Research

Inhibiting Oxidative Phosphorylation: A Novel Strategy in Leukemia
RP140218                                                             Konopleva (PI)                                09/01/2014 – 08/31/2017
Cancer Prevention Research Institute of Texas - Individual Investigator Award
The goal of the portion of this proposal that my laboratory will be contributing is to employ hyperpolarized imaging of pyruvic acid with new OxPhos inhibitor in leukemia mouse models.
Role: Co-Investigator

Non-invasive Colonoscopy by Hyperpolarized Silicon Nanoparticles
RP150701                                                             Bhattacharya (PI)                           06/01/2015 – 05/31/2017
Cancer Prevention Research Institute of Texas - High Risk High Reward Grant
The goal of this project is to apply long lived signal from hyperpolarized 29Si nanoparticles for non-invasive MR imaging of the colon.

Metabolic Imaging of Brain Cancer Aggressiveness in Real-Time
2P50CA127001                                                   Bhattacharya (PI)                           09/01/2016 – 08/31/2017
Brain Tumor SPORE Developmental Research Project
The goal of this proposal is to strive to develop a real-time metabolic imaging platform in animal models of brain cancer in collaboration with Dr. Frederick Lang’s laboratory with the goal of translating this technique in the GBM patients.

Hyperpolarized Metabolic Imaging of Brain Cancer Therapy to Predict Outcome
2P50CA127001                                                   Bhattacharya (PI)                  09/01/2015 – 08/31/2016 NCE
Brain Cancer NCI SPORE Developmental Research Award
The goal of this proposal is to employ 13C hyperpolarization to evaluate efficacy of therapy in brain tumor mouse model.

Non-invasive Assessment of Ovarian Cancer Aggressiveness Using Real-time Hyperpolarized Metabolic Imaging
                                                                                Bhattacharya (PI)                           06/01/2015 – 05/31/2017
2015 Sprint for Life Research Award
The goal of this proposal is to employ hyperpolarized 13C pyruvate and fumarate to determine aggressiveness of the ovarian cancer.

Early assessment of ovarian cancer aggressiveness and therapeutic efficacy by real-time hyperpolarized metabolic imaging
Institutional Research Grant Program     Bhattacharya (PI)                           09/01/2015 – 08/31/2017
The major goal is to develop the capability of distinguishing malignant from benign masses and monitoring ovarian cancer therapy in real-time using a metabolic imaging toll based on hyperpolarization.

Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized Pyruvate
Koch Functional Imaging and Prostate Cancer Project   Logothetis (PI)     12/21/2015 – 12/20/2017
The major goal of this project is to evaluate sensitivity and specificity of an HP compound for detecting, staging and surveillance of prostate cancer and determining the efficacy of a therapeutic approach.
Role: Co-Principal Investigator

Therapeutic Targeting of Glioblastoma
Brain Tumor Moonshot Award                   Heimberger (PI)                             09/01/2014 – 01/31/2017
The University of Texas, MD Anderson Cancer Center
Major Goal: To develop imaging probes to distinguish inflammation from tumor growth.    
Role: Co-Investigator

Interdisciplinary Translational Pre/Postdoctoral Program in Cancer Nanotechnology
1T32CA196561-01                                             Sokolov (PI)                                      09/01/2015 – 08/31/2020
NIH/NCI
The major goal is to enhance the education of the next generation of young scientists in biomedical imaging research using nanotechnologies by combining training in fundamental aspects of nanoscience and nanotechnology with clinical questions faced in cancer imaging and therapy.
Role: Mentor

Hyperpolarized Metabolic Imaging of Prostate Cancer for Risk Stratification and Surveillance
                                                    Bhattacharya, Bankson, Kundra (PI’s)               07/01/2016 – 06/30/2019
General Electric Healthcare/Center for Biomedical Imaging
The goal of this proposal is to employ hyperpolarized pyruvate for prostate cancer risk stratification in preclinical mouse models of prostate cancer and prepare for clinical trial in prostate cancer patients at MD Anderson Cancer Center.
Role: Co-Principal Investigator

Early Detection of PanIN by Hyperpolarized Metabolic MR Imaging
16-65-BHAT                                                        Bhattacharya (PI)                           07/01/2016 – 06/30/2018
Pancreatic Cancer Action Network
Main Goal: To develop the capability of non-invasively detecting advanced pancreatic intraepithelial neoplasia (PanIN) precursor lesions in pancreas prior to invasive disease using metabolic imaging modality.

Targeted Molecular Imaging of Cell Death in Ovarian Cancer
1R21CA181994-01A1                                       Millward S., Lu Z.  (PI)                   02/03/2016 – 01/31/2018
NCI Exploratory/Developmental Research Grant Award
Main Goal: Develop targeted molecular imaging agents to visualize apoptosis and autophagy in vivo by PET and MRI.
Role: Collaborator (in year 2 only)