Publications

Paindelli C, Parietti V, Barrios S, Shepherd P, Pan T, Wang WL, Satcher RL, Logothetis CJ, Navone N, Campbell MT, Mikos AG, Dondossola E*. Bone mimetic environments support engineering, propagation, and analysis of therapeutic response of patient-derived cells, ex vivo and in vivo. Acta Biomater. 2024 Feb 20:S1742-7061(24)00096-5. * Corresponding author

Stanford SM, Nguyen TP, Chang J, Zhao Z, Hackman GL, Santelli E, Sanders CM, Katiki M, Dondossola E, Brauer BL, Diaz MA, Zhan Y, Ramsey SH, Watson PA, Sankaran B, Paindelli C, Parietti V, Mikos AG, Lodi A, Bagrodia A, Elliott A, McKay RR, Murali R, Tiziani S, Kettenbach AN, Bottini N. Targeting prostate tumor low-molecular weight tyrosine phosphatase for oxidation-sensitizing therapy. Sci Adv. 2024 Feb 2;10(5).

Hahn AW, Siddiqui BA, Leo J, Dondossola E, Basham KJ, Miranti CK, Frigo DE. Cancer Cell-Extrinsic Roles for the Androgen Receptor in Prostate Cancer. Endocrinology. 2023 Apr 17;164(6).

Soeung M, Perelli L, Chen Z, Dondossola E, Ho IL, Carbone F, Zhang L, Khan H, Le CN, Zhu C, Peoples MD, Feng N, Jiang S, Zacharias NM, Minelli R, Shapiro DD, Deem AK, Gao S, Cheng EH, Lucchetti D, Walker CL, Carugo A, Giuliani V, Heffernan TP, Viale A, Tannir NM, Draetta GF, Msaouel P, Genovese G. SMARCB1 regulates the hypoxic stress response in sickle cell trait. Proc Natl Acad Sci U S A. 2023 May 23;120(21).

Leo J, Dondossola E, Basham KJ, Wilson NR, Alhalabi O, Gao J, Kurnit KC, White MG, McQuade JL, Westin SN, Wellberg EA, Frigo DE. Stranger Things: New Roles and Opportunities for Androgen Receptor in Oncology Beyond Prostate Cancer. Endocrinology. 2023 Apr 17;164(6).

Parlani M, Boccalatte F, Yeaton A, Wang F, Zhang J, Aifantis I, Dondossola E*. Radium 223 induces transient functional toxicity in bone. J Nucl Med, 2022 Feb 17; jnumed.121.263310. Online ahead of print. *Corresponding author

Sarti M, Parlani M, Diaz-Gomez L, Mikos A.G., Cerveri P, Casarin S*, Dondossola E*. Deep learning systems for automated analysis of cellular and extracellular components of the foreign body response in multiphoton microscopy images. Frontiers in Bioengineering and Biotechnology, 2022 Jan 25;9:797555  *Corresponding authors
 

Paindelli C, Casarin S, Wang F, Diaz-Gomez L, Zhang J, Mikos AG, Logothetis CJ, Friedl, P, Dondossola E*. Enhancing Radium 223 treatment efficacy by anti-beta 1 integrin targeting. J Nucl Med. J Nucl Med. 2022 Jul;63(7):1039-1045   *Corresponding author

Shapiro D.D., Soeung M., Perelli L., Dondossola E., Surasi DS, Tripathi DN, Bertocchio JP, Carbone F, Starbuck MW, Van Alstine ML, Rao P, Katz MHG, Parker NH, Shah AY, Carugo A, Heffernan TP, Schadler KL, Logothetis C, Walker CL, Wood CG, Karam JA, Draetta GF, Tannir NM, Genovese G, Msaouel P.et al. “Association of High-Intensity Exercise with Renal Medullary Carcinoma in Individuals with Sickle Cell Trait: Clinical Observations and Experimental Animal Studies”. Cancers (Basel). Nov 30 2021;13(23):6022.

Bello T, Paindelli C, Shin S, Gomez Diaz L, Melchiorri A, Mikos A, Peter Nelson, Dondossola E* and Gujral T*. Computational modeling identifies multi-targeted kinase inhibitors as effective therapies for metastatic, castration-resistant prostate cancer. Proc Natl Acad Sci U S A, 2021 Oct 5; 118(40):e2103623118 *Equally contributed, corresponding authors

Casarin S and Dondossola E. An Agent-Based Model of Prostate Cancer Bone Metastasis Progression and Response to Radium223. BMC Cancer, 2020 Jun 29;20(1):605

Dondossola E*, Paindelli C. In vitro 3D modeling for prostate cancer, in Biomaterials for 3D Tumor Modeling (Elsevier), 2020, ISBN: 978-0-12-818128-7.  * Corresponding author

Paindelli C, Navone N, Logothetis CJ, Friedl P and Dondossola E*. Engineered Bone for Probing Organotypic Growth and Therapy Response of Prostate Cancer Tumoroids in vitro. Biomaterials, 2019, Mar;197:296-304. * Corresponding author

Dondossola E*, Casarin S, Paindelli C, De-Juan-Pardo EM, Hutmacher DW, Logothetis CJ and Friedl, P*. Radium 223-mediated zonal cytotoxicity of prostate cancer in bone. J Natl Cancer Inst., 2019 Oct 1;111(10):1042-1050.   * Corresponding authors

Dondossola E, Alexander S, Holzapfel BM, Filippini S, Starbuck MW, Hoffman RM, Navone N, De-Juan-Pardo EM, Logothetis CJ, Hutmacher DW, Friedl P. Intravital microscopy of osteolytic progression and therapy response of cancer lesions in bone. Sci Transl Med. 2018 Aug 1;10(452).

Sheth RA, Perkons N, Dondossola E, Subudhi SK, Gade TP, Tam AL. Patient-Derived Xenograft Tumor Models: Overview and Relevance to IR. J Vasc Interv Radiol. 2018 Jun;29(6):880-882.e1.

Dondossola E*, Holzapfel BM, Alexander S, Filippini S, Hutmacher DW, Friedl P*. Dissecting the foreign body response to biomaterials by non-linear intravital microscopy. Nat Biomed Eng. 2016 Dec 19; 1, 0007 (2016).   * Corresponding authors
 

Curnis F, Dallatomasina A, Bianco M, Gasparri A, Sacchi A, Colombo B, Fiocchi M, Perani L, Venturini M, Tacchetti C, Sen S, Borges R, Dondossola E, Esposito A, Mahata SK, Corti A. Regulation of tumor growth by circulating full-length chromogranin A. Oncotarget. 2016 Nov 8;7(45):72716-72732.

Bianco M, Gasparri A, Generoso L, Assi E, Colombo B, Scarfò L, Bertilaccio MT, Scielzo C, Ranghetti P, Dondossola E, Ponzoni M, Caligaris-Cappio F, Ghia P, Corti A. Inhibition of chronic lymphocytic leukemia progression by fulllength chromogranin A and its N-terminal fragment in mouse models. Oncotarget. 2016 Jul 5;7(27):41725-41736.

Dondossola E, Dobroff AJ, Marchiò S, Cardó-Vila M, Hosoya H, Libutti SK, Corti A, Sidman RL, Arap W, Pasqualini R. Self-targeting of TNF-releasing cancer cells in preclinical models of primary and metastatic tumors. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2223-8.

Mintz PJ, Rietz AC, Cardo Vila M, Ozawa MG, Dondossola E, Do KA, Kim JE, Troncoso P, Logothetis CJ, Sidman RL, Pasqualini R, Arap W. Discovery and horizontal follow-up of an autoantibody signature in human prostate cancer. Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2515-20.

Christianson DR, Dobroff AS, Proneth B, Zurita AJ, Dondossola E, Makino J, Kataoka K, Bologa CJ, Oprea T, Smith T, Yao VJ, Gershenwald JE, Sidman RL, Arap W, Pasqualini R.  Ligand-directed targeting of lymphatic vessels uncovers mechanistic insights mediating melanoma metastasis. Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2521-6.  

Dondossola E, Corti A, Sidman RL, Arap W, Pasqualini R. Bone marrow-derived CD13+ cells sustain tumor progression: A potential non-malignant target for anticancer therapy. OncoImmunol. 2014 Jan. 3:1, e27716.

Dondossola E, Rangel R, Guzman-Rojas L, Barbu EM, Hosoya H, St John LS, Molldrem JJ, Corti A, Sidman RL, Arap W, Pasqualini R. CD13-positive bone marrow-derived myeloid cells promote angiogenesis, tumor growth, and metastasis. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20717-22.

Guzman-Rojas L, Rangel R, Salameh A, Edwards JK, Dondossola E, Kim YG, Saghatelian A, Giordano RJ, Kolonin MG, Staquicini FI, Koivunen E, Sidman RL, Arap W, Pasqualini R. Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment. Proc Natl Acad Sci U S A, 2012 Jan 31;109(5):1637-42.

Dondossola E, Crippa L, Colombo B, Elisabetta Ferrero and Corti A. Chromogranin A regulates tumor self-seeding and dissemination. Cancer Research, 2012 Jan 15;72(2):449-59.

Veschini L, Crippa L, Dondossola E, Doglioni C, Corti A and Ferrero E. The vasostatin-1 fragment of chromogranin A preserves a quiescent phenotype in hypoxia-driven endothelial cells and regulates tumor neo-vascularization. Faseb Journal, 2011 Nov; 25(11):3906-14.

Dondossola E, Gasparri A, Colombo B, Sacchi A, Curnis F and Corti A. Chromogranin A restricts drug penetration and limits the ability of NGR-TNF to enhance chemotherapeutic efficacy. Cancer Research, 2011 Sep 1; 71(17):5881-90.

Roatta S, Passatore M, Novello M, Colombo B, Dondossola E, Mohammed M, Losano G, Corti A, Helle KB. The chromogranin A-derived N-terminal peptide vasostatin-I: In vivo effects on cardiovascular variables in the rabbit. Regul Pept. 2011 Jun 7;168(1-3):10-20.

Dondossola E, Gasparri A, Bachi A, Longhi R, Metz-Boutigue, MH, Tota B, Helle KB, Curnis F and Corti A. Role of vasostatin-1 C-terminal region in fibroblast cell adhesion. Cell and Molecular Life Sciences, 2010 Jun;67(12):2107-18.

Curnis F, Longhi R, Crippa L, Cattaneo A, Dondossola E, Bachi A and Corti A. Spontaneous formation of L-isoAspartate and gain-of-function in fibronectin. Journal of Biological Chemistry, 2006 Nov 24; 281(47):36466-76.