Publications

Liu X, Nie L, Zhang Y, Yan Y, Wang C, Colic M, Olszewski K, Horbath A, Chen X, Lei G, Mao C, Wu S, Zhuang L, Poyurovsky MV, James You M, Hart T, Billadeau DD, Chen J, Gan B. Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nat Cell Biol. 2023 Mar;25(3):404-414. doi: 10.1038/s41556-023-01091-2. Epub 2023 Feb 6. PMID: 36747082; PMCID: PMC10027392.

Zhang S, Lee SH, Nie L, Huang Y, Zou G, Jung YS, Jun S, Zhang J, Lien EM, Chen J, Park JI. Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling integrity is required for mammary tumorigenesis. Cancer Commun (Lond). 2023 Jan;43(1):159-163. doi: 10.1002/cac2.12382. Epub 2022 Nov 6. PMID: 36336962; PMCID: PMC9859727.

Hsieh RC, Krishnan S, Wu RC, Boda AR, Liu A, Winkler M, Hsu WH, Lin SH, Hung MC, Chan LC, Bhanu KR, Srinivasamani A, De Azevedo RA, Chou YC, DePinho RA, Gubin M, Vilar E, Chen CH, Slay R, Jayaprakash P, Hegde SM, Hartley G, Lea ST, Prasad R, Morrow B, Couillault CA, Steiner M, Wang CC, Venkatesulu BP, Taniguchi C, Kim YSB, Chen J, Rudqvist NP, Curran MA. ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer. Sci Immunol 7(72):eabl9330, 6/10/2022. e-Pub 6/10/2022. PMID: 35687697; PMCID: PMC9373855.

Wang C, Feng X, Su D, Chen Z, Wang S, Tang M, Huang M, Nie L, Zhang H, Li S, Yin L, Johnson RL, Hart T, Chen J. Integrated screens uncover a cell surface tumor suppressor gene KIRREL involved in Hippo pathway. Proc Natl Acad Sci U S A 119(25):e2121779119, 6/21/2022. e-Pub 6/15/2022. PMID: 35704761; PMCID: PMC9231494.

Feng X, Tang M, Dede M, Su D, Pei G, Jiang D, Wang C, Chen Z, Li M, Nie L, Xiong Y, Li S, Park JM, Zhang H, Huang M, Szymonowicz K, Zhao Z, Hart T, Chen J. Genome-wide CRISPR Screens Using Isogenic Cells Reveal Vulnerabilities Conferred by Loss of Tumor Suppressors. Sci Adv 2022 May 13;8(19):eabm6638. doi: 10.1126/sciadv.abm6638. Epub 2022 May 13. PMID: 35559673; PMCID: PMC9106303.

Tang M, Chen Z, Wang C, Feng X, Lee N, Huang M, Zhang H, Li S, Xiong Y, Chen J. Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in BRCA1-deficient cells.  J Biol Chem. 2022 Apr 25;298(6):101979. doi: 10.1016/j.jbc.2022.101979. Epub ahead of print. PMID: 35472331; PMCID: PMC9127577.

Bian W, Tang M, Jiang H, Xu W, Hao W, Sui Y, Hou Y, Nie L, Zhang H, Wang C, Li N, Wang J, Qin J, Wu L, Ma X, Chen J, Wang W, Li X. Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation. Dev Cell. 2021 Oct 25;56(20):2902-2919.e8. doi: 10.1016/j.devcel.2021.09.015. Epub 2021 Oct 8. PMID: 34626540.

Wang C, Tang M, Chen Z, Nie L, Li S, Xiong Y, Szymonowicz KA, Park JM, Zhang H, Feng X, Huang M, Su D, Hart T, Chen J. Genetic vulnerabilities upon inhibition of DNA damage response. Nucleic Acids Res. 2021 Aug 20;49(14):8214-8231. doi: 10.1093/nar/gkab643. PMID: 34320214; PMCID: PMC8373146.

Chen Z, Wang C, Feng X, Nie L, Tang M, Zhang H, Xiong Y, Swisher SK, Srivastava M, Chen J. Interactomes of SARS-CoV-2 and human coronaviruses reveal host factors potentially affecting pathogenesis. EMBO J. 2021 Sep 1;40(17):e107776. doi: 10.15252/embj.2021107776. Epub 2021 Jul 26. PMID: 34232536; PMCID: PMC8447597.

Tang M, Pei G, Su D, Wang C, Feng X, Srivastava M, Chen Z, Zhao Z, Chen J. Genome-wide CRISPR screens reveal cyclin C as synthetic survival target of BRCA2. Nucleic Acids Res. 2021 Jul 21;49(13):7476-7491. doi: 10.1093/nar/gkab540. PMID: 34197614; PMCID: PMC8287926.

Tang M, Li S, Chen J Ubiquitylation in DNA double-strand break repair. DNA Repair (Amst). 2021 Jul;103:103129. doi: 10.1016/j.dnarep.2021.103129. Epub 2021 May 7. PMID: 33990032; PMCID: PMC8207832.

Hang Q, Zeng L, Wang L, Nie L, Yao F, Teng H, Deng Y, Yap S, Sun Y, Frank SJ, Chen J, Ma L. Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance. Nat Commun. 2021 Jun 29;12(1):4033. doi: 10.1038/s41467-021-24298-z. PMID: 34188037; PMCID: PMC8242032.

Zhang Y, Swanda RV, Nie L, Liu X, Wang C, Lee H, Lei G, Mao C, Koppula P, Cheng W, Zhang J, Xiao Z, Zhuang L, Fang B, Chen J, Qian SB, Gan B. mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation. Nat Commun. 2021 Mar 11;12(1):1589. doi: 10.1038/s41467-021-21841-w. PMID: 33707434; PMCID: PMC7952727.

Kim MJ, Cervantes C, Jung YS, Zhang X, Zhang J, Lee SH, Jun S, Litovchick L, Wang W, Chen J, Fang B, Park JI. PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis. Mol Cell. 2021 Apr 15;81(8):1698-1714.e6. doi: 10.1016/j.molcel.2021.02.001. Epub 2021 Feb 23. PMID: 33626321; PMCID: PMC8052288.

Chen Z, Chen J Mass spectrometry-based protein?protein interaction techniques and their applications in studies of DNA damage repair. J Zhejiang Univ Sci B. 2021 Jan 15;22(1):1-20. doi: 10.1631/jzus.B2000356. PMID: 33448183; PMCID: PMC7818012.

Wang R, Lenoir WF, Wang C, Su D, McLaughlin M, Hu Q, Shen X, Tian Y, Klages-Mundt N, Lynn E, Wood RD, Chen J, Hart T, Li L. DNA polymerase ι compensates for Fanconi anemia pathway deficiency by countering DNA replication stress. Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33436-33445. doi: 10.1073/pnas.2008821117. Epub 2020 Dec 21. PMID: 33376220; PMCID: PMC7777187.

Shen X, Wang R, Kim MJ, Hu Q, Hsu CC, Yao J, Klages-Mundt N, Tian Y, Lynn E, Brewer TF, Zhang Y, Arun B, Gan B, Andreeff M, Takeda S, Chen J, Park JI, Shi X, Chang CJ, Jung SY, Qin J, Li L. A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia. Mol Cell. 2020 Dec 17;80(6):1013-1024.e6. doi: 10.1016/j.molcel.2020.11.040. PMID: 33338401; PMCID: PMC8600940.

Azizian NG, Sullivan DK, Nie L, Pardo S, Molleur D, Chen J, Weintraub ST, Li Y. Selective Labeling and Identification of the Tumor Cell Proteome of Pancreatic Cancer In Vivo. J Proteome Res. 2021 Jan 1;20(1):858-866. doi: 10.1021/acs.jproteome.0c00666. Epub 2020 Dec 8. PMID: 33289385; PMCID: PMC8718109.

Nie L, Wang C, Li N, Feng X, Lee N, Su D, Tang M, Yao F, Chen J. Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation. Mol Cell Proteomics. 2020 Dec;19(12):2015-2029. doi: 10.1074/mcp.RA120.002290. Epub 2020 Sep 21. PMID: 32958691; PMCID: PMC7710139.

Szymonowicz KA, Chen J. Biological and clinical aspects of HPV-related cancers. Cancer Biol Med. 2020 Nov 15;17(4):864-878. doi: 10.20892/j.issn.2095-3941.2020.0370. Epub 2020 Dec 15. PMID: 33299640; PMCID: PMC7721094.

Wang C, Chen Z, Nie L, Tang M, Feng X, Su D, Zhang H, Xiong Y, Park JM, Chen J. Extracellular signal-regulated kinases associate with and phosphorylate DHPS to promote cell proliferation. Oncogenesis. 2020 Sep 28;9(9):85. doi: 10.1038/s41389-020-00271-1. PMID: 32989218; PMCID: PMC7522278.

Wang C, Chen Z, Su D, Tang M, Nie L, Zhang H, Feng X, Wang R, Shen X, Srivastava M, McLaughlin ME, Hart T, Li L, Chen J. C17orf53 is identified as a novel gene involved in inter-strand crosslink repair. DNA Repair (Amst). 2020 Nov;95:102946. doi: 10.1016/j.dnarep.2020.102946. Epub 2020 Aug 15. PMID: 32853826; PMCID: PMC7669678.

Tang M, Feng X, Pei G, Srivastava M, Wang C, Chen Z, Li S, Zhang H, Zhao Z, Li X, Chen J. FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function. Cell Rep. 2020 Aug 11;32(6):108018. doi: 10.1016/j.celrep.2020.108018. PMID: 32783940; PMCID: PMC7458625.

Feng X, Tubbs A, Zhang C, Tang M, Sridharan S, Wang C, Jiang D, Su D, Zhang H, Chen Z, Nie L, Xiong Y, Huang M, Nussenzweig A, Chen J. ATR inhibition potentiates ionizing radiation-induced interferon response via cytosolic nucleic acid-sensing pathways. EMBO J. 2020 Jul 15;39(14):e104036. doi: 10.15252/embj.2019104036. Epub 2020 Jun 2. PMID: 32484965; PMCID: PMC7361286.

Chen Z, Wang C, Lei C, Feng X, Li C, Jung SY, Qin J, Chen J. Phosphoproteomics Analysis Reveals a Potential Role of CHK1 in Regulation of Innate Immunity through IRF3. J Proteome Res. 2020 Jun 5;19(6):2264-2277. doi: 10.1021/acs.jproteome.9b00829. Epub 2020 May 8. PMID: 32314919.

Srivastava M, Su D, Zhang H, Chen Z, Tang M, Nie L, Chen J. HMCES safeguards replication from oxidative stress and ensures error-free repair. EMBO Rep. 2020 Jun 4;21(6):e49123. doi: 10.15252/embr.201949123. Epub 2020 Apr 19. PMID: 32307824; PMCID: PMC7271331.

Huang M, Feng X, Su D, Wang G, Wang C, Tang M, Paulucci-Holthauzen A, Hart T, Chen J. Genome-wide CRISPR screen uncovers a synergistic effect of combining Haspin and Aurora kinase B inhibition. Oncogene. 2020 May;39(21):4312-4322. doi: 10.1038/s41388-020-1296-2. Epub 2020 Apr 16. PMID: 32300176; PMCID: PMC7291820.

Su D, Feng X, Colic M, Wang Y, Zhang C, Wang C, Tang M, Hart T, Chen J. CRISPR/CAS9-based DNA damage response screens reveal gene-drug interactions. DNA Repair (Amst). 2020 Mar;87:102803. doi: 10.1016/j.dnarep.2020.102803. Epub 2020 Jan 16. PubMed PMID: 31991288; PubMed Central PMCID: PMC7034363

Hu Q, Klages-Mundt N, Wang R, Lynn E, Kuma Saha L, Zhang H, Srivastava M, Shen X, Tian Y, Kim H, Ye Y, Paull T, Takeda S, Chen J, Li L. The ARK Assay Is a Sensitive and Versatile Method for the Global Detection of DNA-Protein Crosslinks. Cell Rep. 2020 Jan 28;30(4):1235-1245.e4. doi:10.1016/j.celrep.2019.12.067. PubMed PMID: 31995761; PubMed Central PMCID:PMC7069250

Zhang H, Xiong Y, Chen J. DNA-protein cross-link repair: what do we know now? Cell Biosci. 2020 Jan 7;10:3. doi: 10.1186/s13578-019-0366-z. eCollection 2020. Review. PubMed PMID: 31921408; PubMed Central PMCID: PMC6945406

Chen Z, Wang C, Jain A, Srivastava M, Tang M, Zhang H, Feng X, Nie L, Su D, Xiong Y, Jung SY, Qin J, Chen J. AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair. Mol Cell Proteomics. 2020 Mar;19(3):467-477. doi: 10.1074/mcp.RA119.001794. Epub 2020 Jan 3. PubMed PMID:31900314; PubMed Central PMCID: PMC7050103

Vargas RE, Duong VT, Han H, Ta AP, Chen Y, Zhao S, Yang B, Seo G, Chuc K, Oh S, El Ali A, Razorenova OV, Chen J, Luo R, Li X, Wang W. Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP4 as YAP inhibitor. EMBO J. 2020 Jan 2;39(1):e102406. doi: 10.15252/embj.2019102406. Epub 2019 Nov 29. PubMed PMID:31782549; PubMed Central PMCID:PMC6939200.

Zhang H, Chen Z, Ye Y, Ye Z, Cao D, Xiong Y, Srivastava M, Feng X, Tang M, Wang C, Tainer JA, Chen J. SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair. Nucleic Acids Res. 2019 Nov 4;47(19):10181-10201. doi: 10.1093/nar/gkz769. PubMed PMID: 31495888; PubMed Central PMCID: PMC6821277.

Xu M, Qin J, Wang L, Lee HJ, Kao CY, Liu D, Songyang Z, Chen J, Tsai MJ, Tsai SY. Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway. Sci Adv. 2019 Oct 9;5(10):eaax6366. doi: 10.1126/sciadv.aax6366. eCollection 2019 Oct. PubMed PMID: 31633027; PubMed Central PMCID: PMC6785246.

Li N, Wang Y, Neri S, Zhen Y, Fong LWR, Qiao Y, Li X, Chen Z, Stephan C, Deng W, Ye R, Jiang W, Zhang S, Yu Y, Hung MC, Chen J, Lin SH. Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling. Nat Commun. 2019 Sep 25;10(1):4363. doi: 10.1038/s41467-019-12377-1. PubMed PMID: 31554794; PubMed Central PMCID: PMC6761205.

Huang J, Zhang J, Bellani MA, Pokharel D, Gichimu J, James RC, Gali H, Ling C, Yan Z, Xu D, Chen J, Meetei AR, Li L, Wang W, Seidman MM. Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2. Cell Rep. 2019 May 7;27(6):1794-1808.e5. doi: 10.1016/j.celrep.2019.04.032. PubMed PMID: 31067464; PubMed Central PMCID: PMC6676478.

Wang C, Wang G, Feng X, Shepherd P, Zhang J, Tang M, Chen Z, Srivastava M, McLaughlin ME, Navone NM, Hart GT, Chen J. Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition. Oncogene. 2019 Apr;38(14):2451-2463. doi: 10.1038/s41388-018-0606-4. Epub 2018 Dec 7. PubMed PMID:30532030; PubMed Central PMCID:PMC6450769.

Chen Z, Lei C, Wang C, Li N, Srivastava M, Tang M, Zhang H, Choi JM, Jung SY, Qin J, Chen J. Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics. Nat Commun 10(1):104, 1/2019. e-Pub 1/2019. PMCID: PMC6328551.

Hussain T, Lee J, Abba MC, Chen J, Aldaz CM. Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved. Front Oncol 8:591, 2018. e-Pub 12/2018. PMCID: PMC6300487.

Srivastava M, Chen Z, Zhang H, Tang M, Wang C, Jung SY, Chen J. Replisome Dynamics and Their Functional Relevance upon DNA Damage through the PCNA Interactome. Cell Rep 25(13):3869-3883.e4, 12/2018. PMCID: PMC6364303.

Jung YS, Jun S, Kim MJ, Lee SH, Suh HN, Lien EM, Jung HY, Lee S, Zhang J, Yang JI, Ji H, Wu JY, Wang W, Miller RK, Chen J, McCrea PD, Kopetz S, Park JI. TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling. Nat Cell Biol 20(12):1421-1433, 12/2018. e-Pub 10/2018. PMCID: PMC6261670.

Jung YS, Wang W, Jun S, Zhang J, Srivastava M, Kim MJ, Lien EM, Shang J, Chen J, McCrea PD, Zhang S, Park JI. Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin. Nat Cell Biol 20(11):1303-1314, 11/2018. e-Pub 10/2018. PMCID: PMC6261439.

Xu R, Xu Y, Huo W, Lv Z, Yuan J, Ning S, Wang Q, Hou M, Gao G, Ji J, Chen J, Guo R, Xu D. Mitosis-specific MRN complex promotes a mitotic signaling cascade to regulate spindle dynamics and chromosome segregation. Proc Natl Acad Sci U S A 115(43):E10079-E10088, 10/2018. e-Pub 10/2018. PMCID: PMC6205471.

Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, Sirohi K, Li X, Wei Y, Lee H, Zhuang L, Chen G, Xiao ZD, Hung MC, Chen J, Huang P, Li W, Gan B. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol 20(10):1181-1192, 10/2018. e-Pub 9/2018. PMCID: PMC6170713.

Zhang P, Xiao Z, Wang S, Zhang M, Wei Y, Hang Q, Kim J, Yao F, Rodriguez-Aguayo C, Ton BN, Lee M, Wang Y, Zhou Z, Zeng L, Hu X, Lawhon SE, Siverly AN, Su X, Li J, Xie X, Cheng X, Liu LC, Chang HW, Chiang SF, Lopez-Berestein G, Sood AK, Chen J, You MJ, Sun SC, Liang H, Huang Y, Yang X, Sun D, Sun Y, Hung MC, Ma L. ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer. Cell Rep. 2018 Apr 17;23(3):823-837. doi: 10.1016/j.celrep.2018.03.078. PubMed PMID: 29669287; PubMed Central PMCID: PMC5933875.

Xie J, Li Y, Jiang K, Hu K, Zhang S, Dong X, Dai X, Liu L, Zhang T, Yang K, Huang K, Chen J, Shi S, Zhang Y, Wu G, Xu S. CDK16 Phosphorylates and Degrades p53 to Promote Radioresistance and Predicts Prognosis in Lung Cancer. Theranostics 8(3):650-662, 2018. e-Pub 1/2018. PMCID: PMC5771083.

Huang Y, Hu K, Zhang S, Dong X, Yin Z, Meng R, Zhao Y, Dai X, Zhang T, Yang K, Liu L, Huang K, Shi S, Zhang Y, Chen J, Wu G, Xu S. S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer. Theranostics 8(5):1286-1300, 2018. e-Pub 2/2018. PMCID: PMC5835936.

Wang L, Zhang P, Molkentine DP, Chen C, Molkentine JM, Piao H, Raju U, Zhang J, Valdecanas DR, Tailor RC, Thames HD, Buchholz TA, Chen J, Ma L, Mason KA, Ang KK, Meyn RE, Skinner HD. TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects. Oncogene. 2017 Feb 9;36(6):820-828. doi: 10.1038/onc.2016.250. Epub 2016 Jul 18. PubMed PMID: 27425591; PubMed Central PMCID: PMC5434711.

Li X, Gao M, Choi JM, Kim BJ, Zhou MT, Chen Z, Jain AN, Jung SY, Yuan J, Wang W, Wang Y, Chen J. CRISPR/Cas9-Coupled Affinity Purification/Mass Spectrometry Analysis Revealed a Novel Role of Neurofibromin in mTOR Signaling. Mol Cell Proteomics 16(4):594-607, 4/2017. e-Pub 2/2017. PMCID: PMC5383781.

Zhang A, Peng B, Huang P, Chen J, Gong Z. The p53-binding Protein 1-Tudor Interacting Repair Regulator Complex Participates in the DNA Damage Response. J Biol Chem 292(16):6461-6467, 4/2017. e-Pub 2/2017. PMCID: PMC5399100.

Li X, Han H, Zhou MT, Yang B, Ta AP, Li N, Chen J, Wang W. Proteomic Analysis of the Human Tankyrase Protein Interaction Network Reveals Its Role in Pexophagy. Cell Rep 20(3):737-749, 7/2017. PMID: 28723574.

Bae N, Gao M, Li X, Premkumar T, Sbardella G, Chen J, Bedford MT. A transcriptional coregulator, SPIN-DOC, attenuates the coactivator activity of Spindlin1. J Biol Chem 292(51):20808-20817, 12/2017. e-Pub 10/2017. PMCID: PMC5743059.

Tian Y, Shen X, Wang R, Klages-Mundt NL, Lynn EJ, Martin SK, Ye Y, Gao M, Chen J, Schlacher K, Li L. Constitutive role of the Fanconi anemia D2 gene in the replication stress response. J Biol Chem 292(49):20184-20195, 12/2017. e-Pub 10/2017. PMCID: PMC5724005.

Tang M, Chen J. 53BP1: keep an eye on merotely. Oncotarget 8(30):48527-48528, 7/2017. PMCID: PMC5564702.

Li X, Wang W, Chen J. Recent progress in mass spectrometry proteomics for biomedical research. Sci China Life Sci 60(10):1093-1113, 10/2017. e-Pub 10/2017. PMID: 29039124.

Wang L, Zhang P, Molkentine DP, Chen C, Molkentine JM, Piao H, Raju U, Zhang J, Valdecanas DR, Tailor RC, Thames HD, Buchholz TA, Chen J, Ma L, Mason KA, Ang KK, Meyn RE, Skinner HD. TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects. Oncogene. 2017 Feb 9;36(6):820-828. doi: 10.1038/onc.2016.250. Epub 2016 Jul 18. PubMed PMID: 27425591; PubMed Central PMCID: PMC5434711.

Huen MS, Chen J. H1 provides the missing link. Cell Res 26(1):5-6, 1/2016. e-Pub 11/2015. PMCID: PMC4816129.

Mu Y, Lou J, Srivastava M, Zhao B, Feng XH, Liu T, Chen J, Huang J. SLFN11 inhibits checkpoint maintenance and homologous recombination repair. EMBO Rep 17(1):94-109, 1/2016. e-Pub 12/2015. PMCID: PMC4718411.

Wang X, Jung YS, Jun S, Lee S, Wang W, Schneider A, Sun Oh Y, Lin SH, Park BJ, Chen J, Keyomarsi K, Park JI. PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness. Nat Commun 7:10633, 2/2016. e-Pub 2/2016. PMCID: PMC4743006.

Jun S, Jung YS, Suh HN, Wang W, Kim MJ, Oh YS, Lien EM, Shen X, Matsumoto Y, McCrea PD, Li L, Chen J, Park JI. LIG4 mediates Wnt signaling-induced radioresistance. Nat Commun 7:10994, 3/2016. e-Pub 3/2016. PMCID: PMC4820809.

Liu X, Xiao ZD, Han L, Zhang J, Lee SW, Wang W, Lee H, Zhuang L, Chen J, Lin HK, Wang J, Liang H, Gan B. LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nat Cell Biol 18(4):431-42, 4/2016. e-Pub 3/2016. PMCID: PMC4814347.

Li N, Feng L, Liu H, Wang J, Kasembeli M, Tran MK, Tweardy DJ, Lin SH, Chen J. PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2. Cell Rep 15(4):843-856, 4/2016. e-Pub 4/2016. PMCID: PMC5063668.

Chen Z, Tran M, Tang M, Wang W, Gong Z, Chen J. Proteomic Analysis Reveals a Novel Mutator S (MutS) Partner Involved in Mismatch Repair Pathway. Mol Cell Proteomics 15(4):1299-308, 4/2016. PMCID: PMC4824856.

Zhang W, Wu KP, Sartori MA, Kamadurai HB, Ordureau A, Jiang C, Mercredi PY, Murchie R, Hu J, Persaud A, Mukherjee M, Li N, Doye A, Walker JR, Sheng Y, Hao Z, Li Y, Brown KR, Lemichez E, Chen J, Tong Y, Harper JW, Moffat J, Rotin D, Schulman BA, Sidhu SS. System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. Mol Cell 62(1):121-36, 4/2016. e-Pub 3/2016. PMCID: PMC4988125.

Li X, Wang W, Xi Y, Gao M, Tran M, Aziz KE, Qin J, Li W, Chen J. FOXR2 Interacts with MYC to Promote Its Transcriptional Activities and Tumorigenesis. Cell Rep 16(2):487-97, 7/2016. e-Pub 6/2016. PMCID: PMC4946253.

Li X, Tran KM, Aziz KE, Sorokin AV, Chen J, Wang W. Defining the protein-protein interaction network of the human protein tyrosine phosphatase family. Mol Cell Proteomics 15(9):3030-44, 9/2016. e-Pub 7/2016. PMCID: PMC5013315.

Yi J, Lu L, Yanger K, Wang W, Sohn BH, Stanger BZ, Zhang M, Martin JF, Ajani JA, Chen J, Lee JS, Song S, Johnson RL. LATS1 and LATS2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ. Hepatology 64(5):1757-1772, 11/2016. e-Pub 9/2016. PMCID: PMC5863546.

Suh HN, Jun S, Oh AY, Srivastava M, Lee S, Taniguchi CM, Zhang S, Lee WS, Chen J, Park BJ, Park JI. Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia. Sci Rep 6:38273, 12/2016. e-Pub 12/2016. PMCID: PMC5138641.

Lee YC, Zhou Q, Chen J, Yuan J. RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response. Curr Biol 26(24):3257-3268, 12/2016. e-Pub 11/2016. PMCID: PMC5173396.

Chong Z, Ruan J, Gao M, Zhou W, Chen T, Fan X, Ding L, Lee AY, Boutros P, Chen J, Chen K. novoBreak: local assembly for breakpoint detection in cancer genomes. Nat Methods 14(1):65-67, 1/2017. e-Pub 11/2016. PMCID: PMC5199621.

Chen J, Shukla V, Farci P, Andricovich J, Jogunoori W, Kwong LN, Katz LH, Shetty K, Rashid A, Su X, White J, Li L, Wang AY, Blechacz B, Raju GS, Davila M, Nguyen BN, Stroehlein JR, Chen J, Kim SS, Levin H, Machida K, Tsukamoto H, Michaely P, Tzatsos A, Mishra B, Amdur R, Mishra L. Loss of the transforming growth factor-β effector β2-Spectrin promotes genomic instability. Hepatology 65(2):678-693, 2/2017. e-Pub 12/2016. PMCID: PMC5432427.

Li N, Zhang Y, Han X, Liang K, Wang J, Feng L, Wang W, Songyang Z, Lin C, Yang L, Yu Y, Chen J. Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth. Genes Dev 29(2):157-70, 1/2015. e-Pub 12/2014. PMCID: PMC4298135.

Li X, Wang W, Wang J, Malovannaya A, Xi Y, Li W, Guerra R, Hawke DH, Qin J, Chen J. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol Syst Biol 11(1):775, 1/2015. e-Pub 1/2015. PMCID: PMC4332150.

Wang W, Li X, Lee M, Jun S, Aziz KE, Feng L, Tran MK, Li N, McCrea PD, Park JI, Chen J. FOXKs Promote Wnt/β-Catenin Signaling by Translocating DVL into the Nucleus. Dev Cell 32(6):707-18, 3/2015. PMCID: PMC4374128.

Wang J, Chen J, Gong Z. TopBP1 stabilizes BLM protein to suppress sister chromatid exchange. Mol Cell 57(6):955-6, 3/2015. PMID: 25794614.

Tian Y, Paramasivam M, Ghosal G, Chen D, Shen X, Huang Y, Akhter S, Legerski R, Chen J, Seidman MM, Qin J, Li L. UHRF1 contributes to DNA damage repair as a lesion recognition factor and nuclease scaffold. Cell Rep 10(12):1957-66, 3/2015. e-Pub 3/2015. PMCID: PMC4748712.

Wang W, Xiao ZD, Li X, Aziz KE, Gan B, Johnson RL, Chen J. AMPK modulates Hippo pathway activity to regulate energy homeostasis. Nat Cell Biol 17(4):490-9, 4/2015. e-Pub 3/2015. PMCID: PMC4380807.

Sorokin AV, Nair BC, Wei Y, Aziz KE, Evdokimova V, Hung MC, Chen J. Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis. Cancer Res 75(9):1846-58, 5/2015. e-Pub 4/2015. PMCID: PMC4417433.

Wang W, Li X, Chen J. Energy crisis and the Hippo pathway. Cell Cycle. 2015;14(13):1995-6. doi: 10.1080/15384101.2015.1046788. Epub 2015 May 5. PubMed PMID:25942485; PubMed Central PMCID:PMC4614403.

Xu G, Chapman JR, Brandsma I, Yuan J, Mistrik M, Bouwman P, Bartkova J, Gogola E, Warmerdam D, Barazas M, Jaspers JE, Watanabe K, Pieterse M, Kersbergen A, Sol W, Celie PHN, Schouten PC, van den Broek B, Salman A, Nieuwland M, de Rink I, de Ronde J, Jalink K, Boulton SJ, Chen J, van Gent DC, Bartek J, Jonkers J, Borst P, Rottenberg S. REV7 counteracts DNA double-strand break resection and affects PARP inhibition. Nature 521(7553):541-4, 5/2015. e-Pub 3/2015. PMCID: PMC4671316.

Wang W, Li N, Li X, Tran MK, Han X, Chen J. Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins. Cell Rep 13(3):524-32, 10/2015. e-Pub 10/2015. PMCID: PMC4618173.

Feng L, Li N, Li Y, Wang J, Gao M, Wang W, Chen J. Cell cycle-dependent inhibition of 53BP1 signaling by BRCA1. Cell Discov 1:15019, 2015. e-Pub 8/2015. PMCID: PMC4860855.

Wang W, Li X, Huang J, Feng L, Dolinta KG, Chen J. Defining the protein-protein interaction network of the human Hippo pathway. Mol Cell Proteomics 13(1):119-31, 1/2014. e-Pub 10/2013. PMCID: PMC3879608.

Wang F, Cheng J, Liu D, Sun H, Zhao J, Wang J, Chen J, Su Y, Zou Z. P53-participated cellular and molecular responses to irradiation are cell differentiation-determined in murine intestinal epithelium. Arch Biochem Biophys 542C:21-27, 1/2014. e-Pub 12/2013. PMID: 24315958.

Li N, Chen J. ADP-ribosylation: activation, recognition, and removal. Mol Cells. 2014 Jan;37(1):9-16. doi: 10.14348/molcells.2014.2245. Epub 2014 Jan 27. Review. PubMed PMID:24552704; PubMed Central PMCID:PMC3907000.

Li Y, Fong KW, Tang M, Han X, Gong Z, Ma W, Hebert M, Songyang Z, Chen J. Fam118B, a newly identified component of Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability. J Cell Sci 127(Pt 9):2029-39, 5/2014. e-Pub 2/2014. PMCID: PMCPMC4004977.

Huang Y, Leung JW, Lowery M, Matsushita N, Wang Y, Shen X, Huong D, Takata M, Chen J, Li L. Modularized functions of the fanconi anemia core complex. Cell Rep 7(6):1849-57, 6/2014. e-Pub 6/2014. PMCID: PMC4157997.

Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, Zhang J, Yuan J, Wang M, Chen D, Sun Y, Woodward WA, Liu Y, Dean DC, Liang H, Hu Y, Ang KK, Hung MC, Chen J, Ma L. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol 16(9):864-75, 9/2014. e-Pub 8/2014. PMCID: PMC4150825.

Cleaver JE, Brennan-Minnella AM, Swanson RA, Fong KW, Chen J, Chou KM, Chen YW, Revet I, Bezrookove V. Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage. Proc Natl Acad Sci U S A 111(37):13487-92, 9/2014. e-Pub 8/2014. PMCID: PMC4169934.

Barton O, Naumann SC, Diemer-Biehs R, Künzel J, Steinlage M, Conrad S, Makharashvili N, Wang J, Feng L, Lopez BS, Paull TT, Chen J, Jeggo PA, Löbrich M. Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1. J Cell Biol 206(7):877-94, 9/2014. PMCID: PMC4178966.

Xu S, Li X, Gong Z, Wang W, Li Y, Nair BC, Piao H, Yang K, Wu G, Chen J. Proteomic Analysis of the Human Cyclin-dependent Kinase Family Reveals a Novel CDK5 Complex Involved in Cell Growth and Migration. Mol Cell Proteomics 13(11):2986-3000, 11/2014. e-Pub 8/2014. PMCID: PMC4223486.

Zhang P, Wang L, Rodriguez-Aguayo C, Yuan Y, Debeb BG, Chen D, Sun Y, You MJ, Liu Y, Dean DC, Woodward WA, Liang H, Yang X, Lopez-Berestein G, Sood AK, Hu Y, Ang KK, Chen J, Ma L. miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13. Nat Commun 5:5671, 12/2014. e-Pub 12/2014. PMCID: PMC4377070.

Wang J, Aroumougame A, Lobrich M, Li Y, Chen D, Chen J, Gong Z. PTIP associates with Artemis to dictate DNA repair pathway choice. Genes Dev 28(24):2693-8, 12/2014. PMCID: PMC4265673.

Li X, Wang W, Chen J. From pathways to networks: connecting dots by establishing protein-protein interaction networks in signaling pathways using affinity purification and mass spectrometry. Proteomics. 2015 Jan;15(2-3):188-202. doi: 10.1002/pmic.201400147. Epub 2014 Oct 18. Review. PubMed PMID:25137225; PubMed Central PMCID:PMC4482759.

Kavela S, Shinde SR, Ratheesh R, Viswakalyan K, Bashyam MD, Gowrishankar S, Vamsy M, Pattnaik S, Rao S, Sastry RA, Srinivasulu M, Chen J, Maddika S. PNUTS functions as a proto-oncogene by sequestering PTEN. Cancer Res 73(1):205-14, 1/2013. e-Pub 11/2012. PMCID: PMC3538077.

Yang SH, Zhou R, Campbell J, Chen J, Ha T, Paull TT. The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1. EMBO J 32(1):126-39, 1/2013. e-Pub 11/2012. PMCID: PMC3545304.

Fong KW, Leung JW, Li Y, Wang W, Feng L, Ma W, Liu D, Songyang Z, Chen J. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. J Cell Sci 126(Pt 3):825-37, 2/2013. e-Pub 12/2012. PMCID: PMC3619811.

Wang J, Leung JW, Gong Z, Feng L, Shi X, Chen J. PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis. J Biol Chem 288(5):3174-83, 2/2013. e-Pub 12/2012. PMCID: PMC3561539.

Leung JW, Ghosal G, Wang W, Shen X, Wang J, Li L, Chen J. Alpha Thalassemia/Mental Retardation Syndrome X-linked Gene Product ATRX Is Required for Proper Replication Restart and Cellular Resistance to Replication Stress. J Biol Chem 288(9):6342-50, 3/2013. e-Pub 1/2013. PMCID: PMC3585069.

Wang Y, Leung JW, Jiang Y, Lowery MG, Do H, Vasquez KM, Chen J, Wang W, Li L. FANCM and FAAP24 Maintain Genome Stability via Cooperative as Well as Unique Functions. Mol Cell 49(5):997-1009, 3/2013. e-Pub 1/2013. PMCID: PMC3595374.

Feng L, Fong KW, Wang J, Wang W, Chen J. RIF1 counteracts BRCA1-mediated end resection during DNA repair. J Biol Chem 288(16):11135-43, 4/2013. e-Pub 3/2013. PMCID: PMC3630874.

Wang L, Zeng X, Chen S, Ding L, Zhong J, Zhao JC, Wang L, Sarver A, Koller A, Zhi J, Ma Y, Yu J, Chen J, Huang H. BRCA1 is a negative modulator of the PRC2 complex. EMBO J 32(11):1584-97, 5/2013. e-Pub 4/2013. PMCID: PMC3671259.

Yuan J, Chen J. FIGNL1-containing protein complex is required for efficient homologous recombination repair. Proc Natl Acad Sci U S A 110(26):10640-5, 6/2013. e-Pub 6/2013. PMCID: PMC3696823.

Leung CC, Sun L, Gong Z, Burkat M, Edwards R, Assmus M, Chen J, Glover JN. Structural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control. Structure 21(8):1450-9, 8/2013. e-Pub 7/2013. PMCID: PMC3760280.

Wang Y, Han X, Wu F, Leung JW, Lowery MG, Do H, Chen J, Shi C, Tian C, Li L, Gong W. Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response. Cell Res 23(10):1215-28, 10/2013. e-Pub 9/2013. PMCID: PMC3790240.

Fong KW, Li Y, Wang W, Ma W, Li K, Qi RZ, Liu D, Songyang Z, Chen J. Whole-genome screening identifies proteins localized to distinct nuclear bodies. J Cell Biol 203(1):149-64, 10/2013. PMCID: PMC3798253.

Han X, Liu D, Zhang Y, Li Y, Lu W, Chen J, Songyang Z. Akt regulates TPP1 homodimerization and telomere protection. Aging Cell 12(6):1091-9, 12/2013. e-Pub 8/2013. PMCID: PMC4051222.

Zhang J, Zhang P, Wei Y, Piao HL, Wang W, Maddika S, Wang M, Chen D, Sun Y, Hung MC, Chen J, Ma L. Deubiquitylation and stabilization of PTEN by USP13. Nat Cell Biol 15(12):1486-94, 12/2013. e-Pub 11/2013. PMCID: PMC3951854.

Wang J, Chen J, Gong Z. TopBP1 Controls BLM Protein Level to Maintain Genome Stability. Mol Cell 52(5):667-78, 12/2013. e-Pub 11/2013. PMCID: PMC3880544.

Ghosal G, Chen J. DNA damage tolerance: a double-edged sword guarding the genome. Transl Cancer Res 2(3):107-129, 2013. PMCID: PMC3779140.

Feng L, Chen J. The E3 ligase RNF8 regulates KU80 removal and NHEJ repair. Nat Struct Mol Biol 19(2):201-6, 1/2012. e-Pub 1/2012. PMCID: PMC3888515.

Liu T, Chen H, Kim H, Huen MS, Chen J, Huang J. RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage. DNA Repair (Amst) 11(2):131-8, 2/2012. e-Pub 10/2011. PMCID: PMC3779126.

Leung JW, Wang Y, Fong KW, Huen MS, Li L, Chen J. Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair. Proc Natl Acad Sci U S A 109(12):4491-6, 3/2012. e-Pub 3/2012. PMCID: PMC3311328.

Wu J, Liu C, Chen J, Yu X. RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo. J Biol Chem 287(27):22919-26, 6/2012. e-Pub 4/2012. PMCID: PMC3391110.

Yuan J, Ghosal G, Chen J. The HARP-like Domain-Containing Protein AH2/ZRANB3 Binds to PCNA and Participates in Cellular Response to Replication Stress. Mol Cell 47(3):410-21, 8/2012. e-Pub 6/2012. PMCID: PMC3601832.

Wang W, Huang J, Wang X, Yuan J, Li X, Feng L, Park JI, Chen J. PTPN14 is required for the density-dependent control of YAP1. Genes Dev 26(17):1959-71, 9/2012. PMCID: PMC3435498.

Fei J, Chen J. KIAA1530 is recruited by cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR). J Biol Chem 287(42):35118-26, 10/2012. e-Pub 8/2012. PMCID: PMC3471710.

Ghosal G, Leung JW, Nair BC, Fong KW, Chen J. PCNA-binding protein C1orf124 is a regulator of translesion synthesis. J Biol Chem 287(41):34225-33, 10/2012. e-Pub 8/2012. PMCID: PMC3464530.

Nadkarni A, Shrivastav M, Mladek AC, Schwingler PM, Grogan PT, Chen J, Sarkaria JN. ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells. J Neurooncol 110(3):349-57, 12/2012. e-Pub 10/2012. PMID: 23054561.

Sin HS, Barski A, Zhang F, Kartashov AV, Nussenzweig A, Chen J, Andreassen PR, Namekawa SH. RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids. Genes Dev 26(24):2737-48, 12/2012. PMCID: PMC3533078.

Ghosal G, Chen J. Alteration/deficiency in activation 3 (ADA3): Regulator of DNA repair and genome stability. Cell Cycle. 2012 Dec 15;11(24):4496. doi: 10.4161/cc.22934. Epub 2012 Dec 6. PubMed PMID:23222062; PubMed Central PMCID:PMC3562290.

Wang W, Huang J, Chen J. Angiomotin-like proteins associate with and negatively regulate YAP1. J Biol Chem 286(6):4364-70, 2/2011. e-Pub 12/2010. PMCID: PMC3039387.

Leung CC, Gong Z, Chen J, Glover JN. Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control. J Biol Chem 286(6):4292-301, 2/2011. e-Pub 12/2010. PMCID: PMC3039391.

Yuan J, Chen J. The Role of the Human SWI5-MEI5 Complex in Homologous Recombination Repair. J Biol Chem 286(11):9888-93, 3/2011. e-Pub 1/2011. PMCID: PMC3059048.

Wang J, Gong Z, Chen J. MDC1 collaborates with TopBP1 in DNA replication checkpoint control. J Cell Biol 193(2):267-73, 4/2011. e-Pub 4/2011. PMCID: PMC3080258.

Ichijima Y, Ichijima M, Lou Z, Nussenzweig A, Camerini-Otero RD, Chen J, Andreassen PR, Namekawa SH. MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes Dev 25(9):959-71, 5/2011. PMCID: PMC3084029.

Sy SM, Jiang J, Dong SS, Lok GT, Wu J, Cai H, Yeung ES, Huang J, Chen J, Deng Y, Huen MS. Critical Roles of Ring Finger Protein RNF8 in Replication Stress Responses. J Biol Chem 286(25):22355-61, 6/2011. e-Pub 5/2011. PMCID: PMC3121383.

Gong Z, Chen J. E3 Ligase RFWD3 Participates in Replication Checkpoint Control. J Biol Chem 286(25):22308-13, 6/2011. e-Pub 4/2011. PMCID: PMC3121377.

Leung JW, Leitch A, Wood JL, Shaw-Smith C, Metcalfe K, Bicknell LS, Jackson AP, Chen J. SET Nuclear Oncogene Associates with Microcephalin/MCPH1 and Regulates Chromosome Condensation. J Biol Chem 286(24):21393-400, 6/2011. e-Pub 4/2011. PMCID: PMC3122199.

Ghosal G, Yuan J, Chen J. The HARP domain dictates the annealing helicase activity of HARP/SMARCAL1. EMBO Rep 12(6):574-80, 6/2011. e-Pub 4/2011. PMCID: PMC3128281.

Maddika S, Kavela S, Rani N, Palicharla VR, Pokorny JL, Sarkaria JN, Chen J. WWP2 is an E3 ubiquitin ligase for PTEN. Nat Cell Biol 13(6):728-33, 6/2011. e-Pub 5/2011. PMID: 21532586.

Liu T, Wan L, Wu Y, Chen J, Huang J. hSWS1{middle dot}SWSAP1 Is an Evolutionarily Conserved Complex Required for Efficient Homologous Recombination Repair. J Biol Chem 286(48):41758-66, 12/2011. e-Pub 9/2011. PMCID: PMC3308884.

Rai R, Li JM, Zheng H, Lok GT, Deng Y, Huen MS, Chen J, Jin J, Chang S. The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection. Nat Struct Mol Biol 18(12):1400-7, 12/2011. e-Pub 11/2011. PMCID: PMC3657743.

Yuan J, Chen J. MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX. J Biol Chem 285(2):1097-104, 1/2010. e-Pub 11/2009. PMCID: PMC2801237

Huen MS, Chen J. Assembly of checkpoint and repair machineries at DNA damage sites. Trends Biochem Sci. 2010 Feb;35(2):101-8. doi: 10.1016/j.tibs.2009.09.001. Epub 2009 Oct 28. Review. PubMed PMID: 19875294; PubMed Central PMCID: PMC3209802. 

Huen MS, Sy SM, Chen J. BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol. 2010 Feb;11(2):138-48. doi: 10.1038/nrm2831. Epub 2009 Dec 23. Review. PubMed PMID:20029420; PubMed Central PMCID:PMC3899800.

Richards MW, Leung JW, Roe SM, Li K, Chen J, Bayliss R. A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation. J Mol Biol 395(5):908-15, 2/2010. e-Pub 11/2009. PMCID: PMC2813331.

Gong Z, Kim JE, Leung CC, Glover JN, Chen J. BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control. Mol Cell 37(3):438-46, 2/2010. PMCID: PMC3695484.

Escande C, Chini CC, Nin V, Dykhouse KM, Novak CM, Levine J, van Deursen J, Gores GJ, Chen J, Lou Z, Chini EN. Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest 120(2):545-58, 2/2010. e-Pub 1/2010. PMCID: PMC2810074.

Becherel OJ, Jakob B, Cherry AL, Gueven N, Fusser M, Kijas AW, Peng C, Katyal S, McKinnon PJ, Chen J, Epe B, Smerdon SJ, Taucher-Scholz G, Lavin MF. CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response. Nucleic Acids Res 38(5):1489-503, 3/2010. e-Pub 12/2009. PMCID: PMC2836575.

Huen MS, Huang J, Leung JW, Sy SM, Leung KM, Ching YP, Tsao SW, Chen J. Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1. Mol Cell 37(6):854-64, 3/2010. PMCID: PMC3695488.

Park G, Gong Z, Chen J, Kim JE. Characterization of the DOT1L network: implications of diverse roles for DOT1L. Protein J 29(3):213-23, 4/2010. PMID: 20431927.

Wang J, Chen J. SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60. J Biol Chem 285(15):11458-64, 4/2010. e-Pub 1/2010. PMCID: PMC2857024.

Santos MA, Huen MS, Jankovic M, Chen HT, López-Contreras AJ, Klein IA, Wong N, Barbancho JL, Fernandez-Capetillo O, Nussenzweig MC, Chen J, Nussenzweig A. Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8. J Exp Med 207(5):973-81, 5/2010. e-Pub 4/2010. PMCID: PMC2867275.

Huen MS, Chen J. ATM Creates a veil of transcriptional silence. Cell. 2010 Jun 11;141(6):924-6. doi: 10.1016/j.cell.2010.05.035. PubMed PMID:20550929.

Lim JH, Lee YM, Chun YS, Chen J, Kim JE, Park JW. Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell 38(6):864-78, 6/2010. PMID: 20620956.

Huen MS, Sy SM, Leung KM, Ching YP, Tipoe GL, Man C, Dong S, Chen J. SON is a spliceosome-associated factor required for mitotic progression. Cell Cycle 9(13). e-Pub 7/2010. PMID: 20581448.

Liu T, Ghosal G, Yuan J, Chen J, Huang J. FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand Cross-Link Repair. Science 329(5992):693-6, 8/2010. e-Pub 7/2010. PMID: 20671156.

Yuan J, Adamski R, Chen J. Focus on histone variant H2AX: to be or not to be. FEBS Lett. 2010 Sep 10;584(17):3717-24. doi: 10.1016/j.febslet.2010.05.021. Epub 2010 May 21. Review. PubMed PMID:20493860; PubMed Central PMCID:PMC3695482.

Dray E, Etchin J, Wiese C, Saro D, Williams GJ, Hammel M, Yu X, Galkin VE, Liu D, Tsai MS, Sy SM, Schild D, Egelman E, Chen J, Sung P. Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. Nat Struct Mol Biol 17(10):1255-9, 10/2010. e-Pub 9/2010. PMCID: PMC2950913.

Feng L, Wang J, Chen J. The Lys 63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments. J Biol Chem 285(40):30982-8, 10/2010. e-Pub 7/2010. PMCID: PMC2945589.

Liu T, Huang J, Chen J. RAD18 lives a double life: Its implication in DNA double-strand break repair. DNA Repair (Amst). 2010 Dec 10;9(12):1241-8. doi: 10.1016/j.dnarep.2010.09.016. PubMed PMID: 20971043. 

Wu J, Huen MS, Lu LY, Ye L, Dou Y, Ljungman M, Chen J, Yu X. Histone ubiquitination associates with BRCA1-Dependent DNA Damage Response. Mol Cell Biol 29(3):849-860, 2/2009. e-Pub 11/2008. PMCID: PMC2630672.

Luo K, Yuan J, Chen J, Lou Z. Topoisomerase IIalpha controls the decatenation checkpoint. Nat Cell Biol 11(2):204-10, 2/2009. e-Pub 12/2008. PMCID: PMC2712943.

Gong Z, Cho YW, Kim JE, Ge K, Chen J. Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage. J Biol Chem 284(11):7284-93, 3/2009. e-Pub 1/2009. PMCID: PMC2652327.

Feng L, Huang J, Chen J. MERIT40 facilitates BRCA1 localization and DNA damage repair. Genes Dev 23(6):719-28, 3/2009. e-Pub 3/2009. PMCID: PMC2661609.

Sy SM, Huen MS, Chen J. PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci U S A 106(17):7155-60, 4/2009. e-Pub 4/2009. PMCID: PMC2678481.

Maddika S, Chen J. Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. Nat Cell Biol 11(4):409-19, 4/2009. e-Pub 3/2009. PMCID: PMC2754075.

Maddika S, Sy SM, Chen J. Functional interaction between Chfr and Kif22 controls genomic stability. J Biol Chem 284(19):12998-3003, 5/2009. e-Pub 3/2009. PMCID: PMC2676032.

Huang J, Huen MS, Kim H, Leung CC, Glover JN, Yu X, Chen J. RAD18 transmits DNA damage signalling to elicit homologous recombination repair. Nat Cell Biol 11(5):592-603, 5/2009. e-Pub 4/2009. PMCID: PMC2743127.

Sy SM, Huen MS, Zhu Y, Chen J. PALB2 Regulates Recombinational Repair through Chromatin Association and Oligomerization. J Biol Chem 284(27):18302-10, 7/2009. e-Pub 5/2009. PMCID: PMC2709360.

Cao L, Xu X, Bunting SF, Liu J, Wang RH, Cao LL, Wu JJ, Peng TN, Chen J, Nussenzweig A, Deng CX, Finkel T. A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol Cell 35(4):534-41, 8/2009. PMID: 19716796.

Sy SM, Huen MS, Chen J. MRG15 is a novel PALB2-interacting factor involved in homologous recombination. J Biol Chem 284(32):21127-31, 8/2009. e-Pub 6/2009. PMCID: PMC2755835.

Huang J, Gong Z, Ghosal G, Chen J. SOSS complexes participate in the maintenance of genomic stability. Mol Cell 35(3):384-93, 8/2009. PMCID: PMC2756616.

Fu Z, Regan K, Zhang L, Muders MH, Thibodeau SN, French A, Wu Y, Kaufmann SH, Lingle WL, Chen J, Tindall DJ. Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice. J Clin Invest 119(9):2714-24, 9/2009. e-Pub 8/2009. PMCID: PMC2735912.

Kim JE, Chen J, Lou Z. p30 DBC is a potential regulator of tumorigenesis. Cell Cycle. 2009 Sep 15;8(18):2932-5. doi: 10.4161/cc.8.18.9473. Epub 2009 Sep 8. Review. PubMed PMID:19657230; PubMed Central PMCID:PMC2777512.

Yuan J, Ghosal G, Chen J. The annealing helicase HARP protects stalled replication forks. Genes Dev 23(20):2394-9, 10/2009. e-Pub 9/2009. PMCID: PMC2764499.

Kim JE, Lou Z, Chen J. Interactions between DBC1 and SIRT 1 are deregulated in breast cancer cells. Cell Cycle 8(22):3784-5, 11/2009. e-Pub 11/2009. PMID: 19855164.

Yuan J, Chen J. N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair. J Biol Chem 284(46):31746-52, 11/2009. e-Pub 9/2009. PMCID: PMC2797245.

Ande SR, Chen J, Maddika S. The ubiquitin pathway: an emerging drug target in cancer therapy. Eur J Pharmacol 625(1-3):199-205, 12/2009. e-Pub 10/2009. PMID: 19835866.

Huen MS, Chen J. The DNA damage response pathways: at the crossroad of protein modifications. Cell Res. 2008 Jan;18(1):8-16. doi: 10.1038/cr.2007.109. Review. PubMed PMID:18087291.

Kim JE, Chen J, Lou Z. DBC1 is a negative regulator of SIRT1. Nature 451(7178):583-6, 1/2008. PMID: 18235501.

Huen MS, Sy SM, van Deursen JM, Chen J. Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication. J Biol Chem 283(17):11073-7, 4/2008. e-Pub 3/2008. PMCID: PMC2431066.

Steger DJ, Lefterova MI, Ying L, Stonestrom AJ, Schupp M, Zhuo D, Vakoc AL, Kim JE, Chen J, Lazar MA, Blobel GA, Vakoc CR. DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Mol Cell Biol 28(8):2825-39, 4/2008. e-Pub 2/2008. PMCID: PMC2293113.

Minter-Dykhouse K, Ward I, Huen MS, Chen J, Lou Z. Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis. J Cell Biol 181(5):727-35, 6/2008. e-Pub 5/2008. PMCID: PMC2396806.

Kim H, Chen J. New players in the BRCA1-mediated DNA damage responsive pathway. Mol Cells. 2008 Jun 30;25(4):457-61. Epub 2008 Apr 24. Review. PubMed PMID:18443409; PubMed Central PMCID:PMC3873642.

Huang J, Chen J. VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation. Oncogene 27(29):4056-64, 7/2008. e-Pub 3/2008. PMID: 18332868.

Wu L, Beito T, Chen J. Generation and characterization of novel monoclonal antibodies against human aurora-A. Hybridoma (Larchmt) 27(4):313-8, 8/2008. PMCID: PMC3186696.

Wu L, Luo K, Lou Z, Chen J. MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Proc Natl Acad Sci U S A 105(32):11200-5, 8/2008. e-Pub 8/2008. PMCID: PMC2516250.

Xu C, Wu L, Cui G, Botuyan MV, Chen J, Mer G. Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites. J Mol Biol 381(2):361-72, 8/2008. e-Pub 6/2008. PMCID: PMC2574983.

Fu Z, Malureanu L, Huang J, Wang W, Li H, van Deursen JM, Tindall DJ, Chen J. Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat Cell Biol 10(9):1076-82, 9/2008. PMCID: PMC2882053.

Wood JL, Liang Y, Li K, Chen J. Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair. J Biol Chem 283(43):29586-92, 10/2008. e-Pub 8/2008. PMCID: PMC2570891.

Huen MS, Huang J, Yuan J, Yamamoto M, Akira S, Ashley C, Xiao W, Chen J. Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly. Mol Cell Biol 28(19):6104-12, 10/2008. e-Pub 8/2008. PMCID: PMC2547017.

Lu LY, Wood JL, Ye L, Minter-Dykhouse K, Saunders TL, Yu X, Chen J. Aurora A is essential for early embryonic development and tumor suppression. J Biol Chem 283(46):31785-31790, 11/2008. e-Pub 9/2008. PMCID: PMC2581543.

Lu LY, Wood JL, Minter-Dykhouse K, Ye L, Saunders TL, Yu X, Chen J. Polo-like kinase 1 is essential for early embryonic development and tumor suppression. Mol Cell Biol 28(22):6870-6, 11/2008. e-Pub 9/2008. PMCID: PMC2573299.

Huen MS, Chen J. When loose ends finally meet. Nat Struct Mol Biol. 2008 Dec;15(12):1241-2. doi: 10.1038/nsmb1208-1241. PubMed PMID:19050718; NIHMSID:NIHMS103841.

Kim H, Chen J, Yu X. Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science 316(5828):1202-5, 5/2007. PMID: 17525342.

Kim H, Huang J, Chen J. CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. Nat Struct Mol Biol 14(8):710-5, 8/2007. e-Pub 7/2007. PMID: 17643122.

Ahmed EA, van der Vaart A, Barten A, Kal HB, Chen J, Lou Z, Minter-Dykhouse K, Bartkova J, Bartek J, de Boer P, de Rooij DG. Differences in DNA double strand breaks repair in male germ cell types: lessons learned from a differential expression of Mdc1 and 53BP1. DNA Repair (Amst) 6(9):1243-54, 9/2007. e-Pub 3/2007. PMID: 17376750.

Kim H, Chen J. c-Myc interacts with TRF1/PIN2 and regulates telomere length. Biochem Biophys Res Commun 362(4):842-7, 11/2007. e-Pub 8/2007. PMCID: PMC2047600.

Wood JL, Singh N, Mer G, Chen J. MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem 282(48):35416-23, 11/2007. e-Pub 10/2007. PMCID: PMC2128040.

Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J. RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell 131(5):901-14, 11/2007. e-Pub 11/2007. PMCID: PMC2149842.

Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A, Nagaraju G, Yan C, Alt FW, Chen J, Jackson SP, Scully R. Distinct Roles of Chromatin-Associated Proteins MDC1 and 53BP1 in Mammalian Double-Strand Break Repair. Mol Cell 28(6):1045-1057, 12/2007. PMCID: PMC2275782.

Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW. H2AX prevents DNA breaks from Progressing to Chromosome breaks and Translocations. Mol Cell 21(2):201-214, 1/2006. PMID: 16427010.

Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell 21(2):187-200, 2006. PMID: 16427009.

Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature 440(7080):105-9, 3/2006. e-Pub 1/2006. PMID: 16400328.

Kim JE, Minter-Dykhouse K, Chen J. Signaling networks controlled by the MRN complex and MDC1 during early DNA damage responses. Mol Carcinog. 2006 Jun;45(6):403-8. doi: 10.1002/mc.20221. Review. PubMed PMID:16691596.

Yu X, Fu S, Lai M, Baer R, Chen J. BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP. Genes Dev 20(13):1721-6, 7/2006. PMCID: PMC1522068.

Chini CC, Wood J, Chen J. Chk1 is required to maintain claspin stability. Oncogene 25(30):4165-71, 7/2006. e-Pub 2/2006. PMID: 16501606.

Wu X, Dong X, Liu W, Chen J. Characterization of CHEK2 mutations in prostate cancer. Hum Mutat 27(8):742-7, 8/2006. PMID: 16835864.

Huang H, Regan KM, Lou Z, Chen J, Tindall DJ. CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science 314(5797):294-7, 10/2006. PMID: 17038621.

Lou Z, Chen J. Cellular senescence and DNA repair. Exp Cell Res. 2006 Aug 15;312(14):2641-6. doi: 10.1016/j.yexcr.2006.06.009. Epub 2006 Jun 20. Review. PubMed PMID:16893723.

Lai M, Chen J. The role of Vpr in HIV-1 disease progression is independent of its G2 arrest induction function. Cell Cycle 5(19):2275-80, 10/2006. e-Pub 10/2006. PMID: 16969134.

Chini CC, Chen J. Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function. J Biol Chem 281(44):33276-33282, 11/2006. e-Pub 9/2006. PMID: 16963448.

Botuyan MV, Lee J, Ward IM, Kim JE, Thompson JR, Chen J, Mer G. Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell 127(7):1361-73, 12/2006. PMCID: PMC1804291.

Ward I, Kim JE, Minn K, Chini CC, Mer G, Chen J. The tandem BRCT domain of 53BP1 is not required for its repair function. J Biol Chem 281(50):38472-7, 12/2006. e-Pub 10/2006. PMCID: PMC1853281.

Kim JE, Billadeau DD, Chen J. The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis. J Biol Chem 280(7):5733-9, 2/2005. e-Pub 11/2004. PMID: 15545273.

Andersen JL, Zimmerman ES, DeHart JL, Murala S, Ardon O, Blackett J, Chen J, Planelles V. ATR and GADD45alpha mediate HIV-1 Vpr-induced apoptosis. Cell Death Differ 12(4):326-334, 4/2005. PMID: 15650754.

Yu X, Minter-Dykhouse K, Malureanu L, Zhao WM, Zhang D, Merkle CJ, Ward IM, Saya H, Fang G, van Deursen J, Chen J. Chfr is required for tumor suppression and Aurora A regulation. Nat Genet 37(4):401-6, 4/2005. e-Pub 3/2005. PMID: 15793587.

Ohashi A, Zdzienicka MZ, Chen J, Couch FJ. Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage. J Biol Chem 280(15):14877-83, 4/2005. e-Pub 1/2005. PMID: 15671039.

Lou Z, Minter-Dykhouse K, Chen J. BRCA1 participates in DNA decatenation. Nat Struct Mol Biol 12(7):589-93, 7/2005. e-Pub 6/2005. PMID: 15965487.

Liu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadiñanos J, López-Otín C, Tse HF, Hutchison C, Chen J, Cao Y, Cheah KS, Tryggvason K, Zhou Z. Genomic instability in laminopathy-based premature aging. Nat Med 11(7):780-785, 7/2005. e-Pub 6/2005. PMID: 15980864.

Ward IM, Difilippantonio S, Minn K, Mueller MD, Molina JR, Yu X, Frisk CS, Ried T, Nussenzweig A, Chen J. 53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice. Mol Cell Biol 25(22):10079-86, 11/2005. PMCID: PMC1280262.

Lou Z, Chen J. Mammalian DNA damage response pathway. Adv Exp Med Biol. 2005;570:425-55. doi: 10.1007/1-4020-3764-3_15. Review. PubMed PMID:18727510.

Baker DJ, Chen J, van Deursen JM. The mitotic checkpoint in cancer and aging: what have mice taught us?. Curr Opin Cell Biol. 2005 Dec;17(6):583-9. doi: 10.1016/j.ceb.2005.09.011. Epub 2005 Oct 13. Review. PubMed PMID:16226453.

Lai M, Zimmerman ES, Planelles V, Chen J. Activation of the ATR pathway by human immunodeficiency virus type 1 Vpr involves its direct binding to chromatin in vivo. J Virol 79(24):15443-51, 12/2005. PMCID: PMC1315993.

Karnitz LM, Flatten KS, Wagner JM, Loegering D, Hackbarth JS, Arlander SJ, Vroman BT, Thomas MB, Baek YU, Hopkins KM, Lieberman HB, Chen J, Cliby WA, Kaufmann SH. Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival. Mol Pharmacol 68(6):1636-44, 12/2005. e-Pub 8/2005. PMID: 16126823.

Kim JE, McAvoy SA, Smith DI, Chen J. Human TopBP1 ensures genome integrity during normal S phase. Mol Cell Biol 25(24):10907-15, 12/2005. PMCID: PMC1316943.

Ward IM, Minn K, Chen J. UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress. J Biol Chem 279(11):9677-80, 3/2004. e-Pub 1/2004. PMID: 14742437.

Ward IM, Reina-San-Martin B, Olaru A, Minn K, Tamada K, Lau JS, Cascalho M, Chen L, Nussenzweig A, Livak F, Nussenzweig MC, Chen J. 53BP1 is required for class switch recombination. J Cell Biol 165(4):459-64, 5/2004. PMCID: PMC2172356.

Botuyan MV, Nominé Y, Yu X, Juranic N, Macura S, Chen J, Mer G. Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains. Structure 12(7):1137-46, 7/2004. PMID: 15242590.

Ward I, Chen J. Early events in the DNA damage response. Curr Top Dev Biol. 2004;63:1-35. doi: 10.1016/S0070-2153(04)63001-8. Review. PubMed PMID:15536012.

Chini CC, Chen J. Claspin, a regulator of Chk1 in DNA replication stress pathway. DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1033-7. doi: 10.1016/j.dnarep.2004.03.001. Review. PubMed PMID:15279790.

Sengupta S, Robles AI, Linke SP, Sinogeeva NI, Zhang R, Pedeux R, Ward IM, Celeste A, Nussenzweig A, Chen J, Halazonetis TD, Harris CC. Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol 166(6):801-813, 9/2004. PMCID: PMC2172115.

Yu X, Chen J. DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol Cell Biol 24(21):9478-86, 11/2004. PMCID: PMC522253.

Zimmerman ES, Chen J, Andersen JL, Ardon O, Dehart JL, Blackett J, Choudhary SK, Camerini D, Nghiem P, Planelles V. Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus 1 and induces nuclear BRCA1 and gamma-H2AX focus formation. Mol Cell Biol 24(21):9286-9294, 11/2004. PMCID: PMC522272.

Lou Z, Chen BP, Asaithamby A, Minter-Dykhouse K, Chen DJ, Chen J. MDC1 regulates DNA-PK autophosphorylation in response to DNA damage. J Biol Chem 279(45):46359-62, 11/2004. e-Pub 9/2004. PMID: 15377652.

Lou Z, Minter-Dykhouse K, Wu X, Chen J. MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature 421(6926):957-61, 2/2003. PMID: 12607004.

Lou Z, Chini CC, Minter-Dykhouse K, Chen J. Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control. J Biol Chem 278(16):13599-602, 4/2003. e-Pub 2/2003. PMID: 12611903.

Ward IM, Minn K, van Deursen J, Chen J. p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol Cell Biol 23(7):2556-63, 4/2003. PMCID: PMC150747.

Ward IM, Minn K, Jorda KG, Chen J. Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. J Biol Chem 278(22):19579-82, 5/2003. e-Pub 4/2003. PMID: 12697768.

Lou Z, Chen J. BRCA proteins and DNA damage checkpoints. Front Biosci. 2003 May 1;8:s718-21. doi: 10.2741/1127. Review. PubMed PMID:12700125.

Yamane K, Chen J, Kinsella TJ. Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint. Cancer Res 63(12):3049-3053, 6/2003. PMID: 12810625.

Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J. Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. J Biol Chem 278(32):30051-6, 8/2003. e-Pub 5/2003. PMID: 12766176.

Chini CC, Chen J. Human claspin is required for replication checkpoint control. J Biol Chem 278(32):30057-62, 8/2003. e-Pub 5/2003. PMID: 12766152.

Wu X, Chen J. Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis. J Biol Chem 278(38):36163-8, 9/2003. e-Pub 7/2003. PMID: 12855706.

Yu X, Chini CC, He M, Mer G, Chen J. The BRCT domain is a phospho-protein binding domain. Science 302(5645):639-42, 10/2003. PMID: 14576433.

Rodriguez M, Yu X, Chen J, Songyang Z. Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. J Biol Chem 278(52):52914-8, 12/2003. e-Pub 10/2003. PMID: 14578343.

Wu X, Webster SR, Chen J. Characterization of tumor-associated Chk2 mutations. J Biol Chem 276(4):2971-4, 1/2001. e-Pub 10/2000. PMID: 11053450.

Rappold I, Iwabuchi K, Date T, Chen J. Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. J Cell Biol 153(3):613-20, 4/2001. PMCID: PMC2190566.

Joukov V, Chen J, Fox EA, Green JB, Livingston DM. Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development. Proc Natl Acad Sci U S A 98(21):12078-83, 10/2001. e-Pub 10/2001. PMCID: PMC59770.

Ward IM, Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem 276(51):47759-62, 12/2001. e-Pub 10/2001. PMID: 11673449.

Ward IM, Wu X, Chen J. Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks. J Biol Chem 276(51):47755-47758, 12/2001. e-Pub 10/2001. PMID: 11668173.

Yamane K, Wu X, Chen J. A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. Mol Cell Biol 22(2):555-66, 1/2002. PMCID: PMC139754.

Sum EY, Peng B, Yu X, Chen J, Byrne J, Lindeman GJ, Visvader JE. The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. J Biol Chem 277(10):7849-56, 3/2002. e-Pub 12/2001. PMID: 11751867.

Fernandez-Capetillo O, Chen HT, Celeste A, Ward I, Romanienko PJ, Morales JC, Naka K, Xia Z, Camerini-Otero RD, Motoyama N, Carpenter PB, Bonner WM, Chen J, Nussenzweig A. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol 4(12):993-7, 12/2002. PMID: 12447390.

Scully R, Ganesan S, Vlasakova K, Chen J, Socolovsky M, Livingston DM. Genetic Analysis of BRCA1 function in a defined tumor cell line. Mol Cell 4(6):1093-1099, 12/1999. PMID: 10635334.

Wu X, Petrini JH, Heine WF, Weaver DT, Livingston DM, Chen J. Independence of R/M/N focus formation and the presence of intact BRCA1. Science 289(5476):11-11a, 7/2000. PMID: 10928918.

Chen J. Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage. Cancer Res 60(18):5037-5039, 9/2000. PMID: 11016625.

Wilson CA, Ramos L, Villaseñor MR, Anders KH, Press MF, Clarke K, Karlan B, Chen JJ, Scully R, Livingston D, Zuch RH, Kanter MH, Cohen S, Calzone FJ, Slamon DJ. Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas. Nat Genet 21(2):236-240, 2/1999. PMID: 9988281.

Chen JJ, Silver D, Cantor S, Livingston DM, Scully R. BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway. Cancer Res 59(7 Suppl):1752s-1756s, 4/1999. PMID: 10197592.

Saha P, Chen J, Thome KC, Lawlis SJ, Hou ZH, Hendricks M, Parvin JD, Dutta A. Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. Mol Cell Biol 18(5):2758-67, 5/1998. PMCID: PMC110655.

Geraghty DS, Sucic HB, Chen J, Pederson DS. Evidence that partial unwrapping of DNA from nucleosomes facilitates the binding of heat shock factor following DNA replication in yeast. J Biol Chem 273(32):20463-72, 8/1998. PMID: 9685401.

Chen J, Silver DP, Walpita D, Cantor SB, Gazdar AF, Tomlinson G, Couch FJ, Weber BL, Ashley T, Livingston DM, Scully R. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell 2(3):317-28, 9/1998. PMID: 9774970.

Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T, Livingston DM. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88(2):265-75, 1/1997. PMID: 9008167.

Scully R, Chen J, Ochs RL, Keegan K, Hoekstra M, Feunteun J, Livingston DM. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell 90(3):425-35, 8/1997. PMID: 9267023.

Chen J, Peters R, Saha P, Lee P, Theodoras A, Pagano M, Wagner G, Dutta A. A 39 amino acid fragment of the cell cycle regulator p21 is sufficient to bind PCNA and partially inhibit DNA replication in vivo. Nucleic Acids Res 24(9):1727-33, 5/1996. PMCID: PMC145832.

Leiter LM, Chen J, Marathe T, Tanaka M, Dutta A. Loss of transactivation and transrepression function, and not RPA binding, alters growth suppression by p53. Oncogene 12(12):2661-8, 1996. PMID: 8700525.

Chen J, Saha P, Kornbluth S, Dynlacht BD, Dutta A. Cyclin-binding motifs are essential for the function of p21CIP1. Mol Cell Biol 16(9):4673-82, 9/1996. PMCID: PMC231467.

Chen J, Chen S, Saha P, Dutta A. p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex. Proc Natl Acad Sci U S A 93(21):11597-602, 10/1996. PMCID: PMC38103.

Chen J, Jackson PK, Kirschner MW, Dutta A. Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature 374(6520):386-8, 3/1995. PMID: 7885482.

Chen J, Ding M, Pederson DS. Binding of TFIID to the CYC1 TATA boxes in yeast occurs independently of upstream activating sequences. Proc Natl Acad Sci U S A 91(25):11909-13, 12/1994. PMCID: PMC45345.

Chen J, Pederson DS. A distal heat shock element promotes the rapid response to heat shock of the HSP26 gene in the yeast Saccharomyces cerevisiae. J Biol Chem 268(10):7442-8, 4/1993. PMID: 8463277.