Publications
1. McBeath E, Fujiwara K, Hofmann MC. Evidence-Based Guide to Using Artificial Introns for Tissue-Specific Knockout in Mice. Int J Mol Sci. 2023 Jun 17;24(12):10258. doi: 10.3390/ijms241210258. PMID: 37373404; PMCID: PMC10299402.
2. Hofmann MC, Kunnimalaiyaan M, Wang JR, Busaidy NL, Sherman SI, Lai SY, Zafereo M, Cabanillas ME. Molecular mechanisms of resistance to kinase inhibitors and redifferentiation in thyroid cancers. Endocr Relat Cancer. 2022 Sep 14;29(11):R173-R190. doi: 10.1530/ERC-22-0129. PMID: 35975971; PMCID: PMC9534048.
3. Hofmann MC, McBeath E. Sertoli Cell-Germ Cell Interactions Within the Niche: Paracrine and Juxtacrine Molecular Communications. Front Endocrinol (Lausanne). 2022 Jun 10;13:897062. doi: 10.3389/fendo.2022.897062. PMID: 35757413; PMCID: PMC9226676.
4. Bagheri-Yarmand R, Busaidy NL, McBeath E, Danysh BP, Evans KW, Moss TJ, Akcakanat A, Ng PKS, Knippler CM, Golden JA, Williams MD, Multani AS, Cabanillas ME, Shaw KR, Meric-Bernstam F, Shah MH, Ringel MD, Hofmann MC. RAC1 Alterations Induce Acquired Dabrafenib Resistance in Association with Anaplastic Transformation in a Papillary Thyroid Cancer Patient. Cancers (Basel). 2021 Sep 30;13(19):4950. doi: 10.3390/cancers13194950. PMID: 34638434; PMCID: PMC8507731.
5. McBeath E, Parker-Thornburg J, Fujii Y, Aryal N, Smith C, Hofmann MC, Abe JI, Fujiwara K. Rapid Evaluation of CRISPR Guides and Donors for Engineering Mice. Genes (Basel). 2020 Jun 8;11(6):628. doi: 10.3390/genes11060628. PMID: 32521708; PMCID: PMC7349695.
6. Parekh PA, Garcia TX, Hofmann MC. Regulation of GDNF expression in Sertoli cells. Reproduction. 2019 Mar;157(3):R95-R107. doi: 10.1530/REP-18-0239. PMID: 30620720; PMCID: PMC6602878.
7. Parekh PA, Garcia TX, Waheeb R, Jain V, Gandhi P, Meistrich ML, Shetty G, Hofmann MC. Undifferentiated spermatogonia regulate Cyp26b1 expression through NOTCH signaling and drive germ cell differentiation. FASEB J. 2019 Jul;33(7):8423-8435. doi: 10.1096/fj.201802361R. Epub 2019 Apr 16. PMID: 30991836; PMCID: PMC6593872.
8. Puli OR, Danysh BP, McBeath E, Sinha DK, Hoang NM, Powell RT, Danysh HE, Cabanillas ME, Cote GJ, Hofmann MC. The Transcription Factor ETV5 Mediates BRAFV600E-Induced Proliferation and TWIST1 Expression in Papillary Thyroid Cancer Cells. Neoplasia. 2018 Nov;20(11):1121-1134. doi: 10.1016/j.neo.2018.09.003. Epub 2018 Sep 25. PMID: 30265861; PMCID: PMC6161370.
9. Garcia TX, Parekh P, Gandhi P, Sinha KM, Hofmann MC. The NOTCH ligand JAG1 regulates GDNF expression in Sertoli cells. Stem Cells Dev. 2017 Jan 4. doi: 10.1089/scd.2016.0318
10. Danysh BP, Rieger EY, Sinha DK, Evers CV, Cote GJ, Cabanillas ME, Hofmann MC. Long-term vemurafenib treatment drives inhibitor resistance through a spontaneous KRAS G12D mutation in a BRAF V600E papillary thyroid carcinoma model. Oncotarget. 2016 May 24;7(21):30907-23.
11. Garcia TX, Farmaha JK, Kow S, Hofmann MC. RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche. Development. 2014 Dec;141(23):4468-78.
12. Garcia TX, Costa GM, França LR, Hofmann MC. Sub-acute intravenous administration of silver nanoparticles in male mice alters Leydig cell function and testosterone levels. Reprod Toxicol. 2014 Jun;45:59-70.
13. Garcia TX, Hofmann MC (2013). NOTCH signaling in Sertoli cells regulates gonocyte fate (2013). Cell Cycle 12: 2538-2545.
14. Garcia T, DeFalco T, Capel B and Hofmann MC (2013). Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence (2013). Dev Biol 377:188-201.
15. Ayala-Ramirez M, Palmer JL, Hofmann MC, de la Cruz M, Moon BS, Waguespack SG, Habra MA and Jimenez C (2013). Bone metastases and skeletal related events in patients with malignant pheochromocytoma and sympathetic paraganglioma. J Clin Endocrinol Metab, 98:1492-1497.
16. Gabrielson NP, Desai AV, Mahadik B, Hofmann MC, Kenis PJ, Harley BA (2013). Cell- laden hydrogels in integrated microfluidic devices for long-term cell culture and tubulogenesis assays. Small, 9:3076-81.
17. Garcia T and Hofmann MC (2012). Isolation of undifferentiated and early differentiating type A spermatogonia from POU5F1-GFP reporter mice. Methods Mol Biol 825: 31-44.
18. Simon L, Hofmann MC and Cooke P (2012). Spermatogonial stem cells –an alternate source of pluripotent stem cells for regenerative medicine. In: Tissue Regeneration, from Basic Biology to Clinical Application, Jamie Davis, editor, InTech, 203-220.
19. Lucas BE, Fields C, Joshi N, and Hofmann MC (2012). Mono-(2-ethylhexyl)-phthalate (MEHP) affects ERK-dependent GDNF signaling in mouse stem-progenitor spermatogonia. Toxicology 299: 10-19.
20. Waheeb R and Hofmann MC (2011). Human spermatogonial stem cells: a possible origin for spermatocytic seminoma. Int J Andrology, 34: 296-305.
21. Braydich-Stolle LK, Lucas B, Schrand A, Murdock RC, Lee T, Schlager J, Hussain S and Hofmann MC (2010). Silver nanoparticles disrupt GDNF/Fyn signaling in spermatogonial stem cells. Toxicol Sci,116: 577-589.
22. Simon L, Ekman GC, Garcia T, Carnes K, Zhang Z, Murphy T, Murphy KM, Hess RA, Cooke PS and Hofmann MC (2010). The transcription factor Etv5 regulates Sertoli cell chemokines involved in maintaining stem/progenitor spermatogonia in the niche. Stem Cells, 28: 1882-92.
15. Braydich-Stolle L, Kostereva NV, Dym M and Hofmann MC (2007). Role of Src kinases and N-Myc in spermatogonial stem cell proliferation. Dev Biol. 304: 34-45.
16. Braydich-Stolle L, Hussain S, Schlager J and Hofmann MC (2005) In vitro cytotoxicity of nanoparticles in mammalian germ-line stem cells, Toxicol. Sci. 88: 412-419.