Selected Publications
Peer-reviewed articles
Wooten S, Kleinerman ES. Short-term Changes in Skeletal Muscle Mass After Anthracycline Administration in Adolescent and Young Adult Sarcoma Patients. Journal of Adolescent and Young Adult Oncology. In Press.
Wang, F., Chandra, J., Kleinerman, ES. Exercise Intervention Decreases Acute and Late Doxorubicin-Induced Cardiotoxicity. Cancer Medicine. In Press.
Tao, R-H., Masato, K., Zhang, A., Yang, Y., Kleinerman, ES. Exercise Inhibits Doxorubicin-Induced Damage to Cardiac Vessels and Activation of Hippo/YAP-Mediated Apoptosis. Cancers(13):2740, https://doi.org/10.3390/cancers13112740, 2021
Zhou Y, Slone N, Chrisikos TT, Kyrysyuk O, Babcock RL, Medik YB, Li HS, Kleinerman ES, Watowich SS. Vaccine efficacy against primary and metastatic cancer with in vitro-generated CD103+ conventional dendritic cells. J Immunother Cancer. 2020 Apr;8(1):e000474. doi: 10.1136/jitc-2019-000474. PMID: 32273347.
Wolf-Dennen K, Gordon N, Kleinerman ES. Exosomal Communication by Metastatic Osteosarcoma Cells Modulates Alveolar Macrophages to an M2 Tumor-Promoting Phenotype and Inhibits Tumoricidal Functions. Oncoimmunology 9(1):1747677, 2020. e-Pub 4/2020. PMCID: PMC7153823
Zhou Z, Yang Y, Wang F, Kleinerman ES. Neuronal Repressor REST Controls Ewing Sarcoma Growth and Metastasis by Affecting Vascular Pericyte Coverage and Vessel Perfusion. Cancers 12(1405):1-18, doi:10.3390/cancers12061405, 2020
Zhou Z, Yang Y, Kleinerman E.S. Hypoxia induces lineage modulation of Ewing's sarcoma tumor cells into EWS-FLI-1+ vascular pericytes. Clinical Oncology and Research 2(1):1-12, 3/2019
Kleinerman ES, Yu L, Dao J, Hayes-Jordon A, Lindsey B, Kawedia JD, Stewart J, Gordon N. Aerosol Gemcitabine after Amputation Inhibits Osteosarcoma Metastases but not wound healing. Sarcoma 2018, doi.org/10.1155/2018/3143096, 1/2018
Dhupkar P, Gordon N, Stewart J, Kleinerman ES. Anti-PD-1 therapy redirects macrophages from an M2 to an M1 phenotype inducing regression of OS lung metastases. Cancer Med. e-Pub 5/2018. PMID: 29733528
Livingston JA, Wang WL, Tsai JW, Lazar AJ, Leung CH, Lin H, Advani S, Daw N, Santiago-O'Farrill J, Hollomon M, Gordon NB, Kleinerman ES. Analysis of HSP27 and the autophagy marker LC3B+ puncta following preoperative chemotherapy identifies high-risk osteosarcoma patients. Mol Cancer Ther 17(6):1315-1323, 6/2018. e-Pub 3/2018. PMCID: PMC5984702
Reddy K, Zhou Z, Schadler K, Jia SF, Kleinerman ES. Bone marrow subsets differentiate into endothelial cells and pericytes contributing to Ewing's tumor vessels. Mol Cancer Res 6(6):929-36, 2008. PMID: 18567797.
Meyers PA, Schwartz CL, Krailo MD, Healey JH, Bernstein ML, Betcher D, Ferguson WS, Gebhardt MC, Goorin AM, Harris M, Kleinerman E, Link MP, Nadel H, Nieder M, Siegal GP, Weiner MA, Wells RJ, Womer RB, Grier HE, Children's Oncology Group. Osteosarcoma: The addition of muramyl tripeptide to chemotherapy improves overall survival. A Report from the Children's Oncology Group. J Clin Oncol 26(4):633-638, 2008. PMID: 18235123.
Reddy K, Cao Y, Zhou Z, Yu L, Jia SF, Kleinerman ES. VEGF(165) expression in the tumor microenvironment influences the differentiation of bone marrow-derived pericytes that contribute to the Ewing's sarcoma vasculature. Angiogenesis 11(3):257-67, 2008. PMID: 18344025.
Gordon, N, Koshkina NV, Jia SF, Khanna C, Mendoza Arnulfo, Worth, LL, Kleinerman ES. Corruption of the Fas pathway delays the pulmonary clearance of murine osteosarcoma cells, enhances their metastatic potential and reduces the effect of aerosol gemcitabine. Clin Cancer Res 13:4503-4510, 2007.
Lee TH, Bolontrade MF, Worth LL, Guan H, Ellis LM, Kleinerman ES. Production of VEGF165 by Ewing's sarcoma cells induces vasculogenesis and the incorporation of CD34(+) stem cells into the expanding tumor vasculature. Int J Cancer 119(4):839-46, 2006. PMID: 16557578.
Guan H, Jia SF, Zhou Z, Stewart J, Kleinerman ES. Herceptin down-regulates HER-2/neu and vascular endothelial growth factor expression and enhances taxol-induced cytotoxicity of human Ewing's sarcoma cells in vitro and in vivo. Clin Cancer Res 11(5):2008-17, 2005. PMID: 15756027.
Cao Y, Zhou Z, de Crombrugghe B, Nakashima K, Guan H, Duan X, Jia SF, Kleinerman ES. Osterix, a transcription factor for osteoblast differentiation, mediates antitumor activity in murine osteosarcoma. Cancer Res 65(4):1124-8, 2005. PMID: 15734992.
Zhou Z, Yu L, Kleinerman ES. EWS-FLI-1 regulates the neuronal repressor gene REST, which controls Ewing sarcoma growth and vascular morphology. Cancer 120(4):579-88, 2/2014. e-Pub 1/2014. PMCID: PMC3969734.
Lafleur EA, Koshkina NV, Stewart J, Jia SF, Worth LL, Duan X, Kleinerman ES. Increased Fas expression reduces the metastatic potential of human osteosarcoma cells. Clin Cancer Res 10(23):8114-9, 2004. PMID: 15585647.
Jia SF, Worth LL, Densmore CL, Xu B, Duan X, Kleinerman ES. Aerosol gene therapy with PEI: IL-12 eradicates osteosarcoma lung metastases. Clin Cancer Res 9(9):3462-8, 2003. PMID: 12960138.
Bolontrade MF, Zhou RR, Kleinerman ES. Vasculogenesis Plays a Role in the Growth of Ewing's Sarcoma in Vivo. Clin Cancer Res 8(11):3622-7, 2002. PMID: 12429654.
Book chapters
Koshkina N, Yang Y, Kleinerman ES. Fas signaling as a potential target for the treatment of osteosarcoma metastasis in the lungs. In: Current Advances in Osteosarcoma. Advances in Experimental Medicine and Biology, 2nd. Springer, 2020.
Wolff-Dennen K, Kleinerman ES. Exosomes: Dynamic Mediators of Extracellular Communication in the Tumor Microenvironment. In: Current Advances in Osteosarcoma. Advances in Experimental Medicine and Biology, 2nd. Springer, 2020.
Bhagat A, Kleinerman ES. Anthracycline-Induced Cardiotoxicity: Causes, mechanisms & prevention. In: Current Advances in Osteosarcoma. Advances in Experimental Medicine and Biology, 2nd. Springer, 2020.
Huang G, Nishimoto K, Yang Y, Kleinerman ES. Participation of the Fas/FasL Signaling Pathway and the Lung Microenvironment in the Development of Osteosarcoma Lung Metastases. In: Adv Exp Med Biol, 203-17, 2014.
Gordon N, Kleinerman ES. The role of Fas/FasL in the metastatic potential of osteosarcoma and targeting this pathway for the treatment of lung metastases. In: Pediatric and Adolescent Osteosarcoma: Cancer Treatment and Research. Ed(s) Jaffe N, Bruland O, Bielack S. Springer: New York, Dordrecht, Heidelberg, London, 497-508, 2009.