Arur Laboratory
Swathi Arur, Ph.D.
Principal Investigator
Areas of Research
- Developmental Biology
- miRNAs
- ncRNAs
- Nutrition
- Meiosis
- Cancer Metastasis
Welcome to the Arur Laboratory. We use multidisciplinary approaches and model systems with a goal to gain knowledge into three specific biological questions. We hope to understand the basis of (i) environmental signaling and its role in female and male fertility, (ii) signaling and control of birth defects, with specific focus on Ras pathway and (iii) signaling-based control of post-transcriptional regulation on cancer metastasis.
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Research Focus
- Female and male germ cell development primarily in C. elegans
- Role of Ras signaling on embryonic morphogenesis in C. elegans
- Mechanisms of cancer progression and metastasis using mouse models and human cultured cells.
Research projects in the Arur Laboratory are focused on the following major areas:
- Unraveling the environmentally regulated mechanisms and molecules that control meiotic I progression in female germ cells. We use C. elegans as our model system for this work.
- Determining the role of small RNA pathways and post-transcriptional regulation during male and female germ cell development in C. elegans.
- Understanding the role of Ras signaling during embryonic morphogenesis in C. elegans.
- Identifying principles that regulate tumor progression upon signal-mediated regulation of post-transcriptional regulation rather than through the increase in mutational burden. We use mouse and cultured cells as models for this work.
Explore the various links on our web page and get to know us and our research. We welcome discussions; please contact us using our email address.
Meet the Team
From left to right: Jacob Ortega, Amelia Hongyuana, Janet Cheng, Han Bit Baek, Tokiko Furuta, Melany Puente, Lisa Watson, Nick Newkirk, Deba Das, Kenneth Trimmer, Shin-Yu Chen, Swathi Arur (PI).
Arur Lab News
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October 3, 2024
Congratulations to Jacob Ortega whose work on the identification of novel targets and regulatory mechanisms of small non-coding RNAs piRNAs is published today in Science Advances.
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August 7, 2024
Congratulations to Jacob Ortega on his very successful Ph.D. defense!
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July 12, 2024
Congratulations to Janet on her successful master's thesis defense today!
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March 28, 2024
Congratulations to Swathi for being inducted into the MD Anderson Cancer Center Academy of Health Science Education and conferred the title of MD Anderson Distinguished Educator.
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February 23, 2024
Congratulations to Han Bit Baek for winning the platform talk award at the Annual Department of Genetics Retreat!