Selected Publications

2024

Ortega J, Wahba L, Seeman J, Chen SY, Fire AZ and Arur S. Pachytene piRNAs control discrete meiotic events during spermatogenesis and restrict gene expression in space and time. Science Advances, PMID: 39356768

Rogers CD, Amemiya C, Arur S, Babonis L, Barresi M, Bartlett M, Behringer R, Benham-Pyle B, Bergmann D, Blackman B, Brown CT, Browne B, Camacho J, Chabu CY, Chow I, Cleaver O, Cool J, Dennis MY, Dickinson AJ, Di Talia S, Frank M, Gillmor S, Haag ES, Hariharan I, Harland R, Husbands A, Jerome-Majewska L, Koenig K, Labonne C, Layden M, Lowe C, Mani M, Martik M, McKown K, Moens C, Mosimann C, Onyenedum J, Reed R, Rivera A, Rokhsar D, Royer L, Rutaganira F, Shahan R, Sinha N, Swalla B, Van Norman JM, Wagner DE, Wikramanayake A, Zebell S, Brady SM. Pluripotency of a founding field: rebranding developmental biology. Development. PMID: 38345109

2023

Reyes-Castro R, Chen SY, Seemann J, Kundu ST, Gibbons D, Arur S. Phosphorylated nuclear DICER1 promotes open chromatin state and lineage plasticity of AT2 tumor cells in lung adenocarcinomas. Science Advances: PMID: 37494452

Trimmer KA, Zhao P, Seemann J, Chen SY, Mondal S, Ben-Yakar A and Arur S.  Spatial single-cell sequencing of meiosis I arrested oocytes indicates acquisition of maternal transcripts from the soma. Cell Reports, PMID: 37227820

Furuta, T, Arur S. sart-3 functions to regulate germline sex determination in C. elegans. microPublication Biology. PMCID: 10189541

2022

Reyes-Castro R, Chen SY, Seemann J, Arur S. ERK-dependent DICER1 phosphorylation promotes open chromatin state and lineage plasticity to mediate tumor progression. bioRxiv 2022.11.01.514714; doi: https://doi.org/10.1101/2022.11.01.514714

Das D, Arur S. Regulation of oocyte maturation: Role for ERK Signaling. Molecular Reproduction and Development, PMID: 35908193

Vellano CP, White MG, Andrews MC, Chelvanambi M, Witt RG, Daniele JR, Titus M, McQuade JL, Conforti F, Burton EM, Lastrapes MJ, Ologun G, Cogdill AP, Morad G, Prieto P, Lazar AJ, Chu Y, Han G, Khan MAW, Helmink B, Davies MA, Amaria RN, Kovacs JJ, Woodman SE, Patel S, Hwu P, Peoples M, Lee JE, Cooper ZA, Zhu H, Gao G, Banerjee H, Lau M, Gershenwald JE, Lucci A, Keung EZ, Ross MI, Pala L, Pagan E, Segura RL, Liu Q, Borthwick MS, Lau E, Yates MS, Westin SN, Wani K, Tetzlaff MT, Haydu LE, Mahendra M, Ma X, Logothetis C, Kulstad Z, Johnson S, Hudgens CW, Feng N, Federico L, Long GV, Futreal PA, Arur S, Tawbi HA, Moran AE, Wang L, Heffernan TP, Marszalek JR, Wargo JA.  Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy. Nature. PMID: 35705814

Haversat J, Woglar A, Klatt K, Akerib CC, Roberts V, Chen SY, Arur S, Villeneuve AM and Kim Y. Robust designation of meiotic crossover sites by CDK-2 through phosphorylation of the MutSγ complex. Proc Natl Acad Sci. PMID: 35576467

Williams MK, Arur S. In preprints: buckling under pressure during gastrulation. Development. PMID: 35535741

Barish B, Senturk M, Schoch K, Minogue AL, Lopergolo D, Fallerini , Harland J, Seemann JH, Stong N, Kranz PG, Kansagra S, Mikati MA, Jasien J, El-Dairi M, Undiagnosed Diseases Network, Galluzzi P, Ariani F, Renieri A, Mari F, Wangler MF, Arur S, Jiang YH, Yamamoto S, Shashi S, Bellen HJ. The microRNA processor DROSHA is a candidate gene for a severe progressive neurological disorder. Hum Mol Genet 31(17): 2934–2950. PMID: 35405010

Das D, Trivedi S, Blazickova J, Arur S, Silva N. Phosphorylation of HORMA-domain protein HTP-3 at Serine 285 is dispensable for crossover formation. G3 (Bethesda) PMID: 35389463

Das D, Seeman J, Greenstein DI, Schedl T and Arur S*. Reevaluation of the role of LIP-1 as an ERK/MPK-1 dual specificity phosphatase in C. elegans germline. Proceedings of the National Academy of Sciences.  PMCID: PMC8784128

2021

Arur S, Briscoe J, Helariutta Y, Lecuit T and Roberstson L. Imaging development, stem cells and regeneration. Development, doi: 10.1242/dev.200137 PMID: 34596665

Trimmer KA and Arur S. CRISPR-edit point mutant allele detection (CEPAD)-PCR method for rapid screening of CRISPR edited point mutations. microPublication Biology PMCID: PMC7937030

An interview with Swathi Arur by Alex Eve, Development, 148, dev199366. doi:10.1242/dev.199366

2020

Das D, Chen SY and Arur S*. ERK phosphorylates chromosomal axis component HORMA domain protein HTP-1 to regulate oocyte numbers. Science Advances, Vol. 6, no. 44, eabc5580. PMCID: PMC7608811

2019

Minogue AL, Arur S*. In Situ Hybridization for Detecting Mature MicroRNAs In Vivo at Single-Cell Resolution. Current Protocols in Molecular Biology. e93 Vol. 127. PMCID: PMC6597187

Aryal NK, Pant V, Wasylishen AR, Rimel B, Baseler L, El-Naggar AK, Mutch DG, Goodfellow PJ, Arur S*, Lozano G*. Dicer1 phospho-mimetic promotes tumor progression and dissemination. Cancer Res. PMCID: PMC6522273 *Co-Corresponding Authors

2018

Aryal NK, Pant V, Wasylishen AR, Parker-Thornburg J, Baseler L, El-Naggar AK, Liu B, Kalia A, Lozano G*, Arur S*. Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo. Proc Natl Acad Sci USA. PMCID: PMC6338878  *Co-Corresponding Authors

Minogue AL, Tackett MR, Atabaksh E, Tejada G and Arur S. Functional genomic analysis identifies miRNA repertoire regulating C. elegans oocyte development. Nature Communications (9): 5318.

Furuta T,  Arur S.  GFP::PCN-1 does not reliably mark S phase in C. elegans adult germline progenitor zone cells. microPublication Biology.

Furuta T, Joo HJ, Trimmer KA, Chen SY, Arur S. GSK-3 promotes S-phase entry and progression in C. elegans germline stem cells to maintain tissue output. Development. 14;145(10). PMCID: PMC6001380

2017

Das D, Arur S. Conserved insulin signaling in the regulation of oocyte growth,development, and maturation. Mol Reprod Dev. Review. PMCID:

Burton NO, Furuta T, Webster AK, Kaplan RE, Baugh LR, Arur S, Horvitz HR. Insulin-like signalling to the maternal germline controls progeny response to osmotic stress. Nat Cell Biol. 19 (3):252-257. PMCID: PMC5332277

Chen JJ, Arur S. Discovering Functional ERK Substrates Regulating Caenorhabditis elegans Germline Development. Methods Mol Biol. 1487:317-335. PMCID: PMC5429971

2016

Gervaise AL, Arur S. Spatial and Temporal Analysis of Active ERK in the C. elegans Germline. J Vis Exp. (117). PMCID: PMC5226324.

Snee MJ, Wilson WC, Zhu Y, Chen SY, Wilson BA, Kseib C, O'Neal J, Mahajan N, Tomasson MH, Arur S*, Skeath JB. Collaborative Control of Cell Cycle Progression by the RNA Exonuclease Dis3 and Ras Is Conserved Across Species. Genetics. 203(2):749-62. PMCID: PMC4896191. *Co-Corresponding Author

McCallum KC, Liu B, Fierro-González JC, Swoboda P, Arur S, Miranda-Vizuete A, Garsin DA. TRX-1 Regulates SKN-1 Nuclear Localization Cell Non-autonomously in Caenorhabditis elegans. Genetics. 203(1):387-402. PMCID: PMC4858787

2015

Mattingly, HH, Chen, J, Arur, S*, Shvartsman, SY. A Transport Model for Estimating the Time Course of ERK Activation in the C. elegans Germline. Biophysical Journal. 109(11):2436-45. *corresponding author PMCID: PMC4675862

Arur, S. Context-dependent regulation of Dicer activity and small RNA production: implications to oocyte and embryo transition. Worm, 4(4). PMCID: PMC4826148

2014

Drake, M, Furuta T, Suen KM, Gonzalez G, Liu B, Kalia A, Ladbury JE, Fire AZ, Skeath JB, Arur S. A Requirement for ERK-Dependent Dicer Phosphorylation in Coordinating Oocyte-to-Embryo Transition in C. elegans. Dev Cell. 31(5):614-28. PMCID: PMC4261158.

Arur S, Tim S. Generation and purification of highly specific antibodies for detecting post-translationally modified proteins in vivo. Nature Protocols. 9(2):375-95. PMCID: PMC4124490

2013

Lopez AL 3rd, Chen J, Joo HJ, Drake M, Shidate M, Kseib C, Arur S. DAF-2 and ERK Couple Nutrient Availability to Meiotic Progression during Caenorhabditis elegans Oogenesis. Dev Cell. 27(2):227-40. PMCID: PMC3829605

Berkseth M, Ikegami K, Arur S, Lieb JD, Zarkower D. TRA-1 ChIP-seq reveals regulators of sexual differentiation and multilevel feedback in nematode sex determination. Proc Natl Acad Sci USA. 110(40):16033-16038. PMCID: PMC3791753

Suen KM, Lin CC, George R, Melo FA, Biggs ER, Ahmed Z, Drake MN, Arur S, Arold ST, Ladbury JE.  Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli. Nat Struct Mol Biol. 20(5):620-7. PMCID: PMC4059177

Putty K, Marcus SA, Mittl PR, Bogadi LE, Hunter AM, Arur S, Berg DE, Sethu P, Kalia A. Robustness of Helicobacter pylori infection conferred by context-variable redundancy among cysteine-rich paralogs. PLoS One. 8(3):e59560. PMCID: PMC3608669

2012

Yokoo R, Zawadzki KA, Nabeshima K, Drake M, Arur S, Villeneuve AM. COSA-1 reveals robust homeostasis and separable licensing and reinforcement steps governing meiotic crossovers. Cell. 149(1):75-87. PMCID: PMC3339199

2011

Arur S, Ohmachi M, Berkseth M, Nayak S, Hansen D, Zarkower D, Schedl T. MPK-1 ERK controls membrane organization in C. elegans oogenesis via a sex-determination module. Dev Cell. 20(5):677-88. PMCID: PMC3098718

Green RA, Kao HL, Audhya A, Arur S, Mayers JR, Fridolfsson HN, Schulman M, Schloissnig S, Niessen S, Laband K, Wang S, Starr DA, Hyman AA, Schedl T, Desai A, Piano F, Gunsalus KC, Oegema K. A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue. Cell. 145(3):470-82. PMCID: PMC3086541