Junjie Chen Laboratory
Junjie Chen, Ph.D.
Principal Investigator
- Departments, Labs and Institutes
- Labs
- Junjie Chen Laboratory
Areas of Research
- Breast Cancer
- DNA Damage Response
- DNA Repair
- Genetics
- Genome Stability
- Hereditary Cancer Syndrome
- Homologous Recombination
- Ovarian Cancer
- Proteomics
- Radiation Therapy
- Tumor Suppression
The Chen Laboratory investigates the roles of tumor suppressor genes and oncogenes in DNA repair and other signaling pathways involved in tumor initiation, progression and metastasis.
Research Focus
- Molecular mechanisms of DNA damage response and repair pathways in genome maintenance and tumor suppression
- Proteomic analysis of oncogenic and tumor suppressive pathways
- Investigation of gene-gene and gene-drug interactions involved in cancer development and therapy
The Chen Laboratory studies many aspects of DNA damage response and DNA repair pathways, which include radiation-induced DNA damage response (DDR), BRCA1/2 and homologous recombination repair, replication stress pathway and lesion bypass, Fanconi anemia pathway and interstrand crosslink repair, Spartan/C1orf124/DVC1 and DNA-protein crosslink repair, and more recently the roles of DNA damage response in innate immunity. We also conduct mass spectrometry-based proteomic studies of various signaling pathways involved in tumorigenesis. In addition, we perform whole genome CRISPR/Cas9 screens to investigate gene-gene and gene-drug interactions involved in cancer development and cancer therapy.
Publications
Lab Members
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Contact Information
Principal Investigator
Junjie Chen, Ph.D.
Professor and Chair
Email: jchen8@mdanderson.org
Administrative Contact
Kim Do
Operations Manager
Ph. 832-750-0186
Email: kdo1@mdanderson.org
Location Information
Junjie Chen Laboratory
Experimental Radiation Oncology department
Sheikh Zayed Bin Sultan Al Nahyan Building
The University of Texas MD Anderson Cancer Center
6565 MD Anderson Boulevard,
Houston, Texas 77030
Ph. 713-792-3424
Fax 713-794-5369
Mailing address
1515 Holcombe Boulevard, Unit 1052
Houston, Texas 77030