Hillman Laboratory
R. Tyler Hillman, M.D., Ph.D.
Principal Investigator
- Departments, Labs and Institutes
- Labs
- Hillman Laboratory
Areas of Research
- Ovarian Cancer
- Computational Biology
- Genomics
- Tumor Microenvironment
- Epigenetics
- Chromatin
- Cancer Biology
- Drug Development
- Molecular Biology
The Hillman Laboratory is a joint venture between the Gynecologic Oncology and Reproductive Medicine department and the Genomic Medicine department at The University of Texas MD Anderson Cancer Center. A major focus of the Hillman Lab is pioneering our understanding of the molecular pathogenesis of ovarian granulosa cell tumors. The lab’s work in this area is motivated by Dr. Hillman’s busy international referral practice providing medical and surgical treatment for women affected by this disease. A key long-term goal of the Hillman Lab is to discover new granulosa cell tumor therapeutic vulnerabilities and use these innovations to launch novel early-phase clinical trials focused on this rare disease.
Funding Support
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Cancer Prevention & Research Institute of Texas
Recruitment of First-Time, Tenure-Track Faculty Members (RR2000045) Opens a new window
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The Department of Defense (DOD)
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American Association of Obstetricians and Gynecologists Foundation (AAOGF)
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Jennifer “Jenny” Song Fund for Granulosa Cell Tumor Research
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Alisha B. Smith Granulosa Cell Tumor Hope Fund
Members of the lab employ multidisciplinary computational and experimental approaches that utilize a combination of genetically engineered mouse models, human tissue from institutional biobanks and cell culture model systems to:
- identify promising therapeutic vulnerabilities using unbiased high-throughput screening
- construct and analyze novel cell culture and animal model systems
- generate pre-clinical translational data to support rational clinical trial design for rare gynecologic cancers