Symptom Research Projects
In pursuit of its goals, the Department of Symptom Research employs a translational approach that ranges from bench to bedside and from bedside to bench. Our cross-cutting program integrates both preclinical and clinical research:
- Preclinical and translational research: The department's four Neuroimmunology Laboratories are conducting animal and in vitro studies to discover molecular and cellular mechanisms underlying the symptoms that develop in response to cancer and its treatment — for example, cognitive impairment, pain and fatigue. We are pursuing regenerative medicine and novel agents for treating neurotoxic symptoms.
- Clinical research: The department's Patient-Centered Analytics section engages in observational and interventional studies focused on educational, behavioral and medical interventions for cancer-related and treatment-related symptoms; creates methodologies for designing, validating, and deploying patient-reported outcomes assessment questionnaires; and develops innovative approaches that use machine learning and artificial intelligence to assess, analyze and predict patient outcomes.
Neuroimmunology
Laboratories
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Dantzer Lab
Researching the mechanisms of inflammation-induced sickness and depression-like behavior and cancer-related fatigue
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Grace Lab
Investigating adaptive immune mechanisms that initiate and maintain neuropathic pain after traumatic nerve injury
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Yuan Pan Lab
Seeking insights into the prediction, prevention, and treatment of nervous system cancer and neurological disorders
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Shepherd Lab
Investigating tumor-immune interactions in chemotherapy-induced peripheral neuropathy and musculoskeletal pain
Patient-Centered
Analytics
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Large Data Computation: AI & Machine Learning
Aligning cross-cutting methodologies (AI, data science, and patient-centered outcomes) in clinical practice/research
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Symptom Measurement: Surveys & Methodology
Developing and validating symptom assessment questionnaires in various languages and developing methods for their use
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Cancer-Related Symptom Burden
Using patient-reported outcomes to study symptoms, quality of life, and preferences for symptom control
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Cancer Treatment-Related Toxicity
Investigating the symptomatic and toxic effects of various therapies