Selected Publications
Shi Y, Shen HM, Gopalakrishnan V, Gordon N. Epigenetic regulation of autophagy beyond the cytoplasm: a review. Frontiers Cell and Developmental Biology. In Press.
Hennessy M, Wahba A, Felix K, Cabrera M, Segura MG, Kundra V, Ravoori MK, Stewart J, Kleinerman ES, Jensen VB, Gopalakrishnan V, Pena R, Quach P, Kim G, Kivimäe S, Madakamutil L, Overwijk WW, Zalevsky J, Gordon N. Bempegaldesleukin (BEMPEG; NKTR-214) efficacy as a single agent and in combination with checkpoint-inhibitor therapy in mouse models of osteosarcoma. Int J Cancer 2021 Apr 15;148(8):1928-1937. doi: 10.1002/ijc.33382. Epub 2020 Nov 25. PMID: 33152115. PMCID: PMC7984260. DOI: 10.1002/ijc.33382
Wolf-Dennen K, Gordon N, Kleinerman ES. Exosomal communication by metastatic osteosarcoma cells modulates alveolar macrophages to an M2 tumor-promoting phenotype and inhibits tumoricidal functions. Oncoimmunology 9(1):1747677, 2020. e-Pub 4/2020. PMCID: PMC7153823.
Hollomon MG, Patterson L, Santiago-O'Farrill J, Kleinerman ES, Gordon N. Knock down of Fas-Associated Protein with Death Domain (FADD) Sensitizes Osteosarcoma to TNFα-induced Cell Death. J Cancer 11(7):1657-1667, 2020. e-Pub 1/2020. PMCID: PMC7052864.
Kennis BA, Michel KA, Brugmann WB, Laureano A, Tao RH, Somanchi SS, Einstein SA, Bravo-Alegria JB, Maegawa S, Wahba A, Kiany S, Gordon N, Silla L, Schellingerhout D, Khatua S, Zaky W, Sandberg D, Cooper L, Lee DA, Bankson JA, Gopalakrishnan V. Monitoring of intracerebellarly-administered natural killer cells with fluorine-19 MRI. J Neurooncol 142(3):395-407, 5/2019. e-Pub 2/2019. PMID: 30788681.
Kleinerman ES, Yu L, Dao J, Hayes-Jordan A, Lindsey B, Kawedia JD, Stewart J, Gordon N. Aerosol Gemcitabine after Amputation Inhibits Osteosarcoma Metastases but not Wound Healing. Sarcoma 2018(doi.org/10.1155/2018/3143096), 1/2018.
Livingston JA, Wang WL, Tsai JW, Lazar AJ, Leung CH, Lin H, Advani S, Daw N, Santiago-O'Farrill J, Hollomon M, Gordon NB, Kleinerman ES. Analysis of HSP27 and the autophagy marker LC3B+ puncta following preoperative chemotherapy identifies high-risk osteosarcoma patients. Mol Cancer Ther. e-Pub 3/2018. PMID: 29592877.
Dhupkar P, Gordon N, Stewart J, Kleinerman ES. Anti-PD-1 therapy redirects macrophages from an M2 to an M1 phenotype inducing regression of OS lung metastases. Cancer Med. e-Pub 5/2018. PMID: 29733528.
Santiago-O'Farrill JM, Kleinerman ES, Hollomon MG, Livingston A, Wang WL, Tsai JW, Gordon NB. Phosphorylated heat shock protein 27 as a potential biomarker to predict the role of chemotherapy-induced autophagy in osteosarcoma response to therapy. Oncotarget 9(2):1602-1616, doi.org/10.18632/oncotarget.20308, 1/2018. e-Pub 8/2017. PMCID: PMC5788585.
Moonat HR, Huang G, Dhupkar P, Schadler K, Gordon N, Kleinerman ES. Combination of Interleukin-11Ra Chimeric Antigen Receptor T-cells and Programmed Death-1 Blockade as an Approach to Targeting Osteosarcoma Cells In vitro. Cancer Translational Medicine 3(4):139-45, 3/2017.
Guma SR, Lee DA, Ling Y, Gordon N, Kleinerman ES. Aerosol interleukin-2 induces natural killer cell proliferation in the lung and combination therapy improves the survival of mice with osteosarcoma lung metastasis. Pediatric Blood Cancer. 03/2014. PMID: 24670870
O'Farrill JS, Gordon N. Autophagy in osteosarcoma. Adv Exp Med Biol. 804:147-60. 2014 PMID:24924173
Gordon N, Koshkina NV, Jia SF, Khanna C, Mendoza A, Worth LL, Kleinerman ES. Corruption of the Fas pathway delays the pulmonary clearance of murine osteosarcoma cells, enhances their metastatic potential, and reduces the effect of aerosol gemcitabine. Clin Cancer Res 13(15Pt1):4503-10, 8/2007. PMID: 17671136.
Book chapters
Gordon N, Felix K, Daw NC. Aerosolized Chemotherapy for Osteosarcoma. In: Current Advances in Osteosarcoma. Advances in Experimental Medicine and Biology. 1257, 2nd. Ed(s) Kleinerman E, Gorlick R. Springer, Cham, 2020. PMID: Print ISBN 978-3-030-43031-3 / Online ISBN 978-3-030-43032-0.
Gordon N. Osteosarcoma and Autophagy. In: Current Advances in Osteosarcoma. Advances in Experimental Medicine and Biology. 1257, 2nd. Ed(s) Kleinerman E, Gorlick R. Springer, Cham, 2020.
Kiany S, Harrison D, Gordon N. The Histone Deacetylase Inhibitor Entinostat/Syndax 275 in Osteosarcoma. In: Current Advances in Osteosarcoma. Advances in Experimental Medicine and Biology. 1257, 2nd. Ed(s) Kleinerman E, Gorlick R. Springer, Cham, 2020. PMID: Print ISBN 978-3-030-43031-3 / Online ISBN 978-3-030-43032-0.