Selected Publications
2024
Gracia B, Montes P, Huang M, Chen J, Karras GI. HSP90 buffers deleterious genetic variations in BRCA1. bioRxiv. November 17, 2024
Condic N, Amiji H, Patel D, Shropshire WC, Lermi NO, Sabha Y, John B, Hanson B, Karras GI. Selection for robust metabolism in domesticated yeasts is driven by adaptation to Hsp90 stress. Science. 2024 Jul 26;385(6707):eadi3048. doi: 10.1126/science.adi3048. Epub 2024 Jul 26. PMID: 39052788
Gracia B, Montes P, Gutierrez AM, Arun B, Karras GI. Protein-folding chaperones predict structure-function relationships and cancer risk in BRCA1 mutation carriers. Cell Rep. 2024 Feb 27;43(2):113803. doi: 10.1016/j.celrep.2024.113803. Epub 2024 Feb 17. PMID: 38368609; PMCID: PMC10941025.
2023
Gracia B, Montes P, Gutierrez AM, Arun B, Karras GI. Protein-Folding Chaperones Predict Structure-Function Relationships and Cancer Risk in BRCA1 Mutation Carriers. bioRxiv, 2023. e-Pub 2023. PMCID: PMC10515940
Patel D, Amiji H, Shropshire W, Condic N, Lermi NO, Sabha Y, John B, Hanson B, Karras GI. Ethanol Drives Evolution of Hsp90-Dependent Robustness by Redundancy in Yeast Domestication. bioRxiv, 2023. e-Pub 2023. PMCID: PMC10516021
2022
Economos NG, Thapar U, Balasubramanian N, Karras GI*, Glazer PM*. An ELISA-based platform for rapid identification of structure-dependent nucleic acid-protein interactions detects novel DNA triplex interactors. JBC, PMID: 35988651 PMCID: PMC9493393
* corresponding
2018
Pedley AM, Karras GI, Zhang X, Lindquist S, Benkovic SJ. (2018). Role of HSP90 in the Regulation of de Novo Purine Biosynthesis. Biochemistry 2018 57(23):3217-3221 PMCID: PMC6192518
2017
Karras GI*, Yi S, Sahni N, Fischer M, Xie J, Vidal M, D’Andrea AD, Whitesell L*, Lindquist S. (2017). HSP90 shapes the consequences of human genetic variation. Cell 2017 Feb 23;168(5):856-866. PMCID: PMC5325763
* corresponding
2015
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Kamburov A, Krykbaeva I, Tucker G, Khurana V, Sharma A, Liu Y, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova A, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Charloteaux B, Berger B, Hill DE, Barabási AL, Hao T, Roth FP, Xia F, Walhout AJM, Lindquist S, Vidal M, Wang Y, Kovacs IA, Lam MH. (2015). Widespread Perturbation of Disease-Specific Macromolecular Interactions in Human Genetic Disorders. Cell. 2015 Apr 23;161(3):647-60. PMCID: PMC4441215
2014
Nicolae CM, Aho ER, Vlahos AHS, Choe KN, De S, Karras GI, Moldovan GL. (2014) The ADP-ribosyltransferase PARP10/ARTD10 interacts with Proliferating Cell Nuclear Antigen (PCNA) and is required for DNA damage tolerance. J Biol Chem. 2014 May 9;289 (19):13627-37. PMCID: PMC4036367
2013
Karras GI, Fumasoni M, Siensiki G, Vanoli F, Branzei D, Jentsch S. (2013). Noncanonical role of the 9-1-1 clamp in the error-free DNA damage tolerance pathway. Mol Cell. 2013 Feb 7;49(3):536-46
2012
Taipale M, Krykbaeva I, Koeva M, Kayatekin C, Westover KD, Karras GI, Lindquist S. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell. 2012 Aug 31;150(5):987-1001. PMCID: PMC3894786
2010
Karras GI, Jentsch S. (2010) The RAD6 DNA Damage Tolerance Pathway Operates Uncoupled From the Replication Fork and Is Functional Beyond S-phase. Cell. 2010 Apr 16;141(2):255-67.
2008
Moertl S, Karras GI, Wismüller T, Ahne F, Eckardt-Schupp F. (2008) Regulation of double-stranded DNA gap repair by the RAD6 pathway. DNA Repair (Amst). 2008 Nov 1;7(11):1893-906. Epub 2008 Sep 11.
2005
Karras GI, § Kustatscher G §, Buhecha HR, Allen MD, Pugieux C, Sait F, Bycroft M, Ladurner AG. (2005) The macro domain is an ADP-ribose binding module. EMBO J. 2005 Jun 1;24(11):1911-20. Epub 2005 May 19.PMCID: PMC1142602
§ equal contribution