Selected Publications
2022
Tsai CR, Wang Y, Jacobson A, Sankoorikkal N, Chirinos JD, Burra S, Makthal N, Kumaraswami M, Galko MJ. Pvr and distinct downstream signaling factors are required for hemocyte spreading and epidermal wound closure at Drosophila larval wound sites. G3 (Bethesda). 4;12(1):jkab388. doi: 10.1093/g3journal/jkab388. PMID: 34751396
2021
Drosophila larval epidermal cells only exhibit epidermal aging when they persist to the adult stage. Wang Y, Burra S, Galko MJ. J Exp Biol. doi: 10.1242/jeb.240986. PMID: 33795421
2020
An Improved Assay and Tools for Measuring Mechanical Nociception in Drosophila Larvae. Lopez-Bellido R, Galko MJ. J Vis Exp. (164). doi: 10.3791/61911. PMID: 33191934
2019
Lopez-Bellido R, Himmel NJ, Gutstein HB, Cox DN, Galko MJ. An assay for chemical nociception in Drosophila larvae. Philos Trans R Soc Lond B Biol Sci. 11;374(1785). PMID: 31544619
Tsai CR, Galko MJ. Casein kinase 1α decreases β-catenin levels at adherens junctions to facilitate wound closure in Drosophila larvae. Development. 146(20) PMID: 31511254
Lopez-Bellido R, Puig S, Huang PJ, Tsai CR, Turner HN, Galko MJ, Gutstein HB. Growth factor signaling regulates mechanical nociception in flies and vertebrates. J Neurosci. PMID: 31138657
2018
Turner HN, Patel AA, Cox DN, Galko MJ. Injury-induced cold sensitization in Drosophila larvae involves behavioral shifts that require the TRP channel Brv1. PLoS One 13(12):e0209577. PMID: 30586392
Im SH, Patel AA, Cox DN, Galko MJ. Drosophila Insulin receptor regulates the persistence of injury-induced nociceptive sensitization. Dis Model Mech 11(5). PMID: 29752280 .
2017
Tsai CR, Anderson AE, Burra S, Jo J, Galko MJ. Yorkie regulates epidermal wound healing in Drosophila larvae independently of cell proliferation and apoptosis. Dev Biol.1,427(1):61-71. PMID: 28514643
Turner HN, Landry C, Galko MJ. Novel Assay for Cold Nociception in Drosophila Larvae. J Vis Exp. 3;(122). PMID: 28448025
Jo J, Im SH, Babcock DT, Iyer SC, Gunawan F, Cox DN, Galko MJ. Drosophila caspase activity is required independently of apoptosis to produce active TNF/Eiger during nociceptive sensitization. Cell Death Dis. 11;8(5):e2786. PMID: 28492538
2016
Turner HN, Armengol K, Patel AA, Himmel NJ, Sullivan L, Iyer SC, Bhattacharya S, Iyer EP, Landry C, Galko MJ, Cox DN. The TRP Channels Pkd2, NompC, and Trpm Act in Cold-Sensing Neurons to Mediate Unique Aversive Behaviors to Noxious Cold in Drosophila. Curr Biol. 5;26(23):3116-3128. PMID: 27818173
2015
Im SH, Takle K, Jo J, Babcock DT, Ma Z, Xiang Y, Galko MJ. Tachykinin acts upstream of autocrine Hedgehog signaling during nociceptive sensitization in Drosophila. Elife. 17;4:e10735. PMID:26575288
Wang Y, Antunes M, Anderson AE, Kadrmas JL, Jacinto A, Galko MJ. Integrin Adhesions Suppress Syncytium Formation in the Drosophila Larval Epidermis. Curr Biol. 25(17):2215-27. PMID: 26255846
2014
Anderson AE, Galko MJ. (2014) Rapid clearance of epigenetic protein reporters from wound edge cells in Drosophila larvae does not depend on the JNK or PDGFR/VEGFR signaling pathways. Regeneration 1(2):11-25. PMID: 25114797
2013
Scherfer C, Han VC, Wang Y, Anderson AE, Galko MJ. Autophagy drives epidermal deterioration in a Drosophila model of tissue aging. Aging (Albany NY). 5(4):276-87. PMID: 23599123
Burra S, Wang Y, Brock AR, and Michael J. Galko Using Drosophila Larvae to Study Epidermal Wound Closure and Inflammation. In. Methods Mol.Biol. 1037, 449-61 Book Chapter
2012
Im SH, Galko MJ. (2012) Pokes, sunburn, and hot sauce: Drosophila as an emerging model for the biology of nociception. Dev Dyn. 241(1):16-26.
PMCID: 21932321 Invited Article
Brock AR, Wang Y, Berger S, Renkawitz-Pohl R, Han VC, Wu Y, Galko MJ. Transcriptional regulation of Profilin during wound closure in Drosophila larvae. J Cell Sci. 1:125(Pt 23):5667-76 PMID: 22976306
Chattopadhyay A, Gilstrap AV, Galko MJ. (2012) Local and global methods of assessing thermal nociception in Drosophila larvae. J Vis Exp. 18;(63):e3837. PMID: 2264388
2011
Babcock DT, Shi S, Jo J, Shaw M, Gutstein HB, Galko MJ. Hedgehog signaling regulates nociceptive sensitization. Curr Biol 21(18):1525-33. PMID: 21906949
2010
Lesch C, Jo J, Wu Y, Fish GS, Galko MJ. A Targeted UAS-RNAi Screen in Drosophila Larvae Identifies Wound Closure Genes Regulating Distinct Cellular Processes. Genetics 186(3):943-57. PMID: 20813879
2009
Wu Y, Brock AR, Wang Y, Fujitani K, Ueda R, Galko MJ. A blood-borne PDGF/VEGF-like ligand initiates wound-induced epidermal cell migration in Drosophila larvae. Curr Biol 19(17):1473-7. PMID: 19646875
Babcock DT, Landry C, Galko MJ. Cytokine signaling mediates UV-induced nociceptive sensitization in Drosophila larvae. Curr Biol 19(10):799-806. PMID: 19375319
2008
Babcock DT, Brock AR, Fish GS, Wang Y, Perrin L, Krasnow MA, Galko MJ. Circulating blood cells function as a surveillance system for damaged tissue in Drosophila larvae. Proc Natl Acad Sci U S A 105(105):10017-10022. PMID: 18632567
Postdoctoral
2005
Stramer B, Wood W, Galko MJ, Redd MJ, Jacinto A, Parkhurst SM, Martin P. Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration. J Cell Biol 168(4):567-73. PMID: 15699212
2004
Galko MJ, Krasnow MA. Cellular and genetic analysis of wound healing in Drosophila larvae. PLoS Biol 2(8):e239. PMID: 15269788
Graduate
2000
Galko MJ, Tessier-Lavigne M. Function of an axonal chemoattractant modulated by metalloprotease activity. Science 289(289):1365-1367. PMID: 10958786
Galko MJ, Tessier-Lavigne M. Biochemical characterization of netrin-synergizing activity. J Biol Chem 275(11):7832-8. PMID: 10713098
1994
Serafini T, Kennedy TE, Galko MJ, Mirzayan C, Jessell TM, Tessier-Lavigne M. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell. 12;78(3):409-24. PMID: 8062384