Publications

Zehrbach NM, Oh N, Ishak CA. Insights into LINE-1 reverse transcription guide therapy development. Trends Cancer. 2024 Apr;10(4):286-288. PMID: 38499453

Hosseini A, Lindholm HT, Chen R, Mehdipour P, Marhon SA, Ishak CA, Moore PC, Classon M, Di Gioacchino A, Greenbaum B, De Carvalho DD. Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer. Cell Rep. 2024 Feb 27;43(2):113684. PMID: 38261511 

Viner C, Ishak CA, Johnson J, Walker NJ, Shi H, Sjöberg-Herrera HK, Shen SY, Lardo SM, Adams DJ, Ferguson-Smith AC, De Carvalho DD, Hainer SJ, Bailey TL, Hoffman MM. Modeling methyl-sensitive transcription factor motifs with an expanded epigenetic alphabet. Genome Biol. 2024 Jan 8;25(1):11. PMID: 38191487

Chen R, Ishak CA, De Carvalho DD. Endogenous Retroelements and the Viral Mimicry Response in Cancer Therapy and Cellular Homeostasis. Cancer Discov. 2021 Nov;11(11):2707-2725. PMID: 34649957 Review.

Loo Yau H, Bell E, Ettayebi I, de Almeida FC, Boukhaled GM, Shen SY, Allard D, Morancho B, Marhon SA, Ishak CA, Gonzaga IM, da Silva Medina T, Singhania R, Chakravarthy A, Chen R, Mehdipour P, Pommey S, Klein C, Amarante-Mendes GP, Roulois D, Arribas J, Stagg J, Brooks DG, De Carvalho DD. DNA hypomethylating agents increase activation and cytolytic activity of CD8⁺ T cells. Mol Cell. 2021 Apr 1;81(7):1469-1483.e8. PMID: 33609448 

Ishak CA, Loo Yau H, De Carvalho DD. Spliceosome-Targeted Therapies Induce dsRNA Responses. Immunity. 2021 Jan 12;54(1):11-13. PMID: 33440135 

Mehdipour P, Marhon SA, Ettayebi I, Chakravarthy A, Hosseini A, Wang Y, de Castro FA, Loo Yau H, Ishak C, Abelson S, O'Brien CA, De Carvalho DD. Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency.  Nature. 2020 Dec;588(7836):169-173. PMID: 33087935

Ishak CA, De Carvalho DD. DNA Methylation Profiling of Premalignant Lesions as a Path to Ovarian Cancer Early Detection. Clin Cancer Res. 2020 Dec 1;26(23):6083-6085. PMID: 32988966 (Comment on Methylomic Landscapes of Ovarian Cancer Precursor Lesions, Pianic et al, Clin Cancer Res. 2020)

Kent OA, Saha M, Coyaud E, Burston HE, Law N, Dadson K, Chen S, Laurent EM, St-Germain J, Sun RX, Matsumoto Y, Cowen J, Montgomery-Song A, Brown KR, Ishak C, Rose J, De Carvalho DD, He HH, Raught B, Billia F, Kannu P, Rottapel R. Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes. Nat Commun. 2020 Sep 16;11(1):4673. PMID: 32938917 

Ishak CA, De Carvalho DD. Reactivation of Endogenous Retroelements in Cancer Development and Therapy. Annu Rev Cancer Biol. 2020 Mar; 4:159-176.

Taylor K, Loo Yau H, Chakravarthy A, Wang B, Shen SY, Ettayebi I, Ishak CA, Bedard PL, Abdul Razak A, R Hansen A, Spreafico A, Cescon D, Butler MO, Oza AM, Lheureux S, Stjepanovic N, Van As B, Boross-Harmer S, Wang L, Pugh TJ, Ohashi PS, Siu LL, De Carvalho DD. An open-label, phase II multicohort study of an oral hypomethylating agent CC-486 and durvalumab in advanced solid tumors. J Immunother Cancer. 2020 Aug;8(2):e000883. PMID: 32753546 

Marshall AE, Ishak CA, Dick FA. An RB-Condensin II Complex Mediates Long-Range Chromosome Interactions and Influences Expression at Divergently Paired Genes. Mol Cell Biol. 2020 Jan 3;40(2):e00452-19. PMID: 31685548 

Ishak CA, Lheureux S, De Carvalho DD. DNA Methylation as a Robust Classifier of Epithelial Ovarian Cancer. Clin Cancer Res. 2019 Oct 1;25(19):5729-5731. PMID: 31337645

Ishak CA, Classon M, De Carvalho DD. Deregulation of Retroelements as an Emerging Therapeutic Opportunity in Cancer. Trends Cancer. 2018 Aug;4(8):583-597. PMID: 30064665 Review.

Ishak CA, Cecchini MJ, Howlett CJ, Dick FA. Immunohistochemical Detection of the Retinoblastoma Protein. Methods Mol Biol. 2018;1726:65-75. PMID: 29468544

Ishak CA, Coschi CH, Roes MV, Dick FA. Disruption of CDK-resistant chromatin association by pRB causes DNA damage, mitotic errors, and reduces Condensin II recruitment. Cell Cycle. 2017 Aug 3;16(15):1430-1439. PMID: 28723239 

Ishak CA, Marshall AE, Passos DT, White CR, Kim SJ, Cecchini MJ, Ferwati S, MacDonald WA, Howlett CJ, Welch ID, Rubin SM, Mann MRW, Dick FA . An RB-EZH2 Complex Mediates Silencing of Repetitive DNA Sequences. Mol Cell. 2016 Dec 15;64(6):1074-1087. PMID: 27889452 

Cecchini MJ, Ishak CA, Passos DT, Warner A, Palma DA, Howlett CJ, Driman DK, Dick FA. Loss of the retinoblastoma tumor suppressor correlates with improved outcome in patients with lung adenocarcinoma treated with surgery and chemotherapy. Hum Pathol. 2015 Dec;46(12):1922-34. PMID: 26475095

Ishak CA, Dick FA. Conditional haploinsufficiency of the retinoblastoma tumor suppressor gene. Mol Cell Oncol. 2014 Oct 30;2(1):e968069. PMID: 27308386 

Coschi CH, Ishak CA, Gallo D, Marshall A, Talluri S, Wang J, Cecchini MJ, Martens AL, Percy V, Welch I, Boutros PC, Brown GW, Dick FA. Haploinsufficiency of an RB-E2F1-Condensin II complex leads to aberrant replication and aneuploidy. Cancer Discov. 2014 Jul;4(7):840-53. PMID: 24740996

Forristal C, Henley SA, MacDonald JI, Bush JR, Ort C, Passos DT, Talluri S, Ishak CA, Thwaites MJ, Norley CJ, Litovchick L, DeCaprio JA, DiMattia G, Holdsworth DW, Beier F, Dick FA. Loss of the mammalian DREAM complex deregulates chondrocyte proliferation. Mol Cell Biol. 2014 Jun;34(12):2221-34. PMID: 24710275