Publications

Ren J, Dai C, Zhou X, Barnes JA, Chen X, Wang Y, Yuan L, Shingu T, Heimberger AB, Chen Y, Hu J. Qki is an essential regulator of microglial phagocytosis in demyelination. J Exp Med. 2021 Jan 4;218(1):e20190348. doi: 10.1084/jem.20190348. PMID: 33045062; PMCID: PMC7543092.

Ott M, Tomaszowski KH, Marisetty A, Kong LY, Wei J, Duna M, Blumberg K, Ji X, Jacobs C, Fuller GN, Langford LA, Huse JT, Long JP, Hu J, Li S, Weinberg JS, Prabhu SS, Sawaya R, Ferguson S, Rao G, Lang FF, Curran MA, Heimberger AB. Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration. JCI Insight. 2020 Sep 3;5(17):e134386. doi: 10.1172/jci.insight.134386. PMID: 32721947; PMCID: PMC7526457.

Han KS, Yu Z, Wang H, Redfern PC, Ma L, Cheng L, Chen Y, Hu JZ, Curtiss LA, Xu K, Murugesan V, Mueller KT. Origin of Unusual Acidity and Li⁺ Diffusivity in a Series of Water-in-Salt Electrolytes. J Phys Chem B. 2020 Jun 25;124(25):5284-5291. doi: 10.1021/acs.jpcb.0c02483. Epub 2020 Jun 16. PMID: 32484675.

Chen D, Li G, Ji C, Lu Q, Qi Y, Tang C, Xiong J, Hu J, Yasar FBA, Zhang Y, Hoon DSB, Yao Y, Zhou L. Enhanced B7-H4 expression in gliomas with low PD-L1 expression identifies super-cold tumors. J Immunother Cancer. 2020 May;8(1):e000154. doi: 10.1136/jitc-2019-000154. PMID: 32457124; PMCID: PMC7253052.

Zhou X, He C, Ren J, Dai C, Stevens SR, Wang Q, Zamler D, Shingu T, Yuan L, Chandregowda CR, Wang Y, Ravikumar V, Rao AU, Zhou F, Zheng H, Rasband MN, Chen Y, Lan F, Heimberger AB, Segal BM, Hu J. Mature myelin maintenance requires Qki to coactivate PPARβ-RXRα-mediated lipid metabolism. J Clin Invest. 2020 May 1;130(5):2220-2236. doi: 10.1172/JCI131800. PMID: 32202512; PMCID: PMC7191000.

Zhang Y, Chen C, Hu J, Han Y, Huang M, Xiang J, Li H. Early outcomes of robotic versus thoracoscopic segmentectomy for early-stage lung cancer: A multi- institutional propensity score-matched analysis. J Thorac Cardiovasc Surg. 2020 Nov;160(5):1363-1372. doi: 10.1016/j.jtcvs.2019.12.112. Epub 2020 Jan 25. PMID: 32113718.

Chen Q, Zhao M, Yin C, Feng S, Hu J, Zhang Q, Ma X, Xue W, Shi J. Hypomethylation of 111 Probes Predicts Poor Prognosis for Glioblastoma. Front Neurosci. 2019 Oct 25;13:1137. doi: 10.3389/fnins.2019.01137. PMID: 31708732; PMCID: PMC6823878.

Li F, Deng Z, Zhang L, Wu C, Jin Y, Hwang I, Vladimirova O, Xu L, Yang L, Lu B, Dheekollu J, Li JY, Feng H, Hu J, Vakoc CR, Ying H, Paik J, Lieberman PM, Zheng H. ATRX loss induces telomere dysfunction and necessitates induction of alternative lengthening of telomeres during human cell immortalization. EMBO J. 2019 Oct 1;38(19):e96659. doi: 10.15252/embj.201796659. Epub 2019 Aug 27. PMID: 31454099; PMCID: PMC6769380.

Yao Y, Luo F, Tang C, Chen D, Qin Z, Hua W, Xu M, Zhong P, Yu S, Chen D, Ding X, Zhang Y, Zheng X, Yang J, Qian J, Deng Y, Hoon DSB, Hu J, Chu Y, Zhou L. Molecular subgroups and B7-H4 expression levels predict responses to dendritic cell vaccines in glioblastoma: an exploratory randomized phase II clinical trial. Cancer Immunol Immunother. 2018 Nov;67(11):1777-1788. doi: 10.1007/s00262-018-2232-y. Epub 2018 Aug 22. PMID: 30159779.

Chen D, Chen D, Cao D, Hu J, Yao Y. A signature based on survival-related genes identifies high-risk glioblastomas harboring immunosuppressive and aggressive ECM characteristics. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018 Apr 28;43(4):368-382. doi: 10.11817/j.issn.1672-7347.2018.04.006. PMID: 29774872.

Hwang I, Cao D, Na Y, Kim DY, Zhang T, Yao J, Oh H, Hu J, Zheng H, Yao Y, Paik J. Far Upstream Element-Binding Protein 1 Regulates LSD1 Alternative Splicing to Promote Terminal Differentiation of Neural Progenitors. Stem Cell Reports. 2018 Apr 10;10(4):1208-1221. doi: 10.1016/j.stemcr.2018.02.013. Epub 2018 Mar 29. PMID: 29606613; PMCID: PMC5998560.

Ariyan CE, Brady MS, Siegelbaum RH, Hu J, Bello DM, Rand J, Fisher C, Lefkowitz RA, Panageas KS, Pulitzer M, Vignali M, Emerson R, Tipton C, Robins H, Merghoub T, Yuan J, Jungbluth A, Blando J, Sharma P, Rudensky AY, Wolchok JD, Allison JP. Robust Antitumor Responses Result from Local Chemotherapy and CTLA-4 Blockade. Cancer Immunol Res. 2018 Feb;6(2):189-200. doi: 10.1158/2326-6066.CIR-17-0356. Epub 2018 Jan 16. PMID: 29339377; PMCID: PMC6857638.

Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, Zheng S, Chang E, Gabriel Sauvé CE, Olar A, Lan ZD, Finocchiaro G, Phillips JJ, Berger MS, Gabrusiewicz KR, Wang G, Eskilsson E, Hu J, Mikkelsen T, DePinho RA, Muller F, Heimberger AB, Sulman EP, Nam DH, Verhaak RGW. Tumor Evolution of Glioma- Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell. 2018 Jan 8;33(1):152. doi: 10.1016/j.ccell.2017.12.012. Erratum for: Cancer Cell. 2017 Jul 10;32(1):42-56.e6. PMID: 29316430; PMCID: PMC5892424.

Zhang P, He D, Xu Y, Hou J, Pan BF, Wang Y, Liu T, Davis CM, Ehli EA, Tan L, Zhou F, Hu J, Yu Y, Chen X, Nguyen TM, Rosen JM, Hawke DH, Ji Z, Chen Y. Genome- wide identification and differential analysis of translational initiation. Nat Commun. 2017 Nov 23;8(1):1749. doi: 10.1038/s41467-017-01981-8. PMID: 29170441; PMCID: PMC5701008.

Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, Zheng S, Chang E, Sauvé CG, Olar A, Lan ZD, Finocchiaro G, Phillips JJ, Berger MS, Gabrusiewicz KR, Wang G, Eskilsson E, Hu J, Mikkelsen T, DePinho RA, Muller F, Heimberger AB, Sulman EP, Nam DH, Verhaak RGW. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell. 2017 Jul 10;32(1):42-56.e6. doi: 10.1016/j.ccell.2017.06.003. Erratum in: Cancer Cell. 2018 Jan 8;33(1):152. PMID: 28697342; PMCID: PMC5599156.

Boutin AT, Liao WT, Wang M, Hwang SS, Karpinets TV, Cheung H, Chu GC, Jiang S, Hu J, Chang K, Vilar E, Song X, Zhang J, Kopetz S, Futreal A, Wang YA, Kwong LN, DePinho RA. Oncogenic Kras drives invasion and maintains metastases in colorectal cancer. Genes Dev. 2017 Feb 15;31(4):370-382. doi: 10.1101/gad.293449.116. Epub 2017 Mar 13. PMID: 28289141; PMCID: PMC5358757.

Barthel FP, Wei W, Tang M, Martinez-Ledesma E, Hu X, Amin SB, Akdemir KC, Seth S, Song X, Wang Q, Lichtenberg T, Hu J, Zhang J, Zheng S, Verhaak RG. Systematic analysis of telomere length and somatic alterations in 31 cancer types. Nat Genet. 2017 Mar;49(3):349-357. doi: 10.1038/ng.3781. Epub 2017 Jan 30. PMID: 28135248; PMCID: PMC5571729.

Hu B, Wang Q, Wang YA, Hua S, Sauvé CG, Ong D, Lan ZD, Chang Q, Ho YW, Monasterio MM, Lu X, Zhong Y, Zhang J, Deng P, Tan Z, Wang G, Liao WT, Corley LJ, Yan H, Zhang J, You Y, Liu N, Cai L, Finocchiaro G, Phillips JJ, Berger MS, Spring DJ, Hu J, Sulman EP, Fuller GN, Chin L, Verhaak RGW, DePinho RA. Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth. Cell. 2016 Nov 17;167(5):1281-1295.e18. doi: 10.1016/j.cell.2016.10.039. PMID: 27863244; PMCID: PMC5320931.

Shingu T, Ho AL, Yuan L, Zhou X, Dai C, Zheng S, Wang Q, Zhong Y, Chang Q, Horner JW, Liebelt BD, Yao Y, Hu B, Chen Y, Fuller GN, Verhaak RG, Heimberger AB, Hu J. Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation. Nat Genet. 2017 Jan;49(1):75-86. doi: 10.1038/ng.3711. Epub 2016 Nov 14. PMID: 27841882; PMCID: PMC5453714.

Gao H, Chakraborty G, Zhang Z, Akalay I, Gadiya M, Gao Y, Sinha S, Hu J, Jiang C, Akram M, Brogi E, Leitinger B, Giancotti FG. Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling. Cell. 2016 Jun 30;166(1):47-62. doi: 10.1016/j.cell.2016.06.009. PMID: 27368100; PMCID: PMC4980842.

Shingu T, Holmes L, Henry V, Wang Q, Latha K, Gururaj AE, Gibson LA, Doucette T, Lang FF, Rao G, Yuan L, Sulman EP, Farrell NP, Priebe W, Hess KR, Wang YA, Hu J, Bögler O. Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells. J Transl Med. 2016 Feb 9;14:46. doi: 10.1186/s12967-016-0803-2. PMID: 26861698; PMCID: PMC4746796.

Yuan P, Cao JL, Abuduwufuer A, Wang LM, Yuan XS, Lv W, Hu J. Clinical Characteristics and Prognostic Significance of TERT Promoter Mutations in Cancer: A Cohort Study and a Meta-Analysis. PLoS One. 2016 Jan 22;11(1):e0146803. doi: 10.1371/journal.pone.0146803. PMID: 26799744; PMCID: PMC4723146.

Liebelt BD, Shingu T, Zhou X, Ren J, Shin SA, Hu J. Glioma Stem Cells: Signaling, Microenvironment, and Therapy. Stem Cells Int. 2016;2016:7849890. doi: 10.1155/2016/7849890. Epub 2016 Jan 6. PMID: 26880988; PMCID: PMC4736567.

Muller F, Colla S, Aquilanti E, Manzo VE, Genovese G, Lee J, Eisenson D, Narurkar R, Deng P, Nezi L, Lee M, Hu B, Hu J, Sahin E, Ong D, Fletcher- Sananikone E, Ho D, Kwong L, Brennan C, Wang YA, Chin L, DePinho RA. Corrigendum: Passenger deletions generate therapeutic vulnerabilities in cancer. Nature. 2015 Sep 10;525(7568):278. doi: 10.1038/nature14609. Epub 2015 Jul 8. Erratum for: Nature. 2012 Aug 16;488(7411):337-42. PMID: 26153864.

Yang F, Gardner CO Jr, Bigdeli T, Gao J, Zhang Z, Tao M, Liu Y, Li Y, Wang G, Shi J, Gao C, Zhang K, Li K, Wang X, Liu L, Sun J, Du B, Shi S, Zhang J, Wu W, Wang X, Shen J, Liu T, Gu D, Liang W, Deng H, Pan J, Yang L, Jian H, Jiang G, Meng H, Miao G, Li Y, Hu C, Huang G, Zhang Y, Chen Y, Ha B, Gao S, Fang X, Mei Q, Hong X, Yang D, Liu T, Fengyu Y, Zhong H, Sang H, Chen G, Cai M, Song Y, Dong J, Shen Z, Zhang W, Wang X, Pan R, Liu X, Li Y, Liu Z, Zhang Q, Li G, Flint J, Kendler KS. Clinical features of and risk factors for major depression with history of postpartum episodes in Han Chinese women: A retrospective study. J Affect Disord. 2015 Sep 1;183:339-46. doi: 10.1016/j.jad.2015.05.033. Epub 2015 May 23. PMID: 26052079.

Cai N, Chang S, Li Y, Li Q, Hu J, Liang J, Song L, Kretzschmar W, Gan X, Nicod J, Rivera M, Deng H, Du B, Li K, Sang W, Gao J, Gao S, Ha B, Ho HY, Hu C, Hu J, Hu Z, Huang G, Jiang G, Jiang T, Jin W, Li G, Li K, Li Y, Li Y, Li Y, Lin YT, Liu L, Liu T, Liu Y, Liu Y, Lu Y, Lv L, Meng H, Qian P, Sang H, Shen J, Shi J, Sun J, Tao M, Wang G, Wang G, Wang J, Wang L, Wang X, Wang X, Yang H, Yang L, Yin Y, Zhang J, Zhang K, Sun N, Zhang W, Zhang X, Zhang Z, Zhong H, Breen G, Wang J, Marchini J, Chen Y, Xu Q, Xu X, Mott R, Huang GJ, Kendler K, Flint J. Molecular signatures of major depression. Curr Biol. 2015 May 4;25(9):1146-56. doi: 10.1016/j.cub.2015.03.008. Epub 2015 Apr 23. PMID: 25913401; PMCID: PMC4425463.

Shingu T, Jaskelioff M, Yuan L, Ding Z, Protopopov A, Kost-Alimova M, Hu J. Utilizing murine inducible telomerase alleles in the studies of tissue degeneration/regeneration and cancer. J Vis Exp. 2015 Apr 13;(98):52599. doi: 10.3791/52599. PMID: 25938254; PMCID: PMC4526143.

Kim H, Zheng S, Amini SS, Virk SM, Mikkelsen T, Brat DJ, Grimsby J, Sougnez C, Muller F, Hu J, Sloan AE, Cohen ML, Van Meir EG, Scarpace L, Laird PW, Weinstein JN, Lander ES, Gabriel S, Getz G, Meyerson M, Chin L, Barnholtz-Sloan JS, Verhaak RG. Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution. Genome Res. 2015 Mar;25(3):316-27. doi: 10.1101/gr.180612.114. Epub 2015 Feb 3. PMID: 25650244; PMCID: PMC4352879.

Han KS, Rajput NN, Wei X, Wang W, Hu JZ, Persson KA, Mueller KT. Diffusional motion of redox centers in carbonate electrolytes. J Chem Phys. 2014 Sep 14;141(10):104509. doi: 10.1063/1.4894481. PMID: 25217939.

Chen J, Cai Y, Cong E, Liu Y, Gao J, Li Y, Tao M, Zhang K, Wang X, Gao C, Yang L, Li K, Shi J, Wang G, Liu L, Zhang J, Du B, Jiang G, Shen J, Zhang Z, Liang W, Sun J, Hu J, Liu T, Wang X, Miao G, Meng H, Li Y, Hu C, Li Y, Huang G, Li G, Ha B, Deng H, Mei Q, Zhong H, Gao S, Sang H, Zhang Y, Fang X, Yu F, Yang D, Liu T, Chen Y, Hong X, Wu W, Chen G, Cai M, Song Y, Pan J, Dong J, Pan R, Zhang W, Shen Z, Liu Z, Gu D, Wang X, Liu X, Zhang Q, Li Y, Chen Y, Kendler KS, Shi S, Flint J. Childhood sexual abuse and the development of recurrent major depression in Chinese women. PLoS One. 2014 Jan 29;9(1):e87569. doi: 10.1371/journal.pone.0087569. PMID: 24489940; PMCID: PMC3906190.

Zhu Y, Zhang H, Shi S, Gao J, Li Y, Tao M, Zhang K, Wang X, Gao C, Yang L, Li K, Shi J, Wang G, Liu L, Zhang J, Du B, Jiang G, Shen J, Zhang Z, Liang W, Sun J, Hu J, Liu T, Wang X, Miao G, Meng H, Li Y, Hu C, Li Y, Huang G, Li G, Ha B, Deng H, Mei Q, Zhong H, Gao S, Sang H, Zhang Y, Fang X, Yu F, Yang D, Liu T, Chen Y, Hong X, Wu W, Chen G, Cai M, Song Y, Pan J, Dong J, Pan R, Zhang W, Shen Z, Liu Z, Gu D, Wang X, Liu X, Zhang Q, Li Y, Chen Y, Kendler KS, Flint J, Liu Y. Suicidal risk factors of recurrent major depression in Han Chinese women. PLoS One. 2013 Nov 27;8(11):e80030. doi: 10.1371/journal.pone.0080030. PMID: 24312196; PMCID: PMC3842272.

Hu J, Ho AL, Yuan L, Hu B, Hua S, Hwang SS, Zhang J, Hu T, Zheng H, Gan B, Wu G, Wang YA, Chin L, DePinho RA. From the Cover: Neutralization of terminal differentiation in gliomagenesis. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14520-7. doi: 10.1073/pnas.1308610110. Epub 2013 Aug 5. PMID: 23918370; PMCID: PMC3767545.

Muller FL, Colla S, Aquilanti E, Manzo VE, Genovese G, Lee J, Eisenson D, Narurkar R, Deng P, Nezi L, Lee MA, Hu B, Hu J, Sahin E, Ong D, Fletcher- Sananikone E, Ho D, Kwong L, Brennan C, Wang YA, Chin L, DePinho RA. Passenger deletions generate therapeutic vulnerabilities in cancer. Nature. 2012 Aug 16;488(7411):337-42. doi: 10.1038/nature11331. Erratum in: Nature. 2015 Sep 10;525(7568):278. PMID: 22895339; PMCID: PMC3712624.

Chen AJ, Paik JH, Zhang H, Shukla SA, Mortensen R, Hu J, Ying H, Hu B, Hurt J, Farny N, Dong C, Xiao Y, Wang YA, Silver PA, Chin L, Vasudevan S, Depinho RA. STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA. Genes Dev. 2012 Jul 1;26(13):1459-72. doi: 10.1101/gad.189001.112. PMID: 22751500; PMCID: PMC3403014.

Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik JH, Lim C, Guimaraes AR, Martin ES, Chang J, Hezel AF, Perry SR, Hu J, Gan B, Xiao Y, Asara JM, Weissleder R, Wang YA, Chin L, Cantley LC, DePinho RA. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell. 2012 Apr 27;149(3):656-70. doi: 10.1016/j.cell.2012.01.058. PMID: 22541435; PMCID: PMC3472002.

Hu J, Hwang SS, Liesa M, Gan B, Sahin E, Jaskelioff M, Ding Z, Ying H, Boutin AT, Zhang H, Johnson S, Ivanova E, Kost-Alimova M, Protopopov A, Wang YA, Shirihai OS, Chin L, DePinho RA. Anti-telomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell. 2012 Feb 17;148(4):651-63. doi: 10.1016/j.cell.2011.12.028. PMID: 22341440; PMCID: PMC3286017.

Ding Z, Wu CJ, Jaskelioff M, Ivanova E, Kost-Alimova M, Protopopov A, Chu GC, Wang G, Lu X, Labrot ES, Hu J, Wang W, Xiao Y, Zhang H, Zhang J, Zhang J, Gan B, Perry SR, Jiang S, Li L, Horner JW, Wang YA, Chin L, DePinho RA. Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell. 2012 Mar 2;148(5):896-907. doi: 10.1016/j.cell.2012.01.039. Epub 2012 Feb 16. PMID: 22341455; PMCID: PMC3629723.

Wang L, Qiao D, Li Y, Wang L, Ren J, He K, Sun J, Wang Z, Tian T, Chen C, Yang L, Hu J, Deng H, Wang Q, Li K, Han J, Rong H, Gan Z, Yang H, Zhou P, Pan J, Zhou C, Cui Y, Song L, Zhu Y, Li Y, Wang X, Ye L, Liang W, Chen Y, Tang Q, Guan J, Shi S, Kendler KS, Flint J, Liu L. Clinical predictors of familial depression in Han Chinese women. Depress Anxiety. 2012 Jan;29(1):10-5. doi: 10.1002/da.20878. Epub 2011 Nov 7. PMID: 22065525; PMCID: PMC3429856.

Gan B, Hu J, Jiang S, Liu Y, Sahin E, Zhuang L, Fletcher-Sananikone E, Colla S, Wang YA, Chin L, Depinho RA. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature. 2010 Dec 2;468(7324):701-4. doi: 10.1038/nature09595. PMID: 21124456; PMCID: PMC3058342.

Gan B, Lim C, Chu G, Hua S, Ding Z, Collins M, Hu J, Jiang S, Fletcher- Sananikone E, Zhuang L, Chang M, Zheng H, Wang YA, Kwiatkowski DJ, Kaelin WG Jr, Signoretti S, DePinho RA. FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer Cell. 2010 Nov 16;18(5):472-84. doi: 10.1016/j.ccr.2010.10.019. PMID: 21075312; PMCID: PMC3023886.

Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RA. PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell. 2010 May 18;17(5):497-509. doi: 10.1016/j.ccr.2010.03.020. PMID: 20478531; PMCID: PMC2900858.

Ying H, Zheng H, Scott K, Wiedemeyer R, Yan H, Lim C, Huang J, Dhakal S, Ivanova E, Xiao Y, Zhang H, Hu J, Stommel JM, Lee MA, Chen AJ, Paik JH, Segatto O, Brennan C, Elferink LA, Wang YA, Chin L, DePinho RA. Mig-6 controls EGFR trafficking and suppresses gliomagenesis. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6912-7. doi: 10.1073/pnas.0914930107. Epub 2010 Mar 29. PMID: 20351267; PMCID: PMC2872443.

Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, Xiong Y. WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. Genes Dev. 2008 Apr 1;22(7):866-71. doi: 10.1101/gad.1624008. PMID: 18381890; PMCID: PMC2279197.

Hu JP, Gong XQ, Su JG, Chen WZ, Wang CX. Study on the molecular mechanism of inhibiting HIV-1 integrase by EBR28 peptide via molecular modeling approach. Biophys Chem. 2008 Feb;132(2-3):69-80. doi: 10.1016/j.bpc.2007.09.008. Epub 2007 Sep 29. PMID: 18037557.

He YJ, McCall CM, Hu J, Zeng Y, Xiong Y. DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases. Genes Dev. 2006 Nov 1;20(21):2949-54. doi: 10.1101/gad.1483206. PMID: 17079684; PMCID: PMC1620025.

Hu J, Xiong Y. An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage. J Biol Chem. 2006 Feb 17;281(7):3753-6. doi: 10.1074/jbc.C500464200. Epub 2006 Jan 3. PMID: 16407242.

McCall CM, Hu J, Xiong Y. Recruiting substrates to cullin 4-dependent ubiquitin ligases by DDB1. Cell Cycle. 2005 Jan;4(1):27-9. doi: 10.4161/cc.4.1.1396. Epub 2005 Jan 22. PMID: 15655366.

Hu J, McCall CM, Ohta T, Xiong Y. Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. Nat Cell Biol. 2004 Oct;6(10):1003-9. doi: 10.1038/ncb1172. Epub 2004 Sep 26. PMID: 15448697.