Guocan Wang Laboratory
Guocan Wang, M.D., Ph.D.
Principal Investigator
- Departments, Labs and Institutes
- Labs
- Guocan Wang Laboratory
Areas of Research
- Prostate Cancer
- Liver Cancer
- Kidney Cancer
- Epigenetics
- Tumor Microenvironment
Our research focuses on understanding how the genetic makeup of cancer, the heterogeneity in the tumor microenvironment (TME) and the crosstalk between epigenetic and metabolic reprogramming influence cancer progression, metastasis and therapy resistance at the molecular and cellular levels. Our long-term goal is to translate the basic findings in the laboratory into drug discovery and patient care.
Research Approach
We use a multi-disciplinary approach that includes unbiased computational analyses of multi-OMICS data (transcriptomics, epigenomics, proteomics and metabolomics), genetically engineered mouse models (GEMMs) and cross-species and integrative analyses of human and mouse OMICS data. Importantly, we employ cutting-edge single-cell technologies in our research, including CyTOF, single-cell RNA-seq, single-cell ATAC-seq and imaging mass cytometry.