
Cascone Laboratory
Tina Cascone, M.D., Ph.D.
Principal Investigator
Areas of Research
- Lung Cancer
The Cascone Laboratory is focused on identifying immune-mediated mechanisms of tumor response and resistance to immune checkpoint therapies.
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The Cascone Laboratory uses information generated from preclinical models of spontaneously metastatic non-small cell lung cancer (NSCLC) and samples derived from patients with operable NSCLC treated with perioperative immune-based therapies to identify determinants of tumor resistance to immune-based therapies, discover predictive biomarkers of therapeutic response in primary resected and metastatic NSCLCs, and discover novel therapeutic targets and strategies that may improve the cure rates of patients with operable non-small cell lung cancer by preventing tumor recurrence, enhancing antitumor immunity and augmenting the efficacy of immunotherapies.
Funding Support
for the Cascone Laboratory includes
ASCO Career Development Award: 2018
UT System Rising STARs Award: 2018
MD Anderson Physician Scientist Program: 2018
Khalifa Scholar Award: 2018
CCSG New Faculty Award: 2019
UT Lung SPORE (UTSW/MD Anderson): 2020
Bob Mayberry Foundation
Rexanna’s Foundation for Fighting Lung Cancer: 2021, 2022
ASCI Young Physician Scientist Award: 2021
NIH/NCI R01CA262425-01 (Wu/Cascone MPIs): 2021
Lung SPORE CEP (Lili Chen/Cascone Lab): 2022
Mark Foundation Endeavor Award (MPIs): 2022
Join Our Lab
We are hiring highly motivated and driven postdoctoral fellows
Selected Publications
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Cell Metabolism
Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy Opens a new window
Cascone T, McKenzie JA, Mbofung RM, Punt S, Wang Z, Xu C, Williams LJ, Wang Z, Bristow CA, Carugo A, Peoples MD, Li L, Karpinets T, Huang L, Malu S, Creasy C, Leahey SE, Chen J, Chen Y, Pelicano H, Bernatchez C, Gopal YNV, Heffernan TP, Hu J, Wang J, Amaria RN, Garraway LA, Huang P, Yang P, Wistuba II, Woodman SE, Roszik J, Davis RE, Davies MA, Heymach JV, Hwu P, Peng W. (2018).
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Nature
Neoadjuvant nivolumab or nivolumab plus ipilimumab in operable non-small cell lung cancer: the phase 2 randomized NEOSTAR trial Opens a new window
Cascone, T., William Jr, W. N., Weissferdt, A., Leung, C. H., Lin, H. Y., Pataer, A., Godoy, M. C. B., Carter, B. W., Federico, L., Reuben, A., Khan, M. A. W., Dejima, H., Francisco-Cruz, A., Parra, E. R., Solis, L. M., Fujimoto, J., Tran, H. T., Kalhor, N., Fossella, F. V., ... Sepesi, B. (2021).
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Nature
Nodal immune flare mimics nodal disease progression following neoadjuvant immune checkpoint inhibitors in non-small cell lung cancer Opens a new window
Cascone, Tina & Weissferdt, Annikka & Godoy, Myrna & William, William & Leung, Cheuk & Lin, Heather & Basu, Sreyashi & Yadav, Shalini & Pataer, Apar & Mitchell, Kyle & Khan, Md & Shi, Yushu & Haymaker, Cara & Solis, Luisa & Parra, Edwin & Kadara, Humam & Wistuba, Ignacio & Sharma, Praneal & Allison, James & Sepesi, Boris. (2021).
In the News
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Neoadjuvant combination immunotherapy improves outcomes for...
Contact Us
Tina Cascone, M.D., Ph.D.
Thoracic Head & Neck Medical Oncology
MD Anderson Cancer Center
1515 Holcombe Blvd.
Houston, Texas 77030
TCascone@MDAnderson.org
Michelle Earnest
Administrative Contact
713-792-6363
Laboratory Contact
Room number: T8.3950
Phone: 713-792-1367
