Selected Publications
2023
Shao N, Zhou Y, Yao J, Zhang P, Song Y, Zhang K, Han X, Wang B, Liu X*. A Bidirectional Single-Cell Migration and Retrieval Chip for Quantitative Study of Dendritic Cell Migration *Co-corresponding authors. Adv Sci 10(8):2204544. PMCID: PMC10015900
2022
Emam A, Wu X, Xu S, Wang L, Liu S, Wang B. Stalled replication fork protection limits cGAS-STING and P-body-dependent innate immune signaling. Nat Cell Biol 24 (7):1154-1164, 7/2022. E-Pub 7/2022. PMCID: PMC9924303.
2021
Ye Z, Xu S, Shi Y, Bacolla A, Syed A, Moiani, D, Shen C, Peng G, Leonard PG, Jones DE, Wang B, Tainer JA, Ahmed Z. GRB2 enforces homology-directed repair initiation by MRE11. Sci Adv 7(32):eabe9254, 8/2021. PMCID: PMC8336959.
Wu X and Wang B. Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage. Nat Commun 12(1):4373, 7/2021, PMCID: PMC8285526
Yamaguchi H, Kitami K, Wu X, He L, Wang J, Wang B, Komatsu Y. Alteration of DNA Damage Response Causes Cleft Palate. Front Physiol 12:649492, 3/2021. PMCID: PMC8039291.
2020
Chu Y, Yam C, Chen M, Chan L, Xiao M, Wei Y, Yamaguchi H, Lee P, Han Y, Nie L, Sun X, Moulder SL, Hess KR, Wang B, Hsu JL, Hortobagyi GN, Litton J, Chang JT, and Hung M-C. “Blocking c-Met and EGFR reverses acquired resistance of PARP inhibitors in triple-negative breast cancer". Am J Cancer Res 10(2):648-661, 2/2020, PMCID:PMC7061756.
Zhang P, Yao J, Wang B, Qin L. Microfluidics-Based Single-Cell Protrusion Analysis for Screening Drugs Targeting Subcellular Mitochondrial Trafficking in Cancer Progression. Anal Chem 92(4):3095-3102, 2/2020. e-Pub 1/2020. PMID: 31965790.
2019
Wu X, Liu S, Sagum C, Chen J, Singh R, Chaturevedi A, Horton JR, Cheng X, Bedford MT* and Wang B*. Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne. Genes Dev 33:1702-1717, 12/2019. PMID:31699778. *Co-corresponding authors
Zhang P, Han X, Yao J, Shao N, Zhang K, Zhou Y, Zu Y, Wang B*, Qin L*. High-Throughput Isolation of Cell Protrusions with Single-Cell Precision for Profiling Subcellular Gene Expression. Angew Chem. e-Pub 6/2019. PMID: 31188523. *Co-corresponding authors
2018
Kitami K, Kitami M, Kaku M, Wang B and Komatsu Y. BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development. PLOS Genetics 14(5):1007340, 5/2018. PMCID: PMC5951594.
Zhang H, Li HS, Hillmer EJ, Zhao Y, Chrisikos TT, Hu H, Wu X, Thompson EJ, Clise-Dwyer K, Millerchip KA, Wei Y, Puebla-Osorio N, Kaushik S, Santos MA, Wang B, Garcia-Manero G, Wang J, Sun S-C, and Watowich SS. Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 anti-inflammatory activity in hematopoiesis. Proc Natl Acad Sci USA 115(10):2311-2319, 3/2018. e-Pub 2/2018. PMCID: PMC5878002.
2017
Xu S, Wu X, Wu L, Castillo A, Liu J, Atkinson E, Paul A, Su D, Schlacher K, Komatsu Y, You MJ, Wang B. Abro1 maintains genome stability and limits replication stress by protecting replication fork stability. Genes Dev 31(14):1469-1482, 7/2017. PMCID: PMC5588928.
Paul A, Wang B. RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage. Mol Cell 66(4):458-472, 5/2017. PMCID:PMC5642944.
2016
Wu Q, Paul A, Su D, Mehmood S, Foo TK, Ochi T, Bunting EL, Xia B, Robinson CV, Wang B*, Blunder TL*. Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites. Mol Cell 61(3):434-48, 2/2016. e-Pub 1/2016. PMCID: PMC4747905. *Co-corresponding authors
Ling H, Hu X, Li S, Qiao F, Yao L, Cao Z, Li K, Ye F, Wang B*, Shao Z*. Evaluation of BRCA1 associated A complex with triple negative breast cancer susceptibility in Chinese women. Oncotarget 7(9):9759-72, 2016. PMCID: PMC4891082. *Co-corresponding authors
2014
Castillo A, Paul A, Sun B, Huang TH, Wang Y, Yazinski SA, Tyler J, Li L, You MJ, Zou L, Yao J, Wang B. The BRCA1-Interacting Protein Abraxas Is Required for Genomic Stability and Tumor Suppression. Cell Rep 8(3):807-17, 8/2014. e-Pub 7/2014. PMCID: PMC4149256.
2013
Tian F, Sharma S, Zou J, Lin SY, Wang B, Rezvani K, Wang H, Parvin JD, Ludwig T, Canman CE, Zhang D. BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade. Proc Natl Acad Sci U S A 110(33):13558-63, 8/2013. e-Pub 7/2013. PMCID: PMC3746927.
Desai S, Ding M, Wang B, Lu Z, Zhao Q, Shaw K, Yung WKA, Weinstein, Tan M, Yao J. Tissue-specific isoform switch and DNA hypomethylation of the PKM2 gene in human cancer. Oncotarget 5(18):8202-10, 9/2013. e-Pub 8/2013. PMCID: PMC4226677.
2012
Hu X, Paul A, Wang B. Rap80 protein recruitment to DNA double-strand breaks requires binding to both small ubiquitin-like modifier (SUMO) and ubiquitin conjugates. J Biol Chem 287(30):25510-9, 7/2012. e-Pub 6/2012. PMCID: PMC3408150.
Wang B. BRCA1 Tumor Suppressor Network: Focusing on Its Tail. Cell & Bioscience 2:6, 2012. PMCID:PMC3315748.
2011
Hu X, Kim JA, Castillo A, Huang M, Liu J, Wang B. NBA1/Merit40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36 containing complexes. J Biol Chem 286(13):11734-45, 4/2011. e-Pub 1/2011. PMCID:PMC3064225.
2009
Wang B, Hurov K, Hofmann K, Elledge SJ. NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev 23(6):729-39, 3/2009. PMCID:PMC2661606.
2008
Xiao A, Li H, Schecter D, Ahn SH, Fabrizio LA, Erdjument-Bromage H, Ishibe-Murakami S, Wang B, Tempst P, Hofmann K, Patel DJ, Elledge SJ, Allis CD. WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature 457(7225):57-62, 1/2009. e-Pub 12/2008. PMCID: PMC2854499.
2007
Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi S, Elledge SJ. Abraxas and Rap80 form a BRCA1 protein complex required for the DNA damage response. Science 316(5828):1194-8, 5/2007. PMID: 17525340.
Wang B, Elledge SJ. Ubc 13/Rnf8 ubiquitin ligase controls foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc Natl Acad Sci U S A 104(52):20759-63, 12/2007. e-Pub 12/2007. PMCID: PMC2410075.
2005
Adams MM, Wang B, Xia Z, Morales JC, Lu X, Donehower LA, Bochar DA, Elledge SJ, Carpenter PB. 53BP1 oligomerization is independent of its methylation by PRMT1. Cell Cycle 4(12):1854-61, 11/2005. PMID: 16294047.
2003
Stewart G, Wang B, Bignell CR, Taylor AM, Elledge SJ. MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature 421(6926):961-6, 2/2003. PMID:12607005.
Morales JC, Xia Z, Lu T, Aldrich MB, Wang B, Rosales C, Kellems RE, Hittelman WN, Elledge SJ, Carpenter PB. Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability. J Biol Chem 278(17):14971-7, 4/2003. PMID: 12578828.
2002
Wang B, Matsuoka S, Carpenter PB, Elledge SJ. 53BP1 a mediator of the DNA damage checkpoint. Science 298(5597):1435-8, 11/2002. PMID: 12364621.
Wang B, Kuspa A. CulB, a putative ubiquitin ligase subunit, regulates prestalk cell differentiation and morphogenesis in Dictyostelium spp. Eukaryotic Cell 1(1):126-36, 2002. PMCID: PMC118045.
1999
Wang B, Shaulsky G, Kuspa A. Multiple developmental roles for CRAC, a cytosolic regulator of adenylyl cyclase. Dev Biol 208(1):1-13, 1999. PMID: 10075837.
1997
Wang B, Kuspa A. Dictyostelium development in the absence of cAMP. Science 277:251-4, 1997. PMID:9211856.
1996
Li GD, Wang B, Chen ZY, Wang Y, Gong YT. The expression of HCG epitope fused to hepatitis B virus core antigen. (Chinese) 28(2):177-86, 1996. PMID: 12237700.
Sanchez Y, Desany BA, Jones WJ, Liu Q, Wang B, Elledge SJ. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271:357-60, 1996. PMID:8553072.