Publications
- Wurster W, Lewis RE, Albert ND, Kontoyiannis, DP. Pre-exposure to Isavuconazole increases the virulence of Mucorates but not Aspergillus fumigatus in a Drosophila melanogaster model. Antimicrob Agents and Chemother. In press.
- Tatara AM, Wurster S, Lockworth CR, Albert ND, Walsh TJ, Mikos AG, Eisenhoffer GT, Kontoyiannis DP. Immunosuppressed adult zebrafish model of mucormycosis. Antimicrob Agents and Chemother. 2018 Oct. 24; 62(11).
- Ben Yaakov D, Shadkchan Y, Albert N, Kontoyiannis DP. The quinoline bromoquinol exhibits broad-spectrum antifungal activity and induces oxidative stress and apoptosis in Aspergillus fumigatus. Antimicrob Agents and Chemother. 2017 Aug. 1: 72(8):2263-2272.
- Bellanger AP, Tatara AM, Shirazi F, Gebremariam T, Albert ND, Lewis RE, Ibrahim AS, Kontoyiannis DP. Statin concentrations below the minimum inhibitory concentration attenuate the virulence of Rhizopus oryzae. J Infect Dis. 2016 Jul 1: 214(1):114-21. Epub 2016 Mar 16.
- Shirazi F, Ferreira JA, Stevens DA, Clemons KV, Kontoyiannis DP. Biofilm filtrates of Pseudomonas aeruginosa strains isolated from cystic fibrosis patients inhibit preformed Aspergillus fumigatus biofilms via apoptosis. PLoS One. 2016 Mar 1: 11(3):e0151155.
- Ioannou P, Andrianaki A, Akoumianaki T, Kyrmizi I, Ambert N, Perlin D, Samonis G, Kontoyiannis DP. Albumin enhances Caspofungin activity against Aspergillus species by facilitating drug delivery to germinating hyphae. Antimicro Agents Chemother. 2015 Dec 7; 60(3): 1226-33.
- Shirazi F, Lewis RE, Kontoyiannis DP. Micafungin induced apoptosis in Candida parapsilosis independent of it susceptibility to micafungin. Microb Cell. 2015. Oct 23; 2(11):445-450.
- Shirazi F, Kontoyiannis DP. Micafungin triggers caspase-dependent apoptosis in Candida albicans and Candida parapsilosis biofilms, including caspofungin non-susceptible isolates. Virulence. 2015: 6(4):385-94.
- Bellander AP, Minetos YD, Albert N, Shirazi F, Walsh TJ, Kontoyiannis DP. Glucocorticosteroids do not impact directly growth rate and biomass of Rhizopus arrhizus (syn. R. oryzae) in vitro. Virulence. 2015: 6(5); 441-43.
- Shirazi F, Famakiotis D, Yan Y, Albert N, Do KA, Kontoyainnis DP. Diet modification and metformin have a beneficial effect in a fly model of obesity and mucormycosis. PLoS One. 2014 Sept 30; 9(9):e108635.
- Farmakiotis D, Shirazi F, Zhao Y, Saad PJ, Albert ND, Roilides E, Walsh TJ, Perlin DS, Kontoyiannis DP. Methylprednisolone enhances the growth of Exserohilum rostratum in vitro, attenuates spontaneous apoptosis, and increases mortality rates in immunocompetent Drosophila flies. J Infect. Dis. 2014 Nov 1; 210(9): 1471-75.
- Shirazi F, Kontoyiannis DP. Heat shock protein 90 and calcineurin pathway inhibitors enhance the efficacy of triazoles against Scedosporium prolificans via induction of apoptosis. Microb Cell. 2014 Jun 2; 1(6): 179-188.
- Thompson GR 3rd, Albert N, Hodge G, Wilson MD, Sykes JE, Bays DJH, Firacative C, Meyer W, Kontoyiannis DP. Phenotypic differences of cryptococcus molecular types and their implications for virulence in a Drosophila model of infection. Infect Immun. 2014 Jul; 82(7):3058-65.
- Lewis RE, Liao G, Young K, Douglas C, Kontoyiannis DP. Macrophage reporter cell assay for screening immunopharmacological activity of cell wall-active antifungals. Antimicrob Agents Chemother. 2014 Mar;58(3):1738-43.
- Barbu EM, Shirazi F, McGrath DM, Albert N, Sidman RL, Pasqualini R, Arap W, Kontoyiannis DP. An antimicrobial peptidomimetic induces Mucorales cell death through mitochondria-mediated apoptosis. PLoS One. 2013 Oct 3; 8(10):e7698.
- Zanette RA, Kontoyiannis DP. Paradoxical effect to caspofungin in Candida species does not confer survival advantage in a Drosophila model of candidiasis. Virulence. 2013 Aug 15; 4(6): 497-501.
- Shirazi F, Kontoyiannis DP. The calcineurin pathway inhibitor tacrolimus enhances the in vitro activity of azoles against Mucorales via apoptosis. Eukaryot Cell. 2013 Sept; 12(9): 1225-34.
- Kaluarachchi WD, Cisneros BT, Corr SJ, Albert ND, Curley SA, Kontoyainnis DP. Aspergillus fumigatus hyphal damage caused by noninvasive radiofrequency field-induced hyperthermia. Antimicrob Agents Chemother. 2013 Sept; 57(9): 4444-8.
- Lewis RE, Ben-Ami R, Best L, Albert N, Walsh TJ, Kontoyiannis DP. Tacrolimus enhances the potency of posaconazole against Rhizopus oryzae in vitro and in an experimental model of mucormycosis. J Infect Dis. 2013 Mar; 207(5): 834-41.
- Ben-Ami R, Garcia-Effron G, Lewis RE, Gamarra S, Leventakos K, Perlin DS, Kontoyiannis DP. Fitness and virulence costs of Candida albicans FKS1 hot spot mutations associated with echinocandin resistance. J Infect Dis. 2011 Aug 15;204(4):626-35. PMID: 21791665.
- Ben-Ami R, Lewis RE, Leventakos K, Kontoyiannis DP. Aspergillus fumigatus inhibits angiogenesis through the production of gliotoxin and other secondary metabolites. Blood. 2009 Dec 17; 114(26):5393-9. PMID: 19843884.
- Chamilos G, Lewis RE, Hu J, Xiao L, Zal T, Gilliet M, Halder G, Kontoyiannis DP. Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis. Proc Natl Acad Sci U.S.A. 2008 Jul 8; 105(27): 9367-72.
- Chamilos G, Lewis RE, Lamaris G, TJ Walsh, Kontoyiannis DP. Zygomycetes hyphae trigger an early, robust pro-inflammatory response in human olymorphonuclear neutrophils through Toll like receptor-2 induction but display relative resistance to oxidative damage. Antimicrob Agents Chemother. 2008;52:722-4.
- Kontoyiannis DP, Lewis RE, Lotholary O, Alexander BD, Dromer F, Gupta KL, John TG, Busto R, Klintmalm GB, Somani J, Lyon MG, Pursell K, Stosor V, Munoz P, Limaye AP, Kalil AC, Pruett TL, Garcia-Diaz J, Humar A, Houston S, House AA, Wray D, Orloff S, Dowdy LA, Fisher RA, Heitman J, Albert ND, Wagener MM, Singh N. Calcineurin-inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis. Antimicrob Agents Chemother. 2008;52:735-8.
- Quezada G, Koshkina NV, Zweidler-McKay P, Zhou Z, Kontoyiannis DP, Kleinerman EJ. Intranasal granulocyte-Macrophage colony stimulating factor reduces the Aspergillus burden in an immunosuppressed murine model of pulmonary aspergillosis. Antimicrob Agents Chemother. 2008;52:716-8.
- Chamilos G, Lewis RE, Lamaris GA, Albert ND, Kontoyiannis DP. Genome-wide screening for genes associated with gliotoxin resistance in Saccharomyces cerevisiae. Antimicrob Agents Chemother. 2008;52:1325-1329.
- Lamaris GA, Lewis RE, Chamilos G, Walsh TJ, May GS, Safdar A, Raad II, Kontoyiannis DP. Caspofungin-mediated β-glucan unmasking and enhancement of human polymorphonuclear neutrophil activity against Aspergillus and non-Aspergillus molds. J Infect Dis. 2008;15:186-192 (with accompanying editorial).
- Lewis RE, Chamilos G, Albert N, Kontoyiannis DP. Micafungin vs caspofungin in a neutropenic murine model of invasive pulmonary aspergillosis. J Antimicrob Chemother. 2008;5:1140-1144.
- Qiao J, Kontoyiannis DP, Calderone R, Li D, Wan Z, Li R, Liu W. Afyap1, encoding a bZip transcriptional factor of Aspergillus fumigatus, contributes to oxidative stress response but is not essential to the virulence of this pathogen in mice immunosuppressed by cyclophosphamide and triamcinolone. Med Mycol. 2008;8:1-10.
- Lamaris GA, Ben-ami R, Lewis RE, Kontoyiannis DP. Does pre-exposure of Aspergillus fumigatus to voriconazole or posaconazole in vitro affects its in vivo activity of subsequent posaconazole or voriconazole, respectively? A study in a fly model of aspergillosis. J Antimicrob Chemother. 2008;62:539-542.
- Lewis RE, Albert ND, Kontoyiannis DP. Efficacy of single-dose liposomal amphotericin B or micafungin prophylaxis in a neutropenic murine model of invasive pulmonary aspergillosis. Antimicrob Agents Chemother. 2008;52:4178-4180.
- Garcia-Effron G, Kontoyiannis DP, Lewis RE, Perlin DS. Echinocandin-resistant C. tropicalis breakthrough fungemia in high risk hematology patients. Antimicrob Agents Chemother. 2008;52:4181-4183.
- Yang Z, Kontoyiannis DP (&), Wen X, Xoing C, Albert ND, Li C. Gamma scintigraphy imaging of murine invasive pulmonary aspergillosis with 11In-labeled cyclic peptide. Nucl Med Biol. 2009 Apr;36(3):259-66.
- Lamaris GA, Lewis RE, Chamilos G, Samonis G, Kontoyiannis DP. Increased virulence of Zygomycetes organisms following exposure to voriconazole: a study involving fly and murine models of zygomycosis. J Infect Diseas. 2009;199:1399-406.
- Chamilos G, Nobile CJ, Bruno VM, Lewis RE, Mitchell AP, Kontoyiannis DP. C. albicans cell wall integrity regulator Cas5 is required for virulence in urine and Toll-mutant fly models. J Infect Diseases. 2009; 200: 152-57.
- Ben-Ami R, Lamaris GA, Lewis RE, Kontoyiannis DP. Interstain variability in the virulence of Aspergillus fumigatus and Aspergillus terreus in a Toll-Deficient Drosophila fly model of invasive aspergillosis. Med Mycol, 2009; 29:1-9.
- Chamilos G, Bignell EM, Schrettl M, Lewis RE, Leventakos K, May GS, Haas H, Kontoyiannis DP. Exploring the concordance of Aspergillus fumigatus pathogenicity in mice and Toll-deficient flies. Med Mycol. 2010 May; 48(3): 506-10.
- Ben-Ami R, Lewis RE, Tarrand J, Leventakos K, Kontoyiannis DP. Antifungal activity of colistin against Mucorales species in vitro and in a murine model of Rhizopus oryzae pulmonary infection. Antimicrob Agents Chemother. 2010;54:484-90.
- Lewis RE, Albert ND, Liao G, Hou J, Prince RA, Kontoyiannis DP. Comparative pharmacodynamics of amphotericin B lipid complex and liposomal amphotericin B in a murine model of pulmonary mucormycosis. Antimicrob Agents Chemother. 2010 Mar;54(3):1298-304.
- Ben-Ami R, Lewis RE, May GS, Varga J, Nierman WC, Kontoyiannis DP, Characterization of a 5-azacytidine-induced developmental Aspergillus fumigatus variant. Virulence. 2011; 1(3): 164-173.
- Evans SE, Leventakos K Ben-Ami R, You D, Thakkar SG, Lewis RE, Kontoyiannis DP. Toll-deficient Drosophila are resistant to infection by Pneumocystis spp: additional evidence of specificity to mammalian hosts. Virulence, 2010:1(6) 523-5.
- Ben-Ami R, Lewis RE, Kontoyiannis DP. In vitro interactions among echinocandins against Aspergillus fumigatus: Lack of concordance among methods. Med Mycol. 2011; 49(5): 285-8.
- Lewis RE, Leventakos K, Kontoyiannis DP. Efficacy of caspofungin in neutropenid and corticosteroid-immunosuppressed murine models of invasive pulmonary mucormycosis. Antimicrob Agents Chemother. 2011; 55(7): 3584-7.
- Ben-Ami R, Watson CC, Lewis RE, Albert ND, Arias CA, Raad II, Kontoyiannis DP. Drosophila melanogaster as a model to explore the effects of methicillin-resistant Staphylococcus aureus strain type on virulence and response to linezolid treatment. Microb Pathog. 2013; 55: 16-20.
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