMID: 20564136.

Schellenberg D, Quon A, Minn AY, Graves EE, Kunz P, Ford JM, Fisher GA, Goodman KA, Koong AC, Chang DT. 18Fluorodeoxyglucose PET is prognostic of progression-free and overall survival in locally advanced pancreas cancer treated with stereotactic radiotherapy. Int J Radiat Oncol Biol Phys. 2010 Aug 1;77(5):1420-5. doi: 10.1016/j.ijrobp.2009.06.049. Epub 2010 Jan 7. PubMed PMID: 20056345.

Chennupati SK, Kamaya A, Fisher GA, Ford JM, Kunz P, Itakura H, Welton ML, Shelton A, Van Dam J, Koong AC, Chang DT. Pathological response after chemoradiation for T3 rectal cancer. Colorectal Dis. 2010 Jul;12(7 Online):e24-30. doi: 10.1111/j.1463-1318.2009.02013.x. Epub 2009 Jul 15. PubMed PMID: 19614668.

La TH, Minn AY, Su Z, Fisher GA, Ford JM, Kunz P, Goodman KA, Koong AC, Chang DT. Multimodality treatment with intensity modulated radiation therapy for esophageal cancer. Dis Esophagus. 2010 May;23(4):300-8. doi: 10.1111/j.1442-2050.2009.01004.x. Epub 2009 Aug 28. PubMed PMID: 19732129.

Ho AS, Huang X, Cao H, Christman-Skieller C, Bennewith K, Le QT, Koong AC. Circulating miR-210 as a Novel Hypoxia Marker in Pancreatic Cancer. Transl Oncol. 2010 Apr;3(2):109-13. doi: 10.1593/tlo.09256. PubMed PMID: 20360935; PubMed Central PMCID: PMC2847318.

Courter D, Cao H, Kwok S, Kong C, Banh A, Kuo P, Bouley DM, Vice C, Brustugun OT, Denko NC, Koong AC, Giaccia A, Le QT. The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways. PLoS One. 2010 Mar 10;5(3):e9633. doi: 10.1371/journal.pone.0009633. PubMed PMID: 20224789; PubMed Central PMCID: PMC2835762.

Jayachandran P, Minn AY, Van Dam J, Norton JA, Koong AC, Chang DT. Interfractional uncertainty in the treatment of pancreatic cancer with radiation. Int J Radiat Oncol Biol Phys. 2010 Feb 1;76(2):603-7. doi: 10.1016/j.ijrobp.2009.06.029. Epub 2009 Oct 30. PubMed PMID: 19879062.

Spiotto MT, Banh A, Papandreou I, Cao H, Galvez MG, Gurtner GC, Denko NC, Le QT, Koong AC. Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth. Cancer Res. 2010 Jan 1;70(1):78-88. doi: 10.1158/0008-5472.CAN-09-2747. Epub 2009 Dec 22. PubMed PMID: 20028872; PubMed Central PMCID: PMC2943832.

2009

Chang ST, Zahn JM, Horecka J, Kunz PL, Ford JM, Fisher GA, Le QT, Chang DT, Ji H, Koong AC. Identification of a biomarker panel using a multiplex proximity ligation assay improves accuracy of pancreatic cancer diagnosis. J Transl Med. 2009 Dec 11;7:105. doi: 10.1186/1479-5876-7-105. PubMed PMID: 20003342; PubMed Central PMCID: PMC2796647.

Chang DT, Chapman C, Shen J, Su Z, Koong AC. Treatment of esophageal cancer based on histology: a surveillance epidemiology and end results analysis. Am J Clin Oncol. 2009 Aug;32(4):405-10. doi: 10.1097/COC.0b013e3181917158. PubMed PMID: 19415029.

Minn AY, Schellenberg D, Maxim P, Suh Y, McKenna S, Cox B, Dieterich S, Xing L, Graves E, Goodman KA, Chang D, Koong AC. Pancreatic tumor motion on a single planning 4D-CT does not correlate with intrafraction tumor motion during treatment. Am J Clin Oncol. 2009 Aug;32(4):364-8. doi: 10.1097/COC.0b013e31818da9e0. PubMed PMID: 19398901.

Kothary N, Dieterich S, Louie JD, Koong AC, Hofmann LV, Sze DY. A primer on image-guided radiation therapy for the interventional radiologist. J Vasc Interv Radiol. 2009 Jul;20(7):859-62. doi: 10.1016/j.jvir.2009.03.037. Epub 2009 May 28. Review. PubMed PMID: 19481470.

Liu Y, Adachi M, Zhao S, Hareyama M, Koong AC, Luo D, Rando TA, Imai K, Shinomura Y. Preventing oxidative stress: a new role for XBP1. Cell Death Differ. 2009 Jun;16(6):847-57. doi: 10.1038/cdd.2009.14. Epub 2009 Feb 27. PubMed PMID: 19247368; PubMed Central PMCID: PMC2826168.

Kim J, Quon A, Humke E, Ford JM, Koong AC. Detection of solitary humeral metastasis from pancreatic adenocarcinoma with F-18 FDG PET/CT. Clin Nucl Med. 2009 May;34(5):312-3. doi: 10.1097/RLU.0b013e31819e51bb. PubMed PMID: 19387214.

Romero-Ramirez L, Cao H, Regalado MP, Kambham N, Siemann D, Kim JJ, Le QT, Koong AC. X box-binding protein 1 regulates angiogenesis in human pancreatic adenocarcinomas. Transl Oncol. 2009 Mar;2(1):31-8. doi: 10.1593/tlo.08211. PubMed PMID: 19252749; PubMed Central PMCID: PMC2647700.

Chang DT, Schellenberg D, Shen J, Kim J, Goodman KA, Fisher GA, Ford JM, Desser T, Quon A, Koong AC. Stereotactic radiotherapy for unresectable adenocarcinoma of the pancreas. Cancer. 2009 Feb 1;115(3):665-72. doi: 10.1002/cncr.24059. PubMed PMID: 19117351.

2008

Fels DR, Ye J, Segan AT, Kridel SJ, Spiotto M, Olson M, Koong AC, Koumenis C. Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways. Cancer Res. 2008 Nov 15;68(22):9323-30. doi: 10.1158/0008-5472.CAN-08-2873. PubMed PMID: 19010906; PubMed Central PMCID: PMC3617567.

Schellenberg D, Goodman KA, Lee F, Chang S, Kuo T, Ford JM, Fisher GA, Quon A, Desser TS, Norton J, Greco R, Yang GP, Koong AC. Gemcitabine chemotherapy and single-fraction stereotactic body radiotherapy for locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys. 2008 Nov 1;72(3):678-86. doi: 10.1016/j.ijrobp.2008.01.051. Epub 2008 Apr 18. PubMed PMID: 18395362.

Brown JM, Koong AC. High-dose single-fraction radiotherapy: exploiting a new biology?. Int J Radiat Oncol Biol Phys. 2008 Jun 1;71(2):324-5. doi: 10.1016/j.ijrobp.2008.02.003. PubMed PMID: 18474308.

Choi CY, Chan DA, Paulmurugan R, Sutphin PD, Le QT, Koong AC, Zundel W, Gambhir SS, Giaccia AJ. Molecular imaging of hypoxia-inducible factor 1 alpha and von Hippel-Lindau interaction in mice. Mol Imaging. 2008 May-Jun;7(3):139-46. PubMed PMID: 19123984; PubMed Central PMCID: PMC4157628.

2007

Fredriksson S, Horecka J, Brustugun OT, Schlingemann J, Koong AC, Tibshirani R, Davis RW. Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancer. Clin Chem. 2008 Mar;54(3):582-9. doi: 10.1373/clinchem.2007.093195. Epub 2008 Jan 2. PubMed PMID: 18171715.

Quon A, Chang ST, Chin F, Kamaya A, Dick DW, Loo BW Jr, Gambhir SS, Koong AC. Initial evaluation of 18F-fluorothymidine (FLT) PET/CT scanning for primary pancreatic cancer. Eur J Nucl Med Mol Imaging. 2008 Mar;35(3):527-31. doi: 10.1007/s00259-007-0630-z. Epub 2007 Oct 25. PubMed PMID: 17960376; PubMed Central PMCID: PMC4144989.

Cupp JS, Koong AC, Fisher GA, Norton JA, Goodman KA. Tissue effects after stereotactic body radiotherapy using cyberknife for patients with abdominal malignancies. Clin Oncol (R Coll Radiol). 2008 Feb;20(1):69-75. doi: 10.1016/j.clon.2007.08.009. Epub 2007 Sep 27. PubMed PMID: 17900882.

Tillman GF, Pawlicki T, Koong AC, Goodman KA. Preoperative versus postoperative radiotherapy for locally advanced gastroesophageal junction and proximal gastric cancers: a comparison of normal tissue radiation doses. Dis Esophagus. 2008;21(5):437-44. doi: 10.1111/j.1442-2050.2007.00794.x. PubMed PMID: 19125798.

Le QT, Kong C, Lavori PW, O'byrne K, Erler JT, Huang X, Chen Y, Cao H, Tibshirani R, Denko N, Giaccia AJ, Koong AC. Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys. 2007 Sep 1;69(1):167-75. doi: 10.1016/j.ijrobp.2007.01.071. PubMed PMID: 17707270.

Fredriksson S, Dixon W, Ji H, Koong AC, Mindrinos M, Davis RW. Multiplexed protein detection by proximity ligation for cancer biomarker validation. Nat Methods. 2007 Apr;4(4):327-9. doi: 10.1038/nmeth1020. Epub 2007 Mar 18. PubMed PMID: 17369836.

Patel DA, Chang ST, Goodman KA, Quon A, Thorndyke B, Gambhir SS, McMillan A, Loo BW Jr, Koong AC. Impact of integrated PET/CT on variability of target volume delineation in rectal cancer. Technol Cancer Res Treat. 2007 Feb;6(1):31-6. doi: 10.1177/153303460700600105. PubMed PMID: 17241098.

Koumenis C, Bi M, Ye J, Feldman D, Koong AC. Hypoxia and the unfolded protein response. Methods Enzymol. 2007;435:275-93. doi: 10.1016/S0076-6879(07)35014-3. PubMed PMID: 17998059.

Chang ST, Goodman KA, Yang GP, Koong AC. Stereotactic body radiotherapy for unresectable pancreatic cancer. Front Radiat Ther Oncol. 2007;40:386-394. doi: 10.1159/000106048. Review. PubMed PMID: 17641521.

Winner M, Koong AC, Rendon BE, Zundel W, Mitchell RA. Amplification of tumor hypoxic responses by macrophage migration inhibitory factor-dependent hypoxia-inducible factor stabilization. Cancer Res. 2007 Jan 1;67(1):186-93. doi: 10.1158/0008-5472.CAN-06-3292. PubMed PMID: 17210698; PubMed Central PMCID: PMC2941512.

2006

Petrik D, Lavori PW, Cao H, Zhu Y, Wong P, Christofferson E, Kaplan MJ, Pinto HA, Sutphin P, Koong AC, Giaccia AJ, Le QT. Plasma osteopontin is an independent prognostic marker for head and neck cancers. J Clin Oncol. 2006 Nov 20;24(33):5291-7. doi: 10.1200/JCO.2006.06.8627. PubMed PMID: 17114663.

Le QT, Loo BW, Ho A, Cotrutz C, Koong AC, Wakelee H, Kee ST, Constantinescu D, Whyte RI, Donington J. Results of a phase I dose-escalation study using single-fraction stereotactic radiotherapy for lung tumors. J Thorac Oncol. 2006 Oct;1(8):802-9. PubMed PMID: 17409963.

Koong AC, Chauhan V, Romero-Ramirez L. Targeting XBP-1 as a novel anti-cancer strategy. Cancer Biol Ther. 2006 Jul;5(7):756-9. doi: 10.4161/cbt.5.7.2973. Epub 2006 Jul 1. Review. PubMed PMID: 16861911.

Le QT, Chen E, Salim A, Cao H, Kong CS, Whyte R, Donington J, Cannon W, Wakelee H, Tibshirani R, Mitchell JD, Richardson D, O'Byrne KJ, Koong AC, Giaccia AJ. An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers. Clin Cancer Res. 2006 Mar 1;12(5):1507-14. doi: 10.1158/1078-0432.CCR-05-2049. PubMed PMID: 16533775.

2005

Le QT, Shi G, Cao H, Nelson DW, Wang Y, Chen EY, Zhao S, Kong C, Richardson D, O'Byrne KJ, Giaccia AJ, Koong AC. Galectin-1: a link between tumor hypoxia and tumor immune privilege. J Clin Oncol. 2005 Dec 10;23(35):8932-41. doi: 10.1200/JCO.2005.02.0206. Epub 2005 Oct 11. PubMed PMID: 16219933.

Chen Y, Feldman DE, Deng C, Brown JA, De Giacomo AF, Gaw AF, Shi G, Le QT, Brown JM, Koong AC. Identification of mitogen-activated protein kinase signaling pathways that confer resistance to endoplasmic reticulum stress in Saccharomyces cerevisiae. Mol Cancer Res. 2005 Dec;3(12):669-77. doi: 10.1158/1541-7786.MCR-05-0181. PubMed PMID: 16380504.

Feldman DE, Chauhan V, Koong AC. The unfolded protein response: a novel component of the hypoxic stress response in tumors. Mol Cancer Res. 2005 Nov;3(11):597-605. doi: 10.1158/1541-7786.MCR-05-0221. Review. PubMed PMID: 16317085.

Koong AC, Christofferson E, Le QT, Goodman KA, Ho A, Kuo T, Ford JM, Fisher GA, Greco R, Norton J, Yang GP. Phase II study to assess the efficacy of conventionally fractionated radiotherapy followed by a stereotactic radiosurgery boost in patients with locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys. 2005 Oct 1;63(2):320-3. doi: 10.1016/j.ijrobp.2005.07.002. PubMed PMID: 16168826.

Zhu Y, Denhardt DT, Cao H, Sutphin PD, Koong AC, Giaccia AJ, Le QT. Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer. Oncogene. 2005 Sep 29;24(43):6555-63. doi: 10.1038/sj.onc.1208800. PubMed PMID: 16007184.

Nelson DW, Cao H, Zhu Y, Sunar-Reeder B, Choi CY, Faix JD, Brown JM, Koong AC, Giaccia AJ, Le QT. A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia. Cancer Res. 2005 Jul 15;65(14):6151-8. doi: 10.1158/0008-5472.CAN-04-2602. PubMed PMID: 16024616.

2004

Chen Y, Shi G, Xia W, Kong C, Zhao S, Gaw AF, Chen EY, Yang GP, Giaccia AJ, Le QT, Koong AC. Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling. Cancer Res. 2004 Oct 15;64(20):7302-10. doi: 10.1158/0008-5472.CAN-04-0899. PubMed PMID: 15492250.

Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H, Mori K, Glimcher LH, Denko NC, Giaccia AJ, Le QT, Koong AC. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res. 2004 Sep 1;64(17):5943-7. doi: 10.1158/0008-5472.CAN-04-1606. PubMed PMID: 15342372.

Soltys SG, Le QT, Shi G, Tibshirani R, Giaccia AJ, Koong AC. The use of plasma surface-enhanced laser desorption/ionization time-of-flight mass spectrometry proteomic patterns for detection of head and neck squamous cell cancers. Clin Cancer Res. 2004 Jul 15;10(14):4806-12. doi: 10.1158/1078-0432.CCR-03-0469. PubMed PMID: 15269156.

Koong AC, Le QT, Ho A, Fong B, Fisher G, Cho C, Ford J, Poen J, Gibbs IC, Mehta VK, Kee S, Trueblood W, Yang G, Bastidas JA. Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys. 2004 Mar 15;58(4):1017-21. doi: 10.1016/j.ijrobp.2003.11.004. PubMed PMID: 15001240.

2003

Le QT, Sutphin PD, Raychaudhuri S, Yu SC, Terris DJ, Lin HS, Lum B, Pinto HA, Koong AC, Giaccia AJ. Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas. Clin Cancer Res. 2003 Jan;9(1):59-67. PubMed PMID: 12538452.

2002

Terris DJ, Ho EY, Ibrahim HZ, Dorie MJ, Kovacs MS, Le QT, Koong AC, Pinto HA, Brown JM. Estimating DNA repair by sequential evaluation of head and neck tumor radiation sensitivity using the comet assay. Arch Otolaryngol Head Neck Surg. 2002 Jun;128(6):698-702. doi: 10.1001/archotol.128.6.698. PubMed PMID: 12049567.

2000

Koong AC, Mehta VK, Le QT, Fisher GA, Terris DJ, Brown JM, Bastidas AJ, Vierra M. Pancreatic tumors show high levels of hypoxia. Int J Radiat Oncol Biol Phys. 2000 Nov 1;48(4):919-22. doi: 10.1016/s0360-3016(00)00803-8. PubMed PMID: 11072146.

Koong AC, Denko NC, Hudson KM, Schindler C, Swiersz L, Koch C, Evans S, Ibrahim H, Le QT, Terris DJ, Giaccia AJ. Candidate genes for the hypoxic tumor phenotype. Cancer Res. 2000 Feb 15;60(4):883-7. PubMed PMID: 10706099.

1994

Koong AC, Chen EY, Mivechi NF, Denko NC, Stambrook P, Giaccia AJ. Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2). Cancer Res. 1994 Oct 15;54(20):5273-9. PubMed PMID: 7923153.

Saad AH, Kuo SS, Koong AC, Hahn GM, Giaccia AJ. Modulation of potassium channels by protein tyrosine kinase inhibitors. J Cell Physiol. 1994 Oct;161(1):142-8. doi: 10.1002/jcp.1041610117. PubMed PMID: 7929599.

Koong AC, Chen EY, Kim CY, Giaccia AJ. Activators of protein kinase C selectively mediate cellular cytotoxicity to hypoxic cells and not aerobic cells. Int J Radiat Oncol Biol Phys. 1994 May 15;29(2):259-65. doi: 10.1016/0360-3016(94)90272-0. PubMed PMID: 8195017.

Mivechi NF, Koong AC, Giaccia AJ, Hahn GM. Analysis of HSF-1 phosphorylation in A549 cells treated with a variety of stresses. Int J Hyperthermia. 1994 May-Jun;10(3):371-9. PubMed PMID: 7930803.

Koong AC, Auger EA, Chen EY, Giaccia AJ. The regulation of GRP78 and messenger RNA levels by hypoxia is modulated by protein kinase C activators and inhibitors. Radiat Res. 1994 Apr;138(1 Suppl):S60-3. PubMed PMID: 8146329.

Koong AC, Chen EY, Giaccia AJ. Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues. Cancer Res. 1994 Mar 15;54(6):1425-30. PubMed PMID: 8137243.

1991

Koong AC, Chen EY, Lee AS, Brown JM, Giaccia AJ. Increased cytotoxicity of chronic hypoxic cells by molecular inhibition of GRP78 induction. Int J Radiat Oncol Biol Phys. 1994 Feb 1;28(3):661-6. doi: 10.1016/0360-3016(94)90191-0. PubMed PMID: 8113109.

Koong AC, Giaccia AJ, Hahn GM, Saad AH. Activation of potassium channels by hypoxia and reoxygenation in the human lung adenocarcinoma cell line A549. J Cell Physiol. 1993 Aug;156(2):341-7. doi: 10.1002/jcp.1041560217. PubMed PMID: 8344990.

Kuo SS, Saad AH, Koong AC, Hahn GM, Giaccia AJ. Potassium-channel activation in response to low doses of gamma-irradiation involves reactive oxygen intermediates in nonexcitatory cells. Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):908-12. doi: 10.1073/pnas.90.3.908. PubMed PMID: 8430104; PubMed Central PMCID: PMC45779.

Koong AC, Hirst DG. The influence of chronic anaemia on the radiosensitivity of two mouse tumours. Br J Cancer. 1991 Apr;63(4):499-502. doi: 10.1038/bjc.1991.119. PubMed PMID: 2021532; PubMed Central PMCID: PMC1972338.