Clinical Trials
A Randomized Trial Comparing a Ventilatory Strategy To Prevent Atelectasis versus a Lateral Decubitus Strategy During Robotic Bronchoscopy
2022-0756-"VESPA vs LADS", In the proposed randomized controlled trial, we aim to evaluate if LADS is superior to VESPA in preventing target-obscuring atelectasis during robotic bronchoscopy under general anesthesia. Strategies such as this to prevent atelectasis could improve diagnostic outcomes of peripheral bronchoscopy procedures.
A Pilot study to assess the Concordance Between MyBreathPrint Device results and Tissue Biopsy in patients with suspected lung cancer: Single center, single arm, prospective, observational design.
2024-1004- "VOCXI Health", The purpose of the study is to evaluate the concordance between MyBreathPrint (MBP) results and tissue biopsy findings, determine the predictive value of MBP and a NSCLC diagnosis within 6 months from enrollment, evaluate the utility of the MBP to provide actionable results in the study population, and determine the concordance between MBP and SOC chest imaging.
A Randomized Blinded Controlled Trial Of EXPAREL vs 1% Lidocane As Local Anesthetic In Patients Undergoing Pleuroscopy With Pleural Biopsy And Indwelling Pleural Catheter Placement
2019-0237 -" Exparel Study", This phase II trial investigates the effect of EXPAREL compared to lidocane as a local anesthetic in patients who are undergoing pleuroscopy with pleural biopsy and indwelling pleural catheter placement. This trial aims to see whether EXPAREL or lidocane is able to make patients more comfortable.
A randomized trial of alteplase versus placebo through an indwelling pleural catheter for management of non-draining malignant pleural effusions
2021-0554-" Alteplase", This will be a single-blinded randomized trial of patients with IPC who have evidence of significantly moderate to large symptomatic and septated pleural effusion with inability to drain fully.
A prospective observational cohort study of indwelling pleural catheters versus indwelling pleural catheters plus doxycycline pleurodesis for treatment of malignant pleural effusions
2017-0973 -" Doxy Study", This study is designed to obtain preliminary data comparing indwelling pleural catheters (IPCs) versus IPCs plus doxycycline for pleurodesis as treatments for malignant pleural effusion (MPE). The primary outcome is time to pleural catheter removal. Secondary outcomes include fluid recurrence after IPC removal, assessment of symptom burden, complications, and quality-adjusted survival.
A multicenter study in bronchoscopy combining Stimulated Raman Histology with Artificial Intelligence for rapid lung cancer detection - The ON-SITE study
2022-0400-" ON-SITE", A study in bronchoscopy combining Stimulated Raman Histology with Artificial Intelligence.
Predictive biomarkers for pneumonitis after chemoradiotherapy and immunotherapy
2020-0889- "Pneumonitis Study" To assess the association between the incidence of concurrent chemoradiation and subsequent immunotherapy-related adverse events, particularly radiation and immune-related pneumonitis, in patients with non-small cell lung cancer (NSCLC), and various clinicopathologic, radiologic, tumor, and demographic covariates of interest.
Evaluating clonogenic epithelial cell populations in patients with bronchiolitis obliterans syndrome
2020-0325-" Clonogenic Study with UH", This is a prospective pilot study of epithelial cell phenotypes in two distinct patient populations with BOS. Patients who need bronchoscopy will be enrolled from the clinic or the inpatient pulmonary consultation service at MDACC and from the clinic at Houston Methodist. Bronchoscopy will be performed as per usual institutional protocols. Airway brushings will be obtained using a disposable cytology brush. These brushings will be performed in three unique sub-segments that show no evidence of pulmonary infection, using a separate cytology brush for each sub segment. Brushings will be performed by gently making and forth motions with the brush along the airway and simultaneously moving in a circumferential fashion around the airway. The risk associated with bronchial brushing is minor bleeding limited to the site of brushing, which occurs in less than 1 in 100 patients undergoing the procedure and is self-limiting.
The Longitudinal Impact of Respiratory Viruses on Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Cell Transplantation (The RV-BOS Study)
2022-0033-" The RV-BOS", This protocol describes a multi-center prospective observational study to test the association of respiratory viruses with the development and outcomes of bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic cell transplantation (HCT). The data collected from this study will help elucidate the clinical and physiologic characteristics of early disease and has the potential to inform clinical practice.
Hyperpolarized 129-Xenon Imaging in Adult Hematopoietic Cell Transplant Recipients with Pulmonary Impairment
2020-1170-" XeMRI Study", This study is designed to measure the correlation of hyperpolarized 129-Xe magnetic resonance imaging (129-XeMRI) in allogeneic hematopoietic cell transplant (allo-HCT) recipients at MD Anderson Cancer Center (MDACC) who develop bronchiolitis obliterans syndrome (BOS) or BOS stage 0p (pulmonary impairment not meeting the definition for BOS, defined below) and controls with chronic graft-versus-host disease (cGVHD).
Parametric Response Mapping (PRM) for the detection of chronic lung injury in hematopoietic cell transplant recipients. A multi-center, observational trial.
2023-0248-"PRM BOS", The study focuses on evaluating Protein Reactive Marker (PRM) profiles to predict chronic lung disease (CLD) and lung function decline in patients who have undergone hematopoietic stem cell transplantation (HCT). Cohort 1's primary objective is to correlate PRM profiles at the onset of chronic graft-versus-host disease (GVHD) with progression to CLD over 12 months, with a focus on 1-year CLD-free survival. Cohort 2 aims to assess PRM profiles as predictors of lung function decline in established CLD patients, with the trajectory of FEV1 decline as the primary endpoint. Secondary objectives include characterizing PRM profiles in children with chronic GVHD and correlating these with survival outcomes, as well as profiling CLD in children and restrictive lung disease in adults post-HCT. The exploratory objective is to develop a combined biomarker strategy for predicting CLD in allogeneic HCT recipients, using serologic biomarkers, pulmonary function tests, and PRM measurements.
Exploring the role of nasal mucosal inflammation on the development of lung graft-versus-host disease
2022-0577- "Nasosorption", Our primary hypothesis is among patients who have not yet meet the criteria for BOS but are high risk for BOS, that the development of nasal inflammation will coincide with the development of early pulmonary impairment in patients who subsequently develop BOS (preBOS), but not in patients who subsequently do not develop BOS or in patients who have no pulmonary impairment. An secondary hypothesis is that among patients who develop new-onset BOS, the degree of nasal inflammation will be lower than in those with preBOS and will decline over time. An exploratory hypothesis is that in all patients, the degree of nasal inflammation will decline over time.