Publications

Wible DJ, Parikh Z, Cho EJ, Chen MD, Mukhopadhyay S, Dalby KN, Varadarajan S, Bratton SB. Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control. Cell Death Dis. 2024 Jan 22;15(1)

Wible DJ, Chao H-P, Tang DG, Bratton SB. ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12-ATG5-ATG16L1 complex assembly and autophagy. Cell Discov. 2019 Aug 27;5:42.

Wible DJ, Bratton SB. Reciprocity in ROS and autophagic signaling. Curr Opin Toxicol. 2018 Feb;7:28-36

Wu CC, Bratton SB. Caspase-9 swings both ways in the apoptosome. Mol Cell Oncol. 2017 Jan 20;4(2):e1281865

Wu CC, Lee S, Malladi S, Chen MD, Mastrandrea NJ, Zhang Z, Bratton SB. The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities. Nat Commun. 2016 Nov 24;7:13565.

Nowinski SM, Solmonson A, Rundhaug JE, Rho O, Cho J, Lago CU, Riley CL, Lee S, Kohno S, Dao CK, Nikawa T, Bratton SB, Wright CW, Fischer SM, DiGiovanni J, Mills EM. Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis Nat Commun.  6:8137, 2015.

Lee S, Challa-Malladi M, Bratton SB, Wright CW. Nuclear factor-κB-inducing kinase (NIK) contains an amino-terminal inhibitor of apoptosis (IAP)-binding motif (IBM) that potentiates NIK degradation by cellular IAP1 (c-IAP1). J Biol Chem. 289(44):30680-9, 2014

Mahajan IM, Chen MD, Muro I, Robertson JD, Wright CW, Bratton SB. BH-3-only protein BIM mediates heat shock-induced apoptosis. PLoS One 9(1):e84388, 2014.

Yeh TC, Bratton SB. DrICE resurrects Grim to antagonize DIAP1. Cell Cycle 13(5). e-Pub 1/2014.

Wu CC, Bratton SB. Regulation of the Intrinsic Apoptosis Pathway by Reactive Oxygen Species. Antioxid Redox Signal 19(6):546-58, 8/2013. 

Yeh TC, Bratton SB. Caspase-dependent regulation of the ubiquitin-proteasome system through direct substrate targeting. Proc Natl Acad Sci U S A 110(35):14284-9, 8/2013. 

Lago CU, Nowinski SM, Rundhaug JE, Pfeiffer ME, Kiguchi K, Hirasaka K, Yang X, Abramson EM, Bratton SB, Rho O, Colavitti R, Kenaston MA, Nikawa T, Trempus C, Digiovanni J, Fischer SM, Mills EM.Mitochondrial respiratory uncoupling promotes keratinocyte differentiation and blocks skin carcinogenesis. Oncogene 31(44):4725-31, 2012.

Fisher AA, Labenski MT, Malladi S, Chapman JD, Bratton SB, Monks TJ, Lau SS. The frequency of 1,4-benzoquinone-lysine adducts in cytochrome c correlate with defects in apoptosome activation. Toxicol Sci. 2011;122(1):64-72.

Wu CC, Bratton SB. DARK apoptosome secrets come to light. Structure. 2011;19(1):4-6.

Bratton, S. B. and Salvesen, G. S. (2010) Regulation of the Apaf-1 · caspase-9 apoptosome. J. Cell Sci. 123, 3209-3214.

Son, J. K., Varadarajan, S., and Bratton, S. B. (2010) TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1. Cell Death Differ. 17, 1288-1301.

Lau, S. S., Kuhlman, C. L., Bratton, S. B., and Monks, T. J. (2010) Role of hydroquinone-thiol conjugates in benzene-mediated toxicity. Chem. Biol. Interact. 184, 212-217.

Malladi, S., Challa-Malladi, M., Fearnhead, H. O., and Bratton, S. B. (2009) The Apaf-1•procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer. EMBO J. 28, 1916-1925. [Reviewed in Science Signaling; Adrain, C. and Martin, S. J. (2009) Apoptosis: calling time on apoptosome activity. Sci. Signal. Oct. 6; 2(91):pe62].

Choi, Y. E., Butterworth, M., Malladi, S., Duckett, C. S., Cohen, G. M., and Bratton, S. B. (2009) The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspases-3 and -7 via unique mechanisms at distinct steps in their processing.  J. Biol. Chem. 284, 12772-12782.

Fisher, A. A., Labenski, M. T., Malladi, S., Gokhale, V., Bowen, M. E., Milleron, R. S., Bratton, S. B., Monks, T. J., and Lau, S. S. (2007) Quinone electrophiles selectively adduct "electrophile binding motifs" within cytochrome c. Biochemistry 46, 11090-11100.

Challa, M., Malladi, S., Varadarajan, S., Yin, Y. W., White, K., Bratton, S. B. (2007) Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease. EMBO J. 26, 3144-3156.

Milleron, R. S. and Bratton, S. B. (2007) Visions and Reflections: 'Heated' debates in apoptosis. Cell. Mol. Life Sci., 64, 2329-2333.

Yin, W., Mendenhall, J., Bratton, S. B., Oung, T., Janssen, W. G. M., Morrison, J. H. and Gore, A. C. (2007) Novel localization of NMDA receptors within neuroendocrine gonadotropin-releasing hormone terminals. Exp. Biol. Med. 232, 662-673.

Milleron, R. S. and Bratton, S. B. (2006) Heat shock induces apoptosis independently of any known caspase-activating complex. J. Biol. Chem. 281, 16991-17000.

Chandra, D., Bratton, S. B., Person, M.D., Tian, Y., Martin, A. G., Ayers, M., Fearnhead, H. O., Gandhi, V., Tang, D. G. (2006) Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome c and inhibiting apoptosome. Cell 125, 1333-1346.

Mufti, A. R., Burstein, E., Csomos, R. A., Graf, P. C. F., Wilkinson, J. C., Dick, R. D., Challa, M., Son, J.-K., Bratton, S. B., Su, G. L., Brewer, G. J., Jakob, U. and Duckett, C. S. (2006) XIAP is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders. Mol. Cell 21, 775-785.

Lewis, J., Burstein, E., Birkey-Reffey, S., Bratton, S. B., Roberts, A. B. and Duckett, C. S.  (2004)  Uncoupling of the signaling and caspase-inhibitory properties of XIAP.  J. Biol. Chem. 279, 9023-9029

Bratton, S. B. and Cohen, G. M. (2003) Death receptors leave a caspase footprint that 'Smacs' of XIAP.  Cell Death Differ. 10, 4-6.

Bratton, S. B., Lewis, J., Butterworth, M., Duckett, C. S., and Cohen, G. M. (2002) XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis.  Cell Death Differ. 9, 881-892.

MacFarlane, M., Merrison, W., Bratton, S. B., and Cohen, G. M. (2002) Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro.  J. Biol. Chem. 277, 36611-36616.

Bratton, S. B., Sun, X-M., Butterworth, M., MacFarlane, M., and Cohen, G. M. (2002) Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of XIAP.  J. Biol. Chem. 277, 11345-11351.

Bratton, S. B. and Cohen, G. M. (2002) Caspase cascades in chemically-induced apoptosis.  In:  Biological Reactive Intermediates VI (Dansette, et al., eds.), Klewer Academic/Plenum Press, pgs. 407-420.

Cain, K., Bratton, S. B. and Cohen, G. M. (2002) The Apaf-1 apoptosome: a large caspase-activating complex.  Biochimie 84, 203-214.

Bratton, S. B., Walker, G., Srinivasula, S. M., Sun, X-M., Butterworth, M., Alnemri, E. S. and Cohen, G.M. (2001) Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes.  EMBO J. 20, 998-1009.

Bratton, S. B., Walker, G., Cain, K., and Cohen, G. M. (2001) Caspase-3 cleaves Apaf-1 into an ~30 kDa fragment that associates with an inappropriately oligomerized and biologically inactive ~1.4 MDa apoptosome complex.  Cell Death Differ. 8, 425-433.

Bratton, S. B. and Cohen, G. M. (2001) Apoptotic death sensor:  an organelle1s alter ego.  Trends Pharmacol. Sci. 22, 306-315.

Cain, K., Bratton, S. B., Langlais, C., Walker, G., Brown, D. G., Sun, X-M. and Cohen, G. M. (2000) Apaf-1 oligomerizes into biologically active ~700-kDa and inactive ~1.4- MDa apoptosome complexes.  J. Biol. Chem. 275, 6067-6070.

Bratton, S. B., MacFarlane, M., Cain, K. and Cohen, G. M. (2000) Protein complexes activate distinct caspase cascades in death receptor and stress induced apoptosis.  Exp. Cell Res., 256, 27-33.

Bratton, S. B., Lau, S. S., and Monks, T. J. (2000) The putative benzene metabolite 2,3,5-tris-(glutathion-S-yl)hydroquinone depletes glutathione, stimulates sphingomyelin turnover, and induces apoptosis in HL-60 cells.  Chem. Res. Toxicol. 13, 550-556.

Bratton, S. B., Lau, S. S., and Monks, T. J. (1997) Identification of quinol-thioethers in bone marrow of hydroquinone/phenol-treated rats and mice, and their potential role in benzene-mediated hematotoxicity.  Chem. Res. Toxicol. 10, 859-865.