Hu Laboratory
Jian Hu, Ph.D.
Principal Investigator
Welcome to the Hu Laboratory
The broad research focus areas of our lab are:
- Stem Cells and Glial Biology in the Central Nervous System (CNS)
- Glioma and Neurodegenerative Diseases
- Demyelinating Diseases Such as Multiple Sclerosis
- Lipid metabolism in the CNS
- Chemotherapy-Induced Neurological Defects
Notable Publications
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eLife, 2021
Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis
Xin Zhou, Seula Shin, Chenxi He, Qiang Zhang, Matthew N Rasband, Jiangong Ren, Congxin Dai, Rocío I Zorrilla-Veloz, Takashi Shingu, Liang Yuan,Yunfei Wang, Yiwen Chen, Fei Lan, Jian Hu
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Nature Communications, 2021
Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency
Seula Shin, Hao Zhou, Chenxi He, Yanjun Wei, Yunfei Wang, Takashi Shingu, Ailiang Zheng, Shaobo Wang, Xin Zhou,Hongtao Li, Qiang Zhang, Qinling Mo, Jiafu Long, Fei Lan, Yiwen Chen, Jian Hu
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The Journal of Experimental Medicine, 2020
Qki is an essential regulator of microglial phagocytosis in demyelination
Jiangong Ren, Congxin Dai, Xin Shou, Joseph A Barnes, Xi Chen, Yunfei Wang, Liang Yuan, Takashi Shingu, Amy B. Heimberger, Yiwen Chen, Jian Hu
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The Journal of Clinical Investigation, 2020
Mature myelin maintenance requires Qki to coactivate PPARβ-RXRα–mediated lipid metabolism
Xin Zhou, Chenxi He, Jiangong Ren, Congxin Dai, Sharon R. Stevens, Qianghu Wang, Daniel Zamler, Takashi Shingu, Liang Yuan, Chythra R. Chandregowda, Yunfei Wang, Visweswaran Ravikumar, Arvind U.K. Rao, Feng Zhou, Hongwu Zheng, Matthew N. Rasband, Yiwen Chen, Fei Lan, Amy B. Heimberger, Benjamin M. Segal, Jian Hu
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Nature Genetics, 2017
Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation
Shingu T, Ho AL, Yuan L, Zhou X, Dai C, Zheng S, Wang Q, Zhong Y, Chang Q, Horner JW, Liebelt BD, Yao Y, Hu B, Chen Y, Fuller GN, Verhaak RG, Heimberger AB, Hu J
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Stem Cells International, 2016
Glioma Stem Cells: Signaling, Microenvironment, and Therapy
Liebelt BD, Shingu T, Zhou X, Ren J, Shin SA, Hu J
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Cell, 2012
Anti-telomerase therapy provokes ALT and mitochondrial adaptive mechanisms
Hu J, Hwang S, Liesa M, Gan B, Sahin E, Jaskelioff M, Ding Z, Boutin A, Zhang H, Johnson S, Ivanova E, Kost-Alimova M, Xiao Y, Protopopov A, Wang YA, Shirihai O, Chin L, DePinho RA