Publications

Broz MT, Ko EY, Ishaya K, Xiao J, De Simone M, Hoi XP, Piras R, Basia G, Tessaro FHG, Karlstaedt A, Orsulic S, Lund A., Chan KS, Guarnerio J.
Metabolic targeting of cancer associated fibroblasts overcomes T-cell exclusion and chemoresistance in soft-tissue sarcomas.
Nature Communications. 2024 Mar 20; 15(1):2498 PMID: 38509063

Piras R, Ko EY, Barrett C, De Simone M, Lin X, Broz MT, Tessaro FHG, Castillo-Martin M, Cordon-Cardo C, Goodridge HS, Di Vizio D, Batish M, Lawrenson K, Chen YG, Keith Chan KS, Guarnerio J.
circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment.
Nature Communications. 2022 Nov 25; 13(1):7243 PMID: 36433954

Tessaro FHG, Ko EY, De Simone M, Piras R, Broz MT, Goodridge HS, Balzer B, Shiao SL, Guarnerio J.
Single-cell RNA-seq of a soft-tissue sarcoma model reveals the critical role of tumor-expressed MIF in shaping macrophage heterogeneity.
Cell Reports. 2022 Jun 21;39(12):110977. PMID: 35732118

Nikolos F, Hayashi K, Hoi XP, Alonzo ME, Mo Q, Kasabyan A, Furuya H, Trepel J, Di Vizio D, Guarnerio J, Theodorescu D, Rosser C, Apolo A, Galsky M, Chan KS.
Cell death-induced immunogenicity enhances chemotherapeutic response by converting immune-excluded into T-cell inflamed bladder cancer.
Nature Communications. 2022 Mar 28;13(1):1487. PMID: 35347124

Koppula A, Abdelgawad A, Guarnerio J, Batish M, Parashar V.
CircFISH: A Novel Method for the Simultaneous Imaging of Linear and Circular RNAs.
Cancers (Basel). 2022 Jan 15;14(2). PubMed PMID: 35053590.

Chin A, Mariscal J, Kim M, Guerra G, Victor B, Qian C, Broseghini E, Posadas E, Freeman MR, Sharma S, Gandellini P, Zaffaroni N, You S, Chan KS, Guarnerio J, Fabbri M, Di Vizio D.
miR-1227 targets SEC23A to regulate the shedding of large extracellular vesicles.
Cancers (Basel). 2021 Nov 22;13(22):5850. PMID: 34831007

Shiao SL, Kershaw KM, Limon JJ, You S, Yoon J, Ko EY, Guarnerio J, Potdar AA, McGovern DPB, Bose S, Dar TB, Noe P, Lee J, Kubota Y, Maymi VI, Davis MJ, Henson RM, Choi RY, Yang W, Tang J, Gargus M, Prince AD, Zumsteg ZS, Underhill DM.
Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy.
Cancer Cell. 2021 Sept 13;39(9):1202-1213. PMID 34329585

Guarnerio J, Zhang Y, Cheloni G, Panella R, Katon JM, Simpson M, Matsumoto A, Papa A, Loretelli C, Petri A, Kauppinen S, Garbutt C, Nielsen GP, Deshpande V, Castillo-Martin M, Cordon-Cardo C, Dimitrios S, Clohessy JG, Batish M, Pandolfi PP.
Intragenic antagonistic role for Zbtb7a protein and circRNA in tumorigenesis.
Cell Research. 2019 Aug;29(8):628-640. PMID: 31209250

Mugoni V, Panella R, Cheloni G, Chen M, Pozdnyakova O, Stroopinsky D, Guarnerio J, Monteleone E, Lee JD, Mendez L, Venugopal Menon A, Aster JC, Lane AA, Stone AM, Galinsky I, Zamora JC, Lo-Coco F, Bhasin MK, Avigan D, Longo L, Clohessy JG, Pandolfi PP.
Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy.
Cell Research. 2019 Jun;29(6):446-459. PMID: 31024166

Guarnerio J, Mendez LM, Asada N, Menon AV, Fung J, Berry K, Frenette PS, Ito K, Pandolfi PP.
A non-cell-autonomous role for PML in the maintenance of leukemia initiating cells from the niche.
Nature Communications. 2018; 9(1):66. PMID: 29302031

Bezzi M, Guarnerio J, Pandolfi PP.
A circular twist on microRNA regulation.
Cell Research. 2017; 27(12):1401-1402. PMID: 29086764

German NJ, Yoon H, Yusuf RZ, Murphy JP, Finley LW, Laurent G, Haas W, Satterstrom FK, Guarnerio J, Zaganjor E, Santos D, Pandolfi PP, Beck AH, Gygi SP, Scadden DT, Kaelin WG Jr, Haigis MC.
PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.
Molecular Cell. Sept;2016; 63(6):1006-20. PMID: 27635760

Guarnerio J, Bezzi M, Jeong JC, Paffenholz SV, Berry K, Naldini MM, Lo-Coco F, Tay Y, Beck AH, Pandolfi PP.
Oncogenic role of aberrant fusion-circRNAs derived from cancer associated chromosomal translocations.
Cell. Apr;2016 Apr7;165(2):289-302. PMID: 27040497

Lunardi A, Varmeh S, Chen M, Taulli R, Guarnerio J, Ala U, Seitzer N, Ishikawa T, Carver BS, Hobbs RM, Quarantotti V, Ng C, Berger AH, Nardella C, Poliseno L, Montironi R, Castillo-Martin M, Cordon-Cardo C, Signoretti S, Pandolfi PP.
Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis.
Cancer Discovery. May;2015; 5(5):550-63. PMID: 25653093

Wei S, Kozono S, Kats L, Nechama M, Li W, Guarnerio J, Luo M, You MH, Yao Y, Kondo A, Hu H, Bozkurt G, Moerke NJ, Cao S, Reschke M, Chen CH, Rego EM, Lo-Coco F, Cantley LC, Lee TH, Wu H, Zhang Y, Pandolfi PP, Zhou XZ, Lu KP.
Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.
Nature Medicine. May;2015; 21(5):457-66. PMID: 25849135

Guarnerio J, Riccardi L, Taulli R, Maeda T, Wang G, Hobbs RM, Song MS, Sportoletti P, Bernardi R, Bronson RT, Castillo-Martin M, Cordon-Cardo C, Lunardi A, Pandolfi PP.
A genetic platform to model sarcomagenesis from primary adult mesenchymal stem cells.
Cancer Discovery. 2015 Apr;5(4):396-40 PMID: 25614485

Guarnerio J, Coltella N, Ala U, Tonon G, Pandolfi PP, Bernardi R.
Bone Marrow endosteal mesenchymal progenitors depend on HIF factors for maintenance and regulation of hematopoiesis.
Stem Cell Reports. May;2014. 15;2(6):794-809 PMID: 24936467

Coltella N, Percio S, Valsecchi R, Cuttano R, Guarnerio J, Ponzoni M, Pandolfi PP, Melillo G, Pattini L, Bernardi R.
HIF factors cooperate with PML-RARα to promote acute promyelocytic leukemia progression and relapse.
EMBO Molecular Medicine. May;2014. 6(5):640-50. PMID: 24711541

Papa A, Wan L, Bonora M, Salmena L, Song MS, Hobbs RM, Lunardi A, Webster K, Ng C, Newton RH, Knoblauch N, Guarnerio J, Ito K, Turka LA, Beck AH, Pinton P, Bronson RT, Wei W, Pandolfi PP.
Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function.
Cell. Apr;2014. 157(3):595-610. PMID: 24766807

Lunardi A, Guarnerio J, Wang G, Maeda T, Pandolfi PP.
Role of LRF/Pokemon in lineage fate decisions.
Blood. 2013; 121(15):2845-53. PMID: 23396304

Schiering C*, Guarnerio J*, Basso V, Muzio L, and Mondino A.
Antigen-experienced CD4(+) T cells limit naïve T-cell priming in response to therapeutic vaccination in vivo.
Cancer Research. 2010. 70(15):6161-70. PMID: 20631073 *equal contribution

Caserta S, Alessi P, Guarnerio J, Basso V, and Anna Mondino.
Synthetic CD4 T cell- targeted Antigen-presenting cells elicit protective antitumor responses.
Cancer Research. 2008. 68:3010-3018 PMID:18413771