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Selected Publications

Barekatain, Y., Ackroyd, J.J., Yan, V.C., Khadka, S., Wang, L., Chen, K.-C., Poral, A.H., Georgiou, D.K., Arthur, K., Lin, Y.-H., Satani, N., Ballato, E.S., Behr, E., deCarvalho, A., Verhaak, R., de Groot, J., Huse, J.T., Asara, J.M., Kalluri, R., Muller, F.L. “Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine”. Nat Commun 2021; 12, 4228
Fukumura, K., Malgulwar, P.B., Fischer, G.M., Hu, X., Mao, X., Song, X., Hernandez, S., Zhang, X.H.-F., Zhang, J., Parra, E.R., Yu, D., Debeb, B.G., Davies, M.A., Huse, J.T. “Multi-omic molecular profiling reveals potentially targetable abnormalities shared across multiple histologies of brain metastasis”. Acta Neuropathol 2021; 141, 303-321.
Lee, W.C., Reuben, A., Hu, X., McGranahan, N., Chen, R., Jalali, A., Negrao, M.V., Hubert, S.M., Tang, C., Wu, C.C., San Lucas, A., Roh, W., Suda, K., Kim, J., Tan, A.C., Peng, D.H., Lu, W., Tang, X., Chow, C.W., Fujimoto, J., Behrens, C., Kalhor, N., Fukumura, K., Coyle, M., Thornton, R., Li, J., Wu, C.J., Little, L., Roarty, E., Song, X., Lee, J.J., Sulman, E.P., Rao, G., Swisher, S., Diao, L., Wang, J., Heymach, J.V., Huse, J.T., Scheet, P., Wistuba, I.I., Gibbons, D.L., Futreal, P.A., Gomez, D., Zhang, J.“Multiomics profiling of primary lung cancers and distant metastases reveals immunosuppression as a common characteristic of tumor cells with metastatic plasticity”. Genome Biol 2020; 21, 271.
Barekatain, Y., Yan, V.C., Arthur, K., Ackroyd, J.J., Khadka, S., De Groot, J., Huse, J.T., Muller, F.L. “Robust detection of oncometabolic aberrations by 1H-13C heteronuclear single quantum correlation in intact biological specimens”. Commun Biol 2020; 3, 328.
Zhang, L., Wei, Y., Zhou, Z., Yao, J., Li, P., Qu, J., Badu-Nkansah, A., Yuan, X., Huang, Y.-W., Fukumura, K., Mao, X., Chang, W.-C., Saunus, J., Lakhani, S., Huse, J.T., Hung, M.-C., Yu, D. “Blocking immunosuppressive neutrophils deters pY696-EZH2-driven brain metastases”. Sci Transl Med 2020; 12, eaaz5387.
Wang, Y., Wild, A.T., Turcan, S., Wu, W.H., Sigel, C., Klimstra, D.S., Ma, X., Gong, Y., Huse, J.T., Chan, T.A. “Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH mutant gliomas and cholangiocarcinomas”. Sci Adv 2020; 6, eaaz3221.
Ostrom, Q., Egan, K.L., Nabors, B., Gerke, T., Thompson, R.C., Olson, J.J., LaRocca, R., Chowdhary, S., Eckel-Passow, J.E., Armstrong, G., Wienke, J.K., Bernstein, J.L., Claus, E.B., Il’yasova, D., Johansen, C., Lachance, D.H., Lai, R., Merrell, R.T., Olson, S.H., Sadetzki, S., Schildkraut, J., Shete, S., Houlston, R.S., Jenkins, R.B., Wrensch, M., Melin, B., Amos, C.I., Huse, J.T., Barnholtz-Sloan, J.S., Bondy, M. “Glioma risk associated with extent of estimated European genetic ancestry in African-Americans and Hispanics”. Int J of Cancer 2020; 146, 739-748.
Gates, E.D.H., Yang, J., Fukumura, K., Lin, J.S., Weinberg, J.S., Prabhu, S.S., Long, L., Fuentes, D., Sulman, E.P., Huse, J.T.*, Schellingerhout, D.* “Spatial distance correlates with genetic distance in diffuse glioma”. Front Oncol 2019; 9, 676.
Farooqi, A., Yang, J., Sharin, V., Ezhilarasan, R., Danussi, C., Alvarez, C., Dharmaiah, S., Irvin, D., Huse, J.T., Sulman, E.P. “Identification of patient-derived glioblastoma stem cell (GSC) lines with alternative lengthening of telomeres phenotype”. Acta Neuropath Commun 2019; 7, 76.
Fischer, G.M., Jalali, A., Kircher, D.A., Lee, W.-C., McQuade, J.L., Haydu, L.E., Joon, A.Y., Reuben, A., Petaccia de Macedo, M., Carapeto, F., Yang, C., Srivastava, A., Randjelovic, J., Ambati, C.R., Sreekumar, A., Hudgens, C., Knighton, B., Deng, W., Ferguson, S., Tawbi, H.A., Glitza, I., Gershenwald, J.E., Gopal, Y.N.V., Hwu, P., Huse, J.T., Wargo, J.A., Futreal, A., Putluri, N., Lazar, A.J., Deberardinis, R.J., Zhang, J., Holmen, S.L., Tetzlaff, M.T., Davies, M.A. “Molecular profiling reveals unique immune and metabolic features of melanoma brain metastases”. Cancer Discovery 2019; 9, 628-645.
Wang, Y., Yang, J., Danussi, C., Riggins, G.J., Kannan, K., Sulman, E.P., Chan, T.A., Huse, J.T. “G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma”. Nat Commun 2019; 10, 943.
Jacobs, D.I., Fukumura, K., Bainbridge, M.N., Armstrong, G.N., Tsavachidis, S., Gu, X., Doddapaneni, H.V., Hu, J., Jayaseelan, J.C., Muzny, D.M., Huse, J.T.*, Bondy, M.L.* “Elucidating the molecular pathogenesis of glioma: Integrated germline and somatic profiling of a familial glioma case series”. Neuro-oncol 2018; 20, 1625-1633.
Danussi, C., Bose, P., Parthasarathy, P.T., Silberman, P.C., Van Arnam, J.S., Vitucci, M., Tang. O., Heguy, A., Wang, Y., Chan, T.A., Riggins, G.J., Sulman, E.P. Lang, F., Creighton, C.J., Deneen, B., Miller, C.R., Picketts, D.J., Kannan, K., Huse, J.T. “Atrx deficiency drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling”. Nat Commun 2018; 9, 1057.
Huse, J.T., Snuderl, M., Jones, D.T.W., Brathwaite, C.D., Altman, N., Lavi, E., Saffery, R., Sexton-Oates, A., Blumcke, I., Capper, D., Karajannis, M.A., Benayed, R., Chavez, L., Thomas, C., Serrano, J., Borsu, L., Ladanyi, M., Rosenblum, M.K. “Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway”. Acta Neuropath 2017; 133, 417-429.
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